Title: Mastering the Art of Crafting a Literature Review on Centella Asiatica

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Moreover, preclinical and clinical pharmacokinetic data demonstrated that asiatic acid could be
distributed in many tissues by binding with albumin. EC Agriculture 6.1 (2020): 01-07. Abstract
Centella asiatica is an annual herb which grows in moist marshy soil. It is clinically used for damp-
heat jaundice, carbuncle swelling, bruises, arsenic poisoning, tan poisoning, heat relieving, infectious
hepatitis, epidemic Cerebrospinal meningitis and so on. Rheumatoid arthritis (RA) is a chronic
inflammatory joint disease that usually affects women and elderly people; the main pathological
change is persistent synovitis. Indian J Exp Biol 2001;39:137-142. Farhana K. M., Malueka R. G.,
Wibowo S., Gofir A. (2016). Effectiveness of Gotu Kola Extract 750 mg and 1000 mg Compared
with Folic Acid 3 mg in Improving Vascular Cognitive Impairment after Stroke. Extracts from the
Centella asiatica leaf and the whole plant are used for a variety of conditions including venous
insufficiency, varicose veins, wound healing, scleroderma, and scars. The plant is a perennial
herbaceous creeper that grows in swampy areas. Rapid advancement in the era of biotechnology with
such type of herbs as trouser horse and create boon to pharmaceutical-industry. Login to your
account below Remember Me Forgotten Password. The content on this website is intended for
informational and educational purposes only. Urunu incelemek ve sat?n almak icin buraya
t?klayabilirsiniz. Bu sebeple ciltte ortaya c?kan bircok problemin alt?nda yatan sebebin cildin yetersiz
nemlendirilmesi olmas?, cildi nemlendirme ve zarar gormus cilt bariyerini onarma etkileriyle Centella
bitkisini her cilt taraf?ndan begenilen bir icerik haline getirmektedir. Under normal conditions,
superoxide dismutase (SOD), glutathione peroxidase (GPX), and catalase can act as free radical
scavengers, affecting the level of ROS. Airline flight microangiopathy Physical consequences of
long-distance flights range from simple swelling of the lower limbs to the formation of dangerous
blood clots. Hypertension and atherosclerosis are the mostly studied diseases in involved articles (
Table 5 ). TABLE 5. Lastly, Centella asiatica also demonstrated a positive activation effect on
dermal papilla, improved the viability of dermal papilla cells and increased the expression of
characteristic genes related to hair growth in the cells, thus providing good application prospects for
baldness 93. In summary, Centella asiatica and its extracts had a positive effect on diseases of the
nervous system. Rovectin’in Centella iceren Cica Care serisinde yer alan bu sakinlestirici tonik,
hassas cilde sahip kisilerde s?kca kars?las?lan hormonal akne, roza hastal?g. Clinical studies have
found that Centella asiatica effectively improved the cognitive function of stroke patients 14.
Effects on Rheumatoid Arthritis Animal and cell experiments confirmed that madecassoside exerted
an anti-rheumatoid effect ( Table 9 ). Publish Your Life Sciences or Medicine Research With
Hindawi. The potential therapeutic value of asiatic acid for ovarian cancer is mainly reflected in that
it can promote the apoptosis of ovarian cancer cells and inhibit the growth of ovarian cancer cells by
affecting the cell cycle progression 144. Centella asiatica Attenuates D-Galactose-Induced Cognitive
Impairment, Oxidative and Mitochondrial Dysfunction in Mice. Atlantik Diyeti Hakk?nda Bilmeniz
Gerekenler Sagl?kl. Atopic dermatitis, also known as atopic eczema, is a chronic relapsing
inflammatory skin condition 84. Centella asiatica effects on digestive diseases Centella asiatica and
its triterpenoids also have therapeutic effects on digestive disorders, which is mainly reflected by
improved liver fibrosis, colitis, and gastric mucosal damage; and even reduced Helicobacter pylori
gastric colonization 20. Therefore, C. asiatica might have an anti-fibrotic effect ( Adtani et al., 2017
). Finally, an in vivo experiment found that C. Centella asiatica bitkisinin ozunu iceren en iyi 10 cilt
bak?m urununu sizin icin listeledik. Mitochondria dysfunction and neurodegenerative disorders:
cause or consequence. Paocharoen V. The efficacy and side effects of oral Centella asiatica extract
for wound healing promotion in diabetic wound patients.
Microcirculatory effects of total triterpenic fraction of Centella asiatica in chronic venous
hypertension: measurement by laser Doppler, TcPO2-CO2, and leg volumetry. The plant shows its
potential as respiratory disorders, hepatic, spasmodic, cardiovascular and especially neural disorders.
This paper provides its immense importance as economic plant with medicinal value as well as brief
information of its products in the market launched showing its dependability. Larger well-designed
studies are needed to confirm these effects. Modification of the echogenicity of femoral plaques
after treatment with total triterpenic fraction of Centella asiatica: a prospective, randomized,
placebo-controlled trial. The pharmacological study on madecassoside demonstrated that it can
effectively lessen the related inflammatory factors in arthritis model rats (TNF-. In another study
using Laser doppler evaluation, subjects taking 60 mg triterpenoid fraction of Centella asiatica twice
daily for six weeks demonstrated a 29-percent decrease in resting flux, 52-percent increase in
venoar-teriolar response and 66-mL reduction in leg volume 114. The various biochemicals are
present in the plant e.g. asiaticoside, brahmoside, asiuyatic acid, brahmic acid, centellose,
centelloiside, madecassoside etc used in human as treatment of different types of disorders,
drowsiness, disease of liver, pharmaceutically used as for enhancing memory, clinically used for
treatment of different types of skin problems, leprosy, lupus, varicose ulcer, eczema, diarrhea, fever,
amenorrhea, anxiety etc. ALI is characterized by (1) epithelial and vascular permeability increased,
(2) hypercoagulation and insufficient fibrinolysis, and (3) inflammation and immune regulation (
McVey et al., 2012 ). This review found that pretreatment with asiatic acid can inhibit bleomycin-
induced lung injury and fibrosis in mice. Asiaticoside demonstrates anti-inflammatory effects by
inhibiting lipopolysaccharide-induced fever and inflammatory response, including production of
serum tumor necrosis factor-alpha, interleukin-6, prostaglandin E2, liver myeloperoxidase activity,
and expression of brain cyclooxygenase-2 protein 29. Download Free PDF View PDF Centella
asiatica: from folk remedy to the medicinal biotechnology-a state revision Helmi Y Alfarra Centella
asiatica or “gotu kola” has been used since long time ago as an ethno-pharmacological plant and
supposed to be a potent medicinal plant for its various pharmacological effects favorable for human
health. Pharmacokinetics of the total triterpenic fraction of Centella asiatica after single and multiple
administrations to healthy volunteers. Skin is the largest organ of the human body playing a vital role
in maintaining the body’s physiological homeostasis. In addition, asiatic acid can induce the
dissipation of mitochondrial membrane potential (MMP), ATP depletion, release of cytochrome c
from mitochondria into the cytosol of HepG2 cells, which may induce the death of liver cancer cells
by directly affecting mitochondrial function, it may be a potential therapeutic drug for liver cancer
and colon cancer 128. Moreover, preclinical and clinical pharmacokinetic data demonstrated that
asiatic acid could be distributed in many tissues by binding with albumin. The main chemical
components responsible for Centella asiatica pharmacological activity are triterpenes, mostly
asiaticoside, asiatic acid, madecassoside, and madecassic acid (see Figure 1). The following distinct
areas were identified under C. More rapid maturation and cross-linking of collagen were seen in
animals treated with Centella asiatica extract, as evidenced by elevated stability of acid-soluble
collagen and increases in aldehyde content and tensile strength. Both the diabetic animal model and
the obesity animal model demonstrated that the C. Atopic dermatitis, also known as atopic eczema,
is a chronic relapsing inflammatory skin condition ( Avena-Woods, 2017 ). Compared to control
wounds, rats treated with Centella asiatica had a higher degree of epithelialization and a
significantly more rapid rate of wound contraction 9. Pharmacological studies found that
madecassoside had potential therapeutic effect against osteoporosis, acne, vitiligo, RA, and so forth.
Also, the p38 MAPK signaling pathway can modulate various events regarding Alzheimer’s disease,
such as tau phosphorylation, neurotoxicity, neuroinflammation, and synaptic dysfunction 63. The
malondialdehyde (MDA) level can reflect the ROS level ( Kwiecien et al., 2012 ). Therefore, an
oxidative stress response is also crucial in the process of gastric mucosal injury. Ventricular changes
caused by right ventricular hypertrophy and right ventricular fibrosis affect ventricular function (
Wang and Chesler, 2013 ). It is described as follows: “Centella asiatica, bitter, cold, nontoxic. Avene,
mucizevi etkileriyle bilinen Centella asiatican?n ana kahraman oldugu bir cica serisi c?kard. After
single oral administration of 30 and 60 mg of Centella asiatica extract, maximum plasma levels of
asiatic acid were reached at 4.5 and 4.2 hours, respectively. Centella asiatica has several
pharmacological actions, based primarily on animal experiments. For the treatment of atopic
dermatitis, Centella asiatica significantly reduced the inflammation response (TNF-.
Although in tissues and plasma their concentration is low, they can be detected in feces within 48
hour after oral administration of Centella asiatica extract. Antipyretic and anti-inflammatory effects
of asiaticoside in lipopolysaccharide-treated rat through up-regulation of heme oxygenase-1. Centella
asiatica significantly induced gastric mucin secretion and mucosal cell glycoprotein production,
markers of increased gastric mucosal defense factors 13. In this review, we have done a critical
evaluation of available literature looking for the pharmacological importance of C. asiatica. Further
studies will be helpful to discover more bioactive compounds their exact mode of actions. Topical
use of Centella asiatica extract has led to reports of rash 165. Centella asiatica extract, asiatic acid,
and asiaticoside could effectively increase the content of brain-derived neurotrophic factor (BDNF)
62. It is distributed throughout tropical and subtropical regions of. Atherosclerosis is a disease in
which the inside of arteries narrows due to the buildup of plaque, leading to some serious problems
such as heart attack, stroke, or even death. After trial conclusion, patients taking the herbal extract
experienced a significant decrease in skin flux and rate of ankle swelling compared to baseline values
113. In contrast to other medicinal plants, however, Centella asiatica has been subjected to quite
extensive experimental and clinical investigations. Ventricular changes caused by right ventricular
hypertrophy and right ventricular fibrosis affect ventricular function ( Wang and Chesler, 2013 ). Pdf
Ethnopharmacological Importance Of Centella Asiatica With Special Reference To Neuroprotective
Activity We have previously shown that a water extract of Centella asiatica CAW attenuates ?-
amyloid A?-induced spatial memory.. Uk essay apa referencing my first day at school essay for grade
4 essay on old school days essay of honesty is the best policy. Log In Retrieve your password Please
enter your username or email address to reset your password. Forty-eight patients with diabetic
microangiopathy were randomized to one of three treatment groups for six months: 60 mg
triterpenoid fraction of Centella asiatica twice daily, placebo, or no treatment 116. Main targets are
the middle-aged and elderly people over the age of 50. However, almost 67% of the patients in the
treatment group experienced at least one adverse event, including transient liver, kidney or
gastrointestinal dysfunction, but these symptoms resolved on their own 15. For the treatment of
COPD, it is generally recommended to use appropriate long-acting maintenance bronchodilators and
inhaled corticosteroids; pulmonary rehabilitation can also relieve symptoms 132. Rheumatoid
arthritis (RA) is a chronic inflammatory joint disease that usually affects women and elderly people;
the main pathological change is persistent synovitis. In summary, Centella asiatica and its extracts
had a positive effect on diseases of the nervous system. Evaluation of treatment of diabetic
microangiopathy with total triterpenic fraction of Centella asiatica: a clinical prospective randomized
trial with a microcirculatory model. Angiology. 2001 Oct;52 Suppl 2:S49-54. Generally, surgeries are
conducted to treat endometriosis, but accumulating evidence suggest the use of plant-based drugs
for the treatment, and these medicines usually alleviate the symptoms via their anti-inflammatory,
anti-oxidant, anti-proliferation, and anti-apoptotic effects 140. Expand 6 PDF Save Genetic status of
Centella asiatica (L.) Urb. (Indian pennywort): A review Sakthipriya Mathavaraj K. Moisturizing and
Antiinflammatory Properties of Cosmetic Formulations Containing Centella asiatica Extract.
Hypoxic pulmonary hypertension can cause pulmonary arterial changes, including pulmonary arterial
stiffness and narrowing. This disease occurs due to skin barrier dysfunction, alterations in cell-
mediated immune responses, and Immunoglobulin E(IgE)-mediated hypersensitivity 85. Doxorubicin
causes the peroxidation of organs and reduces the activity of innate antioxidant factors 39 while
upregulating the expression of Nrf2 effectively promotes antioxidant activity and protects cells from
the damage caused by oxidative stress 40. Kore cilt bak?m urunlerinin vazgecilmez icerigi Centella
asiatica nedir. Centella asiatica extracted with methanol contains 0.12% asiatic acid, 0.54%
madecassic acid, 0.25% asiaticoside and 1.02% madecassoside, and was made into a spray with
hydroxypropyl-?-cyclodextrin, Eudragit E100, glycerin, PEG 400, etc., and the spray of triterpenes
content are close to 100% compared with Centella asiatica extract, the wound was healed completely
without any skin irritation 87. Studies have pointed out that the activation of vascular endothelial
cells and the involvement of inflammation responses are essential for the early stages of the
development of acne lesions ( Kircik, 2016 ). Effect of Centella asiatica Linn on physical and
chemical factors induced gastric ulceration and secretion in rats.