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Fraenkel8 SMA ch04
Fraenkel8 SMA ch04
In this activity, you are to pair up with another student to discuss each of the following.
Then report your conclusions to the class.
3. In the summer of 1972, newspapers around the country revealed that for 40 years
the U.S. Public Health Service (PHS) had been conducting a study to investigate
the effects of untreated syphilis on black males in Macon County, Alabama.
Public Health Service physicians had administered a variety of blood tests and
regular examinations to 399 men who were in various stages of the disease and to
200 others who were in a control group. The study was limited strictly to
compiling data on the effects of syphilis and not on ways to treat the disease.
The participants were never told the purpose of the study or for what they
were or were not being treated. No drugs were ever used with these men. A PHS
nurse who was monitoring the participants informed local physicians as to who
was participating in the study and informed them that they were not to be treated
for syphilis. In fact, some of the participants who were offered treatment by other
physicians were told they would be dropped from the study if they took the
treatment.
The participants were never aware of the danger to which they were
exposed by the study. Furthermore, no effort was ever made to explain their
situation to them. In fact, they were enticed with a variety of incentives to
participate, such as hot meals, free treatment for other ailments, free rides to and
from the clinic, even a $50 burial stipend.
What ethical standards were violated in this study?
Activity 4.2:
Some Ethical Dilemmas
2. Almost all clinical trials that have studied the effects of such factors as blood
cholesterol, taking aspirin, or exercise on heart attacks have used middle-aged male
subjects. Women’s groups have complained that this leads to better health information
about men that about women. The researchers reply that in order to get clear results in the
five years or so that such a study lasts, they must choose their subjects from the groups
that are most likely to have heart attacks. That points to middle-aged men. What would
you suggest?
3. The information given to potential subjects in a clinical trial before asking them to
decide whether or not to participate might include:
a. The basic statement that an experiment is being conducted; that is, something
beyond simply treating your medical problem will occur in your therapy.
b. A statement of any potential risks from any of the experimental treatments.
c. An explanation that a coin will be tossed to decide which treatment you get.
d. An explanation that one “treatment” is a placebo and a statement of the
probability that you will receive the placebo.
Listed below in Column A are a number of violations of ethical practice. Match the letter
of the violation from Column B with the example listed in Column A to which the
violation refers.
Figure 4.2 in Chapter 4 in the text presents a number of individuals describing unethical
research practices. Working with a partner, in the space provided below, explain why
each of the statements suggests something that would be unethical.
1. “We are required to ask you to sign this consent form. You needn’t read it; it’s
just routine.”
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2. “A few cases seemed quite different from the rest, so we deleted them”
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3. “Yes, as a student at this university you are required to participate in this study.”
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4. “There is no need to tell any of the parents that we are modifying the school lunch
diet for this study.”
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1. Discuss the following question: What might be some arguments for and against
using prison inmates as the subjects in a research study?
2. The possibilities for harm to participants (if any) are as follows: _________________
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5. In which IRB category (I, II, or III) do you think your proposed study should be
considered? State why.
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