Pharmacogenomics Knowledge Base

The PharmGKB is a pharmacogenomics knowledge resource that encompasses clinical

information including dosing guidelines and drug labels, potentially clinically actionable
gene-drug associations and genotype-phenotype relationships. PharmGKB collects,
curates and disseminates knowledge about the impact of human genetic variation on drug
responses through the following activities:
• Annotate genetic variants and gene-drug-disease relationships via literature reviews
• Summarize important pharmacogenomic genes, associations between genetic
variants and drugs, and drug pathways
• Curate FDA drug labels containing pharmacogenomic information
• Enable consortia examining important questions in pharmacogenomics
• Curate and participate in writing pharmacogenomic-based drug dosing guidelines
• Contribute to clinical implementation projects for pharmacogenomics through
collaborations
• Publish pharmacogenomic-based drug dosing guidelines, very important
pharmacogene summaries and drug-centered pathways
• Display all information on the website and provide comprehensive downloads
Drug bank
• DrugBank is a unique bioinformatics/cheminformatics resource that combines
detailed drug (i.e. chemical) data with comprehensive drug target (i.e. protein)
information.
• The database contains >4100 drug entries including >800 FDA approved small
molecule and biotech drugs as well as >3200 experimental drugs. Additionally,
>14 000 protein or drug target sequences are linked to these drug entries.
• Each DrugCard entry contains >80 data fields with half of the information
being devoted to drug/chemical data and the other half devoted to drug target or
protein data.
• Many data fields are hyperlinked to other databases (KEGG, PubChem,
ChEBI, PDB, Swiss-Prot and GenBank) and a variety of structure viewing
applets.
• The database is fully searchable supporting extensive text, sequence, chemical
structure and relational query searches.
• Potential applications of DrugBank include in silico drug target discovery, drug
design, drug docking or screening, drug metabolism prediction, drug interaction
prediction and general pharmaceutical education.
• DrugBank is available at http://redpoll.pharmacy.ualberta.ca/drugbank/.
A screenshot montage of the DrugBank Database showing several possible views of information
describing the drug Ramipril.

David S. Wishart et al. Nucl. Acids Res. 2006;34:D668-D672