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Natural Way of Reversal of Ageing Process
Natural Way of Reversal of Ageing Process
REVERSAL OF
AGING PROCESS
Etiopathogenesis
The causes of ageing are uncertain.
Recent theories are assigned to the damage concept,
whereby the accumulation of damage (such as DNA
oxidation) may cause biological systems to fail, or to the
programmed ageing concept, whereby internal
processes (such as DNA methylation) may cause ageing.
My Aetiology
My Aetiology Based on following:
Sirtuins Pathway
Telomere
Oxidation of DNA
Sirtuins Pathway
Sirtuins are a class of proteins that possess either Mono-ADP.
Ribosyltransferase or Deacylase activity.
Sirtuins have been implicated in influencing a wide range of cellular
processes like aging, transcription, apoptosis, inflammation and stress
resistance.
Sirtuins activity is inhibited by nicotinamide, agents to treat degenerative
diseases such as cancer, diabetes, atherosclerosis, and gout.
DIABETES: Sirtuins have been proposed as a therapeutic target for
type Il diabetes mellitus.
INFERENCE
Many datapreented in the literature show Sirtuins as a powerful tool in
anti ageing mediine/approach.
Naturalcompounds present in the diet, classed asfunctional food /
Nutraceutics,could be aninvaluable elernent of anti-ageing prophylactics
or even intervention.
Such compoundsare nontoxic, easy touse and commonly available and
could be included into a normal diet for long lasting supplernentation.
Telomere
A
telomere is a region of
repetitive nucleotidesequences at each endof
achromosome,which protects the end of the
chromosomefrom deterioration orfrom fusion
with neighbouring chromosomes.
Over time, due to each celldivision, the telomere ends become shorter.
Telomeres are repetitive nucleotide sequences located at the termini of
linear chromosomes.
Telomeres shorten in part because of the end replication problem that is
exhibited during DNA replication.
Itis becoming apparent that reversing shortening of telomeres through
temporary activation of telomerase may be apotent means to slow aging.
Measurement of Telomere
Dr. Panda Says:"LONGER THE TELOMERE = LONGER THE LIFE SPAN"
Real-Time PCR assayfor telomere length involves determining the
Telomere-to-Single CopyGene (T/S) ratio, which is demonstrated to be
proportional to the average telomere length in a cell.
C Telomeres play acentral role in cell fate and aging by adjusting the cellular
response to stress and growth stimulation on the basis of previous cell
divisions and DNA damage.
5
At least afew hundred nucleotides of ftelomere repeats must
chomosome end to avoid activation1of DNA repair
pathways. "cap each
or Repair
citically short or "uncapped" telomeres by telomerase of
is limited in most somatic cells
triggeredIwhen too many "uncapped"
and apoptosis or cellular
recombination
senescence is
telomeres accumulate.
The chance of the latter increases as the average
telomere
decreases. The average telomere length is setcand length
the germline which typically express high levels of maintained in cells of
telomerase
In somatic cells, telomere length is very heterogeneous but1
declines with age, posing a barrier to tumour growth but typically
to loss of cells with age. calso contributing
Loss of (stem) cells via telomere attrition
provides strong selection for
abnormal and malignant cells, a process facilitated by the genome
instability andaneuploidy triggered by dysfunctional telomeres.
The crucial role of telomeres incell
Datients with 50% of normal telomeraseturnover and aging is highlighted by
one of
levels resulting from a mutation in
the telomerase genes.
Short telomeres in such patients are
implicated in a variety of disorders
including dyskeratosis congenital, aplastic
and cancer. anaemia, pulmonary fibrosis,
Here the role of telomeres and
associated diseases is reviewed.
telomerase in human aging and aging
INFERENCE
Sufficient data is there loss of telomere repeats in
(stem) cells and
lymphocytes contributes to human aging. This notion is widely accepted.
However, studies of model organisms as well as
mutations have shown that short telomeres resultpatients with telomerase
in dire consequences.
It seems plausible that, with age, the
of cells in normal individuals is proliferation of an increasing nume
each time acell divides, the compromised progressive telomere loS
by
When they get too
telomeres get shorter.
short, the cell can no longer divide; it becomes inactive
or"senescent" or it dies.
This shortening process iS associated with aging, cancer, and ahigher risk
ofdeath. So, telomeres also have been Compared with abombfuse.
you can protect and lengthen your telomeres with meditation, exercise,
and adiet full of
healthy fats and vegetables.
OXIDATION OF CELL
Aconstant accumulation of oxidized proteins takes place during aging
Oxidation ofproteins leads to apartial unfolding and. therefore. to
aggregati0n. Protein aggregates impair the activity of cellular proteolytic
systems proteasomes, lyso5omes), resulting in further accumulation of
oxidized proteins.
in addition, the accumulation of highly crosslinked protein aggregates
leads tofurther oxidant formation, damage to macromolecules, and,
finally, to apoptotic cell death. protein oxidation seems to play a role in the
development of various age-related diseases, for example,
neurodegenerative diseases.
The nerVOus system seems to be very susceptible to oxidative damage due
to the high oxygenconsumption
INFERENCE
miunder
sfoldisntganding
cause of diseases associated with excessive he
protein
degradation leading to loss of-tunction phenotypes, as well as and
aggregation associateddegenerative disorders
Cellular proteostasis is key to ensuring successful
development, healthy
aging. resistance to environmental
stresses, and to minimize
INTERVENTION IN PROTEOSTASIS
homeost asis
There are two main approaches
1) Pharmacologic chaperones, (2)
Proteostasis regulators
Pharmacologic chaperones
The balance between protein
synthesis, folding, and degradation is a
closelymonitored and highly dynamic process that is critical to maintan
cellular protein homeostasis, i.e., Proteostasis.
PCT(pharmacological chaperone therapy) appears to have the potentiai o
address some of the medical needs currently available therapies.
Proteostasis Network
Synthesis Folding
Degradation
ALP UPS
HOW TO REVERSE AGEING PROCESS BY
FOODS SUPPLEMENTATION
Sirtuins foods (SIRTFOODS) are having enormous health benefits. These foods
causes incIease in longevity and quality of life:
BLUEBERRY IS THE BEST SUPERFRUIT IN THE WORLD
Blueberry and Heart
The antioxidants in blueberries are
strongly linked to reduced levels of
oxidized LDL. A2-ounce (50-gram)
serving of blueberries lowered LDL
Oxidation by 27% over eight weeks
in obese people whowere obese.
Prof Pandaexplains that
anthocyanins "circulate in the
blood as phenolic acid
metabolites." Ifthe changes we
saw in blood vessel function after
eating blueberries every day could
be sustained for a person's whole
life,it could reduce their riskof
developing cardiovascular disease
by up to 20 %. My findings support This means that blueberries can reduce
past research that shows the
antioxidant-packed berries lower inflammation, whichreduces the risk of
cholesterol and improve how the brain aging and neurodegenerative
arteries function. disease.
intelligence. CKD/Transplant.
9
Blueberry and Eye Green Tea
Eating blueberries regularly can Green Tea is now
improve visionand strengthen
blood vessels in the back of the beverages next towidely
water. consuTTne
It
Complex, Folic acids, cortains B
eyes. Blueberries alsocontain
anthocyanins, which help lower Manganese,
Pototherassium, Magnesium,Caffeine and
both high blood pressure and anti-Oxidants, It
loss, Reduces causes Weight
disease.CholPrevents
esterol, Combat Cardi,
inflammation and also prevent vascular
blockages in the arteries that
feed oxygen to the retina.
Blueberryand Sex
Cups of Tea per day is
,Dermentia.;
good.
Parsley/Dhania Leaves
Worlds Popular herbs. Leaves
contains Zero Cholesterol andFat
rich inAnti-Oxidants, Minerals.
Contains volatile ol, Flavonoids
and Vit K.
13
Walnuts or Commonly
Referred as 'AKHROT'
HEALTH BENEFITS
Pomegranat
Pomegranates aree among the
healthiest fruits on Earth. They
powerful
been that
re so
found to pomegranat e juicethehas
have three times
antGreenioxiTea.dantItactivity
can
of red wine
and
reduce aging process.
14
Chilli
The chili pepper is the foit of plants
from the genus Capsicum which are
members of the nightshade fanily.
Chilipeppers also improve
inflammation and reduce blood
pressure and oxidative stress. Thus
reduces aging Process.
Vitamin C
It Causes cellular Improvement. VITAMIN
Vitamin C can only increases the
muscle and fat atrophy that shrivels
our skin as we get older. It has got a
tremendousanti-ageing property.
Calorie restriction(CR)
by30-40% that is 1000 to 1200
Kcal/Day
Ginseng
It is the root of plants in the
genus Panax, such as Korean
ginseng (P. ginseng), South China
American
ginseng (P. notoginseng) and
ginseng (P. quinquefolius), typicaly
characterized by the presence
of ginsenosides and gintonin.
BENEFITS
Inflammation and aging.
Potent Antioxidant That May Reduce
May Benefit Brain Function.
Could Improve Erectile Dysfunction.
May Boost the Immune System.
Cancer.
May Have Potential Benefits Against
Levels.
May Fight Tiredness and Increase Energy
CouldLower Blood Sugar.
15
ANTIOXIDANTSREVERSES AGEING
Boost yourintake of a vaiety of antioxidants withthese
healthyfoods The
followingis alist of ditteent kinds of antioxidants.s andfoods
.that have high
Alliumsulphur compounds:
Leeks, onions. garlic
Anthocyanins:
Eggplant. gapes, beries
Beta carotene:
Pumpkin, mangoes,apricots,
carots, spinach, parsley
Catechins:
Red wine, tea
Copper:
Seafood, lean meat, milk,
nuts, legumes
Cryptoxanthins:
Redpeppers, pumpkin, Manganese:
mangoes Seafood, lean meat,milk, nuts
Flavonoids: Polyphenols:
Tea, green tea, red wine, citrus Thyme, oregano
fruits, onion, apples Selenium:
Indoles:
Seafood, offal, lean meat,
whole grains
Cruciferous vegetables such as
broccoli, cabbage, cauliflower Vitamin C:
Oranges, berries, kiwi fruit.
Lignans: mangoes, broccoli, spinach.
Sesame seeds, bran, whole peppers
grains, vegetables
Vitamin E:
Lutein: Vegetable oils, nuts, avocados,
Corn, leaty greens (such as seeds, whole grans
spinach)
Zinc:
Lycopene: Seafood, lean meat, milk, nuts
Tomatoes,pink grapefruit, Zoochemicals:
watermelon Offal, fish
161
COMMONLY USED ANTIOXIDANTS
1. Blueberries 10. Carrots 19. Almond
2. Avocado 11. Red Cabbage 20. Turmeric
3. Pomegranates 12. Spinach 21. Garlic
4. Watermelon 13. Cucumber 22. Salmon fish
5. Tomatoes 14. Sweet Potatoes 23. Olive Oil
6. Figs 15. Mushrooms 24. Beans
7. Strawberries 16. Brinjal 25. Walnut
17
2. SPINACH
18
BLUBERRIES
4.
Research shows that those with higher levels
ofantioxidants such as Vitamin C, Eand
selenium tend to have longer telomeres.
Eruits and vegetables are the best sources of
antioxidants, which is why a plant based diet
is highly recommended.
Sodon' tstop at berries when seeking anti
xidizing ettects: carrots, Sweet Potato, yams,
winter squash andgreen leafy vegetables are
packed with them.
Tomatoes, citrus, cantaloupe and potatoes
with skins provide plenty of Vitamin C. Soy,
nuts,and seeds offer Vitamin Eand whole
grains provide selenium,
5. OATS
0atmeal offers an added boost of health
promoting fiber.
Other ways to get your fiber: whole grains of
various types, vegetables, fruit, beans and
lentils. add 1 1/2 tablespoons of chia to my
morning oatmeal--about 3 grams can lengthen
the telomere can increase lifespan.
Put the milk, cinnamon and oats in asmall pan
and heat it take as food can increase your life
Span.
VLCD (Very Low calorie Diet):
While 1,200is the minimum level of calories
that the average person can survive on
without the body going into starvation mode
and stay healthy.
People who have a strenuous fitness routine or
perform many daily activities need more
calories. fyou have reduced your calorie
intake below 1,200 calories a day, you could be
hurting your body in addition to your weight
loss plans.
19
YMPHATIC MASSAGE OF WHOLE BODY &GENITALS
thythmiccal massage
dranageis a gentle, treatment
iymphatic
byaspevill trainedlvnphatic massage therapist to stimulate the
cculation of lvmph
luid around the bodv perlomed
This helpsto rapidlyspeed upthetemovall of wastes and toxins from a
sluggishlymphatic system Aging induces the tbasal activation of per
restrictingthe immune the recruitment
Lvmphatic mast cell of
cells and aftecting the reactionto acute inflammation.
immune systemare manifest on
immune
The effect of aging on the
that includes reduced production of B&Tcells in bone marrow andlevels multiple
thymus and diminished function of mature lymphocytes.
In elderly individuals do not respond to immune challenge asrobustly
the young. Lymphatic massage is non-invasive and generally
a,
safe. as it is focused on soft to moderate stretching of the skinconsidered
Lymphedema Arthritis
Diabetes Irritable Bowel Syndrome (1BS)
Fibromyalgia Migraine episodes
Swelling or oedema Can benefit yoursexual health
Skin disorders (|USED TO ADVICE DIABETES WITHED)
Fatigue Loss of Libido In Female
Insomnia ProstatiC Massage can Reduce Chance
Stress of Prostate Cancer
Digestive problems
It is my advice for all wholebodyandgenitals.
diabetes patient to have regular Lymphatic Massage
Consult me regarding the process particularly Spa &Massage
Cente.
201
SEX AND AGING
Sex reduces aging process by
releasing Anti Aging hormone
Oxytocin andregular sex increases
oestrogen stave off dryness and
improves the elasticity. Over 70
years Iused to give E-Drive COne
tablet once daily for 3 months
along with Himcolin ointment
plus Olive oil over the both the
testes,Squeging Midtesticular
skin, Message to Glans by his wife
or message therapist, then whole
penis. For Ladies with olive oil
message to Pubic area,whole
Labia Majora,Clitoris and l inch of
Vagina bya Female therapist.
HIFUTREATMENT
A
high intensity focused ultrasound facial, or HIFUfacial for short, is a
non-invasive treatment for facial aging. It uses ultrasound energy to
encourage the production of collagen, which results in firmer skin. Several
smallclinical trials have found HIFUto be safe and effective for facial
lifting and refining wrinkles. People were able tosee results in afew
months after treatment, without the risks associated with SURGERY.
The procedure is best suited for clients
between the ages of 30- 75 years, who
have mildto moderate skin laxityor
INFERENCE
Eat a lot less,
looseness, andwho are looking todelay Iive alot
the skin's natural ageing process. HIFU longer, says Ias a
stands for high intensity focused Scientist who clai
that consSuming as
ms
ultrasound and is an innovative,
painless and non-invasive way to reduce little as 600
wrinkles that can last up to two per day addscalories
years and is skin-friendly. lifespan. years to
High intensity focused ultrasound Ifyou want to
add
(HIFU) technology for vaginal serious
life, you
years to your
rejuvenation can help women to restore need to cut
the youthful elasticity and
moisture of serious calories from
their vaginal walls, reducing your diet.
uncomfortable
them to feel likesymptoms and allowing Experts yesterday
themselves once again. revealed
Results last between 18 months and3 that anorexics are
years with yearly top ups addicted to low
recommended. We advise that clients
avoid sexual intercourse for at
calorie food.
hours after the treatment and
least 72 They say it explains
for 24 hours. HIFU adds exercise why those suffering
softer and from the eating
thicker skin and more moisture
both
internally and externally. For those disorder persistently
opt for the wrong
experiencing Vaginal/Nulvar Dryness or food, despite risking
Atrophic Vaginitis, HIFUmakes daily life starvation.
and sexual
intercourse more At her worst, she
comfortable without the use of reduced her intake to
hormones. just 800calories a
day - 1,200 less than
the
recommended daily a
mount.
premier DIABETES HOSPITAL CUM RESEARCH " Kenote Speaker in Melbourne &
CENTRE, INDIA. He has worked in TISCO London (2018)
HOSPITAL, INDIA, BENGHAZI MEDICAL(LIBYA), LIFE MEMBER
MEDWIN HOSPITAL With Repute. He has been . API
awarded as "INDIA' sBEST DOCTOR AWARD: " API (Odisha Branch)
2013(DIABETES)" BY MEDGATE TODAY SURVEY. " IMA
" American Diabetic Association
He Has been Awarded MRCP, FRCP BY ROYAL
COLLEGE OF PHYSICIAN AND SURGEON, He has " Stem CellTheraphy Association,
Singapore
published more than 20 papers in reputed " World Union
journals and serving as Director of DR PANDA
DIABETES INSTITUTE, INDIA. He has been DR.PANDA AWARDS RECEVED
awarded several National & International " Indian's Best Doctor-2013
(Medgate Today Survey)
awards contribution in diabetes. Dr Panda did his Kasturi Award-2012
Certificate Course In Gerontology(USA) in 2019. Subarta Award-2012
Selected for Honorary DSc in Gerontology from Hon. PhD, CU, Misouri, USA-2010
IASR in 08.07,2020, His Research on COVID19 Bharat Chikistak Jyoti Award-2008
concludes "Ivermectin and Dexamethasone is " Bharat Jyoti Award-2008
Wonderful andPotential Treatment in COVID19", Bharatiya Chikistak Ratna Award-2005
Life Time Health Achievement
Dr. Premanidhi Panda Award-2005
Contact number: 919437002621 LIBYAN Medical Council Award-1993
Web: drpandadiabetes.com Brand Ambassador to IMA-2017