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Nanotechnology for precision drug delivery: Advancements in

pharmacology and therapeutics.
Proykova Bawa*
Department of Medical and Health Sciences, University of Auckland, Auckland, New Zealand

Introduction platforms that integrate both therapeutic and diagnostic

Precision medicine, which aims to deliver therapies tailored to
individual patients, has revolutionized the field of healthcare.
Nanotechnology, with its ability to manipulate and control
matter at the nanoscale, has emerged as a powerful tool in
precision drug delivery. By designing and engineering
nanocarriers, researchers can enhance the efficacy, safety, and
targeted delivery of therapeutic agents. This article explores
the advancements in pharmacology and therapeutics achieved
through nanotechnology-enabled precision drug delivery [1].
Nano carriers, such as nanoparticles, liposomes, dendrimers,
and micelles, are designed to encapsulate and deliver
therapeutic agents to specific target sites in the body. These
carriers offer several advantages, including improved drug
solubility, protection from degradation, prolonged circulation
time, and enhanced cellular uptake. Moreover, their small size
allows them to bypass physiological barriers and accumulate
in target tissues more efficiently. Nano carriers can be surface-
functionalized with ligands, antibodies, or peptides to actively
target specific cells or tissues. This active targeting facilitates
the selective accumulation of drugs at the desired site,
reducing off-target effects and enhancing therapeutic efficacy.
By exploiting the unique characteristics of tumor tissues,
nanocarriers can be designed to accumulate preferentially in
cancer cells, resulting in improved anti-cancer drug delivery
while minimizing damage to healthy tissues [2].
Nanotechnology enables the design of drug delivery systems
with controlled release profiles. Various stimuli-responsive
Nano carriers have been developed that can release drugs in
response to specific triggers, such as pH, temperature, light,
or enzymatic activity. This controlled release mechanism
allows for sustained drug release at the target site, optimizing
therapeutic efficacy while minimizing systemic toxicity. The
human body possesses several biological barriers that can
impede drug delivery to target sites. Nanotechnology provides
innovative solutions to overcome these barriers. For instance,
nanocarriers can be engineered to cross the blood-brain barrier,
enabling the delivery of therapeutic agents to the central
nervous system for the treatment of neurological disorders.
Similarly, Nano carriers can be designed to penetrate mucosal
barriers, allowing for efficient drug delivery through oral,
nasal, or ocular routes [3].
Nanotechnology has enabled the development of theranostic
capabilities. Theranostics combines targeted drug delivery
with real-time imaging and monitoring of treatment response.
Nanocarriers can be loaded with contrast agents or imaging
probes, allowing for non-invasive imaging modalities such as
Magnetic Resonance Imaging (MRI), Computed Tomography
(CT), or fluorescence imaging. This integration of diagnostics
and therapeutics facilitates personalized medicine by
providing real-time feedback on treatment efficacy and guiding
therapeutic decision-making. The safety and biocompatibility
of nanocarriers are of paramount importance for their
clinical translation. Extensive research is being conducted
to ensure the biocompatibility of nanomaterials, evaluate
their long-term effects, and assess potential toxicity. Surface
modifications and engineering approaches are employed to
reduce immunogenicity and improve the biodegradability of
nanocarriers, minimizing adverse effects and optimizing their
clinical applicability [4].
Nanotechnology has revolutionized the field of precision
drug delivery, providing innovative solutions to overcome
challenges associated with conventional drug administration.
Through the design and engineering of nanocarriers,
researchers have achieved enhanced targeting, controlled
release, and improved accumulation of therapeutic agents
at specific sites. Nanotechnology-enabled precision drug
delivery has the potential to revolutionize pharmacology
and therapeutics, enabling personalized medicine, improving
treatment outcomes, and reducing adverse effects. Continued
research, collaboration, and regulatory efforts are essential
to further unlock the vast potential of nanotechnology in the
realm of precision drug delivery and advance patient care [5].
References
1. D Mello SR, Cruz CN, Chen ML, et al. The evolving
landscape of drug products containing nanomaterials in the
United States. Nat Nanotechnol. 2017;12(6):523-9.
2. Caster JM, Patel AN, Zhang T, et al. Investigational
nanomedicines in 2016: A review of nanotherapeutics
currently undergoing clinical trials. Wiley Interdiscip Rev
Nanomed Nanobiotechnol. 2017;9(1):1416.
3. Bobo D, Robinson KJ, Islam J, et al. Nanoparticle-based
medicines: A review of FDA-approved materials and
clinical trials to date. Pharm Res. 2016;33:2373-87.

*Correspondence to: Proykova Bawa, Department of Medical and Health Sciences, University of Auckland, Auckland, New Zealand, E-mail: proykova.b@auckland.ac.nz
Received: 27-Jun-2023, Manuscript No. AAAJMR-23-105804; Editor assigned: 29-Jun-2022, PreQC No. AAAJMR-23-105804(PQ); Reviewed: 13-Jul-2023, QC No.
AAAJMR-23-105804; Revised: 17-Jul-2023, Manuscript No. AAAJMR-23-105804(R); Published: 24-Jul-2023, DOI:10.35841/aaajmr-7.4.186

Citation: Bawa P. Nanotechnology for precision drug delivery: Advancements in pharmacology and therapeutics. Allied J Med Res.
2023;7(4):186
1 Allied J Med Res 2023 Volume 7 Issue 4
4. Tran S, DeGiovanni PJ, Piel B, et al. Cancer nanomedicine:
A review of recent success in drug delivery. Clin Transl
Med. 2017;6:1-21.
5. Anselmo AC, Mitragotri S. Nanoparticles in the clinic.
Bioeng Transl Med.2001;10–29.

Citation: Bawa P. Nanotechnology for precision drug delivery: Advancements in pharmacology and therapeutics. Allied J Med Res.
2023;7(4):186
Allied J Med Res 2023 Volume 7 Issue 4 2