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(2.5) Jaringan Epitel
(2.5) Jaringan Epitel
(2.5) Jaringan Epitel
OF
EPITHELIUM
BY : DEPARTEMENT OF HISTOLOGY
0 EPITEL
Terdiri dari sel-sel
0
Tatingandasatnanusia polihedral yang
teragregasi erat
Human body is composed of 4 basic types of tissue dengan
: zat
Epithelial Tissues
t-pitel-g-OPenbuwhdakhbetinakanjt.epite.IT
1. '
→
ekstraseluler yang
sangat sedikit
Composed of closely aggregated polyhedral cells with very
little extracellular substance.
2. Connective Tissues Tat / Kat / Penyokong / Pehdukvng ① Pembuluhdatah
. → .
→
melapisi organ
Epithelium : riepitel petnukaan →
EPITEL
0
Basic function :
1. Protection (skin)
2.
: Absorption (small and large intestine)
3. Transport of material (by cilia)
-
4. -
Secretion (gland)
5. Excretion (tubulus of the kidney)
6.
: Gas exchange (lung alveolus)
7. Gliding between surface (mesothelium)
I
EPITEL
Classified into 3 major categories : 0
1. 1. Simple epithelia : 1 layer of cells
a. simple squamous epithelium
4 ↳pisan dividing
b. Simple cuboidal epithelium
A penbvwbdatah
c. ↳
Simple columnar epithelium
Endothelium : simple epithelium lining the blood and lympatic vessel.J
Mesothelium : simple epithelium lining all body cavities. → Lapis as tohggatubvb
2. 2. Stratified epithelia : 2 or more cell layers
a. ↳ Stratified squamous epithelium :
1.
2.
k Non keratinized
Keratininized : (nuclei absent in the outer layer)
b. ↳ Stratified cuboidal epithelium
c. ↳ Sratified columnar epithelium
3. 3. Pseudostratified epithelium : basal and columnar cells
a. 4 Pseudostratified columnar ciliated epithelium → trachea
b. ↳ Pseudostratified columnar epithelium with stereocilia → epididymis
c. ↳ Transitional epithelium → urinary passage (urothelium)
EPITEL
0
→ Paling Huat
→ Paling Renton
↳ set
any PernaFason .
Pendency2ham
EPITEL
0
> selapis
r
squamous
cgepeng)
columnar Csilindris)
EPITEL
"
☐ lntiselmfatetlihat: gepeng
"
→ "• " Penn" " " ran """" """ trdptdi Gini"
Pewatnaan HE
.
EPITEL
?⃝
0
debts
p dividing
Penbulul
Figure 4—13.
Section of a vein
containing red
blood cells. All
blood vessels are
lined with a
simple
squamous
epithelium
called
endothelium
(arrowheads).
Pararosaniline–
toluidine blue
(PT) stain.
Medium
magnification.
EPITEL
g Inti set bulat
µµ, p
0
Figure 4—16. Simple columnar epithelium formed by long cells with elliptical nuclei. The
epithelium rests on the loose connective tissue of the lamina propria. A basal lamina (not
visible) is interposed between the epithelial cells and the connective tissue. The round nuclei
within the epithelial layer belong to lymphocytes that are migrating through the epithelium
(arrows). H&E stain. Medium magnification. (Courtesy of PA Abrahamsohn.) EPITEL
0
r
> betlapis
→
epitel Keksjzt rnultiselulet → betii Mottos
EPITEL
0
→ ⊖ intisel
EPITEL
↳ set 4g den at Permukaan , Sanya nehilangan inti set .
0
↳ Denton epitcldipetmukaannyspipihtpdidzlamnyakub.us .
EPITEL
↳ klw Non keratinized → Set yg ad di petmukaan Masi adz intinya
0
kelesjdtketib.2.tl
Kubis betkpis → ☐◦
vagus
↳ Khang , hany, 2 lap ,,
a
Inti berbenton bulat
↳ terditidzti 2 lapis
EPITEL
0
→ Sal Kemih
/ neutotcliom
.
>
daetahygdcnstpetrntkanberbentrksilindt.it
Yg di barn belbentuk Kuboid
Epithelial membranes are classified according to the number of cell layers between the basal lamina and the free surface
and by the morphology of the epithelial cells (Table 5–1). If the membrane is composed of a single layer of cells, it is
called simple epithelium; if it is composed of more than one cell layer, it is called stratified epithelium (Fig. 5–1).
The morphology of the cells may be squamous (flat), cuboidal, or columnar when viewed in sections taken
perpendicular to the basement membrane. Stratified epithelia are classified by the morphology of the cells in their
superficial layer only. In addition to these two major classes of epithelia, which are further identified by cellular
morphology, there are two other distinct types: pseudostratified and transitional.
For more information see the Epithelium section of Chapter 5: Gartner and Hiatt: Color Textbook of Histology, 3rd ed. Philadelphia, W.B. EPITEL
Saunders, 2007.
0
tonoobn
cilia ≥ Sito plasma
EPITEL
handing kemih 0
EPITEL
Taringa , Imt
EPITHELIAL CELL POLARITY0
Penonjotdh dati SitoPlasma
1. On apical polarity :
a. -
Cilia > trachea
• For protection
•
: Motile cell projection originating from basal bodies
b. - Microvilli → intestine
• For absorption
•
: Finger like projections of the apical epithelial cell surface
c. •
Stereocilia → epididymis
• Long and branching finger like projections of the apical epithelial cell surface
a.
2. :
Basolateral domain :
Cell adhesion molecules
b. I
Junctional complexes
EPITEL
0
cilia
villi
villi
EPITEL
0
stereosilia
EPITEL
0
i
superfamily (CAMs) and integrins
b. Junctional complexes :
EPITEL
0 Menentukan polaritas
sel epitel dan
1. <
Tight junction (zonula occludens) mencegah difusi bebas
Persimpangan ketat Apekt dam basal
Function : →
lipid dan protein di
antara mereka
• Determine epithelial cell polarity and preventing the free
•
: diffusion of lipids and proteins between them
Mencegah bagian bebas zat
Prevent of free passage of substance across an epithelial
melintasi lapisan selcell
epitel
layer (paracellular pathway barrier) (penghalang jalur paraseluler)
↳ then eegah Subs taxi yy 2h24 Mask / men filter zat
4g narrow /sat Pam
2. -
Anchoring junction below the tight junction
a. Zonula adherens or belt desmosome beti
↳ →
dgn Katan Huat set
sebelahnyz
a beltlike junction associated with actin microfilament
mediated by interaction of cadherin with catenins.
EPITEL
0
a. ↳ Macula adherens or spot desmosome : a spot like junction
• .
1.
•
:Gap Junction
Form by integral membrane protein called connexins
• 6 connexin monomer a connexon
• I
End to end ligament of connexons in adjacent cells provides a
direct channel of communication between cytoplasm of two
adjacent cells
↳ 0th kornmikasi set → spttpd Set Tasting
EPITEL
0
↳ kornnillssi set
EPITEL
0
EPITEL
0
LAMININ, FIBRONECTIN AND THE BASEMENT MEMBRANE
Laminin + Fibronectin :
• Distinct protein of ECM
:
• Associated with collagens, proteoglycans and other protein organize a
basement membrane
EPITEL
0
"ᵗ
Base?"
member
EPITEL
0
GLANDULAR EPITHELIA
• <
Tissue formed by cells specialized to produce secretion
• '
Molecules → secrete → secretory granules
• I Synthesize, store, secrete : protein (pancreas), lipid (adrenal,
sebaceous gland), carbohydrate + protein (salivary gland)
Secrete all substance : mammary glands
EPITEL
0
iᵗ"
Mel2WiDuKtvs@d4Kek2tmebbiKa.p
i let
EPITEL
0
EPITEL
0
° """ "
[
C
EPITEL
0
⊖ Duct
ENDOCRINE →
→ netdii Kapilet
• -
Lack an excretory duct
• i
Their product released into the blood circulation
=) boron sedans → Kent
• Surrounded by fenestrated capillaries
•
: Synthesize and release after stimulation by chemical or
electrical signals
• j Types of endocrine glands :
• The agglomerated cells form anastomosis cords interspersed between
•
: dilated blood capillaries (adrenal gland, parathyroid, anterior lobe of
pituitary)
The cell line a vesicle or follicle filled with noncellular material (thyroid
gland)
EPITEL
0
EXOCRINE → ④ duet
EPITEL
Endokttih dy Eksokttih
0
LIVER
• One cell type may function both ways : endocrine + exocrine
• Cells that secrete bile into the duct system and also secrete
some of their products into the bloodstream
↳ bisa dati duct dan Kapitan
PANCREAS
• Endocrine secretion : the islet cells secrete insulin and
•
: glucagon into the bloodstream
Exocrine secretion : the acinar cells secrete digestive enzymes
into the intestinal lumen
EPITEL
0
Types of secretion :
• Mucous glands : glycoprotein + water
• Serous glands : protein + water
• Mixed glands : mucous + serous cells
• -
EPITEL
0
EPITEL
Epithet Coveting lapisan
§
→
Glandular → Helenjar
pselapis-pbentuhdntinggipbetlapisbet.be
da
7
Covering Epithelia 31h lapisan Simple Pseudostratified Mekka pd
-17 Stratified nembtan basal
'
→ →
, ,
Stratified Squamous Non keratinized ( pipits betlapisitdktcrrietatinasi) → selterluatnys pipits tetapi Masi memilikiintisel .
Pada tidal day Vagina
Pseudo Stratified Columnar ( silihdhy-betlapis-senuj-ta-mpaksepestiberlapi.si Inti set tidztt Pada level Yang Sama beast . Inti set
memanjang Keatas
.
Ttansisional Cttansisi ) →
pernukaanselnyzbes.at betbentuk Kebab / Pada Utetta
,
paying .
Thyroid Gland
Pointer :
Simple cuboidal ephitelium
Kubis setpit
/
inti ada di
tengah day
beset
Colon
Pointer : Simple columnar epithelium
btknya Silindtri
Lihatdsntcliti #°
Panjang
Esofagus
Pointer :
Jaringan : Non-Keratinized stratified
squamous ephitelium
basal
→
µ
Kentinny?