2. Metastasis related topics 3. Tumors: Stages determine LOCAL to SPREAD. Grades determine DIFFERENTIATION 4. Carcinomas vs Sarcomas. Definitions of both. 5. Leukemia - from blood-forming tissues 6. Pre-cancerous or non-malignant growths a. Hyperplasia b. Metaplasia c. Dysplasia 7. Histamine’s function to induce vasodilation. Histamine from mast cells. 8. Vascular response 9. Prostaglandin 10. Acute vs chronic inflammation 11. Acute inflammation a. Neutrophils (polymorphonuclear cells) b. Monocytes (mononuclear cells) 12. Liquefactive definition. Affects the brain. 13. Na/K pumps. Water flows into the cell causing it to swell. 14. Oxidative stress - free radical damage to cell 15. Bilirubin 16. Definitions a. Atrophy - wasting b. Hypertrophy - cell enlargement c. Hyperplasia - new cells formed d. Metaplasia - conversion of one cell type to another e. Dysplasia - reduced functions of cell 17. Sequela vs complications 18. Etiology 19. Idiopathic 20. Iatrogenic ________________________________________________________________________________________ Exudate = fluid that is high in protein, which suggests inflammation