Chemo therap

Use ef drugs to xi
with seleetive to xicit
ciby agonist

Parasike Ex kTnal In esmal

Imuadimg
Bachtrio Cam ce

Chemo theraP) Fum

.PYoto30a
VinU5
Specics spe ci Fic
.Helcmimhe
Chemo neceptov3
PAUL Ehrlich

Basic Psinciple
Biochemical ditfereme -DiFferential Sensilivity

Cell wall Peptideglycam nOHFR Sensii vity

m -
Bactrio
Ribosome 50s 30s T7imehopri
achial
r
Primehamime P Tolgea
- 14 uma m
methohre xak

Compro mised
I mmumo
opportunis tic imfecbion
Clos hidium difFicile

Supe7 i n fection
Coltis)
(Pseudomem bra
mous

:Esophagea Can didiasis

Hospital- acquived imfection

Nosocomial im tection

Staphylo co ccus auyeus

PsevdommaS aerugimo3a

UTT
 Antimicrobial flgents - heneral Principles
Superin fection: A ppearance of ew infection as a

resolt of amtimicYobial thero?

therapy

Broad sgechum Anti biotics Teratytyelimes, Chloramph

cillim) may
Emico Climdomyeim, amimoglyco sides&ampi
oimal tlota amd Tesolt im the developm ent
Kill he
of me imfeetion.

muolved aYe Camdida albitans

The OYgamism

C.d Supevimfeebion may vesolE

Closhidoo diFFicile (C-d).
im Psevdomembranous Colitis for which me honida3ole

is he dvug of choile.
Floia Ui: k Coagulation .
Loss ot Commn

ComcemhaBiom De pern dent iing COK

effect of drug is high when raio of

Kiing a

Comcenbation to mIC is move

Peak

A minoalytosides FluoTOquimolomes
Betler action whem used as a large simgle dose.

Time Dependen uiling TOk

time
Amlimicobial action depends on the lemgth of

above tht mT.

the hat ion Yemaims
Com(en
B-1actoms e m acrolide3.

Moltiple darly doses ave preteyed.

Post Amtibiotic Effect
Amibiotics exert their action even afhey heiy
Com cen balion fallen below MIC
amtimi(vo bials have lomg PAE
Mos of the (a115 hs)
Rifampi cim Prolongs the PAE F isoniazid.

Oue to this Yea Som is0miazid Can be given thrice

weekly whem iven a ¥im Rifampicim

Momofhesa py ef isomiazid meeds daily adminishation.
 Pemicillin Classification
Pemicillin U
xaci llin
Qicloraillin
Mot oral VODCA Clokacillin
Am Picil1im

Pemicillim G Shot acting -Bemza hine PrOcaimne

NaTTOW Spec Amino P: Ampicillin Amoricillin
Resistamce Carboy P: Canbemiillin
Cloxacillin
Ureido P: Aglo cillin Piperacillin
Oxacillin

Nafcillim
B-laetamase inhibts
Oicloxacillim
Me hicillin Clauulamic aud

Su lbattam

methicillim - Nephvitis 7agebatham

af cillim Neyhopemia
Ampici m Diavthota
PTe Cam Seigure
 Pemic; llins

R-C-N
N
COOH

azetidimome
Thiazolidine
- 6en3y' penicilin
Peniciin
penicillin
Natural Pemicilim V
-

phemoxgmc hg

Sem Sym hebic Penicillins

mehicillin
Pemicilima se PesisBamt
la fcillim
Porem teral

Pemicillinase Tesistamt
Oxacillin

Oicloxacillin
OT al

Semsiliue
Carbenicillin Mezlodli n
Pemici linase
TicaTci11im Piperacillin
Parwn tral
B7oad 5peC,

Penicillanse Semsiti ve Ampicilin

Am Kici llin
al
BTad Spe C,

Pemicillim
Pro Caime
yo A
me
cai Bem3 Pemicllin

Reposilo Benza hime

Depot Tm]

imhibiBav
Clavolamid atid
B- lactamast
Syl bat lam
Tag o baclam

PiUampicillin alampicillin
PTodTU B acampicillin
(Aro i ci Mn 0Y0dvua )
 mupio cim
umupYistim/
Dalfeprishin
Tehatyelime
Chlnamp hewco)
A moind gloe sde
Marolidt
Lime 3olid

Pteridimc + PABA
7
-0 OPS
Sulfa
drugs 0HF
DHFR

TT
meTheprin
THF Rifampin
ONA

FluoToGuimolime

Polymyain
B-lactams Vamcomycim
Colistim
Penicilion Bacihacim
Ch closeime
Oaptomycim
Cephalospmin Amphokri cim B
Mono battam Isomiogid yrazinam de
Canbapemem
 Trimelhoprim Ohydrophnoic aid
AlH2
.oCH3
o CH 0ihydro fo lic aud
N T
6CH3
Te ra hydo folic aud

Therapeutic Applications
UTI
Simge agemt-Umcomplicahtd
Co trimoxazole I5 Pixed rahio sulfame hoxazale

Bachimm
UTI, shigellosis,
otitis media,
Sepha Trauelers
diavhea Pmtumotyhi tis
Pneumom/a.

Navsea Ugomiim
AduTse Rash

Guinolomes luaoquinolomes

moA GuimoloNES are

bactericida, laraely as a

Com seguemce oF imhibition of DuA 39rase amd

topoisomemase V -

Key bacterial engymes that dica

the COm frimatiom.

altrs he
NA 0y7ase degree of twistimg of 0NA by
ONA
imhodueim megative Superco ils elasimg bemoi0m al
shess im the omolecole

ONA topoísomra5e 1V detakmats (umties) emchained

dugh DNA mlecoles produced through neplicahion of

Cinculav DuA