Cold Chain Medication List 2021

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Cold Chain

Medication
List
2021
SECOND EDITION
FULL WEB VERSION CAN BE DOWNLOADED FROM:
www.sasmec.iium.edu.my/index.php/pharmacy
JANUARY 2021

This list is constantly being reviewed and will be updated periodically

Copyright® 2021 by Department of Pharmacy, Sultan Ahmad Shah


Medical Centre. All rights reserved. No part of this publication may
be reproduced without permission in writing from the publisher.

Publisher:
DRUG AND POISON INFORMATION SERVICES UNIT (DIS),
SULTAN AHMAD SHAH MEDICAL CENTRE @IIUM (SASMEC @IIUM)
JALAN SULTAN HAJI AHMAD SHAH
25200 KUANTAN
PAHANG

Phone: 09-5912500 Ext: 2558/2672


Email: pharmacy_iiummc@iium.edu.my
Website: www.sasmec.iium.edu.my

Cold Chain Medication List | DIS – Department of Pharmacy (2021)


Madam Che Rokiah Ismail
ADVISOR
Madam Che Rokiah BINtI Ismail

EDITOR
FATIN AZZYATI BINTI PAKURURAZI

CONTRIBUTORS
Najwa Nurdiyana binti Abdubrani
Raihah Bt Abd Rahim

We would like to thank everyone who have contributed


directly or indirectly for this publication

Cold Chain Medication List | DIS – Department of Pharmacy (2021)


After reconstitution/
No. Generic Name Brand Name Storage
opened
Once opened, below
1 Actrapid 100IU/ml Vial Actrapid 2–8 °C1,2
30 °C, for 6 weeks.1,2
2–8 °C3,4
can be stored below
2 Aflibercept Injection Eylea Immediate use4
25°C for up to 24
hours.4
Alprostadil 500mcg Prostin VR Pediatric 2–8 °C5,6,7 Below 25°C for up to
3
Injection 500 mcg/1 ml 24 hours.6,7
 2–8 °C for up to 7
Amphotericin B 50mg Amphotret B Sodium days8,10
4 2–8 °C8,9,10
Injection Deoxycholate  Below 25 oC, stable
for up to 8 hours.9
2–8 °C11,12  Below 25°C for up
Journey for 96 hours to 24 hours.11,12
Anidulafungin 100mg
5 Eraxis up to 25°C is  Excursions
Injection
permitted.12 permitted to 15-
30°C.11,12
Below 25°C for up to
Vitamin C Chewette
6 Ascorbic Acid Tablet Below 25°C13,14 3 months of
(Hovid)
opening.13,14
 Diluted product
must be stored
Atosiban 7.5mg/ml below 25°C and
7 Tractocile 2–8 °C15
Injection used within 24
hours after
preparation.15
 Up to 24 hours at
room
temperature.16
 Diluted solution
stable in daylight
up to 30°C: 24
Atracurium Besylate Atracorium hours (NS), 8
8 2–8 °C17-19
25mg/2.5ml Injection (Hamelin) hours (D5), 8
hours (Ringer’s
Injection), 8 hours
(0.18NaCl with
Glucose 4%), 4
hours (Hartman’s
Solution)17-19
Freeze-dried
9 BCG Vaccine Injection glutamate BCG 2–8 °C20 Use immediately20
Vaccine (Japan)
Beclomethasone 2–8 °C for a max of 15  Below 30°C for a
10 Foster
100mcg/ Formoterol months.21,22 max of 2 months.

Cold Chain Medication List | DIS – Department of Pharmacy (2021)


6mcg Inhaler Not more than
50°C .21
Stable for 60 days
Human Chorionic
11 Pregnyl 15-30°C23,24 when stored
Gonadotropin Injection
between 2-8°C24
Carboprost
Ampoule: 2 - 8°C25,26
12 Tromethamine 250mcg Hemabate Use immediately
Vial: 0 - 6°C25, 26
Injection
Chloral Hydrate
13 Chloral Hydrate Crystals Below 25°C27,28 Use immediately
Crystal
Chloramphenicol Ear 28 days after
14 2–8 °C29,30
Drop opening29,30
Chloramphenicol Eye 28 days after
15 2–8 °C30,31
Drop opening30,31
Clindamycin 150mg/ml 15-25°C32
16 Tidact 150mg/ml 25°C for IV infusion34
Injection Below 25°C33,34
Clostridium Botulinum 2–8 °C for up to 24
17 Dysport 2–8 °C35,36
Injection hours35,36
Desmopressin Acetate
18 Minirin 2-8°C37-39 Use immediately
4mcg/ml Injection
28 days after
Degludec/ Aspart Insulin
19 Ryzodeg 2–8 °C 40,41
opening at room
Prefilled Pen
temperature 40,41
Once removed from
the refrigerator,
must not be exposed
Denosumab 120mg 2-8°C42
20 Xgeva to temperatures
Injection
above 25°C or direct
light and must be
used within 14 days43
Store below -20°C.
Dinoprostone 3mg Bring to room
21 Prostine Use immediately
Pessary temperature prior to
use44,45
Once opened, store
Dulaglutide 0.75mg and
22 Trulicity 2-8°C 46,47
below 30°C for up to
1.5mg Pen
14 days47, 48.
Once removed from
the refrigerator,
Epoetin Beta 2000 store below 25°C
23 Recormon 2-8°C48,49
iu/0.3ml Injection and it can be used up
to 3 days for a single
period.48,49
Once removed from
Filgrastim 0.3ml/ml
24 Neupogen 2-8°C50,51 refrigerator, can be
Injection
used for up to 24

Cold Chain Medication List | DIS – Department of Pharmacy (2021)


hours (max).51
Can be refrigerated or
Follitropin Alpha Discard unused
stored at room
(Recombinant Human reconstituted
25 Gonal F temperature below
FSH) 300iu/0.5ml solution after 28
25°C
Prefilled Syringe days52,53
(2-25°C)52,53
26 Gemeprost Pessary Cervagem below -10°C54,55 Immediate use54,55
20-25°C56-58
27 Glucagon Injection GlucaGen Immediate use56-58
Up to 24 months.58
Hepatitis B Adult Vaccine
28 2-8°C59,60 Immediate use59,60
Injection
Hepatitis B
29 Immunoglobuline Human Hepabig 2- 8°C61,62 Immediate use
100iu Injection
2- 8°C63,64
Hepatitis B Paediatric Up to 25°C, at room
30 Evax B Immediate use
Vaccine Injection temperature
(unopened)64
Human Albumin 20% 2-25°C for 36 Once opened, stable
31 Zenalb 20
Injection months65,66 for 3 hours66
Human Anti-D
2- 8°C for 36
32 Immunoglobulin Rhophylac 300 Immediate use
months67,68
625iu/ml Injection
Human Normal
33 Immunoglobulin IVIG-globulin SN 2- 8°C for 24 months69 Immediate use
2500mg/50ml Injection
Prior to use,
unopened vial at
room temperature
Idarucizumab 50mg/ml 2- 8°C70,71 25°C for up to 48
34 Praxbind
Injection hours, protected
from light. If exposed
to light, stable for up
to 6 hours.70,71
After punctured,
stable at room
Insulin Detemir 100iu/ml 2- 8°C72-74
35 Levemir temperature below
Flexpen
30°C for up to 42
days (6 weeks).72-74
Used pen kept in a
Insulin Glargine 2- 8°C75-76 room temperature
36 Toujeo
450iu/ml Prefilled Pen below 30 is stable
for up to 28 days.75,76
Used pen kept in a
Insulin Novomix 100iu/ml
37 Novomix 30 2- 8°C77,78 room temperature
Flexpen
below 30°C is stable

Cold Chain Medication List | DIS – Department of Pharmacy (2021)


for up to 28 days.77,78
Leucovorin Calcium
38 50mg/5ml (Calcium DBL Leucovorin Ca 2- 8°C79,80 Use immediately
Folinate) Inj
Once reconstituted
with diluent, the
Leuprorelin Acetate 3.75 Store below 25°C. Do
39 LUCRIN Depot suspension may be
mg Inj not freeze.81
stored below 25°C,
for up to 24 hours.81
Once reconstituted
with diluent, the
Leuprorelin Acetate 11.25 Store below 25°C. Do
40 LUCRIN Depot suspension may be
mg Inj not freeze.81
stored below 25°C,
for up to 24 hours. 81
The end-user may
remove the
medicinal product
Methoxy polyethylene from refrigeration
41 glycol-epoetin beta Mircera 2-8°C. Do not freeze.82 for storage at a
Prefilled Syringe room temperature
not above 30°C for
one single period of 1
month82
Once opened, store
below 30°C or store
Novorapid 100iu/ml in a refrigerator
42 Novorapid 2-8°C. Do not freeze.83
Flexpen (2°C–8°C). Used
within 4 weeks. Do
not freeze.83
For prolonged
storage, store at 2-
Once diluted, stable
Octreotide Acetate 8°C. For day-to-day
43 Sandostatin for 24hours stored
0.05mg/ml Injection use, may be stored
below 25°C.84
above 30°C for up to 2
weeks.84
For prolonged
storage, store at 2-
Once diluted, stable
Octreotide Acetate 8°C. For day-to-day
44 Sandostatin for 24hours stored
0.1mg/ml Injection use, may be stored
below 25°C.84
above 30°C for up to 2
weeks.84
Oxytocin 10iu/ml 2-8°C. Avoid freezing.
45 Udoxan injection Use immediately
Injection 85

Oxytocin/Ergometrine
46 Syntometrine 2-8°C86 Use immediately
5UI/ml Injection
Propofol 1% 10mg/ml Store below 25°C. Do
47 Fresofol 1% Use immediately
Injection not freeze.87

Cold Chain Medication List | DIS – Department of Pharmacy (2021)


Proparacaine
Discard 28 days
48 Hydrochloride Alcaine 2-8°C.88
after opening.88
Ophthalmic Solution
Store below 25°C. Do
Prothrombin Complex Stable up to 8 hours
49 Octaplex not freeze.89
Concentrate Injection at 25°C90
2-8°C.90
Ranizumab 10 mg/ml
50 Accentrix 2-8°C. Do not freeze91 Use immediately
Injection

2-8°C. May be stored Immediate use. Once


at room temperature diluted, stable for
Rocuronium Bromide
51 Esmeron up to 30°C for a 72hours at room
50mg/5ml Injection
maximum of 12 temperature up to
weeks. 92 30°C.92

The reconstituted
solution should not
Streptokinase 1,500 000 Streptokinase Store below 25°C. Do
52 be stored for more
Injection Biofactor 1,500 000 not freeze.93
than 12 hours at 2-
8°C. 93
Suxamethonium Once opened, any
53 Chloride 50mg/ml 2-8°C94 unused liquid should
Injection be discarded94
Terlipressin acetate
54 Glypressin 2-8°C95 Use immediately
0.1mg/ml Injection
Once opened, multi
dose vials should be
Tetanus Toxoid 0.5ml kept between 2°C -
55 TT Vaccine 2-8°C96
Injection 8°C and must not be
frozen. Must use
within 4 weeks96
Tetracosactide Acetate
56 Synacthen 2-8°C97 Use immediately
250mg Injection
Multi dose vials may
be used for up to
Tuberculin 2T.U/0.1ml maximum 4 weeks if
57 Tuberculin 2-8°C98
Injection kept in dark at 2°C -
8°C and used
aseptically.98
Diluted solution,
Store below 25°C. Do must be used within
Vasopressin 20IU not freeze.99 24 hours if stored 2-
58
Injection Store between 15- 8°C and within 18
25°C. 100 hours if stored at
room temperature.100
Insulin Intermediate- After first opening or
59 Insulatard® 2-8°C101
Acting 100iu/ml Injection carried as a spare:

Cold Chain Medication List | DIS – Department of Pharmacy (2021)


in 10ml Vial Do not refrigerate.
The in-use shelf life
is 6 weeks when
stored below 25°C.
or 4 weeks when
stored below 30°C. 101

Cold Chain Medication List | DIS – Department of Pharmacy (2021)


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<https://www.mims.com/malaysia/drug/info/actrapid/storage> [Accessed 20 December 2020].
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0Nordisk%20Pharma%207Aug2014%20BM.pdf.
3. Mims.com. 2020. Aflibercept: Indication, Dosage, Side Effect, Precaution | MIMS Malaysia. [online] Available
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<https://www.mims.com/malaysia/drug/info/foster/storage>

Cold Chain Medication List | DIS – Department of Pharmacy (2021)


22. Medicines.org.uk. 2020. Foster 100/6 Inhalation Solution - Patient Information Leaflet (PIL) - (Emc). [online]
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23. Chorionic gonadotrophin: Indication, Dosage, Side Effect, Precaution | MIMS Malaysia. (2020). Retrieved 21
December 2020, from https://www.mims.com/malaysia/drug/info/chorionic%20gonadotrophin
24. Pregnyl. (2020). Retrieved 21 December 2020, from
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25. Hemabate Sterile Solution - Summary of Product Characteristics (SmPC) - (emc). (2020). Retrieved 21
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27. Chloral hydrate: Indication, Dosage, Side Effect, Precaution | MIMS Malaysia. (2020). Retrieved 27 December
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2020, from https://www.mims.com/malaysia/drug/info/dulaglutide?mtype=generic

Cold Chain Medication List | DIS – Department of Pharmacy (2021)


47. Dulaglutide. (2020). Retrieved 29 December 2020, from
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use%20after%20expiration%20date.
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67. Product Leaflet: Rhophylac 500. CSL Behring AG. Retrieved at https://www.fda.gov/media/75013/download
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69. Human normal Immunoglobulins: Indication, Dosage, Side Effect, Precaution | MIMS Malaysia. (2020).
Retrieved at https://www.mims.com/malaysia/drug/info/i-v--globulin%20sn/storage
70. Praxbind(idarucizumab). Boehringer Ingelheim International GmbH. Revised Oct 2015. Retrieved at
https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/761025lbl.pdf
71. Praxbind. BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. April 2018. Retrieved from
https://www.praxbind.com/dosing/storage-handling

Cold Chain Medication List | DIS – Department of Pharmacy (2021)


72. Package Leaflet: Insulin Levemir. Novo Nordisk A/S. June 2005. Retrieved from
https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/021536s015lbl.pdf
73. Levemir Insulin: Indication, Dosage, Side Effect, Precaution | MIMS Malaysia. (2020). Retrieved from
https://www.mims.com/malaysia/drug/info/levemir/storage
74. Package Insert. Lemir PI. Novo Nordisk A/S. Revised Mac 2020. Retrieved from https://www.novo-
pi.com/levemir.pdf
75. Highlights of prescribing information: TOUJEO (insulin glargine injection) U-300. Sanofi-aventis U.S. LLC.
February 2015. Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/206538lbl.pdf
76. Toujeo Insulin: Indication, Dosage, Side Effect, Precaution | MIMS Malaysia. (2020). Retrieved from
https://www.mims.com/malaysia/drug/info/toujeo/storage
77. Novomix 30: Indication, Dosage, Side Effect, Precaution | MIMS Malaysia. (2020). Retrieved at
https://www.mims.com/malaysia/drug/info/novomix%2030/storage
78. Package leaflet: Information for the user. NovoMix® 30 Penfill®. Novo Nordisk A/S, Denmark. 2020. Retrieved
from https://www.medicines.org.uk/emc/files/pil.7915.pdf
79. DBL Leucovorin Ca: Indication, Dosage, Side Effect, Precaution | MIMS Malaysia. (2020). Retrieved from
https://www.mims.com/malaysia/drug/info/dbl%20leucovorin%20ca/storage
80. Consumer Medicine Information: DBL(R) Leucovorin Calcium Injection and Tablets. August 2009. Retrieved
from https://gp2u.com.au/static/pdf/D/DBL_LEUCOVORIN_CALCIUM-CMI.pdf
81. Lucrin Depot Injection I Medsafe Govt. NZ. (2021) Retrieved 5 January 2021, from
https://medsafe.govt.nz/profs/Datasheet/l/LucrinDepot1-month3month6monthDUALinj.pdf
82. Package leaflet: Summary of Product Characteristics. Mircera solution for injection in pre-filled syringe.
Roche. 2021. Retrieved from https://www.medicines.org.uk/emc/product/360
83. Novorapid Storage | MIMS Malaysia. (2021). Retrieved 5 January 2021, from
https://www.mims.com/malaysia/drug/info/novorapid
84. Package leaflet: Octreotide. Novartis Corporation Sdn. Bhd. October 2017
85. Package leaflet: Udoxan Injection 10IU/ml. Duopharma (M) Sdn Bhd.
86. Package leaflet: Syntometrine. Alliance Pharmaceuticals Limited. 2014.
87. Fresofol 1% MCT/LCT (propofol) I Fresenius-Kabi.com. 2021 Retrieved 5 January 2021, from
https://www.fresenius-kabi.com/au/documents/Fresofol_1__MCT-LCT_PI.pdf
88. Alcaine Storage | MIMS Philippines. (2021). Retrieved 5 January 2021, from
https://www.mims.com/philippines/drug/info/alcaine?type=full
89. Package leaflet: Summary of Product Characteristics. Octaplex 500 IU. Octapharma Limited. 2021. Retrieved
fromhttps://www.medicines.org.uk/emc/product/6566
90. Octaplex Storage | MIMS Malaysia. (2021). Retrieved 3 January 2021, from
https://www.mims.com/malaysia/drug/info/octaplex/storage
91. Accentrix Storage | MIMS Malaysia. (2021). Retrieved 5 January 2021, from
https://www.mims.com/malaysia/drug/info/accentrix?type=full
92. Package leaflet: Esmeron 50mg/5ml. Merck Sharp & Dohme Sdn. Bhd. March 2019.
93. Package leaflet: Streptokinase 1 500 000 IU. Biofactor GmbH. (2009)
94. Package leaflet: Summary of Product Characteristics. Suxamethonium Chloride 50mg/ml Solution for
Injection. Advance Pharma. 2021. Retrieved from
https://www.medicines.org.uk/emc/product/5189/smpc#gref
95. Package leaflet: Glypressin 0.1mg/ml. Ferring International Center S.A. (July 2017)
96. Package leaflet: TT Vaccine 0.5ml. Propharma (M) Sdn. Bhd. (1 August 2016)
97. Package leaflet: Summary of Product Characteristics. Synacthen Ampoules 250micrograms. Atnahs. 2021.
Retrieved from https://www.medicines.org.uk/emc/product/10822/smpc
98. Package leaflet: Tuberculin Diluted IP for Mantoux test only. ARKRAY Healthcare Pvt. Ltd.
99. Package leaflet: Cpressin-P 20IU. Samarth Life Sciences PVT. LTD.
100. Vasopressin Storage | MIMS Malaysia. (2020). Retrieved 3 January 2021, from
https://www.mims.com/malaysia/drug/info/vasopressin?mtype=generic
101. Insulatard® Suspension for injection in vial 100iu/ml Product Leaflet. Retrieved 13 January 2021.

Cold Chain Medication List | DIS – Department of Pharmacy (2021)

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