Explain the process of rational drug design, highlighting the key steps

MSC OC 4TH SEM Medicinal involved in target identification, lead compound generation, and
Chemistry optimization. Provide examples of successful drugs developed through
rational design in the field of medicinal chemistry.

Briefly explain the mechanisms of competitive, non-competitive, and

MSC OC 4TH SEM Medicinal uncompetitive enzyme inhibition. Provide examples of drugs that utilize
Chemistry each of these inhibition strategies and their therapeutic applications in
medicinal chemistry.

Describe the process of isolation and purification of natural products from

their sources. Provide an overview of the various techniques and methods
MSC OC 4TH SEM Chemistry of used, highlighting the importance of each step in obtaining pure and
Natural Products structurally characterized compounds.

Discuss the biosynthetic pathways of terpenoids and alkaloids. Include the

key enzymatic reactions, intermediates, and regulatory steps involved in
MSC OC 4TH SEM Chemistry of the formation of these natural products. Highlight any recent
Natural Products advancements in understanding these biosynthetic pathways.

Explain how the nature of the metal center in an organometallic

MSC OC 4TH SEM compound can significantly impact its reactivity and selectivity in various
Organometallic compounds reactions. Provide examples of organometallic compounds with different
metal centers and their respective reactivity differences.

Discuss the pivotal role of organometallic compounds as catalysts in

MSC OC 4TH SEM organic synthesis. Highlight specific examples of reactions that are
Organometallic compounds catalyzed by organometallic complexes, explaining the mechanisms
involved and the advantages they offer over traditional organic catalysts

MSC OC 4TH SEM Pericyclic Explain the Woodward-Hoffmann rules and their significance in predicting
Reactions Free Radicals and the stereochemistry and regiochemistry of pericyclic reactions. Provide
Photo Chemistry specific examples of reactions where these rules are applied.

Discuss the mechanistic differences between thermal and photochemical

pericyclic reactions. Highlight the factors that influence the selectivity and
MSC OC 4TH SEM Pericyclic efficiency of photochemical reactions in organic synthesis, with relevant
Reactions Free Radicals and case studies.
Photo Chemistry