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Midterm Micro-2 Virology Lesson-2
Midterm Micro-2 Virology Lesson-2
Midterm Micro-2 Virology Lesson-2
PPT Presentation
recommended three doses – to protect against cancers
Chapter 29: CLINICAL VIROLOGY
caused by HPV.
DNA VIRUSES The second dose should be given 6-12 months after the
A. Herpesviridae first dose.
B. Hepadnaviridae
C. Adenoviridae
D. Pappillomaviridae
E. Poxviridae
F. Parvoviridae
Double stranded EXCEPT Parvovirus Genital warts Skin warts
Naked EXCEPT Poxvirus, Hepadna, Herpes virus
Nuclear replication EXCEPT Poxvirus FAMILY POLYOMAVIRIDAE
Icosahedral EXCEPT Poxvirus POLYOMAVIRUS
Polyomavirus (family Polyomaviridae), any of a
PAPOVAVIRUSES subgroup of minute oncogenic DNA viruses of the family
Small, naked icosahedral tumor inducing viruses with double Polyomaviridae.
stranded DNA. b. Genus Polyomavirus
Replicate in the nucleus BK Virus – isolated from urine of renal transplant
Includes: patients.
1. Papillomaviridae JC Virus – isolated from brains of patients with
2. Polyomaviridae progressive multifocal leukoencephalopathy
GENUS: (PML).
Papilloma virus
Polyoma virus BK VIRUS
HUMAN PAPILLOMA VIRUS A BK virus (BKV) infection is a common viral infection
HPV is a group of more than 150 related viruses. that usually does not cause problems.
Each HPV virus in this large group is given a number which The BK virus may be spread if you have contact with
is called its HPV type. infected blood or body fluids, such as saliva (spit).
HPV is named for warts (papilloma) some HPV types can It can spread from one person to another during an organ
cause. transplant or from a mother to her baby during birth.
Some other HPV types can lead to cancer. Infection with BK virus may cause respiratory disease,
Men and women can get cancer of mouth/throat, and whereas infection with JC virus can affect the respiratory
anus/rectum caused by HPV infections. system, the kidneys, or the brain.
Men can also get penile HPV cancer. JC VIRUS
In women, HPV infection can also cause cervical, The JC virus, or John Cunningham virus, is a common
vaginal, and vulvar HPV cancers. germ.
But there are vaccines that can prevent infection with the The virus was first discovered in 1971. A doctor found it
types of HPV that most commonly cause cancer. in the brain of a man with Hodgkin’s lymphoma and
Skin warts are the most common signs of infection with named the virus after him.
papillomavirus. In people with very weak immune systems, the virus can
In humans, warts may be of two types – flat (which are bring on a serious brain infection called Progressive
superficial and usually on the hands) or plantar (on the Multifocal Leukoencephalopathy (PML). PML damages
soles of the feet and on the toes). outer coating of your nerve cells. It can cause permanent
Warts also commonly occur on the genitals disabilities and can even be deadly.
(condylomata acuminata) People with HIV/AIDS are most at risk for PML. Those
Some HPVs are linked to cancers. with Hodgkin’s disease, leukemia, or lymphoma are also
HPV is transmitted through intimate skin-to-skin contact. at risk, as are people who take certain immune-
It is most commonly spread during vaginal or anal sex. suppressing drugs because of multiple sclerosis (MS),
rheumatoid arthritis, or organ transplants.
HPV can be passed even when an infected person has no
More than half of all adults have been exposed to it. It
signs or symptoms. You can develop symptoms years after
being infected, making it hard to know when you first doesn’t cause problems for most people, but it can be
became infected. dangerous if you have a weak immune system.
In most cases, HPV goes away on its own and does not cause
POXVIRUSES
any health problems.
Poxviruses are the largest and most complex of viruses.
But when HPV does not go away, it can cause health
problems like genital warts and cancer. Composition: DNA (3%), Protein (90%), Lipid (5%)