Antiviral Drugs

Topic 7
 Expected Learning Outcomes

• At the end of the topic, you should be able to:

a) Name viruses treatable with antiviral drugs.
b) Give target sites of antiviral drugs.
c) Describe classes of antiviral drugs.
d) Provide modes of action of various antiviral drugs.

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 Viruses treatable with antiviral drugs

1) Herpes simplex virus 1 (HSV 1)

2) Herpes simplex virus 2 (HSV 2)
3) Varicella-zoster virus (VZV)
4) Cytomegalovirus (CMV)
5) Human Immunodeficiency virus (HIV)
6) Influenza A and B viruses
7) Hepatitis B virus (HBV)
8) Hepatitis C virus (HCV)

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 Targets of antiviral drugs

1) Virion disruption
2) Inhibition of attachment
3) Interference with penetration and uncoating
4) Inhibition of RNA synthesis
5) Inhibition of DNA synthesis
6) Inhibition of protein synthesis
7) Interference with virion assembly and release

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Continuation:
Antiviral
agents for
HIV therapy

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 Further Reading

• Jawetz, Melnick & Adelberg’s Medical

Microbiology, 26th Edition, chapter 30,
page 441 – 448

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