Physiology of Thyroid

Hormone
Neng Tine Kartinah
Departement of Physiology
 OutLine

01 02
Regulation of Thyroid
hormone

03 04
Action of thyroid hormone Disfunction of thyroid
hormone
Regulation

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1
• trapping

2
• organification

3
• Coupling

4
• Proteolysis of thyroglobulin
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5
• Deiodination Iodothyrosine Your tagline here

6
• Deiodination T4 to T3
TSH Function

calcium
Protect the vital homeostasis
organs

Haemato- poesis
Mechanical
support and
Locomotion
https://www.researchgate.net/publication/264711792_T
riiodothyronine_and_breast_cancer/figures?lo=1
Action of Thyroid hormone

Genomic and
Non genomic
General Metabolism
 Blood Glucose

Glucose
Gluconeogenesis Glycogenolysis
absorption
 Cholesterol
https://www.frontiersin.org/articles/10.3389/fendo.2018.00511/full
 1. METABOLISM

General Metabolism Blood Glucose Blood Cholesterol Protein syntesis

2. CARDIOVASCULAR
3. Growth
4. CNS development
https://onlinelibrary.wiley.com/doi/full/10.1111/jnc.13093
Dysfunction of Thyroid
Hormone
 Hashimoto
Disease

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https://link.springer.com/chapter/10.1007/978-1-4419-
1069-1_9
 Matrix:
Organic
An Organic:

Graves disease
https://www.nejm.org/doi/full/10.1056/NEJM199311113
292007
Myxedema
Myxedema
 Signs and
symptoms

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https://www.researchgate.net/publication/12471641_A
merican_Thyroid_Association_Guidelines_for_Detectio
n_of_Thyroid_Dysfunction/figures?lo=1
Physiology of
Parathyroid Hormone
Neng Tine Kartinah
Departement of Physiology
 OutLine

01 02
The role of PTH in The
Bone and The Kidney

03 04
The role of PTH in GIT Disfunction of PTH
Anatomy of
PTH

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Ca Homeostasis
Regulation of Parathyroid Hormone

Johnson, LR. Essential medical physiology.3rd ed. 2003

https://www.researchgate.net/publication/334986359_A_Narrative_Role_of_Vitamin_D
_and_Its_Receptor_With_Current_Evidence_on_the_Gastric_Tissues/figures?lo=1
https://onlinelibrary.wiley.com/doi/epdf/10.1002/cphy.c140071

Syntesis and release of PTH

Effect of PTH in The Bone
 Fast phase Slow phase

• PTH bind Receptors on

cell membrane

• Increase permeability of
membrane for Ca ions

• Ca pump mechanism

https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.00
12290.g007
Effect of PTH in Kidney
 Vitamin D Metabolism

https://www.jci.org/articles/view/29449/figure/3
 Effect of PTH in The Git (indirectly)

BARRETT KE, BARMAN SM, BOITANO S, BROOKS HL. GANONG’S REVIEW OF MEDICAL PHYSIOLOGY. 24TH ED. 2012
Dysfunction of
Parathyroid Hormone
HyperParathyroidsm
HypoParatiroidsm
Mercury is the closest planet
to the Sun and the smallest
one in the Solar System. It’s a
bit larger than the Moon
Physiology of Adrenal
Hormone
Neng Tine Kartinah
Departement of Physiology
 OutLine

01 02
Regulation of Adrernal
hormone

03 04
Action of cortex –Medulla Crisis adrenal hormone
adrenal hormone
Synthesis of adrenal hormone
Regulation

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Mineralocorticoid:Aldosteron
Angiotensin II
Action of Aldosteron

calcium
Protect the vital homeostasis
organs

Haemato- poesis
Mechanical
support and
Locomotion
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Cortisol & insulin resistance Cortisol & Immune system

https://link.springer.com/chapter/10.1007/978-3-7091-1890-0_5
 Gonadocorticoid: Androgen
&estrogen

Stimulate
development of
sexual characteristic

Sexual drive
Adrenal Medulla
Adrenal insufficiency
https://link.springer.com/chapter/10.1007/978-1-60327-
177-6_3
THANK YOU