Vision Hema

Blood cell image analysis systems

VISION HEMATOLOGY
West Medica
Digital microscopy
Digital microscopy is a digital
environment for managing
and analyzing microscopy
data, which is obtained using
a microscope, a camera, software
and a computer.
Digital microscopy allows
you to attain qualitative
and quantitative results,
which are either impossible
to receive by other means or cost
and time consuming.
2
West Medica feels strongly that innovation is the key to a brighter future
and improves the quality of life for everyone. Development of “Vision” solutions
for digital microscopy is a top priority and the main focus of West Medica.
Technology is an increasingly influential factor in many fields as new
methods are established every day and that’s the reason why West Medica
always tries to be one-step ahead. New analytical procedures are regularly
introduced onto the market and as a result customers are often looking for
solutions to keep up-to-date on the latest scientific developments.
Our market experience and extensive knowledge through research
and close cooperation with end-users and field specialists allow us
to develop and deliver high quality products. Throughout the years West Medica
has participated in numerous congresses and exhibitions, as well as organized
many seminars, workshops and master classes. We strongly feel that through
Vision solutions we share our knowledge and experience with the world.
Continuous analysis and evaluation of our customers’ demands
as well as close observation of market trends secures routine expansion
of our product portfolio. We develop systems for specific applications that can
be grouped in 6 categories. Namely: hematology, microscopy, cytogenetics,
quality control, clinical laboratory and general medicine. Each system is a result
of company’s field experience and extensive research as well as analysis
of customers’ needs. To cater for individual necessities of each client, our systems
are flexible enough to satisfy those requirements.
Our product portfolio, at this moment, includes complete systems for:
1. blood cell image analysis (Vision Hema)
2. analysis, reports and management of digital albums in microscopy
(Vision Album, Vision Report, Vision Bio)
3. analysis, reports and management of digital albums in fluorescence
microscopy (Vision Epi)
4. chromosome analysis (Vision KaryoFISH)
5. internal laboratory quality control (Vision QC)
6. urine analysis (Vision Uri+)
7. sperm analysis (Vision Sperm+)
8. dermatoscopy (Vision Derma)
9. ophthalmoscopy (Vision Omega)
10. digital cameras, software and instruments
Coming developments include: automated chromosome analysis, analysis
of human body fluids, bone marrow and urine sediment, solution for bacterial
colonies analysis, as well as specialized products for cytology, histology,
gynecology and other fields.
 VISION HEMATOLOGY

Improve your daily work

Close attention to an absolute completion of our product means

that each step in a Vision system is closely supervised. Hardware production
and delivery, software development and testing, installation of the system,
user training, consultation and after-sales service and maintenance are most
significant to us. Help and support of each client is always a priority. Success
of our customers is seen as our own and that is why we do our best
to exceed their expectations by ensuring market competitiveness and long-
term performance of each system.

Hardware
Development and manufacturing of hardware (microscopes, digital cameras
and other instruments to complement/simplify the analysis procedure)
consume significant amounts of resources in both energy and materials.
There are ongoing efforts to improve the effectiveness of operation as well
as time and cost of the running. All elements of the system are mutually
compatible to use in conjunction with one another.

Software
Software is necessary for an error-free operation of the system. Storage
of digital samples presents users with an option of extensive documentation
and a possibility of network capabilities. Improved algorithms guarantee
quality control and unbiased analysis results. An overall platform
for all software makes it easy to upgrade very quickly. Every system can
be reconfigured at a later point in time to support a different set of tasks.

Installation and user training

We don't believe in «one-size-fits-all» and for that reason trainings
and workshops are frequently organized in one of our offices or at your
site. Our professional in-house training experts design tailored programs
reflective of your individual practice and the unique end-user tasks. Requests
and wishes of our partners form the basis of cooperation.

After-sales support
Our wide distribution network allows us to provide our customers
with constant product availability and an efficient after-sales service
with qualified personnel. Our specialists are glad to share their extensive
experience and expertise. Mutually beneficial understanding and
investment in relations with any professional are always important for us,
with no differences for big or small business. Our sales network continuously
broadens, as we always search for new distributors.

Vision systems are designed to maximize the use of advanced

technology features and capabilities, optimise and standardize workflow
and staff productivity as well as foster professional growth. Specialists
that are looking for professional development and recognize new digital
technologies are presented with unlimited resources in their field.

Your friendship and trust are very significant to us and our goal
is to provide you with high quality and professional support.

3
VISION HEMATOLOGY

Vision Hemа systems

Applications

clinical laboratory

hematology

oncology

blood transfusion
stations

Efficient and professional solution

pharmaceutics for the hematology laboratory!

Our flagship Vision Hema is a blood cell identification and pre-classification

veterinary system. Its aim is to automate and simplify a complex procedure of blood
smear analysis. You work with a unified system where priority is given
to efficiency and workflow optimization and standardization.

research
Vision Hema 1 — digital system for blood cell image analysis with loading
of 1 slide. Cost-effective solution for small-sized laboratories

education Vision Hema 8 — digital system for blood cell image analysis with simultaneous
loading of up to 8 slides. Optimal solution for small- and medium-sized
laboratories

remote Vision Hema 200 — digital system for blood cell image analysis with autoloader
consultations for loading of up to 200 slides. Effective solution for large-sized laboratories

Vision Hema Assist — digital system for blood cell image study. Budget solution
for laboratories
specialist training

telemedicine

4
 VISION HEMATOLOGY

Main benefits

1 Workflow automation and standardization

2 Automatic generation of blood cell gallery

3 Identification and pre-classification of leucocytes, erythrocytes and platelets

4 Morphological analysis of WBC and RBC

5 Quick validation of analysis results

6 Significant reduction in the qualified personnel's workload

7 Quality control and no “human error” factor

8 Report generation according to individual requirements

9 Full compliance with the rules and protocols of blood cell image analysis

10 Telemedicine and remote consultations with colleagues, education and medical councils

5
VISION HEMATOLOGY

Vision Hema 1
Cost-effective solution for small-sized laboratories

— loading of 1 slide
— bar code reader (option)

Vision Hema 8
Optimal solution for small- and medium-sized laboratories

— simultaneous loading of up to 8 slides

— Walk Away mode
— bar code reader (option)
— automated oil dispenser (option)

6
 VISION HEMATOLOGY

Vision Hema 200

Effective solution for large-sized laboratories

— аutoloader for loading of up to 200 slides

— Walk Away mode
— Random Access
— STAT testing
— continuous loading mode
— bar code reader
— automated oil dispenser

Vision Hema Assist

Budget solution for laboratories

— standardization and automation of blood smear study

— a significant reduction in study complexity and personnel’s workload

7
VISION HEMATOLOGY

Workflow automation and standardization

1 2
It’s much easier to view
an automatically
generated gallery
of blood cells
on the computer
screen rather than
to spend hours looking
into microscope
eyepieces. Vision Hema
offers a wider cell Preparation of microscopic Scanning and cell
differential count and the blood smear slides identification
possibility to view cells
One of the most important analysis Vision Hema automatically scans
provides an additional stages in a laboratory is the pre- a microscopic sample, collects
visual control if there analytical phase as it affects the speed data for analysis, sorts blood cells
and quality of the analysis process. and saves results in the database.
Use standardized tools to prepare
the analysis and stain a blood smear.

8

Only 5 easy steps
3 4
Validation of WBC, RBC
and platelets
The specialist is free from routine
monotonous work. Analysis results
are displayed in galleries of cells
and arranged in groups. All you need
to do is review and verify the results.
Report generation
Report is generated based on analysis
results, which you can send to your
colleagues by email or simply print out.
VISION HEMATOLOGY
5
Benefits of Internet
connection
Connect several workplaces
to a remote server and hold video
conferences with colleagues
from around the world, exchange
analysis results, publish your research
on specialized online networks.
9
VISION HEMATOLOGY

Easy and convenient operation

It only takes a click to see patient records and analysis results

2 3 4 5

Analysis status Warnings and flags Comments

Analysis status is used for convenient Visual signals when analysis results Leave your comments
management of a laboratory workflow are out of the reference range and marks right on the blood
cell image
new
Show group
in process
scanning Enable/disable the display
pause of blood cell group

scanned
error
completed
delayed

10
 VISION HEMATOLOGY

1 Main toolbar Detection control

Basic working tools. Management of patients records, analysis results Color indication
and functions of blood cell image analysis. Connection to a hematology analyzer. of cell type
Report generation.
Quality assessment of sample
preparation and leucocytes
distribution.
2 Patients
All patient data is presented in chart form that can be adjusted individually
by choosing the required fields: ID, name, surname, date of birth, age, etc.
Folders, filters and sorting will help you search quickly.

3 Analyses
All analyses are presented in chart form and contain the following fields:
ID, status, warning flag, analysis date and comments. Scheduled tests are formed
into a worksheet.

4 Results
Results have several modes to review and correct the information: general analysis
information, final page with analysis results, gallery to verify obtained results,
detection control shows the scanning path and distribution of found leucocytes,
morphological analysis of found objects.

5 Blood cell gallery

Gallery shows identified objects according to groups. Place your comments

Neutrophiles
and marks right on the blood cell image.

Lymphocytes

Monocytes

Eosinophiles

Basophiles

11
VISION HEMATOLOGY

Blood cell identification more

then 20 types

and pre-classification of blood

cells

WBC with differentiation in 15 groups*:

1. Band neutrophiles
2. Segmented neutrophiles
3. Eosinophiles
4. Basophiles
5. Monocytes
6. Blasts
7. Promyelocytes
8. Prolymphocytes
9. Myelocytes
10. Metamyelocytes
11. Lymphocytes
12. Large granular lymphocytes
13. Plasma cells
14. Reactive lymphocytes
15. Unknown

RBC with differentiation in 6 groups

1. Erythrocytes
— Identification by size (normocytes, microcytes, macrocytes, megalocytes)
— Identification by color (normochromic, polychromatophilic, hypochromic,
hyperchromic)
— Identification by shape (microspherocytes, target cells, ovalocytes,
stomotocytes, sickle cells, schistocytes, acanthocytes, echinocytes,
teardrop cells)
2. Proerythroblasts
3. Basophilic erythroblasts
4. Polychromatophilic erythroblasts
5. Oxyphilic erythroblasts
6. Erythrocytes with inclusions
— Howell-Jolly bodies
— Cabot rings
— Basophilic granules

Platelets with differentiation in 3 groups

1. Normal
2. Microgeneration
3. Macrogeneration

* Accuracy of identification for normal groups (S.NEU, B.NEU, LYM, MON, EOS, BASO)
is 90-95%. Identification and validation for pathological and young groups is made
by a qualified specialist. Following the requirements of pre-analytical stage is obligatory
for accurate identification.

12
 VISION HEMATOLOGY

Platelet Erythrocyte

Leucocytes

Scanning profiles

Profile settings include the choosing of:

Scanning magnification Adaptive scanning

(objective) 40x, 50x or 100x. system determines
erythrocyte distribution
level and slide edges

Quantity of cells for analysis.

Sample scanning path.

13
VISION HEMATOLOGY

Analysis results

1 3 7

4 8

9
2

10
6

Result interpretation and comments

Brief conclusion for a report on the analysis results
and recommendations for further examination.

Templates
Customize a set
of frequently used text fields
Text templates for the report speed
up the process by selecting a standard
conclusion or recommendation.

14
 VISION HEMATOLOGY

Final results

1 CBC data
Absolute concentration values of various cells and hemoglobin, as well as
the traditional values of various indices calculated, determined by hematology
analyzer.

2 WBC differential
Relative ration of different WBC classes.

3 Erythrocytes
Erythrocyte changes according to the data from morphological research.

4 Price-Jones curve Results of blood

Erythrocytes distribution according to diameter, with indication of mean value.
cell image analysis
performed by Vision
5 Erythrocytes with inclusions Hema system
and counting of cells
The frequency of erythrocyte detection depends on the type of the most common
erythrocytes inclusions (Jolly bodies, Cabot rings, basophilic granules). by an expert match
by 90-100%. The system
6 Erythrocyte parameters considerably reduces
Quantitative presentation of most important features of erythrocyte morphology the workload of highly
(according to size, hemoglobin content and form). skilled personnel

7 Erythrocytes by size

Quantitative description of type and degree of anisocytosis severity.

8 Erythrocytes by color
Quantitative description of erythrocyte distribution by staining degree,
characterization of anisochromia and appearance of polychromatophiles.

9 Erythrocytes by shape
Frequency of erythrocyte appearance with an abnormal cell form, characterizing
quantitative type and degree of poikilocytosis.

10 Platelets
Distribution of various platelet generation according to their relative content.

15
VISION HEMATOLOGY

Blood cell validation

Validation

Identification of blood cells is primarily made according

to the algorithms included in Vision Hema system, forming
image galleries. After the scanning process for blood smear
is completed, laboratory personnel performs the validation
of analysis results, makes corrections if necessary
and confirms the analysis results.

Tree of analysis objects

You can add new groups of blood cells for manual classification, place non-identified cells in these groups
and carry out morphological measurements. Each folder can include unlimited number of sub-folders.

Multi-gallery mode
Working with several galleries simultaneously. Quicksort between the galleries.

16
 VISION HEMATOLOGY

“Hot” keys Marks and comments

Validation is made in “one click”, Color marks and comments.
and object moves from one folder
to another.

Masks Show on slide

Displays masks of nucleus Live microscopy of objects
and cytoplasm of the cell. presented in the gallery.

Quick preview
Magnification of a single cell allows
to quickly assess morphology
of the object.

Drag&Drop

Validation
Simply grab a cell with the mouse
and drag it to the required cell group.

17
VISION HEMATOLOGY

Morphological analysis

Morphological analysis

Morphological
cell analysis is one
of the most important
parts in hematological
research. Vision
Hema system provides
this possibility
Classify analysed objects using required criteria to generate a report.
Select a required number of groups and define a measurement range
for each one of them:

— size of selected objects

— location
— optical parameters
— quantity

The system will measure and display results visually in a histogram form
and breakdown the gallery into appropriate groups.

You can save frequently used methods to make them easily accessible
in the future.

18
 VISION HEMATOLOGY

Analysis example

Neutrophile research

1 Select cell group for analysis.

Choose analysis method:

2
classification and/or measurements.

Classify objects into groups,

3 selecting a range for each one.

4 Select measurement parameters that are of interest.

5 Generate and print out your analysis report.

19
VISION HEMATOLOGY
Various features
Atlas
Atlas of microscopic objects
has a customizable hierarchic
structure. Add the required
sections and text comments
to microscopic images.
Refractory anemia
with excess blasts
Acute leukemia
Iron-deficiency anemia
Vision Hema+
Expand the capacity
of your laboratory by connecting
a hematology analyzer
with Vision Hema system.
A modern approach to diagnosis
that combines microscopy, digital
image processing and analytical
data from hematology analyzer.
20
Quality control
Assessment of diagnostic sensitivity,
specificity and efficiency. Signals
about problems and errors to correct
blood smear preparation procedure
or service the functional parts
of the system.
Leucocyte distribution
Detection control to assess leucocyte
distribution and quality of sample
preparation. Color indication
of cell type.
Scanning while working
While blood smear is being scanned,
you can still work with other samples
and analyses, prepared earlier.
Diagnoses
Adjustable reference guide
of diagnoses allows to track
the formulation, modification
or clarification of the diagnosis.
Veterinary application*
Collection and identification of animal's
blood cells. Scientific research
and complete blood count.
* Information on request
 VISION HEMATOLOGY

Virtual sample preparation

Scanning of microscopic slides

and generation of digital samples

A digital sample is indispensable when you have

an object that can’t be seen entirely in the field of view
with the required magnification — it is just not possible
to see it completely without creating a “virtual sample”

I keep microscopic
slides as digital samples

I organize them the way

I want and I always

for easily. Digital

slides never fade or get
damaged like the glass.
I do not worry about
breaking or losing it
Working with frames
The feature “show on slide” allows
to find the requested field of view
during repeated microscopy.

21
VISION HEMATOLOGY

Remote access and network capabilities

Laboratory 1

Laboratory 2

Connecting several working places

to a remote server allows an organization
of a single information environment
for the medical institution
Laboratory 3
Analyses are performed on one working
place, for example, in laboratory,
and a doctor can make validation
on another one — for example, in his office

Data import/export to other information

networks (LIS/HIS).

22
 VISION HEMATOLOGY

Medical councils
Discuss difficult cases simultaneously
with several specialists
Formulate an accurate diagnosis, as well as tactics and strategy
for further examination and treatment, together with your colleagues.

Education
Education today is easier and more effective
using modern technologies
Demonstration and discussion of the practical and theoretical material
on the screen makes the learning process clearer and easier.

Share information with people wherever they are. Send your reports by email.

Organize video conferences with colleagues from around the world.

Publish your research on specialized online networks.

23
VISION HEMATOLOGY

Report

Vision system offers report Report form

templates for every case
— from simple analysis
on 1/3 of the page to detailed
conclusions on the research 1 Report name 13 Platelets
carried out. Use a standard
report form or design it yourself
according to your requirements.
2 Laboratory logo 14 Erythrocytes by size

3 Analysis information 15 Erythrocytes by color

4 Patient information 16 Erythrocytes by shape

5 Date and time of sample 17 Interpretation of results

collection/delivery/report

6 Institution information 18 Comments

7 Comments about a patient/ 19 Diagnoses

sample, etc.

8 CBC data 20 Previous diagnoses

9 WBC differential 21 Validation

10 Leucocyte gallery 22 Date and time of validation

11 Erythrocytes 23 Signature

12 Price-Jones curve 23 Page number

24
 VISION HEMATOLOGY

Report example 1

1 2

3 5

4 6

10

23

24

25
VISION HEMATOLOGY

Report example 2

1 2

3 5

4 6

24

26
 VISION HEMATOLOGY

10

11 14

15

12

16

13

21

22

23

24

27
VISION HEMATOLOGY

Comparative characteristics

Description

Motorized biological microscope with “infinitive” optics and Vision digital camera. Preview live video on monitor screen.
Loading 1 slide.
Motorized biological microscope for 8 slides with “infinitive” optics and Vision digital camera. Preview live video on monitor
screen. Simultaneous loading of up to 8 slides.
Motorized biological microscope with “infinitive” optics and Vision digital camera. Preview live video on monitor screen.
Barcode reader for automated sample identification. Autoloader for loading of up to 200 slides.
Personal computer with Vision software and a high resolution monitor. Scanning the blood smear.

Identification and pre-classification of blood cells, including differentiation of leucocytes, erythrocytes and platelets.

Morphological analysis of blood cells. Classification of objects according to a required criteria.

Atlas of microscopic objects. Customizable diagnoses reference guide.

Audible indication of service system messages, for example an end of the scanning process or error.

Special application: scientific research and animal blood studies (option).

“Hot” keys, masks, quick preview, color marks and comments for captured cells in the sample. Drag&Drop feature.

Quality control assesses correctness of blood smear preparation and functions of the system.

Detection control to assess leucocyte distribution and quality of sample preparation. “Show on slide” feature.

Autofocus.

Complete blood count form. Customizable reference guide to generate reports, following your personal requirements.

Report: information about laboratory, patient and analysis, WBC differential, images, erythrocytes, Price-Jones curve,
identification of erythrocytes by size, color and shape, interpretation of results, comments, diagnoses, date and time
and signature.
Report text templates — adjustable set of most commonly used text fields.

Data storage in the database, statistic handling, quick search, remote connection to the Internet and integration into other
information networks (LIS/HIS).
Remote access and network capabilities. Connecting several working places to a remote server.

Walk Away mode. Scanning series of slides without continuous presence of the operator.

Random Access. Various scanning and analysis modes for each slide.

STAT testing. Testing of urgent samples.

Continuous slide loading mode. Loading slides in a queue during scanner operation. Organization of continuous process
for blood cell image analysis.

28
 VISION HEMATOLOGY

Vision Hema 1 Vision Hema 8 Vision Hema 200 Vision Hema Assist

29
VISION HEMATOLOGY

V-Sampler
Instrument for preparation
of standardized blood smears

— standardized process for blood smear

preparation of high quality

— simultaneous preparation of 2 smears

— setting of thickness and size of the smear

— compact and lightweight

— simple and easy to use

Quality blood smear in 3 simple steps

1 2 3

Place a drop of blood Depress the lever carefully Get a clean, thin film
on the target area but firmly and release it containing a large area

30
 VISION HEMATOLOGY

Ordering information

Description Code

Vision Hema 1 system 70.0101.02

Set includes: MT5300M motorized trinocular microscope with specimen stage for 1 slide,
Vision digital camera, Vision Hema software, PC and monitor.
Vision Hema 8 system 70.8101.00
Set includes: Zeiss AxioScope motorized trinocular microscope with specimen stage for 8 slides,
Vision digital camera, Vision Hema software, PC and monitor.
Vision Hema 200 system 70.2101.01
Set includes: Zeiss AxioImager motorized trinocular microscope with specimen stage, autoloader
for 200 slides, Vision digital camera, automated oil dispenser, barcode reader, barcode label
printer, Vision Hema software, PC and monitor.
Vision Hema Assist 70.0106.00
Set includes: MT4300M motorized trinocular microscope with specimen stage for 1 slide,
Vision digital camera, Vision Hema Assist software, PC and monitor.

Additional

V-Sampler 80.0001.00
Instrument for preparation of standardized blood smears.
Automated oil dispenser 80.0006.00
Barcode reader 80.0004.00
Barcode label printer 80.0005.00

31
VISION HEMATOLOGY

Title

WEST MEDICA
Franz-Siegel-Gasse 1
2380 Perchtoldsdorf, Austria
tel.: +43 (1) 804 81 84
fax: +43 (1) 804 81 85
vienna@westmedica.com

www.vision-at.com

We reserve the right to change specification without notice.

Official distributor Rev 4.1/10.2012 EN