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Linkage Theory
Linkage Theory
- Gregor Mendel's experiments with pea plants involved the careful crossbreeding of plants with
specific traits (e.g., round or wrinkled seeds). He observed that traits were inherited in a predictable
manner, leading to the formulation of Mendel's first law, the Law of Segregation. This law states that
alleles (gene variants) segregate during gamete formation.
- Mendel's second law, the Law of Independent Assortment, proposed that different genes segregate
independently of one another during inheritance.
- Carl Correns, Hugo de Vries, and Erich von Tschermak independently rediscovered Mendel's work,
emphasizing the significance of his principles in understanding inheritance.
- Walter Sutton suggested that Mendel's hereditary factors (genes) must be located on the
chromosomes, based on observations of chromosome behavior during cell division.
- Morgan's research with fruit flies revealed that certain traits, such as eye color and wing shape, were
often inherited together. This implied that genes for these traits were physically close on the same
chromosome.
- Alfred Sturtevant and Calvin Bridges conducted experiments that demonstrated how genetic
recombination occurred through crossing over, where sections of homologous chromosomes exchange
genetic material during meiosis.
- Alfred Sturtevant created the first genetic map for Drosophila, establishing the linear order of genes
on a chromosome based on the frequency of recombination events between them.
- Geneticists started constructing linkage maps for various organisms, including humans, which allowed
researchers to visualize the relative positions of genes on chromosomes.
- Ronald A. Fisher, J.B.S. Haldane, and Sewall Wright developed the concept of recombination
frequency, expressed in centimorgans (cM), as a measure of the likelihood of genetic recombination
between linked genes.
- James Watson and Francis Crick's discovery of the DNA double helix structure elucidated how genetic
information was physically stored and provided a molecular framework for understanding gene linkage.
These historical milestones collectively contributed to the establishment of linkage theory and the
broader field of genetics, allowing scientists to unravel the complexities of gene inheritance and
chromosomal linkage in greater detail.