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Eden Bio Worksheet
Eden Bio Worksheet
Eden Bio Worksheet
A alleles
B genes
C genotype
D phenotype
3 What is a mutation?
A height
B length of foot
C tongue rolling
D weight
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5 The diagram shows the age structure of a human population.
A 60 and over
B 45-59
C 30-44
D under 15
6 The table shows the birth rates and death rates in four countries.
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1 (a) Define the term genetic engineering.
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(b) Fig. 6.1 is a flow diagram that shows how insulin can be produced using genetic engineering.
R
L
Q
Fig. 6.1
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Table 6.1 shows stages in the production of insulin by genetic engineering.
Complete Table 6.1. The first row has been done for you.
Table 6.1
letter from
name description
Fig. 6.1
M chromosomes threads of DNA found in the nucleus
section of DNA removed from human cell
plasmid
type of cell that is genetically engineered
specific chain of amino acids coded by the
section of DNA removed from the human
cell
fermenter
[5]
Explain the advantages of asexual reproduction for insulin production by genetic engineering.
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[Total: 10]
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2 Antibiotics are used to treat human diseases.
Many bacteria have become resistant to antibiotics. Some antibiotics can no longer be used
to treat certain diseases.
Samples of bacteria were taken from a person who had an infectious disease. They were
spread onto four Petri dishes of agar (agar plates). Three of these agar plates contained the
antibiotics 1, 2 or 3.
agar plate contains agar plate contains agar plate contains agar plate contains
no antibiotic antibiotic 1 antibiotic 2 antibiotic 3
key
bacterial growth
no bacteria
Fig. 2.1
[1]
[1]
PhysicsAndMathsTutor.com
(iii) only a small number of bacteria grew with antibiotic 1.
[2]
(b) Explain why it is important to carry out a test similar to that shown in Fig. 2.1 before
giving an antibiotic to a person infected with a bacterial disease.
[2]
[4]
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(d) Hormones are used to treat a variety of conditions.
The most common hormonal treatment is the use of insulin to treat diabetes. Most of
the insulin is produced using cells that are grown in large fermenters. These cells have
been genetically engineered to produce human insulin.
Fig. 2.2 shows the stages involved in transferring the gene for insulin from human cells
to bacterial cells.
Fig. 2.2
(i) Put the stages into the correct sequence. Two have been done for you.
S Q
[1]
(ii) Diabetes is often treated with human insulin that has been produced by genetically
modified cells. In most countries this type of insulin has replaced the insulin that
was prepared from animals.
Suggest the advantages of providing human insulin to people with diabetes rather
than insulin obtained from animals.
[3]
[Total: 14]
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AS 8 PROTEIN SYNTHESIS Do not
write in
QUESTIONSHEET 20 margin
(a) Read through the following account of DNA replication and then complete it by filling in the spaces with the
most appropriate word or words.
During DNA replication the enzyme ...................................... binds to the DNA double ................................
This makes the DNA ..................................... and breaks the .................................... bonds between the
nucleotides. These nucleotides are bound together at .................................................. . The base adenine
binds with .................................... and ................................................. binds with guanine. Free nucleotides
found in the ........................................ bind with the exposed bases producing two strands of DNA. The
process is said to be ..................................... because in both of the two DNA strands produced, one sequence
of nucleotides is new and the other is from the .......................................... DNA. [10]
(b) (i) When a sample of DNA was chemically analysed it was found that 36% of the bases were adenine.
What were the percentages of the other bases? Explain your anserws.
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....................................................................................................................................................................... [4]
(ii) Is it possible to forecast the percentages of bases that would be present in the messenger RNA transcribed
from this DNA? Explain your answer.
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....................................................................................................................................................................... [2]
TOTAL / 16
AS 8 PROTEIN SYNTHESIS Do not
write in
QUESTIONSHEET 1 margin
Read through the following account of protein synthesis and then fill in the spaces with the most appropriate word
or words.
Messenger RNA formed by ............................................ from the nuclear DNA passes through pores in the
........................................ amino acids are brought to the mRNA by the molecules of ......................................
This is released and passes to the .................................................... where it associates with other similar
TOTAL / 11
1 Cells are formed by the division of existing cells. Four different cells are shown.
2 Albinism is an inherited condition in which pigment does not develop in the skin, hair and eyes.
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3 The diagram represents processes in sexual reproduction.
cells in R
reproductive gametes
organs
zygote cells of
Q
embryo
A alleles
B genes
C genotype
D phenotype
A X allele
B X chromosome
C Y allele
D Y chromosome
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6 Owners of successful race horses hope that the horses’ offspring will be like their parents.
7 In pea plants the allele for tall, T, is dominant to the allele for dwarf, t.
A TT × Tt B Tt × Tt C Tt × tt D tt × tt
A fat
B fatty acid
C glycerol
D lipase
A a pair of chromosomes
B different versions of the same gene
C the total number of genes on one chromosome
D two genes side by side on the same chromosome
10 A pure-breeding plant with smooth stems was crossed with a heterozygous plant with hairy
stems.
What will be the ratio of hairy : smooth stems in the resulting plants?
A 1 hairy : 1 smooth
B 1 hairy : 3 smooth
C 3 hairy : 1 smooth
D all hairy
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11 Which statement about the human sex chromosomes is correct?
13 What will be the genotypes of the offspring resulting from a genetic cross between two
individuals, one of which is homozygous dominant, (TT), and the other heterozygous?
A all Tt
B 50% TT, 50% tt
C 50% TT, 50%Tt
D 25%T
25% Tt,
A liver cell
B red blood cell
C sperm cell
D zygote
A a dominant allele
B a dominant chromosome
C a recessive allele
D a recessive chromosome
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16 Some fruit flies have orange eyes and others have red eyes.
If two orange-eyed fruit flies are crossed, their offspring always have orange eyes.
If two red-eyed fruit flies are crossed, their offspring sometimes include both orange-eyed and
red-eyed flies.
A Crossing an orange-eyed fly with a red-eyed fly will produce a 1 : 1 ratio in the offspring.
B The allele for orange eyes is dominant.
C The allele for red eyes is dominant.
D We could determine which allele is dominant only by doing a cross that produces a 3 : 1 ratio.
mitosis meiosis
parental genotypes Tt × Tt
gametes T t T t
offspring E
A
C
21 The diagram shows the chromosomes in the nucleus of a cell that divides by mitosis.
Which diagram shows the chromosomes in the nucleus of one of the daughter cells produced?
A B
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22 The diagram shows the fusion of gametes to produce a son and a daughter.
father mother
parents
gametes Q
offspring R
son daughter
23 What are the sex chromosomes for human females and males?
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24 In fruit flies, the allele for grey body, G, is dominant over the allele for black body, g.
A Gg × gg B Gg × Gg C GG × gg D GG × Gg
25 A plant has two different alleles of a gene resulting in it having a green seed.
Which row describes the phenotype and genotype of the seeds of this plant?
henotype genotype
A Gg heterozygous
B Gg homozygous
C green heterozygous
D green homozygous
26 The shape of a person’s earlobes is determined by a single gene. This gene has dominant and
recessive alleles.
The allele for detached earlobes is dominant to the allele for attached earlobes.
parents
attached detached
children
attached detached detached
What is the probability of the next child from the same parents having detached earlobes?
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27 Which sex chromosomes are present in all mature human sperm cells?
DNA strand
DNA strand
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29 The chart shows the inheritance of fur colour in a small mammal.
If the allele for white fur is dominant, which animal must be heterozygous for the gene controlling
fur colour?
A B
1 2 3 4 5 6 8
9 10 11 12 13 14 15 16
17 18 19 20 21 22
What can be deduced about the person who has these chromosomes?
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31 Genetics is the study of
A development of organisms.
B mechanisms of inheritance.
C nuclear division.
D variation between species.
A blood group
B body mass
C health
D height
34 Most birds have a coloured pigment in their feathers, but in a few individuals, pigment is absent
and the birds are albinos.
Albinism occurs when a bird is homozygous recessive for the gene which creates the coloured
pigment.
If two albino birds mated, what describes the appearance of their offspring?
A all albino
B all coloured
C 50% coloured, 50% albino
D 75% coloured, 25% albino
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35 In an animal, the allele for straight fur is dominant to the allele for curly fur.
A pair of these animals mate and have nine offspring with straight fur and three with curly fur.
F represents the allele for straight fur and f represents the allele for curly fur.
Parents who do not suffer from the condition produce an albino child.
What is the probability that their second child will be born albino?
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39 The diagram shows the inheritance of flower colour in pea plants.
F1 genotypes Pp × Pp
phenotype purple flowers white flowers Y
gametes P p P p
F2 genotypes PP Pp Pp pp
phenotype purple flowers white flowers
ratio 3 : 1
40 In cats, the allele for short hair is dominant to the allele for long hair. A short-haired cat gives birth
to five kittens. Two of them have long hair.
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41 Cystic fibrosis is an inherited disease that occurs when an individual is homozygous for a
recessive allele.
If parents are both heterozygous for this characteristic, what is the probability that their first child
will have cystic fibrosis?
43 When white-flowered pea plants are crossed with red-flowered pea plants, the offspring (F1) all
have red flowers.
If these F1 plants pollinate themselves, the next generation (F2) contains both red and white-
flowered plants.
A The allele for red flowers is dominant and the F1 plants are heterozygous.
B The allele for red flowers is dominant and the F1 plants are homozygous.
C The allele for red flowers is recessive and the F1 plants are heterozygous.
D The allele for red flowers is recessive and the F1 plants are homozygous.
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44 A pure-breeding white mouse was crossed with a pure-breeding black mouse. All their offspring
were black.
Then, one of the offspring was bred with a pure-breeding white mouse. They produced 10 baby
mice.
45 How does a haploid nucleus differ from a diploid nucleus of the same species?
47 What is an allele?
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48 Which types of variation can be inherited?
50 A short-toed animal was crossed with a long-toed animal of the same species. All the offspring
had short toes. One of these offspring was crossed with another long-toed animal of the same
species.
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1 In pea plants, the allele for tall stems is dominant to the allele for short stems.
A heterozygous tall plant is crossed with a short plant, and 100 offspring are produced.
A 25 B 50 C 75 D 100
How many chromosomes are there in the nucleus of a sperm from this fly?
A 3 B 6 C 12 D 24
3 In a species of plant, the allele for red flowers (R) is dominant over the allele for white flowers (r).
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4 The diagram shows a potato tuber that developed from the stem of a parent potato plant. Three
shoots are starting to grow from the tuber.
shoot
tuber
How do the genotypes of the shoots compare with the genotypes of the tuber and of the parent?
A mouse with black fur was crossed with a mouse with white fur. All the offspring had black fur.
What would be the most likely ratio in several litters of offspring if two of these black offspring
were crossed?
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6 What is always found in female gametes and may be found in male gametes?
A one X chromosome
B one Y chromosome
C two X chromosomes
D one X chromosome and one Y chromosome
7 In rabbits, the allele for dark fur, R, is dominant to the allele for white fur, r.
The diagram shows a cross between a rabbit with dark fur and a rabbit with white fur.
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1 Catalase is an enzyme that breaks down hydrogen peroxide inside cells. Red blood cells contain
catalase.
Some dogs have an inherited condition in which catalase is not produced. This condition is known
as acatalasia and it is caused by a mutation in the gene for catalase.
gene...................................................................................................................................
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gene mutation....................................................................................................................
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[2]
The geneticist made the diagram in Fig. 3.1 to show the inheritance of acatalasia in a family
of dogs. The shaded symbols indicate the dogs with acatalasia.
normal male
1 2 3
normal female
Fig. 3.1
(i) State the genotypes of the dogs identified as 1, 2 and 3 in Fig. 3.1.
1 .............................................................................................................................
2 .............................................................................................................................
3 ............................................................................................................................. [3]
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(ii) The geneticist crossed dog 4 with dog 5. Approximately half of the offspring had
acatalasia and half the offspring did not have acatalasia.
dog 4 dog 5
parental phenotypes normal has acatalasia
+
gametes .......... , .......... ..........
Punnett square
offspring genotypes................................................................................................
(iii) State the name given to the type of cross that you have completed in (b)(ii).
................................................................................................................................ [1]
[Total: 9]
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2 Anthocyanin is a red pigment found in carnation flowers. Some carnation plants have a gene for
making anthocyanin.
................................................................................................................................
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................................................................................................................................ [3]
(ii) Explain the disadvantages of using sexual reproduction to breed red carnations.
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................................................................................................................................ [2]
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(c) Carnation plants show co-dominance for the anthocyanin gene. There are two alleles:
A
• F – allele for anthocyanin pigment (red flowers)
N
• F – allele for no anthocyanin pigment (white flowers)
(i) State the genotype of a carnation plant that is heterozygous for this gene.
................................................................................................................................ [1]
(ii) Describe the phenotype of a heterozygous carnation plant for this gene.
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................................................................................................................................ [1]
A N A A
(iii) The breeder crossed a F F carnation plant with a F F carnation plant. Predict, using
a genetic diagram, the proportion of pure breeding carnation plants in the offspring.
+
gametes ........... ........... ........... ...........
Punnett square
[4]
[Total: 13]
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3 (a) Sex in cats is determined in the same way as in humans.
gametes X X
......
male cat
(.........)
......
The gene for coat colour is located on the X chromosome. The gene has two alleles:
• B black
• b orange.
B
The X chromosome with the allele for black is represented by X .
b
The X chromosome with the allele for orange is X .
orange male
1 2
black male
calico female
orange female
3 4 5 6 7
black female
Fig. 3.1
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(i) State the genotypes of cats 1, 4, and 5 in Fig. 3.1.
cat 1 .......................................................................................................................
cat 4 .......................................................................................................................
................................................................................................................................
................................................................................................................................
................................................................................................................................
................................................................................................................................
................................................................................................................................
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................................................................................................................................ [3]
[Total: 9]
PhysicsAndMathsTutor.com
8 In some animals, B is the allele for normal skin (without spots) and b is the allele for spotted skin.
A BB × BB B Bb × Bb C Bb × bb D bb × bb
9 Which type of reproduction and which type of cell division produces nuclei with half the number of
chromosomes?
10 The diagram shows a family tree and the inheritance of the ability to taste a certain substance.
2nd generation
key
Which statement about the genotypes of the sisters Mary and Jeanne is correct?
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11 The family tree shows the inheritance of the ability to taste a certain substance. The allele for the
ability to taste this substance is dominant to the allele for the inability to taste it.
2nd generation
Peter Hannah
3rd generation ?
key
What is the chance of the second child of Peter and Hannah being a ‘non-taster’?
A 1 in 1 B 1 in 2 C 1 in 3 D 1 in 4
12 Albinism is an inherited condition in which pigment does not develop in the skin, hair and eyes.
A 0% B 50 % C 75 % D 100 %
13 In cats, the allele for short hair is dominant to the allele for long hair.
A short-haired cat and a long-haired cat had several families of offspring (kittens). All their kittens
were short-haired.
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14 The diagram shows a maize (corn) cob with purple and yellow fruits. Purple (P) is dominant to
yellow (p).
yellow fruit
purple fruit
A PP × Pp B PP × pp C Pp × Pp D pp × Pp
15 What is true of the chromosomes present in the daughter nuclei after meiosis and after mitosis?
How many chromosomes are there in the nuclei of its pollen grains?
A 8 B 16 C 32 D 64
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17 The diagram shows the offspring of a cross between two wolves.
brown
× wolf W
Brown colour is caused by a dominant allele B and white colour by a recessive allele b.
18 In the life cycle of a mammal, what describes the eggs or sperms and the cells of the embryo?
19 Which cross shows how a boy inherits sex chromosomes from his parents?
A B C D
mother father mother father mother father mother father
XY XX XY XY XX XY XX XY
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20 What causes humans to have different blood groups?
A differences in climates
B differences in diets
C differences in genes
D differences in hormones
21 The genetic diagram shows a breeding experiment that starts with crossing a homozygous tall
plant (TT) with a homozygous short plant (tt).
TT × tt
Tt Tt Tt × Tt
TT Tt Tt × tt
Tt Tt tt × tt
tt tt tt tt
A Tt × Tt B TT × tt C Tt × tt D tt × tt
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22 The diagram shows the fusion of gametes to produce a son and a daughter.
father mother
parents
gametes Q
offspring R
son daughter
A age at death
B blood group
C dietary deficiency disease
D lung cancer
24 A dominant allele
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