Professional Documents
Culture Documents
Efectos Biopsicosocial de La Ludopatia
Efectos Biopsicosocial de La Ludopatia
by TIMOTHY W. FONG MD
22 Psychiatry 2005 [ M A R C H ]
athological
P gambling is a
disorder that
can have
many diverse
and unintended conse-
quences. From a medical
perspective, pathological
gamblers are at increased
risk to develop stress-relat-
ed conditions, such as
hypertension, sleep depri-
vation, cardiovascular dis-
ease, and peptic ulcer dis-
ease. Common psychiatric
sequelae of pathological
gambling include exacer-
bation and initiation of
major depressive episodes,
anxiety disorders, or sub-
stance use disorders.
Unintended psychological
consequences may also
24 Psychiatry 2005 [ M A R C H ]
nized in general mental health
treatment, and even when they are [Pathological gambing] can create conditions of
seeking treatment,
there are only a limited
number of gambling
chronic stress that will lead to
treatment specialists
available.10 Given its physical consequences, such as
increased availability
and the amount of hypertension, cardiovascular disease,
attention gambling is being given by
the media, legislatures, and indus- peptic ulcer disease, and exacerbation
try, researchers have just recently
started to examine gambling in a
formal fashion.
of baseline medical problems.
The consequences of pathologi-
cal gambling stretch across the behaviors because there are no neu- In addition to biochemical alter-
biopsychosocial perspective and rotoxic substances, such as cocaine ations, pathological gambling can
may include financial losses, wors- or methamphetamine, to confound affect general health status.
ening of emotional and physical interpretations or explain abnormal Pathological gamblers often report
health, legal problems, and inter- behaviors. prolonged gambling sessions that
personal difficulties. Some of these Neuroimaging work by Potenza can last anywhere from several
consequences may be permanent suggests that the brain regions hours up to two or three days
while others tend to resolve as the involved in pathological gambling, straight, often without sleep or
gambling behavior is controlled. namely anterior cingulate, food. The impact of this kind of
This article will review these conse- orbitofrontal cortex, and the mid- physical and emotional stress can
quences highlighting the direct and brain reward circuitry, are similar to be dramatic. One study on the
indirect effects of pathological gam- the one involved in substance use cause of deaths in New Jersey’s
bling. Clinicians need to be aware of disorders.11,12 Neurochemical studies Atlantic City casinos reported that
these consequences in order to be have implicated alterations in the the majority were cardiac related,
able to prevent, identify, and man- dopamine, serotonin, and norepi- suggesting and implicating stress as
age problems that arise due to con- nephrine systems of pathological a precipitating factor. In this study,
tinued gambling. gamblers.13 Bergh reported that con- casino-related deaths (number of
This is the first installment of centrations of dopamine were lower pathological gamblers were not
three articles that will focus on in the cerebrospinal fluid of patho- reported) from 1982 to 1986 were
pathological gambling; the second logical gamblers as compared with reviewed: 398 people died inside
will describe the clinical populations controls, but that levels of its casinos and of these, 330 were sud-
that are most vulnerable to becom- metabolites 3,4-dihydroxypheny- den cardiac deaths.17 In many
ing pathological gamblers; and the acetic acid and homovanilic acid pathological gamblers, elevated
third will describe psychotherapeu- were higher, suggesting increased stress levels are not confined to the
tic approaches to pathological release of dopamine in the brain.14 casino, especially as the course of
gamblers. The results of studies on serotonin pathological gambling progresses.
in pathological gamblers have been As a result of escalating debt, there
BIOLOGICAL CONSEQUENCES OF mixed, with some studies showing will be an increasing urgency to
PATHOLOGICAL GAMBLING increased levels and others showing gamble along with spending more
Recent studies have begun to decreased metabolism.15 Roy found time and energy involved with the
examine the impact of pathological increased noradrenergic activity in gambling and covering up the gam-
gambling on the brain and body and pathological gamblers through bling—all together, this can create
have shown altered neurobiological increased levels of the metabolite of conditions of chronic stress that will
processes. What remains unclear is noradrenaline, 3-methoxy-4-hydrox- lead to physical consequences, such
whether these biological changes yphenylglycol, in the CSF of patho- as hypertension, cardiovascular dis-
are a direct consequence of gam- logical gamblers.14,15 Exactly how ease, peptic ulcer disease, and
bling or whether they existed these neurochemical differences exacerbation of baseline medical
before the onset of gambling. contribute to pathological gambling problems.17
Nevertheless, research into the bio- behavior requires further study, but In addition to chronic stress,
logical components of pathological they are thought to affect individual pathological gamblers have been
gambling will lead to a better under- responses to reward, impulsivity, shown to have an abnormal
standing of the process of addictive learning, and self control. response to acute stress. Meyer has
26 Psychiatry 2005 [ M A R C H ]
circuitry—the same pathway impli- of self-medication. Depressive Others report that gambling is a
cated in substance use disorders.29 symptoms that arise within the con- way of reducing generalized anxiety
Could it be that overuse of this cir- text of problems created by gam- by providing an escape from reality
cuit may have direct neuronal toxic- bling may resolve with the cessation and a temporary avoidance from life
ities? Again, unraveling whether of gambling. Either way, as the stress and responsibility. Thus, for
these neuropsychological deficits course of pathological gambling pro- some, gambling can initially have an
were present before or after the gresses, it is likely that gamblers will anxiolytic effect. Further epidemio-
onset of pathological gambling will express escalating symptoms of logical data is needed to establish
be an intriguing area of future hopelessness, guilt, shame, and des- the comorbidity rates of generalized
research. peration.32 One of the most sobering anxiety disorder, post-traumatic
In summary, pathological gam- consequences of pathological gam- stress disorder, and social phobia in
blers are more likely to smoke, bling is an increased rate of suicidal pathological gamblers but existing
drink alcohol, possibly overeat, be ideation and attempts. Seventeen to data suggests that there is an
sleep-deprived, and suffer from 24 percent of pathological gamblers increased risk.38 As with mood disor-
higher levels of acute and chronic will attempt suicide during their ders, more work is needed to
stress. Together, these conse- lives, most likely occurring immedi- demonstrate how continued gam-
quences of pathological gambling ately after sustaining a large loss.33,34 bling can impact and worsen the
may dramatically impact the mor- Furthermore, close to 80 percent of morbidity of anxiety disorders. In
bidity and mortality of pathological gamblers calling a gambling helpline contrast, pathological gambling can
gamblers. Future studies need to reported feeling suicidal at the time have direct, anxiogenic conse-
look at health profiles of pathologi- of calling35 and nearly two-thirds of quences, especially seen with “chas-
cal gamblers and how they are attendees to Gamblers Anonymous ing” behaviors. Chasing refers to a
affected by prevention and early have contemplated suicide.36 gambler who will repeatedly return
treatment efforts. Repeatedly, Las Vegas and Atlantic to recoup losses, usually within the
City have been shown to have the same day. There is a desperate
PSYCHIATRIC CONSEQUENCES highest suicide rates in the nation, urgency to recover losses immedi-
OF PATHOLOGICAL GAMBLING although a direct link to pathologi- ately; to not do so results in a feel-
Winning, losing, and the arduous cal gambling has not been con- ing of intense anxiety, fear, and
process of continuing to find ways firmed.20 Suicidal ideation and worry.39 In turn, this creates even
28 Psychiatry 2005 [ M A R C H ]
phisms at dopamine receptor fraud, and the use of loan sharks to nicians who work with a homeless
genes, the serotonin transporter finance ongoing gambling.36 In a population should screen for this
gene, and the monoamine-oxidase survey of Gambler’s Anonymous, disorder.
A gene.48 This area of research is nearly 57 percent admitted to steal-
expanding but provides enough evi- ing in order to finance gambling.36 CONCLUSION
dence to show that pathological Although there is a high frequency Pathological gambling is a psy-
gambling can be passed onto to of criminal acts, the rate of violence chiatric disorder that has many
succeeding generations. by pathological gamblers has not unintended consequences, many of
By definition, pathological gam- been reported to be higher than which could be prevented with
blers spend large amounts of time expected, but there are a few early recognition, intervention, and
gambling, thinking about gambling, reports of impulsive acts of violence treatment. Most people who gamble
or covering up the consequences of committed to cover the damage will be able to do so without perma-
gambling. In terms of overall costs from pathological gambling.20 nent consequences, yet for the vul-
to society, lost productivity and A final and often overlooked con- nerable population who do become
time are thought to be even more sequence of pathological gambling pathological gamblers, the conse-
significant consequences than is its effect on homelessness. quences are intense and destruc-
financial losses. Lost productivity at Several cities have completed sur- tive. In order to reduce the morbidi-
work will lead to lost opportunities veys showing that gambling was a ty of pathological gambling from its
to advance and also to difficulties in contributing factor to homeless- medical to psychiatric to social con-
securing future employment ness.36 One formal study by Shaffer sequences, clinicians are urged to
because of the damage sustained by reported a pathological gambling screen for gambling problems in
prior gambling problems. prevalence rate of 5.5 percent every patient that presents to treat-
Employers are not likely to notice among homeless individuals in ment. Unlike substances of abuse,
gambling problems when they are Boston.49 These data suggest that gambling behavior cannot be
in the early stages, but they are future research is needed to under- detected by a laboratory test, and if
likely to notice the problems associ- stand this relationship and that cli- patients are not asked about the
ated with ongoing gambling: late-
ness, absenteeism, decreased pro-
ductivity, and even embezzlement.
Past-year job loss rates have been
reported to be twice as high in
pathological gamblers as compared
to non-pathological gamblers (10%
vs. 5%).20,36
Legal consequences of pathologi-
cal gambling usually arise after the
onset of financial problems.
Researchers have estimated that
close to 30 to 40 percent of many of
the white-collar crimes are some-
how tied to pathological gambling.1
Desperate gamblers have been
known to resort to stealing, prosti-
tution, embezzlement, insurance
30 Psychiatry 2005 [ M A R C H ]