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Deipan - 2003886 - CWU - Emergency Medicine RI
Deipan - 2003886 - CWU - Emergency Medicine RI
CLINICAL CASE
Chief Complaint
Family History
Mr A is single. He is the eldest of 2 siblings, he has 1 sister. His parents and sister are healthy
with no chronic diseases.
Social History
Mr A is a durian farm worker in Raub, Pahang. He is a nonsmoker and non-drinker. His diet is
normal, and he is not a vegan. His work involves a lot of physical exertion. He has no recent
travel history.
PHYSICAL EXAMINATION
Anthropometric Measurement
Weight: 53 kg
Height: 165 cm
Body Mass Index: 19.46 kg/m2
Interpretation: Mr. A is in normal range (18.5-24.9)
Vital Signs
Airway Mr A was able to talk and there was no noisy breathing such as stridor and
gurgling sound. He was also able to swallow his own saliva. Facial hair singed.
No soot seen. Airway is patent.
Breathing Mr A was tachypnoeic. Respiratory rate was 38 breaths/min, SpO2 was 100%
under room air. Equal chest was observed. On auscultation, air entry was equal
on both lungs and there were no crepitations. Trachea was central. On inspection,
burn injuries were seen on his chest. Palpation was unremarkable. Percussion
revealed resonance over all lung fields. Lung fields were clear on auscultation.
Circulation Pulse rate was 114 beats/min, capillary refill time was less than 2 seconds and
blood pressure was 160/95 mmHg. On auscultation, both S1 and S2 were heard,
and no gallop sounds were heard.
Disability Patient was conscious and alert. GCS was 15. Pupils were 3mm in size and
reactive to light.
Exposure Body temperature was 36.9 °C. There were burn injuries on his back
On general inspection at the end of the bed, Mr. A was lying supine at a 30-degree angle with
his head rested on a pillow. He was alert, well-orientated, pink, and not irritable. He was
tachypnoeic. There were 2 branulas attached on his right forearm and left calf.
On inspection of his hand, there were circumferential burns over bilateral upper limbs and
shoulder. The burns were a mix of deep partial thickness and full thickness burns. His upper
limbs had leathery skin appearance and some parts of the skin had a red appearance with body
hair burned away. Capillary refill time was less than 2 seconds. Radial pulse had regular rhythm
with normal volume and character. Total body surface area (TBSA) burned on his bilateral upper
limbs were mixed deep partial and full thickness burn of 14%. His hair appeared singed.
On examination of face, there was no scleral icterus or conjunctival pallor. Bilateral pinna had
deep partial thickness burns. There were no nasal deformities or discharge. Gums were healthy.
There were no abnormalities on the tongue. No central cyanosis can be seen from the tongue.
There was no fetor hepaticus, aphthous ulcers or noticeable tooth decay. The tonsils were not
enlarged. Both upper and lower lips appear swollen. His eyebrows and moustache were singed.
His face appeared darker due to the burns.
On inspection of the neck, there was almost circumferential mixed deep partial thickness and
full thickness burns sparing the right lateral side of his neck. The neck skin had leathery
appearance and some parts of the skin had a red appearance. TBSA burned on his neck, head and
face were mixed deep partial and full thickness burn of 6%.
On examination of lower limbs, circumferential full thickness burns were seen over bilateral
lower limbs from thigh up to foot. Skin had leathery appearance and some parts of the skin had a
red appearance. Posterior tibialis and dorsalis pedis pulsations can be felt with regular rhythm
and good volume and character. TBSA burned on his bilateral lower limbs were mixed deep
partial and full thickness burn of 30%
On examination of his back and trunk, deep partial thickness and full thickness burns were
noticed. Skin had a leathery appearance, and some parts of the skin had a red appearance. TBSA
burned on his trunk and back were mixed deep partial and full thickness burn of 34%.
Lymph node examination could not be carried out.
Hydration Status
His eyes were not sunken. Oral mucosa was moist. Skin turgor test could not be carried out.
Respiratory Examination
Patient was examined in lying position with head of bed raised to 30° with neck and chest
exposed.
Inspection- Patient was tachypnoeic and under high flow mask 15L/min. Anterior trunk had
circumferential deep partial thickness and full thickness burns extending to the neck.
Palpation: No tracheal deviation. Apex can be felt at 5th intercostal space midclavicular line.
Chest expansion was normal and equal on both sides. Vocal fremitus could not be carried out.
Percussion: Resonance all over the lung fields
Auscultation: Vesicular breath sounds were heard and equal air entry on both sides
Cardiovascular Examination
Patient was examined in lying position with head of bed raised to 30° with neck and chest
exposed.
Inspection- Patient was tachypnoeic and under high flow mask 15L/min. Anterior trunk had
circumferential deep partial and full thickness burns extending to the neck. His chest was
symmetrical. Apex beat was not visible.
Palpation- Radial pulse present with regularly regular rhythm, normal character, and good pulse
volume. No radio-radial delay, radio-femoral delay or collapsing pulse. Carotid pulse was felt on
both sides. Apex beat was not palpable. No parasternal heaves or palpable thrills in the mitral,
tricuspid pulmonary and aortic regions. No sacral oedema.
Auscultation- S1 and S2 were heard over mitral, tricuspid, pulmonary and aortic regions, with
no additional heart sounds or murmurs. No neck bruits.
Abdominal Examination
Inspection: Deep partial thickness and full thickness burns were seen on the abdomen. Skin had
leathery appearance. Axillary hair appeared singed. The umbilicus was centrally located and
inverted. Hernia orifices were intact.
Palpation: Abdomen was soft. His liver and spleen were not palpable, and kidneys are not
ballotable.
Percussion: Fluid shift was negative. Shifting dullness could not be assessed.
Auscultation: Normal bowel sounds were heard. No liver, aortic or renal bruits.
Neurological Examination
Patient was examined in sitting position, conscious, alert and well communicative.
Inspection: There was no winging of scapula, no upward or downward drift, no deformities, no
muscle wasting or fasciculations of both upper and lower limbs.
Palpation: There were no changes in temperature over both upper and lower limbs. Some parts
of his bilateral upper and lower limbs were tender to touch.
Sensory, motor coordination and reflex: Could not be assessed.
Musculoskeletal Examination
Inspection: Swelling were noted on bilateral upper and lower limbs. No deformities were
observed on bilateral upper and lower limbs.
Palpation: Range of motion could not be assessed.
SUMMARY OF CASE
Mr A, a 37-year-old Burmese gentleman was involved in an alleged fire accident 6 pm a day
before admission. Patient used petrol to burn rubbish and dried leaves. A sudden explosion
occurred while using petrol and the flames from the explosion and hit him in his face and entire
body. Patient came to ED department 20 hours post injury.
Upon arrival at ED, he was tachycardic (114 beats per minute), tachypnoeic (38 breaths per
min) and hypertensive (160/95 mmHg). Mr A was alert and well-oriented with GCS full score of
E4V5M6. He had extensive mixed deep partial and full thickness burns on his bilateral lower
limbs, bilateral upper limbs, anterior trunk, back, neck and face. TBSA burned was estimated to
be 84%.
PROVISIONAL DIAGNOSIS
Alleged burn injury with 84% TBSA with deep and partial and full thickness burns secondary to
fire accident, 20 hours post exposure.
Investigation Indication
Venous Blood Gas To assess the intravascular status and presence of acid
base disturbance (by looking at pH, HCO3, PaCO2)
To monitor efficacy of oxygenation and ventilation
Interpretation: Patient has a low blood pH indicating acidosis and a low PCO This indicates a
2.
metabolic acidosis. Using Winter’s formula, predicted PCO value should fall between 21.9-25.9
2
mmHg. Since measured PCO value is higher than predicted value, this indicates that there is a
2
concurrent respiratory acidosis present. This patient has both metabolic acidosis and respiratory
acidosis.
Interpretation: Patient has hyponatremia due to sodium exciting extracellular space due to
increased vascular permeability. Hyperkalaemia present due to leakage of potassium from cell
lysis and tissue necrosis. This indicates patient is in acute phase of burn injury.
Liver Function Test
Parameter Reference Range Results Interpretation
Total bilirubin(µmol/L) 5.0-21.0 8.9 Normal
Total protein (g/L) 66.0-83.0 35 Low
Alkaline phosphatase (U/L) 0-104 37 Normal
Albumin (g/L) 35.0-52.0 18 Low
Globulin (g/L) 20-35 17 Low
Albumin/Globulin Ratio - 1.05 Normal
Alanine transaminase (U/L) 10-49 65 High
Aspartate Transaminase (U/L) 0-33 190 High
Interpretation: Patient has decreased protein and albumin levels indicating patient is in acute
phase of burn injury. Increased AST and ALT indicates hepatocyte necrosis which might
represent cellular damage due to the burns.
Creatine Kinase
Reference Range Results Interpretation
55-170 (U/L) 3510 High
Interpretation: Elevated CK level indicates extensive muscle damage due to the burn injury.
Troponin-I (hsTnI)
Reference Range Results Interpretation
<14 (ng/L) 390.4 High
Coagulation Profile
Interpretation: Patient has prolonged PT and aPTT. This indicates traumatic coagulopathy due
to the burn injuries.
9/1/2024 2:54 pm
Day 1 Management
Progress
FBC: Hb 20.7/ TWC 23.3/ Hct 62/ Platelets 311
ABG: pH 7.1/ PCO 22/ PO 403/ K 4/ HCO 6.8
2 2 3
-
Management
Bactigras dressing
Change to nasal prong 3L/minute
Start IV Cefobid 2g stat
Start IV Omeprazole 40mg 2 times a day
Continue IV infusion fentanyl 3mL/hour
IVD 2L Hartmann’s Solution bolus
Repeat blood gas
Renal profile post bolus
Awaiting input from plastic surgery
Progress
BP 160/95 PR 114 RR 18 SpO 99% on HFM
2
CCTVR good
No shortness of breath, chest pain or palpitations
No abdominal pain
No GI losses
Completed 2L bolus
GCS full, pink, not tachypnoeic, good perfusion
ABG on HFM 15L/minute: pH 7.2/ PO 403/ PCO 22/HCO 6.8/ Na 124/ K
2 2 3
-
9:26 pm
Management
Keep nasal prong
Keep MAP >65mmHg
Close vital signs monitoring
Continue current medications
Another 2L bolus over 2 hours
Awaiting surgical admission
Progress
BP 153/82, PR 100, RR 19, SpO 100% on nasal prong 3L/minute
2
CCTVR good
Complete 3.5L bolus
Noted branula over right hand dislodged
Bactigras dressing done
No shortness of breath, chest pain or palpitations
No abdominal pain
Alert, pink, speaking in full sentences, good perfusion, moist oral mucosa
Explained to patient he needs aggressive fluid resuscitation but no vascular
access
Will be inserting triple lumen
Risk of procedure explained (hematoma, infection, neurovascular injury,
catheter dislodgement and bleeding)
Patient understood and asked no further questions
Right inguinal area cleaned and draped
Area of interest infiltrated with lignocaine
Femoral vein identified through ultrasound and large bore needle advanced
into right femoral vein
Guide wire inserted and needle removed
Insertion site dilated
Triple lumen advanced easily through guide wire
Guide wire removed
Good outflow and inflow of all lumen
Catheter anchored to skin using brilon 2/0
Dressing applied
CBD: 200cc concentrated urine
VBG post 3.5L bolus: pH 7.14/ HCO 10.6/ Na 123/ K 4.7/ Ca 0.84/ Glucose
3
-
11:52 pm
Management
Keep nasal prong
Keep MAP >65mmHg
Close vital signs monitoring
Continue IV infusion fentanyl 5mL/hour
Another 2L bolus Hartmann’s Solution over 2 hours (total 7L)
Then IVD 6 pints of normal saline maintenance as per surgical plan
Aim urine output 0.5-1 mL/kg/hour
Awaiting surgical admission
Progress
BP 153/82, PR 100, SpO 100% on nasal prong
2
GCS full
Warm peripheries
Good pulse volume
Good pulse volume
CRT <2 seconds
CBD total drain: 300cc urine until 10:30 pm
VBG post 6.5L bolus: pH 7.17/ HCO 16/ Glucose 5.9/ Lactate 6.8
3
-
Progress
BP 120/80, PR 102, SpO 100% on high flow mask
2
Afebrile
Saturating under high flow mask 15L/minute
Alert, conscious, not tachypnoeic, not tachycardic
Progress
No odynophagia or dysphagia
No drooling, able to take own saliva
Normal voice, talk in full sentences
Alert, full GCS
Comfortable under high flow mask 15L/minute
Not tachypnoeic, no stridor
Facial burn injury
Singed eyebrow and hairs
Bilateral pinna 2nd degree burns with blisters
No abnormality detected on bilateral mastoid
Otoscope: No abnormality detected on bilateral external auditory canal, no
abnormality detected on bilateral tympanic membrane
Airway patent
Upper and lower lips swollen
No abnormality detected on tongue
Floor of mouth not raised
No abnormality detected on palate
Uvula not oedematous
No abnormality detected on bilateral anterior and posterior pillars
Bilateral tonsils grade 1
Posterior pharyngeal wall clear and no oedema seen
Neck: Almost circumferential 2nd degree burn injury of the neck(sparring right
lateral side of neck)
Laryngeal framework palpable
Trachea is central
Flexible Nasopharyngoscopy: Singed vibrissae, anterior of bilateral IT
inflamed, nasopharynx clear, no abnormalities detected on bilateral ET/FOR,
no abnormalities detected on base of tongue, no abnormalities detected on
bilateral aryepiglottic folds, arytenoids, and pyriform fossa, bilateral vocal
cords mobile and symmetric, no oedema or pooling of saliva, no soot seen
Surgical Review
9/1/2024 4:05 pm
Day 1
Management
Nil by mouth with IVD 6 pints of normal saline
Run bolus 2 pints of Hartmann’s Solution each over 1 hour
Central venous line insertion (informed ED team as existing peripheral line at
left calf not functioning)
Refer anaesthesiology for ICU admission
IV Flagyl 500mg stat and thrice daily
IV Cefobid 2g stat and 1g twice daily
IV Pantoprazole 40mg twice daily
RT FF and 4 hourly aspirate
Strict intake/ output charting
Refer HKL plastic surgery team
IV Tramadol 50mg 4 times a day
IV Paracetamol 1g 4 times a day
Keep in view for subcutaneous morphine if pain score not controlled
IV Pethidine 50mg stat 30 minutes before dressing
Jelonet and normal saline dressing over burn wound
Upper and lower limbs circulation dressing
Refer ophthalmology
Vital signs hourly monitoring
Urine output hourly charting
Trace pending blood investigation sent
Progress
BP 161/58, PR 114, SpO 100% on high flow mask
2
6:24 pm
Management
For ICU admission as planned
Not for HKL takeover as bed unavailable
For elective intubation for protection of airway (possibility of respiratory
distress and developing acute pulmonary oedema is high)
Warm wash of chlorhexidine with Jelonet dressing over trunk and back
Warm wash of normal saline and Jelonet dressing over face (to be done under
OT if possible, for pain control and without hypothermia)
Continue IVD 6 pints of normal saline for maintenance
Strict intake/output charting
Ensure urine output 1-2 cc/kg/hour
If require escharotomy, to proceed in HA
If require escharotomy over upper and lower limbs, to refer Orthopaedic
Surgery
To update plastic surgery team everyday regarding patient progress
10/1/2024 1:12 am
Day 2
Management
For ICU admission if possible
For elective intubation to secure airway
IVD 5 pints of normal saline D5 for maintenance
Close monitoring of vital signs
Adequate analgesia
Ensure urine output 1-2 cc/kg/hour (bolus fluids as necessary)
IV Pantoprazole 40mg once daily
Keep MAP >65mmHg
Keep normothermia (apply bear hugger, blanket, radiant farmer)
Hourly monitoring of all 4 limbs
Watch out for signs of abdominal/ limbs compartment syndrome, respiratory
alkalosis- for escharotomy if deemed necessary
Scrub down burn areas with chlorhexidine, apply Jelonet/wet gauze over face,
Jelonet/chlorhexidine dressing over other wounds
Daily dressing of wounds
Pending ophthalmology review
Update daily regarding condition of patient
12:45 pm
Management
For IV Magnesium Sulphate 1 ampoule
IV Lytic cocktail stat
IV Unasyn 3g twice daily
Insert Ryle’s tube
Start feeding today
Allow clear fluids, if tolerating for nourishing fluids
Distal circulation charting every 2 hours
Check blood glucose every 8 hours
Vital signs and urine output monitoring
Continue IVD normal saline D5 5 pints every 24 hours
Continue analgesia
Daily dressing of wounds (aseptic technique)
High protein diet
Not for NSAIDS (AKI)
Investigations: FBC, RP, LFT, VBG, Blood C&S
Progress
6:14 pm
Management
Increase IVD normal saline D5 to 6 pints per 24 hours
Keep nil by mouth at 4am
Aim for wound debridement in OT
Watchout for respiratory distress
Keep SpO >95%
2
Progress
BP 147/73, PR 112, SpO 98% on nasal prong 3L/minute
2
10:59 pm
Management
Keep nil by mouth at 4am
Aim for wound debridement in OT
Watchout for respiratory distress
Keep SpO >95%
2
Progress
Vital signs stable
Saturating under nasal prong 3L/min
Alert, GCS full, not tachypnoeic, tachycardic
No shortness of breath, chest pain or palpitations
No fever
No GI losses
Tolerable pain
On IVD normal saline D5 6 pints per 24 hours
Generalised deep partial and full thickness burn
Face/head/neck- Deep partial thickness burn TBSA 6%
Trunk and back- Mix of deep partial and full thickness burn TBSA 34%
Upper limb- Mix of deep partial and full thickness burn TBSA 14%
Lower limb- Mix of deep partial and full thickness burn TBSA 30%
Distal pulses: Bilateral dorsalis pedis and radial arteries palpable
Doppler limb- present, triphasic
11/1/2024 2:17 pm
Day 3 Management
IVD Hartmann’s Solution 1L over 2 hours
Repeat VBG, RP, lactate
To transfuse 4 units of platelet, standby another 4 units of platelet in blood
bank
Strict intake/output charting
Aim urine output >70cc/hour
Escalate to IV Tazocin 2.25g four times a day
Keep nil by mouth with IVD 6 pints (3 pint normal saline D5, 3 pints
sterofundin)
Aim for wound debridement and dressing in OT once platelet and acidosis
optimised
Trace blood C&S
Distal circulation charting every 2 hours
Check blood glucose every 8 hours
Vital signs and urine output monitoring
Daily dressing of wounds (aseptic technique)
High protein diet
Not for NSAIDS (AKI)
Progress
BP 161/58, PR 114, SpO 100% on high flow mask
2
Alert, GCS full, not tachypnoeic, tachycardic
No shortness of breath, chest pain or palpitations
No fever
No GI losses
Tolerable pain
Generalised deep partial and full thickness burn
Face/head/neck- Deep partial thickness burn TBSA 6%
Trunk and back- Mix of deep partial and full thickness burn TBSA 34%
Upper limb- Mix of deep partial and full thickness burn TBSA 14%
Lower limb- Mix of deep partial and full thickness burn TBSA 30%
Distal pulses: Bilateral dorsalis pedis and radial arteries palpable
On Ryle’s tube
Right femoral triple lumen
Worsening AKI with metabolic acidosis
Creatine kinase 3640
On IV Unasyn 3g stat- Day 1
7:02 pm
Management
IVD Hartmann’s Solution 1L over 2 hours
Repeat VBG, RP, lactate
To transfuse 4 units of platelet, standby another 4 units of platelet in blood
bank
Strict intake/output charting
Aim urine output >70cc/hour
Escalate to IV Tazocin 2.25g four times a day
Keep nil by mouth with IVD 6 pints (3 pint normal saline D5, 3 pints
sterofundin)
Aim for wound debridement and dressing in OT once platelet and acidosis
optimised
Trace blood C&S
Distal circulation charting every 2 hours
Check blood glucose every 8 hours
Vital signs and urine output monitoring
Daily dressing of wounds (aseptic technique)
High protein diet
Not for NSAIDS (AKI)
Progress
BP 161/58, PR 114, SpO 100% on high flow mask
2
12/1/2024 3:23 pm
Day 4
Management
Dressing bedside today
Syrup morphine/ fentanyl during dressing
IV Lasix 40mg once daily for 3 days
Reduce IVD to 4 pints (2 normal saline, 2 D5)
High protein diet
Start nourishing fluid
Oralise paracetamol
Not to transfuse platelet first
Strict intake/output charting
Aim urine output>70cc/hour
Continue IV Tazocin 2.25g 4 times a day
Trace blood C&S
Distal circulation charting every 2 hours
Check blood glucose every 8 hours
Vital signs and urine output monitoring
Daily dressing of wounds (aseptic technique)
High protein diet
Not for NSAIDS (AKI)
Progress
BP 173/115, PR 98, SpO 99% on nasal prong
2
8:24 pm
Management
Patient unable to press PCA fentanyl
Fentanyl 25mcg stat
Oral nutrition 4 scoops thrice daily
IV Lasix 40mg once daily for 3 days
Reduce IVD to 4 pints (2 normal saline, 2 D5)
High protein diet
Start nourishing fluid
Oralise paracetamol
Not to transfuse platelet first
Strict intake/output charting
Aim urine output>70cc/hour
Continue IV Tazocin 2.25g 4 times a day
Trace blood C&S
Distal circulation charting every 2 hours
Check blood glucose every 8 hours
Vital signs and urine output monitoring
Daily dressing of wounds (aseptic technique)
High protein diet
Not for NSAIDS (AKI)
Progress
BP 173/115, PR 98, SpO 99% on nasal prong
2
Progress
BP 138/84, PR 67, SpO 100% on nasal prong
2
Alert, GCS full,
No shortness of breath, chest pain or palpitations
No fever
No GI losses
Tolerable pain
Generalised deep partial and full thickness burn
Face/head/neck- Deep partial thickness burn TBSA 6%
Trunk and back- Mix of deep partial and full thickness burn TBSA 34%
Upper limb- Mix of deep partial and full thickness burn TBSA 14%
Lower limb- Mix of deep partial and full thickness burn TBSA 30%
Distal pulses: Bilateral dorsalis pedis and radial arteries palpable
On Ryle’s tube
Right femoral triple lumen
Maggots noted over bilateral lower limbs
Urine output: 40-50 cc/hour
14/1/2024 11:40 am
Day 6 Management
Continue IVD
Keep in view for turpentine dressing if maggots present
High protein diet
Strict intake/output charting
Aim urine output>70cc/hour
Continue IV Tazocin 2.25g 4 times a day
Trace blood C&S
Distal circulation charting every 2 hours
Check blood glucose every 8 hours
Vital signs and urine output monitoring
Daily dressing of wounds (aseptic technique)
High protein diet
Not for NSAIDS (AKI)
Progress
BP 170/101, PR 100, SpO 99% on nasal prong 3L/minute
2
Progress
Vital signs stable
Alert, GCS full, mildly tachypnoeic, speaking in full sentences
No shortness of breath, chest pain or palpitations
No fever
No GI losses
Tolerable pain
Generalised deep partial and full thickness burn
Face/head/neck- Deep partial thickness burn TBSA 6%
Trunk and back- Mix of deep partial and full thickness burn TBSA 34%
Upper limb- Mix of deep partial and full thickness burn TBSA 14%
Lower limb- Mix of deep partial and full thickness burn TBSA 30%
Distal pulses: Bilateral dorsalis pedis and radial arteries palpable
On Ryle’s tubeRight femoral triple lumen
Summarize the progress and management accordingly- not copy paste all written in case
notes eg Day 1 in ED, Day 2 ? ward etc
What about secondary injuries due to explosion?
SUBSEQUENT INVESTIGATIONS DONE
Result
Blood Components Reference 10/1 11/ 11/1 13/1 14/ 15/1
Range 1 1
Red Blood Cell (10⁶ / µL) 4.53-5.95 6.42 5.97 5.14 4.14 3.43 3.38
Haemoglobin (g / dL) 13.5 - 17.4 18.1 16.8 14.4 11.7 9.7 9.6
Haematocrit (%) 30.1 - 50.6 51.7 47.6 40.3 33.2 27.3 27.5
Mean Cell Volume (fL) 80.6 – 95.5 80.5 79.7 78.4 80.2 79.6 81.4
Mean Cell Haemoglobin (pg) 26.9 - 32.3 28.2 28.1 28.0 28.3 28.3 28.4
Mean Cell Haemoglobin 31.9 - 35.3 35.0 35.3 35.7 35.2 35.5 34.9
Concentration (g / dL)
Platelet Count (K / µL) 142 - 350 80 44 40 19 48 57
Red Cell Distribution Width (%) 12.0 - 14.8 14.5 14.7 14.7 15.3 15.1 15.7
White Blood Cell Count (K / µL) 4.1 - 11.4 6.6 8.4 3.2 2.3 5.1 5.2
White Cell Component Reference 10/5 11/ 12/5 15/5 16/ 17/5
Range 5 5
Absolute Neutrophil (K/µL) 3.9 - 7.1 5.7 7.4 2.8 1.8 4.1 4.3
Absolute Lymphocyte (K/µL) 1.8 - 4.8 0.4 0.3 0.2 0.3 0.7 0.5
Absolute Monocyte (K/µL) 0.4 - 1.1 0.5 0.5 0.2 0.2 0.3 0.3
Absolute Eosinophil (K/µL) 0.0 - 0.8 0.0 0.0 0.0 0.0 0.0 0.0
Absolute Basophil (K/µL) 0.0 - 0.1 0.0 0.0 0.0 0.0 0.0 0.0
Interpretation: Patient initially haemoconcentration but slowly shows signs of anaemia over
subsequent days. Anaemia could be explained by from erythrocyte extravasation and destruction.
Venous Blood Gas
Indications To assess the intravascular status and presence of acid base disturbance
: (by looking at pH, HCO3, PaCO2)
To monitor efficacy of oxygenation and ventilation
Result
Parameters Reference 11/1 11/1 11/1 12/1 13/1
Range
pH 7.35 – 7.45 7.27 7.29 7.4 7.45 7.35
PCO 2 35.0 – 45.0 29 37 34 31 45
(mmHg)
PO 2 30 - 40 149 49 171 186 34
(mmHg)
HCO 3
-
22 -26 13.3 17.8 21.1 21.5 24.8
(mmol/L)
Lactate 0.5-2.2 3.3 3,6 3,0 - -
(mmol/L)
Interpretation: Patient’s VBG shows normalisation over his hospital stay
Renal Profile and Serum Electrolytes
Result
Component Reference 10/ 11/1 11/1 11/ 12/1 13/1 14/ 15/1
Range 1 1 1
Urea (mmol / L) 2.8 – 7.2 17.5 21.8 21.0 18.7 18.3 17.5 12.6 9.2
Sodium (mmol / L) 136 – 146 134 132 136 138 138 148 153 165
Potassium (mmol / L) 3.4 – 4.5 4.9 5.7 4.7 4.3 4.2 3.7 3.1 3.1
Chloride (mmol / L) 101-107 103 105 109 109 114 119 116 110
Creatinine (mmol / L) 59 – 104 374 356 280 210 224 145 87 77
Calcium (mmol / L) 2.08 – 2.65 1.89 1.82 - - 2.14 2.14 2.04 2.02
Magnesium (mmol / L) 0.85 – 1.1 0.87 0.7 - - 1.08 1.06 0.91 0.93
Phosphate inorganic 0.78 – 1.65 1.83 1.99 - - 1.61 1.77 0.84 0.99
(mmol / L)
Interpretation: Patient has deranged parameters in his renal profile and serum electrolytes
pointing towards acute kidney injury (AKI)
Creatine Kinase
Result
Reference Range 11/1 11/1
55-170 (U/L) 3640 2037
Interpretation: Patient has extensive muscle damage
Liver Function Test
Result
Parameter Reference Range 10/1 11/1
Total bilirubin(µmol/L) 5.0-21.0 20.8 16.4
Total protein (g/L) 66.0-83.0 41 49
Alkaline phosphatase (U/L) 0-104 82 61
Albumin (g/L) 35.0-52.0 20 23
Globulin (g/L) 20-35 21 26
Albumin/Globulin Ratio - 0.88 0.95
Alanine transaminase (U/L) 10-49 72 83
Aspartate Transaminase (U/L) 0-33 257 139
Interpretation: Patient has damage to hepatocytes, as indicated by low level of proteins and
increased ALP and AST.
Coagulation Profile
Result
The final diagnosis of Mr A is Alleged burn injury with 84% TBSA with deep and partial and
full thickness burns secondary to fire accident, 20 hours post exposure.
Signs and symptoms of deep partial thickness burns include:
- Vesicles/bullae
- Mottled coloration of skin with red/and or white patches
- Intact pain perception (pain typically felt on applying pressure)
- Wound not blanchable/ very slow refill
In the case of Mr. A, he had a mix of deep partial thickness and full thickness burns. Some of
the burn wounds had a whitish appearance and some of them had a leathery appearance. He also
felt only moderate pain which he gave a pain rating of 4/10.
Total body surface area (TBSA) is the total area of skin involved in an injury or disease.
TBSA calculated using methods such as the Wallace’s rule of nines, Lund-Browder chart, or
palmar method. In this case, Wallace’s rule of nines method was used to measure the TBSA
involved in the burn injury.
In this case, Mr. A had a total TBSA of 84%:
- Face/Head/Neck: TBSA 6%
- Trunk and Back: TBSA 34%
- Upper Limbs: TBSA 14%
- Lower Limbs: TBSA 30%
Mr. A fulfilled the criterion for classification of major burn according to American Burn
Association Burn Classification. The criterion is:
- Partial thickness >25% TBSA, age 10-50 years old
- Partial thickness >20% TBSA, age <10 or >50 years old
- Full thickness >10% TBSA in anyone
- Burns involving hands, face, feet, or perineum
- Burns crossing major joints
- Circumferential burns of an extremity
- Burns complicated by inhalational injury
- Electrical burns
- Burns complicated by fracture or other trauma
- Burns in high-risk patients
Mr. A has partial thickness >25% TBSA, aged 37 years old and burns involving hands, face
and feet, burns crossing major joints and circumferential burns of extremities. Thus, he is
classified as a major burn patient. ? inhalational injury?
Critical Discussion
Skin has 2 layers, epidermis, and dermis. The thickness of skin is variable depending on age
and location. Based on the age factor, skin is thinner at extremes of ages. Based on location
factor, skin is thicker on palms, soles, and upper back as these are areas of maximum frictional
force.
The skin has several functions such as being a semipermeable barrier to evaporative water loss,
protection against assault from the environment and plays a role in the control of the temperature
of the body, sensation, and excretion.
Thermal injury results in a spectrum of local and systemic homeostatic disorders such as
disruption of sodium pump, intracellular influx of sodium and water, extracellular efflux of
potassium, depression of myocardial contractility (>60% TBSA burned), increased systemic
vascular resistance, metabolic acidosis, increase in haematocrit, increase in viscosity of blood,
secondary anaemia from erythrocyte extravasation and destruction, local tissue injury and release
of histamines, kinins, serotonins, arachidonic acids, and free oxygen radicals. As seen in this
patient, there was metabolic acidosis present, increase in blood pressure signalling increased
systemic vascular resistance, and there was increase in haematocrit in the early stages and
anaemia in the subsequent days.
Inhalational injury has become the main cause of mortality in burn patients and most deaths
are due to smoke inhalation. Direct thermal injuries usually are limited to the upper airway.
Smoke contains small particles that may reach to the terminal bronchioles. This can initiate
inflammation that will progress to bronchospasm and oedema. In this patient, an ORL
examination was done, and no soot was found.
Evidence-Based Management
Initial Assessment
Immediate management of moderate and major burns should prioritize the ABCDE approach.
Airway
o Early intubation is indicated if an inhalation injury is suspected prior to airway
oedema or if burns involve > 30% TBSA.
o Do not delay intubation if needed, as fluid resuscitation can increase laryngeal
swelling.
Breathing
o Administer 100% oxygen, if carbon monoxide poisoning is suspected.
o Escharotomy is indicated in circumferential burns of the trunk and neck
Circulation: Fluid resuscitation with crystalloids is indicated to ensure
sufficient perfusion in patients with major burns.
o Hartmann’s Solution is preferred over hypertonic saline (HTS) because HTS may
cause hyperchloremic metabolic acidosis.
o The volume for 24 hours of initial fluid therapy with Hartmann’s Solution is
calculated using the Parkland formula:
Because of the risk of serious complications from over resuscitation
(e.g., pleural effusion and compartment syndrome), current ATLS and
American Burn Association guidelines recommend adjusting the Parkland
formula as follows:
Individuals ≥ 14 years of age: half the volume calculated using
the Parkland formula
Individuals < 14 years of age who are ≥ 30 kg: initial fluid
therapy with LR for a 24-hour period using 3 mL x [%
of TBSA affected by 2nd- and 3rd-degree burns] × weight (in kg)
Children < 30 kg: 24 hours of initial fluid therapy followed by 24
hours of maintenance fluid therapy with a glucose-
containing solution is required.
Half of the recommended fluid volume should be administered within the
first 8 hours and the remaining half over the course of the next 16 hours.
o Combining crystalloids with colloids (e.g., albumin, plasma) or high-dose vitamin
C can reduce fluid requirements.
o After initial stabilization, patients who require aggressive fluid
resuscitation should undergo urethral catheterization to monitor urine output and
adjust fluids accordingly.
Management of the burn area
o Remove clothing, dirt, and debris.
o Cool the burnt area with room-temperature or cool running water or saline-
soaked gauze and cover the wound with a sterile dressing.
Core body temperature should be monitored for hypothermia; if body
temperature is < 35°C, warm IV fluids can be given.
Cool with caution or not at all in patients with burns >10% TBSA because
of the high risk of hypothermia.
Subsequent Management
Indications for treatment in a special burn unit
o 2nd-degree burns involving > 10% of TBSA or 3rd-degree burns involving >
5% of TBSA
o Inhalation injury
o Burns involving the hands, feet, genitalia, or major joints
o High-voltage electrical burns and chemical burns
Wound care
o Early debridement of necrotic tissue
o Wound dressing depends on specific burn characteristics. Options include:
Free-skin grafts (split thickness or full thickness)
Flap reconstruction with free or pedicled flaps
o Topical antibiotics (e.g., silver sulfadiazine, bacitracin, neomycin)
Nutritional support
o Enteral feeding via a nasogastric or nasoduodenal feeding tube is preferred over
parenteral.
o Early initiation of nutritional support helps to control the hypermetabolic
response.
Pain management: NSAIDs, opioids
Anxiety management: benzodiazepines
Prophylaxis
o Proton pump inhibitors or H2 antagonists: curling ulcer prophylaxis
o Vaccination: tetanus prophylaxis
o Antibiotic therapy: Routine prophylactic systemic antibiotic therapy is not
recommended.
If infection or sepsis occur, treat empirically (e.g., with vancomycin)
until MRSA can be ruled out.
Treat for Pseudomonas (e.g. with cefepime) if suspected.
Supportive measures: physical therapy
Eschar
Circumferential eschar: Perform a Doppler test and check capillary refill time,
peripheral pulses, sensation, and pulse oximetry in the limb hourly for 24–48 hours to
assess for vascular/respiratory compromise or compartment syndrome.
o No vascular/respiratory compromise or compartment syndrome
Raise the legs or upper body
Perform a range-of-motion exercises as tolerated
o Vascular/respiratory compromise or compartment syndrome
Escharotomy: an incision of the burnt necrotic tissue to prevent
constriction of the skin
Fasciotomy is indicated if compartment syndrome develops.
Chest/neck eschars: escharotomy in impending or active respiratory compromise
In this case Mr A was started on high flow mask 15L/minute. He was resuscitated with
Hartmann’s Solution. He was given IV cefuroxime and IV flagyl as he presented to the ED 20
hours post injury which increases the risk of wound contamination. He was also given fentanyl to
provide analgesia. A CBD was also inserted to measure urine output to monitor the resuscitation.
Dressing was then done with bactigras dressing which is a medicated paraffin gauze. He was
then started on IV omeprazole as prophylaxis for curling ulcer.
Prognosis
Important prognostic factors in thermal injuries are severity of burn, presence of inhalational
injury, associated injuries, age of patient, comorbid conditions, and acute organ system failure.
This patient fulfils criteria for major burns and has a low chance of survival according to
research done in November 2023.
Complications
Shock, sepsis, and respiratory failure
o Most common causes of death from burns.
o Common causative organisms of sepsis include Staphylococcus
aureus (including MRSA), Enterococcus (including VRE), and Pseudomonas.
Circumferential burns may lead to:
o Compartment syndrome
o Acute limb ischemia (e.g., weak/absent pulse, paraesthesia, pallor in the affected
limb)
o Abdominal compartment syndrome
o Increased intraabdominal pressure (e.g., jugular venous
distension, hypotension, tachycardia)
Curling ulcers
Keloid formation, contractures
Marjolin ulcer
In this case, Mr A has circumferential burns. This increases the risk of him developing
compartment syndrome, acute limb ischemia, abdominal compartment syndrome and increased
intraabdominal pressure. He is also at risk of developing curling ulcers, keloid formation and
contractures.
Before taking the history from Mr. A, I approached him and introduced myself as a 3rd year
medical student from UTAR. I asked for permission to take history from him and informed him
that I will be jotting down the information that he tells me. I also assured him that all information
shared will be confidential and will not be misused in any shape or form. After gaining consent, I
moved on to my clerking. I ensured that Mr. A was in a comfortable position and made sure to
not interrupt his chain of conversation and let him finish his sentences. Before performing
physical examination, I explained briefly to him about the examination that will be done, and I
asked him if it is fine with him to be examined without the curtains on as there were no curtains
around his bed. I then sanitized my hands with alcohol hand rub and wore gloves and wore
medical gown to prevent cross contamination. I enquired about any pain present before touching
the patient. I also made sure to keep an eye on the patients face to see if he was in any
discomfort. Upon completing my examination, I covered up the patient, thanked the patient for
his cooperation and time. I then sanitized my hand before leaving the patient. I then disposed my
gloves and medical gown in the biohazard bin.
REFERENCES
Cartotto, R., Greenhalgh, D. G., & Cancio, C. (2017). Burn state of the science: Fluid
resuscitation. Journal of Burn Care and Research, 38(3), e596–e604.
https://doi.org/10.1097/BCR.0000000000000541
Hettiaratchy, S., & Papini, R. (2004). Initial management of a major burn: II—assessment and
resuscitation. BMJ, 329(7457), 101–103. https://doi.org/10.1136/BMJ.329.7457.101
Hettiaratchy, S., & Dziewulski, P. (2004). Pathophysiology and types of burns. BMJ, 328(7453),
1427. https://doi.org/10.1136/BMJ.328.7453.1427
Overview of the management of the severely burned patient - UpToDate. (n.d.). Retrieved
January 16, 2024, from https://www.uptodate.com/contents/overview-of-the-management-of-the-
severely-burned-patient/print