Ayugi Fiddrella Rowena

DCM2
March 7, 2024

Cardiovascular pharmacology 47.5% (38/80)

1. Under physiological conditions the rate limiting enzyme in the generation of angiotensin I is
0/2 POINTS

A Renin

B Angiotensinogen

C Kininase ii

D Aldosterone

E I have no idea 😞

2. A semiconscious patient of haemorrhagic cerebral stroke has been brought to the emergency.
His blood pressure is 240/120 mmHg. Select the most appropriate therapy
0/2 POINTS

A Sublingual Nifedipine

B Intravenous Hydralazine

C Intravenous Propranolol

D Intravenous Clonidine

E I have no idea 😞

3. A woman in the 28th week of pregnancy has developed

pregnancy induced hypertension with a blood pressure
reading of 150/100 mmHg. Select the most appropriate antihypertensive drug for her
2/2 POINTS

A Captop il

B Methyldopa

C Amlodipine

D Losa tan

E I have no idea 😞
4. The following antihypertensive is used topically to treat hair loss
2/2 POINTS

A Enalap il

B Atenolol

C Propranolol

D Minoxidil

E I have no idea 😞

5. Methyldopa works by
2/2 POINTS

A Blockage of beta adrenergic receptors

B Antagonism of aldosterone receptors hence causing diuresis

C Generating α-methyl noradrenaline in brain which reduces sympathetic tone

D Activating vascular dopamine receptors

E I have no idea 😞

6. The following drug has been found to improve urine flow in elderly males with benign prostatic
hypertrophy
0/2 POINTS

A Telmisa tan

B Tamsulosin

C Furosemide

D Hydrochlorothiazide

E I have no idea 😞

7. Relationship between a te ial blood pressure BP , cardiac outpur CO and pe ipheral vascular
resistance PVR can be desc ibed as
2/2 POINTS

A BP = COxPVR

B BP = PVR/CO

C BP = CO/PVR

D BP = CO - PVR

E I don't know math 😞

8. In case of acute pain of angina pecto is the most effective treatment would be to administer
2/2 POINTS

A Mannitol hexanitrate

B E yth ityl tetranitrate

C Sodium nitrate

D Nitroglyce in

E I have no idea 😞

9. Glyce yl t initrate GTN is administratered by all of the following routes except

2/2 POINTS

A Oral

B Sublingual

C Intravenous

D Intramuscular

E I have no idea 😞

10. The dihydropy idines block the following type of calcium channels.
2/2 POINTS

A L-type voltage sensitive channels

B T-type voltage sensitive channels

C N-type voltage sensitive channels

D Receptor operated calcium channels

E I have no idea 😞

11. Which of the following is not a calcium channel blocker?

0/2 POINTS

A Amlodipine

B Verapamil

C Diltiazem

D Nifedipine

E Eplerenone

F I have no idea 😞
12. The dose of captop il in adults is
0/2 POINTS

A 25mg 8hrly

B 25g 8hrly

C 25mcg 8hrly

D 25mg 12hrly

E I have no idea 😞

13. This d ug is a Class IC antia rhythmic d ug:

0/2 POINTS

A Flecainide

B Sotalol

C Lidocaine

D Verapamil

E I have no idea 😞

14. An asthmatic hype tensive should NOT be given

2/2 POINTS

A Hydrochlorothiazide

B Nifedipine

C Propranolol

D Methyldopa

E I have no idea 😞

15. In a diabetic hype tensive patient, the least preferable d ug is

2/2 POINTS

A Furosemide

B Atenolol

C Captop il

D Losa tan

E I have no idea 😞
16. ACEIs have all the following advantages Except:
0/2 POINTS

A They induce no change in hea trate

B They prese ve renal function

C They induceno change in potassium level

D They reduce cardiovascular mo tality

E I have no idea 😞

17. Beneficial effects of beta blockers in hea t failure include:

0/2 POINTS

A Block renin release

B Block catecholamines & Angiotensin II induced a rhythmia & myocardial damage

C Decrease hea t rate, increasing corona y flow; decrease afterload & 02 demand.

D Resensitize the downregulated beta 1 receptors & improve LV remodehng

E All of the options

F I have no idea 😞

18. Low dose HMG CoA reductase inhibitors are indicated in all patients with cardiovascular isk
factors
2/2 POINTS

T T ue

F False

19. A 70-year-old man is seen in follow-up at your office after he has been hospitalized for a
myocardial infarction MI . He unde went successful angioplasty and is cu rently asymptomatic.
In the hospital, his blood pressure was consistently elevated. The patient’s discharge
medications include an ACE inhibitor, a statin, aspi in, and metoprolol
Metoprolol is a
2/2 POINTS

A Selective Beta blocker

B Non selective Beta blocker

C Alpha blocker

D Mixed beta and alpha blocker

E I have no idea 😞
20. Which of the following patients would not benefit from beta blockers?
0/2 POINTS

A 64-year-old female with daily migraines

B 35-year-old female with hype thyroidism and symptomatic tachycardia and tremors

C 56-year-old male with erectile dysfunction

D 74-year-old male with histo y of systolic hea t failure that is stable

E I have no idea 😞

21. A 34-year-old man is presc ibed labetalol for hype tension. The effect on the cardiovascular
system is a result of its action as an antagonist at which of the following?
0/2 POINTS

A α-Adrenoceptors

B β-Adrenoceptors

C Both α- and β-adrenoceptors

D Musca inic cholinoreceptors

E I have no idea 😞

22. A 64-year-old female with a past medical histo y of corona y a te y disease, hype tension, and
congestive hea t failure CHF presents with dyspnea at rest and with exe tion, o thopnea, and
lower extremity pitting edema. Her symptoms have worsened over the last 2 weeks and also
include o thopnea, worsening exercise tolerance, and tachypnea. On examination, she is
notably dyspneic and tachypneic, and also has jugular venous distension, 2+pitting edema, and
rales on lung examination. Patient is also found to have an audible S3. Her chest x-ray, pro-
Brain Nat iuretic Peptide BNP level, and echocardiogram confi m the clinical suspicion of CHF
exacerbation with pulmona y edema. She is already on maximal medical therapy with an ACE
inhibitor, beta blocker, statin, and aspi in. She is approp iately placed on oxygen and given
intravenous furosemide.
What is the mechanism of action of furosemide?
0/2 POINTS

A Cause diuresis by Inhibiting active NaCl reabsorption in the ascending limb of the loop of Henle

B Cause diuresis by Inhibiting active NaCl reabsorption in the descending limb of the loop of
Henle

C Causes diuresis by Inhibiting active NaCl reabsorption in the ascending limb of the proximal
convoluted tubule
D Cause diuresis by Inhibiting active NaHCO3 reabsorption in the loop of Henle

E I have no idea 😞
23. The main electrolyte advantage of spironolactone is that it doesn't cause
0/2 POINTS

prevention of potassium secretion by anatgonism of mineroco ticoids receptors.

24. A 65-year-old male with CHF exacerbation is given IV furosemide. Which of the following
adverse events are not associated with this medication?
2/2 POINTS

A Transient neurotoxicity from high dose

B Hypotension

C Worsening renal function

D Hyperkalemia

E I have no idea 😞

25. A 72-year-old man presents to the office for routine follow-up. He is under treatment for
hype tension and congestive hea t failure with enalap il and a diuretic. His blood pressure is
under acceptable control, and he has no symptoms of hea t failure at present. He does
complain that he has been coughing frequently in the past few months. Histo y and
examination reveal no other cause of a chronic cough, so you decide to discontinue his
enalap il and sta t him on losa tan.
What is the mechanism of action of enalap il?
2/2 POINTS

A Inhibits the conversion of angiotensin I to angiotensin II

B Inhibits the conversion of Renin to angiotensin I

C Inhibits the vasoconst iction action of aldosterone

D Inhibits the action of renin

E I have no idea 😞

26. What is the likely cause of the cough seen in ACE inhibitors?
2/2 POINTS

A Side effects

B Hypersensitivity

C Bradykinin accumulation

D Histamine release

E I have no idea 😞
27. Which of the following is an advantage of losa tan over enalap il?
0/2 POINTS

A Better efficacy in lower blood pressure

B Better prevention of seconda y myocardial events

C Less cost

D Less incidence of angioedema

E I have no idea 😞

28. What is the effect of digoxin on the failing hea t?

2/2 POINTS

A Increased stroke volume and increased cardiac output.

B Decreased stroke volume and decreased cardiac output.

C Vasodilation

D Decreased hea t rate

E I have no idea 😞

29. Digoxin is a positive ______ agent

0/2 POINTS

inotropic

and negative chromotropic

30. Mechanism of Action Inhibition of the activity of the Na+/K ATPase; this indirectly increases
intracellular

Which d ug is this?
0/2 POINTS

diazoxide

Minoxidil

31. Lidocaine belongs to class _________ of antia rhythmic d ugs

0/2 POINTS

Class lb
32. A 26-year-old woman complains of the ab upt onset of her chest pounding. She is diagnosed
with paroxysmal vent icular tachycardia. Which of the following is the most effective agent for
conve ting paroxysmal vent icular tachycardia to no mal sinus rhythm?
2/2 POINTS

A Adenosine

B Atropine

C Digoxin

D Lidocaine

E I have no idea 😞

33. Which of the following best desc ibes a pha macologic prope ty of amiodarone?
2/2 POINTS

A α-Adrenergic agonist

B β-Adrenergic agonist

C Activation of Ca 2 channels

D Inhibition of K + channels

E I have no idea 😞

34. List one d ug that works in the following mechanisms;

Inhibit active reabsorption of NaCl in the distal convoluted tubule by inte fe ing with a specific
Na + /Cl − cotranspo ter.
0/2 POINTS

f usemide

35. List one class of diuretic d ugs that work on the RAAS
0/2 POINTS

carbonic an hydrase inhibitors

loop diuretics

36. Nifedipine is in pregnancy catego y ____

2/2 POINTS

A A

B B

C C

D X

E I have no idea 😞
37. The usual adult dose of telmisa tan is _____ mg/day
0/2 POINTS

20mg/day

80mg/day

38. Oral furosemide is given in doses of 20mg up to ______mg in severe oedematous states
0/2 POINTS

160mg

39. Norepineph ine is a potent bronchoconst ictor but a potent vasodilator

0/2 POINTS

T T ue

F False

40. Which of the following antihype tensive d ug classes is impo tant in opthalmology and
psychiat y
2/2 POINTS

A Beta blockers

B Alpha blockers

C Loop diuretics

D Thiazide diuretics

E Calcium channel blockers

F I have no idea 😞