MCQs (One best type)

Q.1. In insulin dependent diabetes mellitus antibodies are formed against

a. Pancreatic tissue
b. Multiple organs
c. Antibodies have absolute specificity for B-cells of Islets
d. Glomerular basement membranes
e. Pancreas and kidney

Q.2. Sjogren Syndrome most commonly occurs in association with

a. Scleroderma
b. Systemic Lupus Erythematosus
c. Rheumatoid Arthritis
d. Thyroiditis
e. Vasculitis

Q.3. The rim or peripheral pattern of nuclear fluorescence is commonly indicative of

a. Antibodies to histones
b. Antibodies to Sm antigen
c. Antibodies to RNA
d. Antibodies to Chromatin
e. Antibodies to double-Stranded DNA

Q.4. In patients of SLE high titres of double-stranded DNA antibodies are usually
associated with
a. Active renal disease
b. Higher risk of neurologic disorder
c. Low risk of nephritis
d. Higher incidence of serositis
e. Low risk of Arthritis
Q.5. Antiphospholipid Antibodies are
a. Present in all patient of SLE
b. Directed against plasma proteins complexed to phospholipids
c. Always associated with recurrent spontaneous abortion
d. Directed against anionic phospholipids
e. Diagnostic of Sjogren Syndrome

Q.6. Patient of diffuse system sclerosis with positive serology for anti Scl-70 (anti
DNA topoisomerase I antibodies) is associated with
a. better prognosis
b. Increased occurrence of pulmonary fibrosis and peripheral vascular
disease
c. CREST Syndrome
d. Increased association with SLE
e. Primary defect in fibroblasts and collagen

Q.7. A 30 years old female with skin rash on face and photosensitivity has presented
with puffy face. Lab investigations revealed +++ proteinuria. The most helpful /
diagnostic antibody is
a. Anti Nuclear RNP
b. Anti double-stranded DNA
c. Anti Sm
d. Anti mitochondrial
e. SS-A (Ro)
Q.8. A 40-year-old female presented with burnning and irritation of eyes, arthritis and
submandibular swelling. Serological examination revealed SS-A (Ro) and SS-B (La)
antibodies. The most likely diagnosis is
a. Drug induced SLE
b. Vasculitis
c. Discoid LE
d. Polymyositis
e. Sjogren Syndrome

Q.9. In Dermatomyositis inflammatory infiltrate is predominantly found

a. in endomysinm
b. around capillaries
c. in perimysium alone
d. around small blood vessels and in perimysium
e. in areas of muscle fibre degeneration

Q.10. A 40-year-old lady presented with fever and arthralgias. She has been on
medication for high blood pressure. Her serology is positive for Anti-Sm
antibodies. The most likely diagnosis is
a. Lupus Nephritis
b. Discord lumpus Erythematosus
c. Sjogren Syndrome
d. Subacute cutaneous Lupus erythematosus
e. Drug-induced lupus erythematosus

Q.11. Biopsy of enlarged lymph node in early stages of HIV infection reveal
a. Follicles depleted of cells
b. Marked follicular hyperplasia
c. Hyalinized germinal centres
d. Expanded mantle zone
e. Disruption of follicular dendritic cells
Q.12. Di George syndrome is an example of a T-cell deficiency that
a. is a familial disorder
b. results from hyperplasia of thymus
c. does not affect cell-mediated immunity
d. derives from failure of development of 3rd and 4th pharyngeal pouches
e. causes plasma cell depletion in lymphoid tissue

Q.13. Regarding HIV

a. M-tropic strains can infect only monocytes / macrophages
b. T-cell tropic strains can infect only freshly isolated T cells
c. during the course of infection M-tropic strains never evolve into T-tropic
strains
d. M-tropic strains can infect both monocytes / macrophages and invitro
propagated T-cell lines
e. T-cell tropic strains can infect T-cells both freshly isolated and retained in
culture

Q.14. Among AIDS-related lymphomas

a. Primary CNS lymphoma constitute 80% of all lymphomas
b. Body cavity-based lymphomas develop in females only
c. All patients with AIDS develop Non-Hodgkin’s lymphoma during their
life time
d. T cells lymphomas predominate over B cell lymphomas
e. EBV genome is found in all lymphomas primary in the CNS

Q.15. Amyloid deposits composed of AA protein are

a. localized in the synovium and tendon sheaths
b. associated with familial amyloidotic neuropathies
c. the hallmark of immunocyte dyscrasias
d. may occur in association with renal cell carcinoma
e. always reversible with treatment
Q.16. A 9 year-old girl presented with retained deciduous teeth. On examination she had
short stature, coarse skin and low intelligence level. Oral examination revealed
thickened lips and enlarged tongue. The diagnosis is
a. Rickets
b. Thyrotoxicosis
c. Pseudohypo parathyroidism
d. Cretinism

Q.17. Regarding cleft lip

a. 80% cases are bilateral
b. 70% cases are associated with cleft palate
c. 70% of unilateral cleft lips occur on the left side
d. Frequency is higher in females

Q.18. A 45 year-old lady complained of swelling of the upper lip on left side with nasal
obstruction on same side. Examination revealed small soft swelling of lip with
elevation of ala of nose on left side while no radiographic changes were seen on X-
ray. The most likely diagnosis is
a. Nasolabial cyst
b. Thyroglossal cyst
c. Dermoid cyst
d. Follicular cyst of the skin

Q.19. Peripheral ossifying fibroma

a. represents the soft tissue counterpart of central ossifying fibroma
b. occurs exclusively on the gingiva
c. most lesions are >2 cm in size
d. is always pedunclulated

Q.20. A 5 year-old boy has presented with rapidly increasing swelling of right maxilla.
Incisional biopsy is done. Histopathology of this biopsy revealed a cellular tumour
comprising predominantly of small round cells with hyperchromatic nuclei and
scattered large round to oval cells with moderate eosinophilic cytoplasm.
Immunohistochemistry was performed and tumour cells were Myogenin positive.
The morphological and IHC findings are consistent with
a. Alveolar rhabdomyosarcoma
b. Embryonal rhabdomyosarcoma
c. Synovial sarcoma
d. Leiomyosarcoma
Q.21. Aging pigment is known as
a) Lipofuscin
b) Melanin
c) Bilirubin
d) Haemosiderin

Q.22. Which type of necrosis is a feature and suggestive of tuberculosis

a) Coagulative necrosis
b) Caseous necrosis
c) Liquefective necrosis
d) Fat necrosis

Q.23. . Increase in number of cell is known as

a) Hypertrophy
b) Anaplasia
c) Hyperplasia
d) Dysplasia

Q.24. Replacement of are mature epithelium or tissue by another mature

epithelium or tissue is called
a) Metaplasia
b) Hypertrophy
c) Hyperplasia
d) Dysplasia

Q.25. Pathway of cell death that is induced by a tightly regulated intracellular

program in which cells destined to deactivate enzyme that degrade cells is
known as
a) Ischemic cell injury
b) Necrosis
c) Apoptosis
d) Atrophy
KEY

Q.1. C
Q.2. C
Q.3. E
Q.4. A
Q,5. B
Q.6. B
Q.7. B
Q.8. E
Q.9. D
Q.10. E
Q.11. B
Q.12. D
Q.13. E
Q.14. E
Q.15. D
Q.16. D
Q.17. C
Q.18. A
Q.19. B
Q.20. B
Q.21 A
Q.22 B
Q.23 C
Q.24 A
Q.25 C