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Dextromethorphan Abuse
Dextromethorphan Abuse
Dextromethorphan Abuse
()
5 2553
dextromethorphan d-3-methoxy-N-methylmorphinan
(DXM) 4 2553
DXM 50
DXM
2546 DXM
2548
DXM 4x100
.. 2005 (USFDA)
DXM 5
DXM DXM
DXM
DXM
DXM
DXM
DXM
15-30 mg 4-6 120 mg
(euphoric effect)
DXM
DXM dextrorotatory stereoisomer methylated derivative levorphanol
analog codeine medulla
threshold opiate -receptor
DXM
DXM 15-30
5-6 DXM cytochrome P-450 (CYP) isoenzyme
2D6 dextrorphan N-methyl-D-aspartate receptors (NMDA
receptors antagonist) phencyclidine (PCP) (euphoria)
(hallucinations) 5-HT receptors
lysergic acid diethylamide (LSD)
DXM NMDA receptors
dextrorphan phencyclidine enzyme
CYP 2D6 ( genetic polymorphism)
DXM 7-10 DXM
dextrorphan dextrorphan
phencyclidine
DXM
400 mg
(hallucination) (vivid imagination)
phencyclidine ketamine 6
DXM 600 mg
DXM DXM
dextromethorphan Robitussin-DM Vicks formula 44 D
2543 Cincinati Poison Control Center
(dextromethorphan 30 mg
chlorpheniramine 4 mg) LSD
DXM
CCC, robo, red devil, poor mans PCP, DXM Dex
DXM
DXM
National Guideline Clearinghouse
- decontamination
1 1
- (sedative) naloxone
pure opioid receptor antagonist opioid overdose
- benzodiazepine
40 hyperthermia
DXM ... .. 2510
(non-prescription
drug) DXM
Illinois DXM
DXM
Shaul WL, Wandell M, Robertson WO. Dextromethorphan toxicity: reversal by naloxone. Pediatrics 1977; 59:
117-8.
Stephen M, Timothy B. Abuse of over-the-counter dextromethorphan by teenagers. Southern Medical Journal
1993; 86: 1151-3.
Waknine Y. FDA warns public of OTC dextromethorphan abuse. Available at
http://www.medscape.com/viewarticle/505410. Accessed February 4, 2010.
Wolfe TR, Caravati EM. Massive dextromethorphan ingestion and abuse. Am J Emerg Med 1995; 13: 174-6.