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Test Report
Remarks
The sample submitted for Maternal Serum Screen 2 is screen negative both for Trisomy 21 and Trisomy
18/13. A combination of Nuchal translucency (NT) and biochemical tests improves detection rate for
chromosomal anomalies.
Advice: Revert for risk recalculation with USG details including CRL (38-84 mm) and NT value
Note
· Screening tests are based on statistical analysis of patient demographic and biochemical data. They
simply indicate a high or low risk category. Confirmation of screen positives is recommended by
Chorionic Villus Sampling (CVS).
· The interpretive unit is MoM (Multiples of Median) which takes into account variables such as
gestational age (ultrasound), maternal weight, race, insulin dependent Diabetes, multiple gestation, IVF
(Date of Birth of Donor, if applicable), smoking & previous history of Down syndrome. Accurate
availability of this data for Risk Calculation is critical.
· Detection rate for Down syndrome is 60% with a false positive rate of 5% if only biochemical risk is
estimated. A combination of Nuchal translucency and biochemical tests (Combined test) has detection
rate of Down syndrome 82 to 87% at 5% false positive rate. Addition of absent nasal bone status can
improve detection rate up to 93% at false positive rate of 2.5%
Comments
First trimester screening for Prenatal disorders (Trisomy 21, 18 & 13) is essential to identify those women at
sufficient risk for a congenital anomaly in the fetus to warrant further evaluation and follow up. For Open neural
tube defects, second trimester screening before 20 weeks is recommended. Screening cutoffs are
established by using MoM values that maximize the detection rate and minimize false positives. This is a risk
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Test Report
estimation test and not a diagnostic test. An increased risk result does not mean that the fetus is affected and
a low-risk result does not mean that the fetus is unaffected. Reported risks should be correlated according to
the absence/presence of sonographic markers observed in the anomaly/malformation scan.
IMPORTANT INSTRUCTIONS
ŸTest results released pertain to the specimen submitted .ŸAll test results are dependent on the quality of the sample received by the Laboratory .
ŸLaboratory investigations are only a tool to facilitate in arriving at a diagnosis and should be clinically correlated by the Referring Physician .ŸReport
delivery may be delayed due to unforeseen circumstances. Inconvenience is regretted .ŸCertain tests may require further testing at additional cost
for derivation of exact value. Kindly submit request within 72 hours post reporting.ŸTest results may show interlaboratory variations .ŸThe
Courts/Forum at Delhi shall have exclusive jurisdiction in all disputes /claims concerning the test(s) & or results of test(s).ŸTest results are not valid
for medico legal purposes.ŸThis is computer generated medical diagnostic report that has been validated by Authorized Medical
Practitioner/Doctor. ŸThe report does not need physical signature.
(#) Sample drawn from outside source.
If Test results are alarming or unexpected, client is advised to contact the Customer Care immediately for possible remedial action.
Tel: +91-11-49885050,Fax: - +91-11-2788-2134, E-mail: lalpathlabs@lalpathlabs.com
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Biochemical data
Sampling Date: 19/12/2023 Gestational age: 10 weeks and 2 days
Laboratory code: 455907056
Free beta hCG 1T: 69.89 ng/ml 1.74 MoM
PAPP‐A: 0.96 mIU/ml 0.83 MoM
Ultrasound data
Ultrasound date: 07/12/2023 Gestational age: 8 weeks and 4 days
CRL: 20 mm
Observations
The risks calculations are statisticals approaches and have limited diagnostic value
The calculated risk by the software depends on the accuracy of USG details and patient details provided
DOWN SYNDROME: The calculated risk for Trisomy 21 is LESS than the screening cutoff which represents a low
risk.
TRISOMY T18/T13: The calculated risk for Trisomy 18/13 is LESS than the screening cutoff which represents a low
risk.
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