Title: Mastering the Art of Literature Review for Congenital Diaphragmatic Hernia

Welcome to our guide on crafting a comprehensive literature review for Congenital Diaphragmatic
Hernia (CDH). As researchers and students delve into the depths of medical studies, they often
encounter the formidable task of composing a literature review. Among the various medical
conditions, CDH presents unique challenges in synthesizing existing research due to its complex
nature and evolving treatment modalities.

Undoubtedly, writing a literature review for CDH demands meticulous attention to detail, rigorous
analysis, and a profound understanding of the subject matter. Researchers must navigate through a
vast array of scholarly articles, clinical trials, case studies, and medical databases to extract relevant
information while critically evaluating the quality and reliability of each source.

One of the primary difficulties in crafting a literature review for CDH lies in the sheer volume of
available literature and the need to sift through it to identify pertinent studies. Moreover, ensuring the
inclusion of recent advancements, emerging therapies, and updated guidelines adds another layer of
complexity to the process.

Furthermore, synthesizing diverse perspectives, conflicting findings, and disparate methodologies

into a coherent narrative requires both expertise and finesse. Researchers must skillfully analyze the
data, identify patterns, and extrapolate meaningful insights to provide a comprehensive overview of
the current state of knowledge regarding CDH.

Amidst these challenges, seeking professional assistance can significantly alleviate the burden and
enhance the quality of your literature review. At ⇒ StudyHub.vip ⇔, we specialize in providing
tailored writing services to researchers, scholars, and students grappling with the intricacies of
academic writing.

By entrusting your literature review to our team of experienced writers and subject matter experts,
you can rest assured that your paper will be meticulously crafted to meet the highest standards of
academic excellence. Whether you need assistance in conducting a thorough literature search,
synthesizing complex information, or structuring your review effectively, we are here to support you
every step of the way.

In conclusion, mastering the art of writing a literature review for Congenital Diaphragmatic Hernia is
undoubtedly a daunting task. However, with the right guidance, expertise, and support, you can
navigate through the complexities of academic writing with confidence. Order your literature review
from ⇒ StudyHub.vip ⇔ today and let us help you showcase your expertise and contribute to the
advancement of medical knowledge.
A better insight into the mechanisms regulating diaphragm development and genetic causes leading
to CDH appeared essential to the development of a personalized approach, new therapeutic
strategies, and evidence-based genetic counselling to parents. Lally 8, Leif Nelin 9, Michael Cotten
10, Jonathan Klein 11, Stephanie Guilford. HH and KL served as surgical consultants on the
subcommittee and edited, reviewed and approved the final version of this manuscript. From this, it
follows the importance of stra6 expression and the role of vitamin A during embryonic development.
Expand Save Prevalence of Acute Kidney Injury in Neonates with Congenital Diaphragmatic Hernia
A. Ryan M. Gilhooley N. Patel B. Reynolds Medicine Neonatology 2019 TLDR AKI is common in
CDH cases treated in a single national centre and is associated with adverse outcomes, and
prevention and early recognition of contributory factors for AKI may improve outcomes inCDH.
Inodilators in nitric oxide resistant persistent pulmonary hypertension of the newborn. Milrinone
enhances relaxation to prostacyclin and iloprost in pulmonary arteries isolated from lambs with
persistent pulmonary hypertension of the newborn. Prophylactic intravenous use of milrinone after
cardiac operation in pediatrics (PRIMACORP) study. European Journal of Investigation in Health,
Psychology and Education (EJIHPE). Expand 139 PDF 1 Excerpt Save. 1 2 3. Related Papers
Showing 1 through 3 of 0 Related Papers Figures 25 References Related Papers Figure 1 showing
bowel loops in left hemithorax Published in 2016 Congenital diaphragmatic hernia: a case report and
review of literature R. Hajong M. Anand N. Naku Debobratta Hajong K. Singh N. Majumdar
Semantic Scholar Semantic Scholar's Logo Figure 1 of 1 Stay Connected With Semantic Scholar
Sign Up What Is Semantic Scholar. A population pharmacokinetic analysis of milrinone in pediatric
patients after cardiac surgery. If ventilation or oxygenation cannot be maintained on conventional
ventilation, the infant may be switched to a high frequency ventilator (either oscillatory ventilation
or jet ventilation). The DSMC is independent of the trial investigators and sponsors. The presence of
other anomalies (especially cardiac defects), location of the liver (intraabdominal vs. Grizelj
Medicine Journal of Pediatric Surgery 2015 16 1 Excerpt Save. 1 2 3 4 5. Related Papers Showing 1
through 3 of 0 Related Papers Figures 2 Citations 102 References Related Papers Stay Connected
With Semantic Scholar Sign Up What Is Semantic Scholar. Neonatal persistent pulmonary
hypertension treated with milrinone: four case reports. We developed this pilot study to determine if
milrinone infusion would improve oxygenation in neonates ?36 weeks postmenstrual age (PMA)
with CDH. MG wrote the statistical analysis section of the manuscript, planned the study, edited,
reviewed and approved the final version of this manuscript. Rollins Medicine Current opinion in
pediatrics 2012 TLDR As a result of advancements in perinatal care, more severely affected
newborns with CDH are now surviving and a multidisciplinary approach to the long-term care of
these patients will allow early identification and management of these morbidities. KZB reviewed
the study protocol and adverse events sections of the manuscript, edited, reviewed and approved the
final version of this manuscript. The allocation will be unknown to the members of the clinical and
research teams and all staff at the coordinating center except the pharmacist compounding the
medication. Higgins Authors Satyan Lakshminrusimha View author publications You can also search
for this author in. Expand 27 1 Excerpt Save Congenital Diaphragmatic Hernia: Review of Current
Concept in Surgical Management E. Kesieme C. Kesieme Medicine ISRN surgery 2011 TLDR
Advances in surgical management include delayed surgical approach that enables preoperative
stabilization, introduction of fetal intervention due to improved prenatal diagnosis, the introduction
of minimal invasive surgery, in addition to the standard open repair, and the use of improved
prosthetic devices for closure. Journal of Pharmaceutical and BioTech Industry (JPBI). It causes
systemic vasodilation and reduces afterload in patients with heart failure. This large trial will need to
be a multicenter, international trial where randomization is based on oxygenation status and
echocardiographic criteria with a clinically meaningful outcome such as survival without ECMO. PH
associated with CDH (CDH-PH) is frequently resistant to conventional pulmonary vasodilator
therapy including inhaled nitric oxide (iNO) possibly due to right and left ventricular dysfunction.
Expand 26 1 Excerpt Save Late versus early surgical correction for congenital diaphragmatic hernia
in newborn infants. V. Moyer F. Moya D. Tibboel P. Losty M. Nagaya K. Lally Medicine Cochrane
Database of Systematic Reviews 2002 TLDR There is no clear evidence which favors delayed (when
stabilized) as compared with immediate (within 24 hours of birth) timing of surgical repair of
congenital diaphragmatic hernia, but a substantial advantage to either one cannot be ruled out. Using
inclusion and exclusion criterion, study staff will determine if the infant is eligible for randomization.
Expand 95 PDF Save Congenital diaphragmatic hernia in a developing country. Y. R. Bhat V. Kumar
A. Rao Medicine Singapore medical journal 2008 TLDR Greater than 50 percent survival of neonates
with CDH was observed in a centre with conventional ventilation, suggesting poor outcome is likely
in neonates who present within 12 hours of life.
Baseline characteristics will be compared between treatment groups using chi-square and Fisher’s
exact test for discrete variables and t-test and ANOVA for continuous variables. Hedrick Medicine
Prenatal Diagnosis 2012 TLDR To investigate the prognostic value of magnetic resonance?calculated
fetal lung volumes (FLV) in fetuses with isolated left congenital diaphragmatic hernia who receive
standardized prenatal and postnatal care at a single institution, magnetic resonance-calculated lung
volumes are used. We hypothesize that a combination of milrinone with “gentle” ventilation will
improve oxygenation and response to pulmonary vasodilator therapy in CDH. Cox regression models
(with adjustment for HRF severity) will be used to plot proportion of responders who survive
without ECMO against survival time in hours. Milrinone enhances relaxation to prostacyclin and
iloprost in pulmonary arteries isolated from lambs with persistent pulmonary hypertension of the
newborn. COUP-TFII is expressed in the developing diaphragm, in PPFs, and in the transverse
septum. The DSMC is independent of the trial investigators and sponsors. Survey of CDH patients
in the network current vasodilator therapy A brief survey of the NRN centers was conducted in early
2013 (there were 18 centers in the network during that cycle. Inhaled NO is the most commonly
used pulmonary vasodilator in CDH-PH and more than half of CDH patients received iNO during
some part of their hospital course in the NICU. The Cochrane database of systematic reviews.
2010;10(11):CD007802. Milrinone pharmacokinetics and pharmacodynamics in neonates with
persistent pulmonary hypertension of the newborn. Infants that are diagnosed postnatally, or born to
mothers that could not be consented during the prenatal period or transferred from outside hospitals
may be approached in the first 168 h of postnatal life (7 days). Expand 26 1 Excerpt Save Late
versus early surgical correction for congenital diaphragmatic hernia in newborn infants. V. Moyer F.
Moya D. Tibboel P. Losty M. Nagaya K. Lally Medicine Cochrane Database of Systematic Reviews
2002 TLDR There is no clear evidence which favors delayed (when stabilized) as compared with
immediate (within 24 hours of birth) timing of surgical repair of congenital diaphragmatic hernia, but
a substantial advantage to either one cannot be ruled out. The degree of pulmonary hypoplasia is
almost impossible to assess before and immediately after birth, and in most cases, the degree of
pulmonary hypoplasia is an important determining factor in the outcome. You can download the
paper by clicking the button above. ZFPM2 protein interacts primarily with gata4, which in turn
modulates embryonic development. For the sake of simplicity, no echocardiograms are mandated
prior to randomization. Prenatal diagnosis of CDH is possible as early as 12 weeks of gestation
during first trimester ultrasound screen; CDH ultrasound detection is successful in 50% of cases at a
mean gestational age of 24 weeks. Other continuous outcomes will be analyzed similarly.
Institutional Review Board Statement Not applicable in a review article. Expand 27 1 Excerpt Save
Congenital Diaphragmatic Hernia: Review of Current Concept in Surgical Management E. Kesieme
C. Kesieme Medicine ISRN surgery 2011 TLDR Advances in surgical management include delayed
surgical approach that enables preoperative stabilization, introduction of fetal intervention due to
improved prenatal diagnosis, the introduction of minimal invasive surgery, in addition to the standard
open repair, and the use of improved prosthetic devices for closure. Tropical Medicine and Infectious
Disease (TropicalMed). Results Three hundred thirty-seven infants with CDH were admitted to NRN
NICUs in 2011 and 2012 of which 275 were ?36 weeks PMA and were exposed to the following
pulmonary vasodilators: iNO (39%), sildenafil (17%), milrinone (17%), inhaled epoprostenol (6%),
intravenous epoprostenol (3%), and intravenous PGE1 (1%). Expand 12 PDF 1 Excerpt Save
Pediatric bilateral Morgagni-Larrey diaphragmatic hernia: Is diagnosis with computed tomography
required in the era of laparoscopic approach? A. Saxena E. Ruttenstock G. Singer Medicine Hernia
2012 TLDR The use of evidence-based, structured approaches to procedural sedation should be used
to reduce the risk of serious morbidity and mortality in infants and children with Morgagni-Larrey’s
hernia. Significant center variation was observed in iNO use for CDH-PH (varying from 13 to 100%
of patients). Compatibility Milrinone is compatible with 5% dextrose, normal saline and Lactated
Ringers solution. Expand 15 1 Excerpt Save Unusual varieties of diaphragmatic herniae. K. Stokes
Medicine Progress in pediatric surgery 1991 TLDR A number of techniques for closure of large
diaphragmatic defects are described with recommendation of those procedures which can be
performed rapidly and effectively in a critically ill infant. Milrinone is a phosphodiesterase 3 (PDE3)
inhibitor and is currently approved for adult patients with heart failure. The NRN is a well-
established Eunice Kennedy Shriver National Institute of Child Health and Human Development
(NICHD) funded network of 15 universities and affiliated academic hospitals across the US that has
collaborated to improve neonatal care. Feature papers are submitted upon individual invitation or
recommendation by the scientific editors and must receive.
All authors have read and agreed to the published version of the manuscript. Funding
Ri.Cli.Ped.—University of Parma, Parma, Italy (PED-2021-03). Classification of congenital
diaphragmatic hernia (CDH). Compatibility Milrinone is compatible with 5% dextrose, normal saline
and Lactated Ringers solution. The majority of CDH cases are sporadic and appear to be
multifactorial. Neonatal persistent pulmonary hypertension treated with milrinone: four case reports.
Eligible infants will be stratified based on the severity of HRF into the moderate or severe categories
at the time of randomization. The allocation will be unknown to the members of the clinical and
research teams and all staff at the coordinating center except the pharmacist compounding the
medication. Editor’s Choice articles are based on recommendations by the scientific editors of MDPI
journals from around the world. After completing the study infusion, surgical details, and mortality
information will be collected. The primary team managing pulmonary vasodilator therapy is
distributed between neonatal and surgical services. Expand 8 PDF Save. 1 2 3 4 5. Related Papers
Showing 1 through 3 of 0 Related Papers 13 Citations 43 References Related Papers Stay Connected
With Semantic Scholar Sign Up What Is Semantic Scholar. The design of this pilot study includes
randomization based on oxygenation status and not on underlying cardiac physiology. Expand 69
Save Congenital diaphragmatic hernia: review of the literature in reflection of unresolved dilemmas
S. Management of Congenital Diaphragmatic Hernia (CDH): Role of Molecular Genetics. Detailed
compatibility information is listed in Table 2. Journal of Manufacturing and Materials Processing
(JMMP). The sample size will be sufficient to provide estimates of adverse event rates in the
treatment group. Mullassery M. Ba'ath E. Jesudason E. Jesudason Paul D. Losty Paul D. Losty
Medicine Ultrasound in Obstetrics and Gynecology 2010 Intrathoracic liver herniation (ILH) is being
used to estimate prognosis and hence guide antenatal interventions in fetal congenital diaphragmatic
hernia (CDH). Semantic Scholar is a free, AI-powered research tool for scientific literature, based at
the Allen Institute for AI. Open-label milrinone use Immediately after completion of study
intervention, open-label milrinone is permitted at the discretion of the clinical team. From this, it
follows the importance of stra6 expression and the role of vitamin A during embryonic development.
Filly Medicine Journal of Pediatric Surgery 1997 242 1 Excerpt Save Abdominal muscle flap repair
for large defects of the diaphragm S. B. Joshi S. Sen J. Chacko G. Thomas S. Karl Medicine
Pediatric surgery international (Print) 2005 TLDR Nine defects in congenital diaphragmatic hernia
and eventration are described by using an abdominal muscle flap comprising the transversus
abdominis and internal oblique muscles based on the intercostal and subcostal vessels. This pilot will
provide data and enable further studies evaluating pulmonary vasodilator therapy in CDH. Higgins
View author publications You can also search for this author in. Liver position is a survival index:
liver herniation (liver up) is associated with a worse prognosis. Overview of candidate genes and
signaling pathways for congenital diaphragmatic hernia (CDH). Expand 147 Save Late-Presenting
Left-Sided Morgagni Congenital Diaphragmatic Hernia in a 9-Year-Old Male Jennifer M. Pulmonary
hypoplasia, intestinal malrotation, and left hearth hypoplasia may coexist with isolated CDH and are
usually considered part of a sequence. CDH was described quite earlier but good survival after repair
was not achieved until the 20th century. Despite its high impact on neonatal health, pathogenesis and
etiology of CDH remain poorly understood.
The general guidelines for management shown in Fig. 3 are provided to all centers. Arrangements for
randomization, allocation concealment and blinding Central randomization with computer random
number generation will be implemented with 1:1 allocation, stratified by severity of HRF. Pulmonary
hypoplasia, intestinal malrotation, and left hearth hypoplasia may coexist with isolated CDH and are
usually considered part of a sequence. Classification of congenital diaphragmatic hernia (CDH).
Prophylactic intravenous use of milrinone after cardiac operation in pediatrics (PRIMACORP) study.
Right- versus left-sided congenital diaphragmatic hernia: postnatal outcome at a specialized tertiary
care center. If the medical service overseeing ECMO treatment or if the surgical team prefers to
discontinue the study drug, this indication should be recorded and study drug weaned as per
protocol. This pilot will provide data and enable further studies evaluating pulmonary vasodilator
therapy in CDH. Please let us know what you think of our products and services. In cases of patients
with long previouses symptoms and various accesses to PED is important to emphasize history of
respiratory distress, dysphagia and failure to thrive and should be considered a chest X-ray. The
pharmacokinetics of milrinone in pediatric patients after cardiac surgery. AW wrote the initial draft of
the manuscript, edited, reviewed and approved the final version of this manuscript. The NINOS-
CDH study failed to demonstrate any benefit of iNO; in fact, the need for ECMO was significantly
increased in iNO treated infants. The diaphragm is a passageway for structures from the thorax to
the abdomen: the major orifices are the aortic hiatus, vena caval foramen, and the oesophageal hiatus.
Many neonates are born without a prenatal diagnosis. A second cranial ultrasound will be obtained
preferably within 24 h (maximum - within 96 h) of completion of the study drug. It is possible that
subjects with CDH-PH without LV dysfunction and strict pulmonary arterial hypertension respond
well to inhaled pulmonary vasodilator such as iNO. The patients in this study had an OI of
approximately 45 with standard deviations of 16.3 and 14.5 in control and treatment groups
respectively. Patients will be stratified based on the severity of HRF into two categories at the time
of randomization. Semantic Scholar is a free, AI-powered research tool for scientific literature, based
at the Allen Institute for AI. Clinical criteria for ECMO The decision to place an infant with CDH
on ECMO is entirely up to the clinical team. Phosphodiesterase-3 inhibition prevents the increase in
pulmonary vascular resistance following inhaled nitric oxide withdrawal in lambs. The VICI-trial:
high frequency oscillation versus conventional mechanical ventilation in newborns with congenital
diaphragmatic hernia: an international multicentre randomized controlled trial. Infants will be
randomized to either the milrinone arm or the placebo arm using a web-based system in a 1:1 ratio.
Conclusion Infants with CDH continue to have high mortality with high morbidity among survivors.
All articles published by MDPI are made immediately available worldwide under an open access
license. No special. We will also evaluate systemic blood pressure changes with the study drug.
Milrinone pharmacokinetics and pharmacodynamics in neonates with persistent pulmonary
hypertension of the newborn. Expand 147 Save Late-Presenting Left-Sided Morgagni Congenital
Diaphragmatic Hernia in a 9-Year-Old Male Jennifer M. This article is an open access article
distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( ).