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  • Fractional Flow Study

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    shafiscfhs2023
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    Fractional Flow study

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    7 views17 pages

    Fractional Flow Study

    Uploaded by

    shafiscfhs2023

    Copyright:

    © All Rights Reserved
    Download as PDF or read online from Scribd
    Flag for inappropriate content
    Download as pdf
    of 17
    weounes Fractional Flow Reserve-Guided PCI as Compared with Coronary Bypass Surgery. (Chock Full Ton Access @ Meals Lary and ied. 20PC 20a 20m ard 20h 70C ornary 208 yea 20Suraer A les The 2ONw'0Enoland aural: 200P470madiineBh fora 53344068 dt Abstract Patients with three-vessel coronary artery disease have been found to have better outcomes with coronary-artery bypass grafting (CABG) than with percutaneous coronary intervention (PCD), but studies in which PCI is guided by measurement of fractional flow reserve (FFR) have been lacking {In this multicenter, international, noninferiority trial, patents with three-vessl coronary artery disease were randomly assigned to undergo CABG or FFR-guided PCT with current-generation zotarolimas-cluting stents The primary end point was the oecurrence within I year of a major adverse cardiac or cerebrovascular event, defined as death from any cause, myocardial infarction, stroke or tepeat revascularization. Noninferiority of FFR-guided PCT to CABG was prespecified as an upper boundary of less than 1.65 forthe 95% confidence interval of the hazard ratio, Secondary end points included a composite of death, myocardial infarction, or stoke; safety was also assessed. ‘A total of 1500 patients underwent randomization at 48 centers, Patients assigned to undergo PCT received a mean (48D) of 3.74.9 stents, and those asigned to undergo CABG received 3.41.0, distal anastomoses. The 1-year incidence ofthe composite primary end point was 10.6% among, patients randomly assigned to undergo FFR-guided PCI and 6.9% among those assigned to ‘undergo CABG (hazard ratio, 5; 95% confidence interval [CI], 1.1 to 2.2, findings that were not consistent with noninferiority of FFR-guided PCI (P =0.35 for noninferiority). The incidence of

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