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• Flow chart:
– Miing operation: which aims to deliver the API with uniform particle
size!
DR. BLENDING : OR
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DR.
GRANULATION :
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1. DR. GRANULATION
You're Reading a Preview
• Upload
In dr granulation" your
the dr documents
powder toma
particles download.
be brought together
mechanicall via &o%pression to /or% s#gs" or more fre9uentl via
Upload to Download
compaction b a roller compactor.
-ET GRANULATION
• !ith wet granulation" extra process steps are necessar to produce a tablet
mass with sufficient tableting properties.
• After dr blending the tablet mixture to uniformit" a binder solution is added
to the mixture to moisten the particles.
• Introduction of the binder solution improves binding between the particles and
therefore can produce stronger tablets.
• 'his wet mass is then screened to remove large lumps" and dried in oven to
remove granulation fluid.
• ,inall" the granules are sieved to remove the agglomerates that are formed
during dring followed b lubrication of the granules.
Dire&t Co%pression
•
You're Reading a Preview
'he other techni9ue for tablet production is direct compression
•
Uploadall
In direct compression" your
thedocuments to download.
powder mixture is blended to form a uniform
mixture and is directl compressed into tablets without an modification of its
phsical nature. Upload to Download
• OR
0ubrication step ma be necessar to prevent the mixture from adhesing to
the die and punches during compression.
Additives=
*iluents
*isintegrating agents
rganoleptic additives
4lidants" anti>adhesives" lubricants
PBA
in3pro&ess1
pa&'aging1
a+eing1 an"
/inise" pro"#&t testing
as ,e as +at& a#"iting an" sta+iit$ %onitoring!
assures that at each stage of manufacturing the necessar test are made C
the product is not released until it has passed these tests.
'o assure that the testing results are in compliance with the standards or"
specifications
OR
It is concerned with planning, organizing and controlling the #ow o!
materials !rom their initial purchase through internal operations to
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the ser"ice point through distriution$
full documents.
Upload to Download
4asic raw materials are starting material, which is used in
production o! fnal product$
OR
:) is la ased
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:A is company ased
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