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This review intends to provide an updated overview of the recent trends over the past few years in
solid dispersion preparation techniques and polymer used. DSC thermogram indicated entrapment of
simvastatin in PVP K30 and the conversion of crystalline simvastatin into an amorphous form.
Bioavailability is the amount of drug that enters the systemic circulation. The Drug content was
found to be higher i.e. 94.89 in the F7 batch. The FT-IR spectra revealed that there was no interaction
between drugs and carriers. The pure drug and solid dispersions were characterized by in vitro
dissolution study. This study aims to obtain a solid dispersion formula that can increase the solubility
of Simvastatin. Characterization of solid dispersion was done by phase solubility, drug content,
Fourier transformed infrared spectroscopy (FT-IR), Differential Scanning Calorimetry (DSC) and in-
vitro dissolution studies. Fullscreen Sharing Deliver a distraction-free reading experience with a
simple link. Plantago ovate mucilage (2-8%) was employed as a natural super disintegrant, while
Cross carmellose sodium (2-8%) was used as a synthetic super disintegrant in the direct compression
method. The prepared solid dispersions were characterized by differential scanning calorimetry
(DSC), Fourier transforms infrared spectroscopy (FTIR), and evaluated for drug content, percentage
yield, saturation solubility, in vitro dissolution studies. The main aim of this study is to improve the
bioavailability of ritonavir with the help of Polyvinyl Pyrrolidone (PVP) K-30 by using solid
dispersion technique. HPMCAS, Locust Bean Gum, Sodium Alginate, and TPGS are four candidate
polymers that will be selected by in silico study to make a solid dispersion formula. The drug is
practically insoluble in water and exhibits exceptionally slow and intrinsic dissolution rate with poor
bioavailability. Preparation of water soluble formulation could be the technique to improve
bioavailability of such drug. Though solid dispersion has been outlined as an efficient drug delivery
system, the design of specific dosage forms for pharmaceutical therapy is necessary to improve the
solubility and bioavailability of poorly water-soluble drugs. To browse Academia.edu and the wider
internet faster and more securely, please take a few seconds to upgrade your browser. However its
absolute bioavailability is 5 % hence to increase it further solid dispersions were prepared. The
characterisation FTIR data demonstrate that the drug molecules are disseminated inside the polymer,
and the PXRD diffractogram demonstrated a deacrease in crystallinity to the amorphous phase, and
the DSC thermogram also demonstrated changes in thermal behavior. The study shows that the
dissolution rate of Simvastatin can be enhanced to considerable extent by solid dispersion technique
with PVP-K30. Conclusion: Solid dispersion is a promising method for increasing the solubility of
simvastatin. Natural super disintegrants were found to be superior in compression to synthetic super
disintegrantes with enhanced dissolving in the current study. Solid dispersions were prepared with
PVP-K30 at different drug: polymer ratios. You can download the paper by clicking the button
above. It was found that by varying the drug polymer ratio and by using different methods of
preparation of solid dispersion, the dissolution rate of pure drug can be enhanced. Solid dispersion
has been considered one of the major evolutions in overcoming these issues with several successfully
marketed products. GIFs Highlight your latest work via email or social media with custom GIFs.
Materials were evaluated by solubility and dissolution studies, then characterized using FTIR, DSC,
and PXRD. You can download the paper by clicking the button above. Solid dispersion can be
prepared by several methods such as solvent evaporation, melting, and supercritical fluid technology.
And the major current challenges of the pharmaceutical industry are apropos strategies that improve
the water solubility of drugs.
FTIR studies showed no interactions among drug and polymers. Download Free PDF View PDF
Journal of Applied Pharmaceutical Science Enhancement of Simvastatin dissolution by surface solid
dispersion: effect of carriers and wetting agents ebtessam essa Download Free PDF View PDF Effect
of carriers on solid dispersions of Simvastatin (SIM): Physicochemical characterization and
dissolution studies BANKIM CHANDRA NANDY Download Free PDF View PDF See Full PDF
Download PDF Loading Preview Sorry, preview is currently unavailable. In order to improve
bioavailability, many techniques like solid dispersions, nanoparticles, liposomes, encapsulation
methods were present. Solubilization may be affected by co solvent water interaction, micellar
solubilization, reduction in particle size, inclusion complexes, solid dispersion, and change in
polymorph. This review intends to provide an updated overview of the recent trends over the past
few years in solid dispersion preparation techniques and polymer used. The drug is practically
insoluble in water and exhibits exceptionally slow and intrinsic dissolution rate with poor
bioavailability. To browse Academia.edu and the wider internet faster and more securely, please take
a few seconds to upgrade your browser. The results of DSC analysis showed that endothermic peak
melting point of solid dispersion occurred, and the morphology of solid dispersion was more
irregular than pure glibenclamide based on SEM characterization Conclusion: The solid dispersion of
glibenclamide using PVP: HPMC as carriers can increase the solubility and dissolution rate
compared to pure glibenclamide. Methods: In the present study, solid dispersions of simvastatin
were prepared by Kneading and Solvent evaporation methods. The bioavailability is affected by
various factors like solubility, dissolution and stability. Solid dispersions prepared with solvent
evaporation method were more soluble than solid dispersions prepared with kneading method with
carrier PVP K30. Materials were evaluated by solubility and dissolution studies, then characterized
using FTIR, DSC, and PXRD. You can download the paper by clicking the button above. In the
present study, diacerein and I?-cyclodextrin (I?-CD) solid dispersions were prepared with a view to
study the effect and influence of I?-CD on the solubility and dissolution rate of this poorly aqueous
soluble drug. Along with the va. Download Free PDF View PDF globalresearchonline.net Solid
Dispersion: Strategy to Enhance Solubility Dr. Dheeraj Baviskar The solubility behavior of drugs
remains one of the most challenging aspects in formulation development. The main aim of this study
is to improve the bioavailability of ritonavir with the help of Polyvinyl Pyrrolidone (PVP) K-30 by
using solid dispersion technique. Download Free PDF View PDF Journal of Drug Delivery and
Therapeutics Bioavailability Enhancement of Ritonavir by Solid Dispersion Technique rama rao
Nadendla Ritonavir is an antiretroviral agent used in the treatment of HIV-infection. Articles Get
discovered by sharing your best content as bite-sized articles. GIFs Highlight your latest work via
email or social media with custom GIFs. Methods: Solid dispersions were prepared by solvent
evaporation method by using methanol as solvent, hydroxypropyl methylcellulose (HPMC) and
polyvinyl pyrrolidone (PVP) as polymers. Natural super disintegrants were found to be superior in
compression to synthetic super disintegrantes with enhanced dissolving in the current study. Help
Center Here you'll find an answer to your question. Phase solubility profile revealed that the
solubility of diacerein was significantly increased in the presence of I?-CD and indicating the
possible 1:1 stoichiometric inclusion complex with a stability constant of 339.66 M-1. Effect of
variable such as drug: Carrier ratios were studied. Characterization of solid dispersion was done by
phase solubility, drug content, Fourier transformed infrared spectroscopy (FT-IR), Differential
Scanning Calorimetry (DSC) and in-vitro dissolution studies. Solid dispersion can be prepared by
several methods such as solvent evaporation, melting, and supercritical fluid technology. In the
present study, SDs of simvastatin different drug-carrier ratios were prepared by kneading method.
Results: Each drug-polymer ratio showed an increase in solubility and dissolution, but the SV-LBG
formula (1:4) showed the largest increase, with a 4 folded increase in solubility and a roughly 2
folded increase in dissolution. Social Posts Create on-brand social posts and Articles in minutes. This
review highlight various techniques of solubility enhancement with special emphasis on Chemical
modification methods.
Statistics Make data-driven decisions to drive reader engagement, subscriptions, and campaigns.
Conclusion: The solubility of simvastatin was successfully enhanced through the solid dispersion
technique. In order to improve bioavailability, many techniques like solid dispersions, nanoparticles,
liposomes, encapsulation methods were present. To browse Academia.edu and the wider internet
faster and more securely, please take a few seconds to upgrade your browser. In the present study,
SDs of simvastatin different drug-carrier ratios were prepared by kneading method. The Drug
content was found to be higher i.e. 94.89 in the F7 batch. The FT-IR spectra revealed that there was
no interaction between drugs and carriers. Though solid dispersion has been outlined as an efficient
drug delivery system, the design of specific dosage forms for pharmaceutical therapy is necessary to
improve the solubility and bioavailability of poorly water-soluble drugs. Add Links Send readers
directly to specific items or pages with shopping and web links. This review highlight various
techniques of solubility enhancement with special emphasis on Chemical modification methods.
Characterization of solid dispersion was done by phase solubility, drug content, Fourier transformed
infrared spectroscopy (FT-IR), Differential Scanning Calorimetry (DSC) and in-vitro dissolution
studies. Results: The F7 formulation was found to be an optimized formulation containing PVP K30
in the ratio 1:1 prepared by solvent evaporation technique. From the above study it can be concluded
that solid dispersion of Simvastatin improved the drug dissolution profile. This study aims to
determine the solid dispersion formulation of simvastatin using soluplus as a polymer with a ratio of
1:1, 1:2, 1:3, and 1:4 which is employed to increase the solubility and dissolution rate of simvastatin.
Articles Get discovered by sharing your best content as bite-sized articles. You can download the
paper by clicking the button above. Plantago ovate mucilage (2-8%) was employed as a natural super
disintegrant, while Cross carmellose sodium (2-8%) was used as a synthetic super disintegrant in the
direct compression method. Orally administered drugs obtained completely absorb only when they
show fair solubility in gastric medium and such drugs shows good bioavailability. Enhancement of
solubility of drug is the most challenging job in drug development process. Adobe InDesign Design
pixel-perfect content like flyers, magazines and more with Adobe InDesign. Preparation of water
soluble formulation could be the technique to improve bioavailability of such drug. Methods: The
solid dispersion was prepared with two polymers, Locust Bean Gum (LBG), which has no hydrogen
bonds with Simvastatin, and Sodium Alginate (SA), which has hydrogen bonds with Simvastatin,
made by the ratio of mass 1:1, 1:2, 1:3, 1:4. This study aims to obtain a solid dispersion formula that
can increase the solubility of Simvastatin. The prepared product was evaluated by the saturated
solubility test and the dissolution rate test. Social Posts Create on-brand social posts and Articles in
minutes. Methods: The solid dispersion was prepared with two polymers, Locust Bean Gum (LBG),
which has no hydrogen bonds with Simvastatin, and Sodium Alginate (SA), which has hydrogen
bonds with Simvastatin, made by the ratio of mass 1:1, 1:2, 1:3, 1:4. Bioavailability is the amount of
drug that enters the systemic circulation. Different formulations were made with varied
concentrations of polymer. Materials were evaluated by solubility and dissolution studies, then
characterized using FTIR, DSC, and PXRD. With the advent of combinatorial chemistry and high
throughput screening, the number of poorly water soluble compounds has dramatically increased.
GIFs Highlight your latest work via email or social media with custom GIFs.
Materials were evaluated by solubility and dissolution studies, then characterized using FTIR, DSC,
and PXRD. This study aims to determine the solid dispersion formulation of simvastatin using
soluplus as a polymer with a ratio of 1:1, 1:2, 1:3, and 1:4 which is employed to increase the
solubility and dissolution rate of simvastatin. More Features Connections Canva Create professional
content with Canva, including presentations, catalogs, and more. Solid dispersions prepared with
solvent evaporation method were more soluble than solid dispersions prepared with kneading
method with carrier PVP K30. The pure drug and solid dispersions were characterized by in vitro
dissolution study. Furthermore, characterization was carried out using IR spectrophotometry,
differential scanning calorimetry (DSC), and powder X-ray diffraction (PXRD). Solid dispersions
were prepared by using polyethylene glycol 6000 (PEG-6000), HPMC, HPC and Poloxomer in
different drug-to-carrier ratios (1:2, 1:4, 1:6, 1:8, 1:10). To browse Academia.edu and the wider
internet faster and more securely, please take a few seconds to upgrade your browser. You can
download the paper by clicking the button above. The present work concluded that solid dispersion
technology can be used successfully to enhance the dissolution rate of poorly soluble drugs. Frijlink
Download Free PDF View PDF Abdul Sayeed, Dr.Pawan Kumar, Dr. Syed Areefulla Hussainy
FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF
CLONAZEPAM USING NATURAL AND SYNTHETIC SUPER DISINTEGRANTS Editor iajps
In this work, natural and synthetic super disintegrants were used to produce mouth dissolving tablets
for anticonvulsant drugs utilizing the direct compression method. With the advent of combinatorial
chemistry and high throughput screening, the number of poorly water soluble compounds has
dramatically increased. Phase solubility profile revealed that the solubility of diacerein was
significantly increased in the presence of I?-CD and indicating the possible 1:1 stoichiometric
inclusion complex with a stability constant of 339.66 M-1. Effect of variable such as drug: Carrier
ratios were studied. It was found that by varying the drug polymer ratio and by using different
methods of preparation of solid dispersion, the dissolution rate of pure drug can be enhanced. The
solubility and dissolution properties of drugs perform an valuable role in the process of formulation
development. Conclusion: The solubility of simvastatin was successfully enhanced through the solid
dispersion technique. Help Center Here you'll find an answer to your question. Conclusion: A solid
dispersion was formed in an amorphous state, as evidenced by the fact that the results of
characterization using IR spectrophotometry showed no new functional groups were formed in the
solid dispersion, the results of characterization using Differential Scanning Calorimetry (DSC)
showed a decrease in melting point, and the results of x-ray diffraction characteristics did not show a
sharp peak. Materials were evaluated by solubility and dissolution studies, then characterized using
FTIR, DSC, and PXRD. Issuu turns PDFs and other files into interactive flipbooks and engaging
content for every channel. Plantago ovate mucilage (2-8%) was employed as a natural super
disintegrant, while Cross carmellose sodium (2-8%) was used as a synthetic super disintegrant in the
direct compression method. The prepared product was characterized by Fourier transform infrared
spectroscopy (FT-IR), differential scanning calorimetry (DSC), and powder X-ray diffraction
(PXRD) and Scanning Electron Microscopy (SEM). Characterization of solid dispersion was done
by phase solubility, drug content, Fourier transformed infrared spectroscopy (FT-IR), Differential
Scanning Calorimetry (DSC) and in-vitro dissolution studies. Simvastatin is a selective competitive
inhibitor of HMG CoA reductase. You can download the paper by clicking the button above. Digital
Sales Sell your publications commission-free as single issues or ongoing subscriptions. You can
download the paper by clicking the button above. Physical characterization of the solid dispersion
was characterized by Fourier transform infrared spectroscopy (FT-IR), Differential scanning
calorimetry (DSC) and X-ray diffraction studies (XRD). Teams Enable groups of users to work
together to streamline your digital publishing. This review highlight various techniques of solubility
enhancement with special emphasis on Chemical modification methods.
And the major current challenges of the pharmaceutical industry are apropos strategies that improve
the water solubility of drugs. Download Free PDF View PDF International Journal of Applied
Pharmaceutics Improvement of Simvastatin Solubility Using Hpmcas, Locust Bean Gum, Sodium
Alginate and TPGS as a Polymer with Solid Dispersion Method Iyan Sopyan Objective: Simvastatin
(SV) is a cholesterol-lowering drug that classified in BCS (Biopharmaceutics Classification System)
Class II class with high permeability but low solubility value. Solid dispersions were prepared with
PVP-K30 at different drug: polymer ratios. Solid dispersions prepared with solvent evaporation
method were more soluble than solid dispersions prepared with kneading method with carrier PVP
K30. Simvastatin is a selective competitive inhibitor of HMG CoA reductase. The use of locust bean
gum polymer was proven to increase the solubility and dissolution of simvastatin with the best
formula SV-LBG (1:4). Results: Each drug-polymer ratio showed an increase in solubility and
dissolution, but the SV-LBG formula (1:4) showed the largest increase, with a 4 folded increase in
solubility and a roughly 2. Adobe InDesign Design pixel-perfect content like flyers, magazines and
more with Adobe InDesign. Solubilization may be affected by co solvent water interaction, micellar
solubilization, reduction in particle size, inclusion complexes, solid dispersion, and change in
polymorph. Natural super disintegrants were found to be superior in compression to synthetic super
disintegrantes with enhanced dissolving in the current study. Adobe Express Go from Adobe Express
creation to Issuu publication. HPMCAS, Locust Bean Gum, Sodium Alginate, and TPGS are four
candidate polymers that will be selected by in silico study to make a solid dispersion formula. DSC
thermogram indicated entrapment of simvastatin in PVP K30 and the conversion of crystalline
simvastatin into an amorphous form. Preparation of water soluble formulation could be the technique
to improve bioavailability of such drug. Frijlink Download Free PDF View PDF Abdul Sayeed,
Dr.Pawan Kumar, Dr. Syed Areefulla Hussainy FORMULATION AND EVALUATION OF
MOUTH DISSOLVING TABLETS OF CLONAZEPAM USING NATURAL AND SYNTHETIC
SUPER DISINTEGRANTS Editor iajps In this work, natural and synthetic super disintegrants were
used to produce mouth dissolving tablets for anticonvulsant drugs utilizing the direct compression
method. Video Say more by seamlessly including video within your publication. It is a BCS class IV
drug having poor aqueous solubility leading to poor bioavailability. Methods: The solid dispersion
was prepared with two polymers, Locust Bean Gum (LBG), which has no hydrogen bonds with
Simvastatin, and Sodium Alginate (SA), which has hydrogen bonds with Simvastatin, made by the
ratio of mass 1:1, 1:2, 1:3, 1:4. Clonazepam was used as a model drug to evaluate its release
characteristics from different matrices. More Features Connections Canva Create professional
content with Canva, including presentations, catalogs, and more. The pure drug and solid dispersions
were characterized by in vitro dissolution study. Enhancement of solubility of drug is the most
challenging job in drug development process. To browse Academia.edu and the wider internet faster
and more securely, please take a few seconds to upgrade your browser. Social Posts Create on-brand
social posts and Articles in minutes. Methods: There are many techniques to improve the solubility of
poorly water-soluble drug; one of them is solid dispersion prepared by the solvent evaporation
method. Issuu turns PDFs and other files into interactive flipbooks and engaging content for every
channel. The best formula of the solid dispersion was selected according to the solubility and
dissolution data. Extracting the drug with 0.1 N HCl and pH 6.8 phosphate buffer and measuring the
absorbance at 254nm was used to estimate the anticonvulsant drug in the produced tablet
formulations. Materials were evaluated by solubility and dissolution studies, then characterized using
FTIR, DSC, and PXRD. You can download the paper by clicking the button above.
From the above study it can be concluded that solid dispersion of Simvastatin improved the drug
dissolution profile. Results: Each drug-polymer ratio showed an increase in solubility and
dissolution, but the SV-LBG formula (1:4) showed the largest increase, with a 4 folded increase in
solubility and a roughly 2. The drug is practically insoluble in water and exhibits exceptionally slow
and intrinsic dissolution rate with poor bioavailability. The results of Xray diffraction analysis
showed an amorphous form in all solid dispersion formulas. Materials were evaluated by solubility
and dissolution studies, then characterized using FTIR, DSC, and PXRD. The best formula of the
solid dispersion was selected according to the solubility and dissolution data. Statistics Make data-
driven decisions to drive reader engagement, subscriptions, and campaigns. Frijlink Download Free
PDF View PDF Abdul Sayeed, Dr.Pawan Kumar, Dr. Syed Areefulla Hussainy FORMULATION
AND EVALUATION OF MOUTH DISSOLVING TABLETS OF CLONAZEPAM USING
NATURAL AND SYNTHETIC SUPER DISINTEGRANTS Editor iajps In this work, natural and
synthetic super disintegrants were used to produce mouth dissolving tablets for anticonvulsant drugs
utilizing the direct compression method. Download Free PDF View PDF Journal of Applied
Pharmaceutical Science Enhancement of Simvastatin dissolution by surface solid dispersion: effect
of carriers and wetting agents ebtessam essa Download Free PDF View PDF Effect of carriers on
solid dispersions of Simvastatin (SIM): Physicochemical characterization and dissolution studies
BANKIM CHANDRA NANDY Download Free PDF View PDF See Full PDF Download PDF
Loading Preview Sorry, preview is currently unavailable. Adobe Express Go from Adobe Express
creation to Issuu publication. To browse Academia.edu and the wider internet faster and more
securely, please take a few seconds to upgrade your browser. The F7 formulation showed maximum
drug release i.e. 98.60% in 60 min which is 2 times greater than pure drug making it an optimized
formulation. Physical characterization of the solid dispersion was characterized by Fourier transform
infrared spectroscopy (FT-IR), Differential scanning calorimetry (DSC) and X-ray diffraction studies
(XRD). Embed Host your publication on your website or blog with just a few clicks. The main aim
of this study is to improve the bioavailability of ritonavir with the help of Polyvinyl Pyrrolidone
(PVP) K-30 by using solid dispersion technique. Download Free PDF View PDF International
Journal of Applied Pharmaceutics Improvement of Simvastatin Solubility Using Hpmcas, Locust
Bean Gum, Sodium Alginate and TPGS as a Polymer with Solid Dispersion Method Iyan Sopyan
Objective: Simvastatin (SV) is a cholesterol-lowering drug that classified in BCS (Biopharmaceutics
Classification System) Class II class with high permeability but low solubility value. Fullscreen
Sharing Deliver a distraction-free reading experience with a simple link. HPMCAS, Locust Bean
Gum, Sodium Alginate, and TPGS are four candidate polymers that will be selected by in silico
study to make a solid dispersion formula. Results: Each drug-polymer ratio showed an increase in
solubility and dissolution, but the SV-LBG formula (1:4) showed the largest increase, with a 4 folded
increase in solubility and a roughly 2 folded increase in dissolution. Bioavailability is the amount of
drug that enters the systemic circulation. Methods: In the present study, solid dispersions of
simvastatin were prepared by Kneading and Solvent evaporation methods. The prepared product was
characterized by Fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry
(DSC), and powder X-ray diffraction (PXRD) and Scanning Electron Microscopy (SEM). The low
solubility of Simvastatin showed by low bioavailability so modification is required for its solubility.
You can download the paper by clicking the button above. Methods: The solid dispersion was
prepared with two polymers, Locust Bean Gum (LBG), which has no hydrogen bonds with
Simvastatin, and Sodium Alginate (SA), which has hydrogen bonds with Simvastatin, made by the
ratio of mass 1:1, 1:2, 1:3, 1:4. The solid dispersions were prepared by solvent method. Methods:
Solid dispersions were prepared by solvent evaporation method by using methanol as solvent,
hydroxypropyl methylcellulose (HPMC) and polyvinyl pyrrolidone (PVP) as polymers. The
polymeric carriers like Polyethylene glycol (PEG) 6000 and Polyvinyl Pyrrolidone (PVP) K30 were
used in different ratios (ratio of drug: carrier was 1:1, 1:2) to formulate solid dispersions. Download
Free PDF View PDF Journal of Drug Delivery and Therapeutics Bioavailability Enhancement of
Ritonavir by Solid Dispersion Technique rama rao Nadendla Ritonavir is an antiretroviral agent used
in the treatment of HIV-infection. In order to improve bioavailability, many techniques like solid
dispersions, nanoparticles, liposomes, encapsulation methods were present.