STEP 1 REVIEW COURSE - PART 1

SET 8

SET 8

1. What enzymes do obligate anaerobes lack?

(FA18 p127) (FA19 p127) (SU p318)

2. A 24-year-old woman reports having two miscarriages over the past six months and
has been trying to become pregnant over the past year. What embryological structural
abnormalities might account for her multiple miscarriages? What structures arise from the
paramesonephric ducts? What other name is given to the paramesonephric ducts?
(FA18 p604-605) (FA19 p608-609) (SU p196, 201) (R p992)

3. What organism causes Hansen disease? What animal serves as the reservoir for this
organism in the U.S.? Where in the body does this organism live?
(FA18 p141) (FA19 p141) (SU p467-468)

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STEP 1 REVIEW COURSE - PART 1

SET 8
4. What is BNP, and how is it useful in cases of heart failure?
(FA18 p291) (FA19 p294) (H p1746)

5. Which adrenergic antagonists can be used to treat hypertension, as well as urinary

retention, in patients with benign prostatic hyperplasia (BPH)? What is the difference
between the prostate exam findings in BPH versus adenocarcinoma of the prostate?
(FA18 p635) (FA19 p639) (SU p76))

6. How many half-lives does it take for a drug infused at a constant rate to reach 94% of
steady state? What variables determine the half-life of a drug?
(FA18 p229) (FA19 p233) (SU p395)

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 STEP 1 REVIEW COURSE - PART 1
SET 8
7. Describe the anatomical layers of the penis.
(COA p419-420)

8. A 32-year-old man is being treated for alcohol dependence with disulfiram. One night, he
begins drinking and later has severe nausea and vomiting. What is the mechanism of action
of disulfiram? What other drugs have a disulfiram-like effect?
(FA18 p72, 246) (FA19 p72, 250) (SU p305) (GG p643-644)

9. What is PPAR-γ? How is it relevant to the treatment of diabetes mellitus?

(FA18 p348) (FA19 p348) (SU p181)

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 STEP 1 REVIEW COURSE - PART 1
SET 8
10. A kidney transplant patient begins to experience renal failure seven years after receiving
her kidney transplant. What type of rejection is this, and how is it mediated?
(FA18 p119) (FA19 p119) (SU p385)

*Page references are as follows:

FA18: First Aid for the USMLE Step 1 2018

FA19: First Aid for the USMLE Step 1 2019
SU: Step-Up to USMLE Step 1 2015
R: Robbins and Cotran Pathologic Basis of Disease, 9th ed. (2015)
Phys: Guyton and Hall Textbook of Medical Physiology, 13th ed. (2016)
H: Harrison’s Principles of Internal Medicine, 19th ed. (2015)
COA: Clinically Oriented Anatomy, 7th ed. (2014)
GG: Goodman and Gilman’s Pharmacological Basis of Therapeutics, 12th ed. (2011)

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