Professional Documents
Culture Documents
Ahmad Et Al 2024 Fixation in Maxillofacial Surgery Past Present and Future A Narrative Review Article
Ahmad Et Al 2024 Fixation in Maxillofacial Surgery Past Present and Future A Narrative Review Article
review-article20242023
FACXXX10.1177/27325016231221424FACEAhmad et al.
Review
FACE
Review Article
Abstract
Introduction:The present review explores the existing documentation in the literature related to the fixation of mandibular
fractures undertaken in maxillofacial surgery. Methods: English language articles were searched in various databases
such as Pubmed, Scopus, Science Direct and Google Scholar. The keyword used for searching are “Mandible Fracture,”
“Maxillomandibular fixation,” “Fixation” and “Recent Advancements.” Results about the history of fixation: Extended
history into the pre-Christian era, early medieval, through the 17th, 18th and 19th, 20th, 21st centuries have been dealt
in the narrative review. Emphasis on the present plating system with focus on present and future prospects like AI, virtual
reality as well as Magnesium based plating systems have also been dealt here. Conclusions: The present review spotlights
on understanding present, past, and future aspects of fixation of mandibular fractures. Currently, titanium plates are being
used and the most popular materials though future holds good prospects for polymer based and magnesium based materials.
Keywords
maxillomandibular fixation, internal fixation, mandible fracture, recent advancements
Introduction the mandible and using fingers under the chin to guide it
back into place. Simple jaw fractures were treated with ban-
History plays a crucial role in understanding the past and pre- dages soaked in honey and egg whites, while fresh meat was
dicting the future, providing a foundation for the development applied to wounds on the first day. In ancient India, pedicle
of new approaches and improving our understanding of cur- flaps sourced from either the forehead or cheek were used to
rent procedures. This narrative review article explores the his- repair defects concerning the nose or lips, as a means of pun-
tory of fracture treatment in maxillofacial surgery, highlighting ishment. Asklepios, renowned for his war wound care during
key advancements and notable contributions from ancient the Trojan Wars, became a symbol for the medical profes-
civilizations to the modern era. Various databases like Pubmed, sion, represented by the Caduceus. Hippocrates, born in 460
Scopus, Science Direct and Google Scholar were utilized for B.C., introduced the concept of connecting loose teeth with a
searching English language articles. Keywords used for gold or linen thread until the bone healed. Bandaging with
searching were “Mandible Fracture,” “Maxillomandibular Carthaginian leather strips provided support for jaw frac-
fixation,”“Fixation.” By tracing the evolution of fracture man- tures. Hippocrates cautioned that incorrect bandaging could
agement techniques, we can gain valuable insights into the cause harm despite its limited benefits for jaw fractures.
development of current practices and appreciate the progress
made in craniofacial fracture treatment.
The Early Medieval Period
Past During the Roman Empire, there were no significant
advancements in the treatment of maxillofacial injuries, and
The Pre-Christian Era
Hammurabi’s ancient law system, documented on clay tab- 1
Aligarh Muslim University, Aligarh, Uttar Pradesh, India
lets, includes an early reference to fracture care in 5000 B.C.
Corresponding Author:
The Edwin Smith papyrus, translated by Prof. Breasted,1 was
Akash Ganguly, Department of Oral and Maxillofacial Surgery, Dr.
discovered in Egypt around 1600 B.C. and seems to be a Ziauddin Ahmad Dental College, Aligarh Muslim University, AMU
military surgeon’s work. It provides instructions for reducing Campus, Medical Rd, Civil Lines, Aligarh, Uttar Pradesh 202001, India.
a dislocated mandible by placing the thumbs on the ends of Email: akashganguly.dr@gmail.com
2 FACE 00(0)
resulted in a notable number of injuries to the maxillofacial favorable configurations. Diverse hardware designs and
region. Major Gillies established a special center for these techniques are accessible for MMF, including arch bars, ivy
injuries, promoting cooperation between plastic surgeons, loops, and MMF screws. Utilizing arch bars for MMF pro-
anesthetists, and dental surgeons. This period saw advance- vides the added advantage of creating a tension band at the
ments in dental treatment by Captain Kelsey Fry and the alveolar component of maxillomandibular fractures, aiding
invention of endotracheal anesthesia by Major Magill. in withstanding tensile forces near the teeth.
X-rays were discovered by Roentgen which assisted the sur-
geons in aligning bone fragments. The introduction of skin Rigid versus functionally stable fixation. The concept of rigid
grafting intraorally and the identification of the tube pedicle versus functionally stable fixation was explored, with rigid
by Gillies19 in 1917 marked the initiation of facial recon- fixation aiming to prevent interfragmentary movement
struction. Despite this, during that period, jaw splints were between fracture segments. Non-rigid fixation techniques,
fashioned as single units, and the fragments were adjusted such as the one given by Champy for mandibular angle frac-
within the splint during the reduction process.20 tures, allow for controlled interfragmentary motion during
healing.
The intervening years. During the interwar period between the At a histologic level, when rigid internal fixation is
2 World Wars, notable progress was scarce. Notable excep- employed with a minimum gap between bone segments, it
tions included the introduction of the temporal approach for offers the advantage of facilitating primary bone healing
treating depressed zygomatic bones and the innovation of through haversian remodeling. In this process, osteoclasts
interdental eyelet wiring. cross the fracture gap, followed by angiogenesis and the
deposition of osteoid by nearby osteoblasts. Over time, the
The Second World War (1939-1945). The Second World War bone undergoes remodeling, resulting in the development of
marked a turning point for maxillofacial surgery, with the mature haversian bone. The situation is different for fractures
establishment of maxillofacial units at home and in the mili- that have a significant gap or interfragmentary movement
tary and the specialties of plastic surgery, anesthesia, and between the fragments, as they heal through secondary inten-
dental surgery would have to co-operate with the neurosur- tion with the formation of an intermediate hematoma and
geon and the ophthalmic surgeon. Significant progress bone callus.
occurred in both intra-oral and extra-oral fixation methods, In 1978, Champy explained the application of a single
bolstered by advancements in dental laboratory technology. miniplate adapted to the superior border of fractures occur-
The introduction of the locking plate technique by Kelsey ring at the angle of the mandible. This approach has been
Fry, Shepherd, McLeod, and Parfitt enabled personalized fit- referred to as “functionally stable” since it permits mandibu-
ting and precise alignment of jaw fragments, ensuring the lar movement during the healing process, even when there is
seamless continuity of the jaw structure. Other techniques, movement between the fractured segments.24
such as extra-oral pin fixation and the Brenthurst clamp,
were also developed. In 1942, Adams21 brought forth the Compression plate osteosynthesis. Compression plating tech-
idea of internal skeletal fixation by employing subcutaneous niques have found extensive application in maxillofacial sur-
suspension wires threaded through perforations drilled in gery for managing fractures of the mandible. The primary
either the zygomatic process of the frontal bone, the inferior objective of compression osteosynthesis, as outlined by AO,
orbital rim, or the zygomatic bone. This method was aimed is to attain complete stability along the fracture site, thereby
at providing support to either the maxilla or the mandible. minimizing motion. This fosters an optimal setting for direct
bone healing by generating friction among compressed bone
Development of fixation. The AO-ASIF guidelines underscore segments and decreasing the gap between them.25 Dynamic
the fundamental principles of rigid fixation, encompassing compression plates (DCPs) are specifically designed with
actions such as reducing bony segments, stable fixation, eccentric holes and inclined planes, generating interfragmen-
immobilization, safeguarding blood supply, and encouraging tal pressure through the “spherical gliding principle.” (Figure
early functionality.22 Titanium hardware remains the prevail- 2) The horizontal movement of screws in the plate holes
ing choice, featuring a variety of plate and screw sizes and approximates the fracture surfaces and creates interfragmen-
shapes that cater to surgeons’ requirements. In scenarios tal pressure, promoting compression. However, compressive
where surgical exposure might jeopardize blood supply or in plating techniques, including DCPs, require precise tech-
cases of contaminated wounds, temporary use of skeletal pin nique and are prone to operator error.
external fixation might be employed.23 Before the advent of
contemporary internal fixation techniques, maxillomandibu- Noncompressionosteosynthesis. Noncompressionosteosynthe-
lar fixation (MMF) or interdental fixation was extensively sis techniques, such as non-compression bone plates and
employed. MMF compresses fractures at the alveolus, yet reconstruction plates with locking mechanisms, offer wider
there might still be a gap along the inferior border of the uses and little room for error compared to compression
mandible. MMF contributes to achieving anatomically osteosynthesis.
4 FACE 00(0)
The evolution of fixation systems has seen advancements to refine these technologies and overcome their associated
in dynamic compression plates, lag screws, bio-absorbable limitations.
plates, mini plates, and locking plates. Each type offers spe- Artificial intelligence (AI) is the ability of intelligent
cific advantages and disadvantages in terms of compression, machines to predict unknown variables by using algorithms
cost, strength, and incidence of inflammatory complications. and internal statistical patterns and information structures.
The working areas of AI in maxillofacial and plastic sur-
Biomechanical principles of fixation. Biomechanical principles gery are wide and in the fields of rhinoplasty, orthognathic
play a crucial role in the development of fixation systems. surgery, cleft lip and palate, augmentation in implants, and
Understanding masticatory stress distribution in the mandi- diagnosis and determination of survival rate in cancer patients.
ble is essential for designing and positioning osteosynthesis Data-driven algorithms can be built by machines, and
plates effectively. Considerations include re-establishment thus, they can solve prediction problems without human
of occlusion, anatomical reduction, stable fixation, and intervention. Several AI applications in maxillofacial sur-
maintenance of blood supply. gery utilize digital imaging, 3D photography, intraoral scans,
and 3D photographs to predict results and plan surgeries, for
Future of fixation in maxillofacial surgery. The twentieth cen- example, after skeletal trauma.37-39
tury witnessed rapid discoveries and global dissemination of
knowledge. In the field of maxillofacial surgery, advance-
ments in histology/anatomy and biology/physiology have
Future Materials That Can be Used for
laid the foundation for significant changes. Technological Maxillofacial Surgery
progress, such as computer-based surgical navigation33 and Magnesium-based materials are gaining attention in maxillo-
3D printing, has revolutionized surgical practices and paved facial surgery as a promising alternative to traditional titanium
the way for robotic surgery. Engineering-assisted tissue plates and screws due to their comparable physical properties.
repair has also made great strides, enabling the development These materials address the limitations of synthetic polymeric
of biomaterials and dental implants. Non-IMF reduction pro- plates, offering resorbable options and enhanced biocompati-
cedures and endoscopic techniques offer alternative bility. Research, including animal studies, has been actively
approaches to mandibular fracture therapy and facial fracture conducted to assess magnesium’s suitability in osteofixation
treatment, respectively, with potential benefits such as faster for facial fractures. Studies explore corrosion resistance and
healing and reduced scarring. Biodegradable metals, particu- potential surface modifications to improve biocompatibility.
larly Mg-, Zn-, and Fe-based materials, have diverse applica- Notable experiments with hydroxyapatite-coated magnesium
tions in oral and maxillofacial regions, promoting tissue plates and promising results in beagle dog cases highlight the
regeneration.34 Future research goals include exploring the potential benefits of magnesium-based solutions. While mag-
mechanical properties of biodegradable plates and screws, nesium-based headless screws applied to the fractures of the
investigating degradation mechanisms, developing new condylar head in human cases exhibit excellent biocompatibil-
materials like bone glues and staplers, and evaluating rapid ity and comparable results to titanium,40 further clinical stud-
fixation procedures, require minimal equipment, and have ies are needed to assess their viability for broader use in
low morbidity and cost-effectiveness. maxillofacial surgery.
foreign-body responses, the ability to regulate the rate at 23. Rai A, Datarkar A, Borle RM. Are maxillomandibular fixa-
which they are absorbed by the body, and improved ease of tion screws a better. Option than Erich arch bars in achieving
use in procedures like plate bending and self-tapping. maxillomandibular fixation? A randomized clinical study. J
Oral Maxillofac Surg. 2011;69:3015-3018.
24. Bissada E, Abou-Chacra Z, Ahmarani C, Poirier J, Rahal A.
Declaration of Conflicting Interests
Intermaxillary screw fixation in mandibular fracture repair. J
The author(s) declared no potential conflicts of interest with respect Otolaryngol Head Neck Surg. 2011;40:211-215.
to the research, authorship, and/or publication of this article. 25. Ahmad N, Lyles J, Panchal J, Deschamps-Braly J. Outcomes
and complications based on experience with resorbable plates
Funding in pediatric craniosynostosis patients. J Craniofac Surg.
The author(s) received no financial support for the research, author- 2008;19:855-860.
ship, and/or publication of this article. 26. Haers PE, Suuronen R, Lindqvist C, Sailer H. Biodegradable
polylactide plates and screws in orthognathic surgery: technical
note. J Craniomaxillofac Surg. 1998;26:87-91. doi:10.1016/
Ethical Approval
S1010-5182(98)80045-0
Institutional Review Board approval was not required. 27. Chen Y, Zhang H. Ultrasound-aided biodegradable osteosyn-
thesis system: application in fixation of oral and maxillofacial
ORCID iD fractures. Zhonghua Yi Xue Za Zhi. 2013;93:1418-1421.
28. Goelzer JG, Avelar RL, de Oliveira RB, et al. Self-drilling and
Akash Ganguly https://orcid.org/0000-0002-8724-0175
self-tapping screws: an ultrastructural study. J Craniofac Surg.
2010;21:513-515. doi:10.1097/SCS.0b013e3181d023bd
References
29. Palani T, Panchanathan S, Rajiah D, et al. Evaluation of 3D
1. Breasted JH. Edwin Smith Surgical Papyrus. Chicago, trapezoidal plates in open reduction and internal fixation of
University of Chicago Press; 1930. subcondylar fractures of mandible: a clinical trial. Cureus.
2. Salicetti G. PraxeosTotiusMedicinae. De Chirurgia; 1275. 2021;13:1-14. doi:10.7759/cureus.15537
3. Pare A. The Workes of the Famous Chirurgion Ambroise 30. Sikora M, Sielski M, Stąpor A, Chlubek D. Use of the delta
Parey. Translated Out of the Latina and Compared With the plate for surgical treatment of patients with condylar fractures.
French.Johnson, T. London, Cotes and Young; 1634. J Craniomaxillofac Surg. 2016;44:770-774. doi:10.1016/j.
4. Fauchard P. Traite de ChirurgieDentaire. Mariette; 1728. jcms.2016.04.008
5. Chopart E, Desault PJ. Traite Des Maladies Chirurgicales. 31. Yaremchuk MJ. Mandibular augmentation. Plast Reconstr
Paris, Villier; 1779. Surg. 2000;106:697-706. doi:10.1097/00006534-200009010-
6. Graefe CF. J der Chir u Augenheilk. 1823;i:583-593. 00030
7. Graham H. Surgeons All. London, Rich, and Cowan; 1939 32. Weigele B. EinVersuch am Bau des Unterkiefers die Gesetze
8. Ringelmann KF. Der Organismus Des Mundes. Riegel und der Mechanik und statikaufzufinden. Korresp Bl Zahnärzte.
Weissner; 1824. 1921;47:3-19.
9. Baudens JB. Fracture de La Machoire Inf6rieure, Vol. 5. Bull 33. Winkler R. Der funktionellebau des menschlichenKieferappa-
Acad. de Med; 1840:341. rates. DtschZahnheilkd. 1922;55:84-155.
10. Annandale T. Case of Fracture through Both Rami of the 34. Louvrier A, Martyn P, Weber E, et al. Meyer How useful is
Lower Jaw, Treated by External Incision and the Wire Suture. 3D printing in maxillo-facial surgery? (2017). doi:10.1016/j.
Br Med J. 1875;1:170. jormas.2017.07.002
11. Buck G. New Y J Med 2006. 1847;211. 35. Brunzini A, Mazzoli A, Pagnoni M, Mandolini M. An innova-
12. Kinloch RA. Rare form of fracture of the lower jaw, successfully tive mixed reality approach for maxillofacial osteotomies and
treated by suture of the fragments. Am J Med Sci. 1859;38:67. repositioning. Virtual Real. 2023;27:3221-3237.
13. Hamilton FH. Buffalo Med J. 1857;13:385. 36. Ackermann, J, Liebmann F, Hoch A, et al. Augmented reality
14. Guerin A. Arch Gen de Med Paris. 1866;8:1. based surgical navigation of complex pelvic osteotomies—a
15. Gunning TB. NY Med J. 1866;3:433. feasibility study on cadavers. Appl Sci 2021;11 (3): 1228.
16. Gunning TB. NY Med. J. 1867;4:514. 37. McCullough M, Ly S, Auslander A, et al. Convolutional neural
17. Gilmer TL. A case of fracture of the lower jaw with remarks on network models for automatic preoperative severity assessment
treatment. Arch Dent. 1887;4:388. in unilateral cleft lip. Plast Reconstr Surg. 2021;148:162-169.
18. Angle EH. Brit J Dent Sc. 1890;33:484. 38. Spoer DL, Kiene JM, Dekker PK, et al. A systematic review of
19. Le Fort R. Etude experimentale sur les fractures de la machoire artificial intelligence applications in plastic surgery: looking to
superieure. Rev de Chir. 1901;1:208, 260, 479. the future. Plast Reconstr Surg Glob Open. 2022;10:e4608.
20. Gillies HD, Kilner TP, Stone D. Fractures of the Malar- 39. On SW, Cho SW, Byun SH, Yang BE. Bioabsorbable osteofixa-
zygomatic compound: with a description of a new X-ray posi- tion materials for maxillofacial bone surgery: a review on poly-
tion. Br J Surg. 2006;14:651-656. mers and magnesium-based materials. Biomedicines. 2020;8:300.
21. Adams WM. Internal wiring fixation of facial fractures. 40. Leonhardt H, Franke A, McLeod NMH, Lauer G, Nowak
Surgery. 1942;12:523. A. Fixation of fractures of the condylar head of the mandible
22. Helfet DL, Haas NP, Schatzker J, et al. AO philosophy and with a new magnesium-alloy biodegradable cannulated head-
principles of fracture management-its evolution and evalua- less bone screw. Br J Oral Maxillofac Surg. 2017;55:623-625.
tion. J Bone Joint Surg Am. 2003;85:1156-1160. doi:10.1016/j.bjoms.2017.04.007