Professional Documents
Culture Documents
توصيف مقررات معادلة
توصيف مقررات معادلة
Contents Page
5 Program regulations 10
6. List of Courses 15
1
13.Relationship between program courses, 250
goals, objectives and assessment tools of
Pharm D program
2
College Vision, Mission and Values
Vision
Mission
Values
3
Professional Competencies for the Pharm D program:
1. Patient Care:
Graduates will be able to provide patient care in cooperation with patients, prescribers, and
other members of an inter-professional health care team based upon sound therapeutic
principles and evidence-based data, taking into account relevant legal, ethical, social, cultural,
economic, and professional issues, emerging technologies, and evolving biomedical,
pharmaceutical, social/behavioral/administrative, and clinical sciences that may impact
therapeutic outcomes.
2. System Management:
Graduates will be able to manage and use resources of the health care system, in cooperation
with patients, prescribers, other health care providers, and administrative and supportive
personnel, to promote health; to provide, assess, and coordinate safe, accurate, and time-
sensitive medication distribution; and to improve therapeutic outcomes of medication use.
3. Public health:
Graduates will be able to promote health improvement, wellness, and disease prevention in
cooperation with patients, communities, at-risk populations, and other members of an inter-
professional team of health care providers.
4
List of Goals & Objectives for the PharmD Program
Goal 1:To provide the basic principles and fundamentals of the profession of clinical
pharmacy.
Objectives
To provide an understanding of the basic sciences used in clinical pharmacy
To enable students to apply the principles of clinical pharmacy in pharmacy practice
To develop students' ability to achieve and continuously update information in the field of
clinical pharmacy
Goal 2:To develop essential skills such as teamwork, leadership, creative thinking, work
ethics, and to provide instruction in how to responsibly and confidently make the
correct decisions in the profession of clinical pharmacy.
Objectives
To develop skills of teamwork, leadership, creativity, and responsibility among students
To provide standard guidelines on pharmacy law and ethics to students
Goal 3:To build intellectual and professional confidence in students to enable them to
meet the current and future challenges in the field of pharmacy.
Objectives
To provide adequate intellectual and professional abilities to meet the challenges of today and
of the future in the field
To provide appropriate problem solving skills for making the right decision at the right time.
Goal 4:To provide skills in information technology and written and spoken professional
communication as well as numerical skills for the field of pharmacy.
Objectives
To provide sufficient knowledge concerning all types and tools of communication in
healthcare
To provide training in the use of various programs related to clinical pharmacy in the
treatment of patients
Goal 5:To train in new technologies to develop the knowledge and skills necessary for a
clinical pharmacist.
Objectives
To place proper emphasis on program courses that develop student skills in diagnosis and
treatment
To prepare students to enable them to use current technology to meet future challenges in
clinical pharmacy
5
Goal 6: To train students to conduct distinguished scientific research in clinical
pharmacy.
Objectives
To provide students with knowledge and skills necessary to conduct basic and applied
pharmacy research that serves the profession of pharmacy and pharmacy practice
Goal 7: To conduct community awareness programs on healthy lifestyle, use and misuse
of medications.
Objectives
To provide students with knowledge and skills necessary to understand and meet the
challenges of community service programs
6
Learning outcomes of the Pharm D program
Knowledge
Summary description of the knowledge to be acquired
The student must demonstrate knowledge of the following theoretical foundations of the
profession and apply these to individual practice settings.
Describe the role of the pharmacist in the healthcare team, the means of promoting health,
dispensing medicines; medicines management and pharmacy care.
Describe the retrieval, analysis, and interpretation of the professional, lay, and scientific
literature to provide drug information and counseling to patients, their families or care givers,
and other involved health care providers.
Recognize the main sources of drugs, ways in which drugs are purified, characterized, and
analyzed; their physico-chemical properties; properties drugs display as biologically active
molecules in living systems; mechanism of action, dosage, side effects, and contraindications
of drugs, as well as drug interactions.
Describe how medicines are developed, manufactured, brought to the market place and
supplied in accordance with legal, ethical, social, economic, and professional guidelines.
Assessment methods
Midterm examinations
Final examinations
Assignments
Presentations
TBL
Practical examinations
Teaching strategies
Combination of lectures, seminars, team based learning, and assignments
Computer based learning
Laboratory classes, prescription interpretation exercises
Cognitive skills
1. Cognitive skills to be developed and level of performance expected
Design, implement, monitor, evaluate and adjust pharmacy care plans that are patient specific;
address health literacy, cultural diversity, and behavioral psychological issues; and are
evidence based.
Evaluate the quality of basic science and clinical research evidence to appropriately apply
study results to practice decision.
Apply research approaches and methods to managing scientific and practice related issues
7
Assessment methods
Laboratory reports.
Problem solving exercises, oral examination, OSCPE
Theoretical examinations
Interpretative exercises
Seminars
Teaching methods
Laboratory work, exercises.
Lectures, workshops and problem solving exercises, simulation, presentation.
Patient profiles and research project.
Assessment methods
Testing of all interpersonal skills is through a combination of project report and written
examinations throughout the courses
Preceptor evaluation.
Teaching methods
Acquisition of these skills are principally through assignments, laboratory classes.
Lectures and workshops
Project reports.
Assessment methods
Posters and seminars
8
Theoretical exam and problem solving
Preceptor evaluation
Self-assessment.
Teaching methods
Numeracy is initiated in lectures, workshops, and class exercises and is developed and
reinforced throughout the course in laboratory classes, workshops.
Poster presentations and seminars
Psychomotor skills
Description of psychomotor skills to be developed
Perform effectively laboratory, technical and clinical tasks relevant to Pharmacy
Assessment methods
Continuous Lab Evaluation
Practical exam
Objective Structure Clinical Examination (OSCE)
Teaching methods
Practical
9
Program regulations
Admission requirements
The applicant must successfully pass the preparatory year with cGPA >3.75/5
Classrooms
Students must arrive in the classroom before the start of the class.
Attendance should be taken once, for the whole class session, and not for every hour.
A student will be counted as present if he/she is in class within 10 minutes of the start
of class.
Students coming more than 10 minutes late but within 15 minutes of the start of class
may be allowed to attend the class without being marked present.
Students coming more than 15 minutes after the class starting time will not be allowed
to attend the class that day.
Break time will be strictly followed and students will not be allowed to take more
than the stipulated 10 minute break.
The instructor may combine two break times of 10 minutes each for a class of 3
hours, to allow students to have one 20 minutes break.
Students not returning to class on time or not returning at all after the break time will
be marked absent for the whole class.
10
Examination Rules & Regulations
Students are required to produce a college ID during the examination. If the college
ID is not available, any other government issued photo ID will be accepted. If no ID is
present, then Student Affairs Unit must be contacted to obtain approval to write the
examination.
Cell phones are not allowed inside the examination hall. All cell phones must be
submitted at the front desk before the start of the examination.
No study materials are allowed inside the examination hall.
Students should bring their own calculators.
Students are not allowed to enter the examination room more than 30 minutes after
the beginning of the exam and are not allowed to leave the examination room until 30
minutes after the start of the examination during mid-terms.
Students are not allowed to enter the examination room more than 1 hour after the
beginning of the exam and not allowed to leave the examination room until 1 hour
after the start of the examination during finals.
Students who are found cheating will be barred from three future examinations.
General Regulations
First: Early Registration
Early registration is possible according to the Deanship of Admission and
Registration and in coordination with the College of Pharmacy.
Students registering online should confirm their registration schedule through their
personal accounts in the university system during the active registration period.
11
Unconfirmed registrations will remain inactive with the computer message
“interrupted due to non-registration”, and the student will not be allowed into courses.
Fifth: Warnings
Students achieving a cumulative grade point average (cGPA) of 2 in a 5 point system will
receive a warning.
Attendance
Students who record a 25% absence rate without acceptable excuses will not be
permitted to write final examinations.
The above students will be given the grade “failed, DN” in the corresponding courses.
Attendance-based prohibitions from writing examinations are determined by the
College Council, which will determine the list of students prohibited from writing
exams before the beginning of the final examination period.
Students recording more than a 50% absence rate are advised to make their case to the
University Council; the college will not consider such a rate of absence.
Withdrawals
Students are permitted to withdraw from a semester with the permission of the Vice
Dean, provided that students advise of the withdrawal in writing and complete all
required forms.
The specified time frame to complete all requirements for withdrawing from a
semester is three weeks before the date of final examinations for that semester, based
on the University academic calendar.
Students withdrawing from a semester are required to re-register by the end of their
leave.
With the permission of the Vice Dean, students are allowed to drop courses within
eight (8) weeks from the start of the semester
Female students are required to present the consent of their parents or guardians when
applying for withdrawal.
12
Dropping Courses/Freezing Registrations
Students are allowed to drop a maximum of two consecutive semesters or a total of
three semesters in a full-length program at the University, unless the Senate or
College Council recommends otherwise in exceptional cases.
Married female students accompanying their husbands are allowed to freeze
registrations for a maximum of five (5) years. They may re-register to pursue studies
as follows:
They are required to make up for any changes in their previous curricula and
academic planning at the University or College, and complete all graduation
requirements.
If there are no changes, they may resume registration to pursue her studies normally.
Female students, who are absent for more than five (5) years, will have their seats
reserved to pursue studies as new students.
The period of the frozen registration is excluded calculations of the maximum time
allowed for graduation from a program.
Students returning from a withdrawal must activate their registrations or their
accounts will remain inactive.
Female students are required to present the consent of their parents or guardians.
Transfers
13
Requirements for Graduation
Must successfully obtain 15 credit hours required by the University.
Must successfully obtain 150 credit hours required by the College
Must successfully complete Advanced Pharmacy Practice Experiences
(APPE)(equivalent to 30 credit hours)
Important Terms
Academic Year
Two semesters and a summer semester
Semester
A 15 week study period, excluding registration and examination periods.
Summer semester
An intensive 8-week study period, excluding registration and examination periods.
Level
According to the academic plan in place, it indicates one of the ten levels required to
complete the program.
Study Plan
All required, elective, APPE, training, and preparatory courses that are required for the
completion of the program to obtain the PharmD degree in the college.
Syllabus
Details of courses in a program. It is specified by a code, name, and number. While some
courses have pre-requisites, others do not. Courses in the program are routinely evaluated for
their outcomes in the program.
Study Unit
A 50 minute lecture or clinical study or a 100 minute practical session.
Academic Warning
A warning issued to students whose grades are less than 2, following which his payment
stops. After the 4th warning, students are asked to withdraw from the university.
Semester Grade
The grades of a single semester of work comprised of exams, research projects, and all
academic activities from the courses taken. It is advisable to separate annual academic studies
into mid-terms I and II and practical examinations.
14
Final Exams
An annual exam, one per semester according to the academic plan of the university
Final Exam Grade
The result of the final exam of each course at the end of each semester; the results are shown
in terms of a percentage only (%).
Final Grades
The results of the semester’s activities plus the result of the final exam; final grades are
shown as a percentage (%).
Grades
The result expressed as a percentage or a letter grade of the final exam in any course.
Incomplete Grade
An incomplete grade shown as “L” or “IC” indicates that the course requirements were not
completed within specified timeframe.
15
120 PHP Introduction to Pharmacy Profession 1(1+0+0) NONE
101IC Introduction to Islamic Culture 2(2+0+0) NONE
121PHP Biostatistics 2(2+0+0) 135MATH
122PHC Pharmaceutical Organic Chemistry 4(3+1+0) 103PHC
123PHT Pharmaceutical Microbiology 3(2+1+0) 106BIOL
124PHC Pharmaceutical Analytical Chemistry 4(3+1+0) 103PHC
Pre
Code Level (6) Hrs.
req.
327PHC Pharmacopeial Analysis 4(3+1+0) 124PHC
320PHC Medicinal Chemistry-III 3(2+1+0) 315PHC
16
322PHP Pathophysiology-II 2(2+0+0) 310PHP
323PHT Pharmaceutics-III 3(2+1+0) 223PHT
324PHG Pharmacology-III 3(2+1+0) 314PHG
325PHP Scientific Writing & Seminar-I 1(1+0+0) 216PHP
17
424PHG Drug of Abuse 2(2+0+0) 334PHG
420PHP Pharmacotherapy-IV 3(3+0+1) 410PHP
425PHP Graduation Project 2(1+1+0) 343PHP
18
Advanced Pharmacy Practice Experiences (APPEs)
APPEs includes 10 clinical rotations. These include 7 core rotations and 3 elective rotations.
The students need to choose 3 rotations out of 18 elective rotations. The duration of each
rotation is of 5 weeks, 8 hours/day and 40 hours/week.
Through the APPEs, the College provides an experiential learning environment for the
students to develop sufficient, relevant and experiential knowledge base to utilize appropriate
resources necessary to provide patient centered care, individualized therapeutic planning,
intervention and evaluation. The program fosters clinical skills in students to assume
responsibility and accountability for therapeutic outcomes in the process of providing
pharmaceutical care. The program develops professionalism and interpersonal skills in
students to work as a team member of the healthcare providers, which is necessary for the
provision of optimal patient care and pharmaceutical services.
19
Categorization of courses per domainsBasic Biomedical Sciences
Course Name Credit hours
Human Biology 4
Organic Chemistry 2
Human Anatomy and Histology 4
Biostatistics 2
Pharmaceutical Microbiology 3
Biochemistry -I 2
Physiology-I 3
General Immunology 2
Biochemistry-II 3
Physiology-II 2
Pathophysiology-I 2
Pathophysiology-II 2
Pharmaceutical Biotechnology 2
Pharmacogenomics 2
Total 35
Course Name Credit hours
Pharmaceutical Organic Chemistry 4
Pharmaceutical Analytical Chemistry 4
Pharmaceutics-I 3
Pharmacognosy 3
Medicinal Chemistry -I 3
Pharmacology-I 4
Molecular Pharmacology 2
Pharmaceutics-II 3
Medicinal Chemistry-II 3
Pharmacology-II 4
Natural Products Chemistry 3
Pharmacopeial Analysis 4
Medicinal Chemistry-III 3
Pharmaceutics-III 3
Pharmacology-III 3
Pharmacology-IV 2
Toxicology 2
Basic Pharmacokinetics 2
Radiopharmacy 1
Biopharmaceutics 2
Applied Pharmacokinetics 2
Total 60
20
Social/Behavioral/Administrative Pharmacy Sciences
Course Name Credit hours
Introduction to Pharmacy Profession 1
Computer for Health Sciences 2
Scientific Writing & Seminar-I 1
Ethics in Pharmacy 2
Pharmacoeconomics & Epidemiology 3
Pharmacy Management 2
Evidence Based Pharmacy 2
Pharmacy Law 1
Scientific Writing & Seminar-II 2
Graduation Project 2
Total 18
Clinical Sciences
Course Name Credit hours
Medical Terminology 2
Pharmacy Practice 2
Psychology and Health 2
Pharmacotherapy-I 3
Dispensing of Medication 3
Clinical Communication Skills 2
Chemotherapy 2
Pharmacotherapy-II 3
Drug and Poison Information Services& Literature 3
Evaluation
Over the Counter Drugs 2
Patient Assessment & First Aid 1
Pharmacotherapy-III 3
Clinical Nutrition &IV. Administration 4
Drug of Abuse 2
Pharmacotherapy-IV 3
Total 37
21
Clinical Sciences Biomedical
(37 credit hours) Sciences (35 credit
hours)
Social/Behavioral/Administrative
Sciences (18 Credit hours)
Pharmaceutical
Sciences (60 credit
hours)
22
Description of Courses taught in the Pharm D program
Medical Terminology
Course Name: Medical Terminology المصطلحات الطبية :اسم المقرر
Course Code & No.: 102 PHP مصد102 :رقم المقرر ورمزه
Credits:2(2+0+0) 2(2+0+0) : المعتمدة:عدد الساعات
Prerequisite: None بدون : السابق:المتطلب
Level:1 1 :المستوى
Objectives:
Upon successful completion of this course, students will be able to:
Understand the common biomedical terminology in simplified English.
Show knowledge of word roots, combining forms, prefixes and suffixes related to
each system studied.
Understand words associated with anatomical structures, and pathological processes
of common diseases.
Break down and build pharmaceutical, medical & dental terms according to word
parts and descriptions.
Define directional terms associated with body topography.
Identify selected common medical abbreviations and symbols used by pharmacy,
medical and dental specialties.
Learning outcomes
Course Contents:
Introduction to written & spoken language of Pharmacy -with emphasis on
subdivisions-, medicine and dentistry.
The root of words associated with medical terminology such as diseases, organs,
systems.
The prefixes and suffixes of various medical, dental and pharmacy terms.
The Differentiation between spelling and pronunciation of related terms.
23
The spelling and definition of medical terminology associated with various body
systems including: nervous (autonomic and CNS), musculoskeletal, cardiovascular and
lymphatic, digestive, urinary, respiratory, reproductive, and endocrine.
Pharmaceutical Terminology related to Clinical Pharmacy and Therapeutics.
Pharmaceutical Terminology related to medicinal chemistry and Formulations.
Pharmaceutical Terminology related to Pharmacognosy.
Pharmaceutical Terminology related to Pharmacology and Toxicology.
Pharmaceutical Terminology related to Pharmaceutics.
Text Book(s):
Willis MC. Medical Terminology: A programmed Learning Approach to the Language of
Health Care. 1st. Edition, 2002. Lippincott Williams & Wilkins.
English for health professions. An elementary course for non-native speakers of English 1st.
edition, 2001. Najd Commercial Printing Press.
24
Additional suggested readings:
Gylys BA and Wedding ME. Medical terminology: A Systems Approach 4th. Edition, April
1999. F A DavisCo.
Gylys BA and Masters RM. Medical terminology Simplified: A Programmed learning
2nd Approach by body Systems. 2nd. Edition, March 1998. F A DavisCo.
Cohen BJ. Medical Terminology: an illustrated Guide. 4th. Edition.
25
Mathematics for Pharmacy
Course Name: Mathematics for Pharmacy الرياضيات للصيدلة :إسم المقرر
Course Code & No.: 135 MATH ريض135 :رقم المقرر ورمزه
Level:1 1 :المستوى
Objectives:
Upon successful completion of this course, students will be able to:
Show understanding of the basic principles of calculus.
Gain an understanding of basic single-variable calculus and its applications including
functions, limits, differentiation, Integration and differential equations and their
applications.
Be exposed to the properties of exponential functions and inverse functions and
logarithms.
Show understanding of the integration of various functions including algebraic,
trigonometric, exponential and inverse functions.
Show understanding of the application of derivatives in analysis of curves and
evaluating maxima and minima.
Show understanding of the various techniques of integration including integration by
substitution, partial fractions, integrating factor and integration by parts.
Apply the fundamental theorem of calculus to evaluate definite integrals.
Be familiar with separable linear first-order differential equations and their solution
by finding the antiderivative.
Course Contents:
Real Numbers.
26
Functions:
Definition
Properties
Types of functions
Trigonometric functions
Slopes of linear functions
Increments and rates
Limits
Continuity
Derivative
Definition
Rules of derivative
Higher order derivatives
Applications of derivatives
Analysis of curves
Maxima and minima and their applications
Monotone functions
Convexity and concavity
Plotting of functions
Exponential and Logarithmic Functions
Exponential function
Logarithmic functions
Linear semi-log, and log plots
Linearization of nonlinear plots
Natural logarithms and exponents
Exponential growth and decay
Integration
Antiderivatives
Integration techniques:
Integration by substitution
Integration of logarithmic and exponential functions
Integration by parts
Integrating factor
Integration by partial fractions
The definite Integral
Polar coordinates
Areas
Volumes
Differential Equations:
Separable equations
27
Linear first-order equations
Teaching/learning methods and Contact hours
Lecture Tutorial Laboratory Practical Other Total
Contact Hours 28 14 42
Credit 2 2
Text Book(s):
Arya JC, Lardner RW. Mathematics for the Biological Sciences. Prentice-Hall ISBN: 0-
13-562439-8.
Hughes-Hallet. Calculus: Answer Book. 1994. John Wiley & Sons Inc. 1st. edition. ISBN:
0-47-111305-0
Additional suggested readings:
Fleming W. App fled Calculus for Management, Social, and Life Sciences. 1991. Prentice
Hall.ISBN:0-13-39769-5.
Human Biology
Course Name: Human Biology علم األحياءالبشري :إسم المقرر
Course Code & No.: 106 BIOL بيول106 : ورمزه:رقم المقرر
Credits:4 (3+1+0) 4(3+1+0) : المعتمدة:عدد الساعات
Prerequisite: None ال يوجد : السابق:المتطلب
Level:1 1 :المستوى
28
Course Description (AIM):
This course serves as an introduction to the basic principles of biology with emphasis on
structure and function at the molecular and cellular levels. Practical lab sessions are devoted
to brief study of histology, anatomy and physiology of body systems, for example, digestive,
urogenital, urinary system. In addition, student will also be trained for experimental biology
and lab animal handling.
Objectives:
This course aims to introduce students to:
1) Basic knowledge and understanding of the major integrating concepts of the biological
systems such as chemical basis of life, cell structure, inheritance, anatomy and physiology.
2) Structure and function of the human body.
Learning Outcomes:
1. Knowledge (80%):
Upon successful completion of this course, students will be able to:
a. Describe construction and list functions of different cellular components nucleus,
cytoplasm, plasma membrane, ribosomes, mitochondria, lysosomes, centriolesetc.
b. Explain how formation and function of molecules depend on chemical bonding
between atoms.
c. State the molecular as well as the chromosomal basis of inheritance.
d. Define the roles of and differences between mitosis and meiosis.
e. Describe the structure and processes of human respiratory system, digestive system,
cardiovascular system, urinary system, mammalian reproduction along with
integration of endocrine and nervous systems.
3. Psychomotor (15%):
Upon successful completion of this course, students will be able to:
a. Draw structures of various body systems and demonstrate the ability to examine
histological slides under the microscope.
Course Contents:
The Chemical Context of Life
Cell Structure and Function
Organization and Regulation of Body Systems
Digestive system
29
Cardiovascular System
Respiratory System
Urinary System
Chromosomal basis of inheritance
Molecular basis of inheritance
Nervous System
Lymphatic and Immune System
Endocrine System
Nervous system
Required Textbooks
Campbell N.A., Reece J. B. Biology. Latest edition, Benjamin Cummings Company Inc.
Sylvia S. Mader and Michael Windelspecht. Human Biology, 12th Edition, Mc Graw
30
Hill International Edition.
Recommended textbooks and Reference material
Gary A. Thibodeau and Kevin T. Patton. Structure and Function of the Body, 12th
Edition, Mosby.
Michael D. Johnson. Human Biology Concepts and Current Issues, 6th Edition, Pearson
Inc.
Electronic Materials
Online resources available at
http://www.library.qu.edu.sa/Pages/default.aspx
http://www.pharmacylibrary.com.ezproxy.qu.edu.sa/public/about
http://accesspharmacy.mhmedical.com.ezproxy.qu.edu.sa/ss/About.aspx
http://search.proquest.com/
Organic Chemistry
Course Name: Organic Chemistry الكيمياء العضوية :إسم المقرر
Course Code & No.: 103 PHC كمص103 :رقم المقرر ورمزه
Credits: 2 (2+0+0) 2 (2+0+0) :عدد الساعات
بدون :المعتمدة
Prerequisite: None : السابق:المتطلب
Level:1 1 :المستوى
Objectives:
The primary goal of this course is to understand organic chemistry and to develop thinking
skills related to the subject matter
31
1. Knowledge
Upon successful completion of this course, students will be able to:
a. Recognize the principles of organic chemistry such as structures, nomenclature,
classification and stereochemistry
b. Write the methods of preparations, reactions and reaction mechanisms of different
functional groups.
2. Cognitive Skills
Upon successful completion of this course, students will be able to:
a. Describe the atomic structure and types of hybridization and bonds
b. Write the sterochemistry of organic molecules..
Course Contents:
Introduction (definition, structure of atoms, atomic orbitals, electronic configuration,
bonding, types of hybridization, electron availability, resonance, inductive effect,
electronegativity, polarity and dielectric constant, arrows in chemistry, reactions
yields).
Stereochemistry.
Alkanes and cycloalkanes.
Alkenes and dienes.
Alkynes.
Alkyl halides.
Alcohols.
Ethers and epoxides.
32
Course outcome Method of Assessment
Course Name: Human Anatomy and Histology تشريح اإلنسان وعلم األنسجة :إسم المقرر
1 Outcome 1 W
Course
2 Code &2No.: 111 ANAT
Outcome شرح111
W :رقم المقرر ورمزه
Credits:4(3+1+0) 4(3+1+0) : المعتمدة:عدد الساعات
Prerequisite: None بدون : السابق:المتطلب
Level:1 1 :المستوى
W: Written
Required Textbooks
T.W. Graham Solomon, Organic Chemistry, John Wiley & Sons, Inc,
Ralph J. Fessenden, Organic Chemistry, Brooks Cole.
I. L. Finar, Organic Chemistry: The Fundamental Principles, John Wiley & Sons
Recommended Textbooks and Reference Material
Jerry March & Michael B. Smith, Advanced Organic Chemistry, 6th Ed, John Wiley &
Sons
Electronic Materials
Online resources available at:
https://www.khanacademy.org/science/organic-chemistry
http://www.chemguide.co.uk/orgmenu.html
http://www.library.qu.edu.sa/Pages/default.aspx
Human Anatomy and Histology
Objectives:
Upon successful completion of this course, the following objectives should be covered:
Cell membrane, normal locations and structures of various body organs.
Relations between the different organs and systems.
Differences between the components of the central nervous system and the autonomic
nervous system.
Tissues, Glands, Bones and muscles
Learning outcomes:
33
1. Knowledge:
a. Gain knowledge regarding the normal locations and structures of various body organs.
b. Explain the relations between the different organs and systems.
c. Gain the basic knowledge regarding the differences between the components of the
central nervous system and the autonomic nervous system.
d. Differentiate between the different parts and compartments of the brain.
e. Understand the connections between the brain and the spinal cord.
f. Define euchromatin and heterochromatin and relate them to DNA coiling and cell
activity
g. Describe features of cytoplasmic organelles and inclusions, and mention functions of
each
h. Mention characteristic features of blood cells and describe the basic aspects of
hemopoiesis
2. Cognitive skills:
a. Explain features of the cell membrane, its functions
b. Explain phases of the cell cycle
c. Differentiate meiosis and mitosis
d. Classify body tissues and describe them
e. Explain bone, its features and locations of each type, and describe development and
growth of cartilage and bone, cells of the immune system, mention functions of each
f. Describe the basic histological features:mucous membrane of the oral cavity,
esophagus, stomach and intestine, salivary glands, liver and exocrine pancreas,
endocrine glands and pancreatic islets, heart and blood vessels, kidney, ureter and
urinary, male and female genital system, CNS, ganglia, eye and ear
Course Contents:
The general anatomical and histological structures and the relations between the
following systems:
The Central Nervous System:
The Autonomic Nervous System.
The Cardiovascular System.
The Respiratory System.
The Gastrointestinal Tract.
The Renal and Urinary System.
The Reproductive System.
The Sensory Organs.
34
The Lymphatic System.
The musculoskeletal system.
Practical
All the features of Organs of following systems:
The Central Nervous System:
The Autonomic Nervous System.
The Cardiovascular System.
The Respiratory System.
The Gastrointestinal Tract.
The Renal and Urinary System.
The Reproductive System.
The Sensory Organs.
The Lymphatic System.The musculoskeletal system
35
Course Name: Introduction to Pharmacy المدخل إلى مهنة الصيدلة :إسم المقرر
Profession
Course Code & No.: 120 PHP مصد120 :رقم المقرر ورمزه
Credits:1(1+0+0) 1(1+0+0) :عدد الساعات
بدون :المعتمدة
Prerequisite: None : السابق:المتطلب
Level:2 2 :المستوى
Course Description:
This course is designed to provide students with a broad perspective on pharmacy as a
profession in a changing health care environment. Students will learn to think critically about
health and health care from the patient's perspective and about the historical and
philosophical contexts of the profession as it continues to evolve toward patient focused care.
Objectives:
This course aims to introduce students to:
Role of the pharmacist and the new dimesnions of different pharmacy practice
settings in Saudi Arabia.
Dosage forms of pharmaceuticals, route of administration of drug delivery and
prescription and medication order interpretation
Importance of quality assurance of pharmaceutical care and information about the
different drug resources, professional ethics and communication
Required Textbooks
John Gibson. Modern Physiology and Anatomy. (2002). Blackwell, London.
Alexandra P. Spence. Mason, E.B. Human Anatomy and Physiology. (2002).
Benjamin, California, USA.
Electronic Materials
Online resources available at:
http://www.library.qu.edu.sa/Pages/default.aspx
http://www.pharmacylibrary.com.ezproxy.qu.edu.sa/public/about
http://www.pubmed.com
Learning outcomes:
1. Knowledge
Upon successful completion of this course, students will be able to:
36
a. Define the role of the pharmacy practitioner and different field of pharmacy practice
in Saudi Arabia
b. Describe the basic principles of drug developments, medication dosage forms and
their advantages and disadvantages
c. List different medical terminologies, abbreviations and their meanings.
d. Outline different sources of medication information
e. Discuss the basic principles of Pharmaceutical care and professional ethics and
communication.
Course Contents:
Pharmacy: history and philosophy
The health care system and financial aspects of health care
Overview of pharmacy practice
Key pharmaceutical care concepts and drug related problems
Pharmacy settings and functions
Roles and duties of pharmacists
Medication dosage forms, routes of administration and drug delivery systems
Introduction to quality assurance concepts
Prescription and medication order terminology and abbreviations
Prescription and medication order interpretation
Drug development
Pharmacy Information sources
Pharmacy organizations
Pharmacy laws and professional ethics
Professionalism and communication
37
Required Textbook
Pharmacy : an introduction to profession by L. Michael Posey, 2nd Edition
Foundation in Pharmacy Practice by Ben Whalley
Course outcome
Developing Method
Pharmacy Practice (a focus on patient care) Handbook of Assessment
2006 Edition
1 Outcome
Electronic 1
Materials W
2
OnlineOutcome
resources2available at: W
3 Outcome 3
http://www.library.qu.edu.sa/Pages/default.aspx W
4 Outcome 4 W
http://www.pharmacylibrary.com.ezproxy.qu.edu.sa/public/about
http://accesspharmacy.mhmedical.com/ss/About.aspx
http://accesspharmacy.mhmedical.com.ezproxy.qu.edu.sa/ss/About.aspx
http://search.proquest.com/
Course outcomes and Assessment
W: Written
Biostatistics
38
Course Name: Biostatistics اإلحصاء الحيوي :إسم المقرر
Course Code & No.: 121PHP مصد121 :رقم المقرر ورمزه
Credits:2(2+0+0) 2(2+0+0) : المعتمدة:عدد الساعات
Prerequisite:135MATH ريض135 : السابق:المتطلب
Level:2 2 :المستوى
Course Description (AIM):
This course is designed to provide students with a basic understanding of biostatistics. The
course covers of descriptive statistics with concepts of dispersion, central tendency
measurements. Graphical and tabular displays are also covered. Simple inferential statistics
involving probability, sampling, confidence intervals and tests of significance are presented.
Simple linear regression and correlations are also covered. Understanding concepts and
rational for various methods are emphasized with use of computer statistical software (such
as Excel, SPSS) for graphs and calculations.
Objectives:
This course aims to introduce students to:
Basic concepts and theoretical aspects in biostatistics
Requirements and steps needed to perform descriptive and inferential statistics
Important formulae used for descriptive and inferential statistics
Common statistical tests used in data analyses
Application of statistical concepts, theoretical aspects and formulae on some practical
scenarios and cases provided as examples
Learning outcomes:
1. Knowledge
Upon successful completion of this course, students will be able to:
a. Describe the key features of health data.
2. Cognitive Skills
Upon successful completion of this course, students will be able to:
a. Interpret mean, median, mode, ranges, variance, standard deviation and confidence
intervals.
39
b. Calculate mean, median, mode, ranges, variance, standard deviation and confidence
intervals.
c. Perform statistical inference such as confidence intervals and tests of significance.
d. Operate computer statistical software to carry out all the calculations
Course Contents:
Basic concepts
Definitions-, statistics, biostatistics, data
Definitions-variables (discrete and continuous).
Descriptive statistics
Preliminary data analysis
Measures of central tendency (mean, median, mode).
Measures of dispersions - range, mean deviation, variance, and standard deviation.
Graphical representation of data - dot plot, box plot, bar diagrams, and histograms.
Frequency of distributions.
Skewness, Kurtosis.
Distributions and Probability
Definitions, conditional probability
Discrete and continuous probability distributions
Bernoulli, Binomial, Normal and Poisson distributions.
Elementary sampling and sampling distributions.
Inferential statistics
Estimation of unknown parameters.
Test of hypothesis and significance
Comparing two means.
Comparing two proportions.
Simple Linear Regression and Correlations.
40
Course outcomes and Assessment
Course outcome Method of Assessment
1 Outcome 1 W
2 Outcome 2 W, PB
3Required Textbooks
Outcome 3 W, PB, AP
Wayne Daniel. (2010). Biostatistics: Basic concepts and methodology for the Health
Sciences (9th edition). John Wiley & Sons, Inc
Wayne Daniel. (1999). Biostatistics: a foundation for analysis in the health sciences
(7th edition). New York, Singapore, Toronto: John Wiley & Sons, Inc.
Bernard Rosner. Fundamentals of Biostatistics.
Recommended Textbooks and Reference Material
Glaser, A.N. (2001). High- yield biostatistics. Philadelphia, Baltimore, New York,
London, Buenos Aires, Hong Kong, Sydney, Tokyo: Lippincott Williams & Wilkins
Electronic Materials
Online resources available at:
http://www.library.qu.edu.sa/Pages/default.aspx
http://www.pharmacylibrary.com.ezproxy.qu.edu.sa/public/about
http://accesspharmacy.mhmedical.com/ss/About.aspx
http://accesspharmacy.mhmedical.com.ezproxy.qu.edu.sa/ss/About.aspx
http://search.proquest.com/
W: Written PB: Performance-Based AP: Assignment Project P: Portfolio
41
Course Name: Pharmaceutical Organic Chemistry كيمياء العضوية الصيدالنية: اسم المقرر
Course Code & No.:122 PHC كمص122: ورمزه:رقم المقرر
Credits: 4 (3+1+0) :4(3+1+0 ) عدد الساعات
Prerequisite:103 PHC كمص103: المتطلب
Level: 2 2:المستوى
Objectives:
To make the students to understand about the various functional group in
organic/medicinal compounds
To develop the student’s ability to understand the organic reactions and their
mechanism.
Learning outcomes:
1. Knowledge
Upon successful completion of this course, students will be able to:
a. Recognize the various classes and subclasses of organic compounds and how the
chemical and physical properties influence their behavior
b. Describe the chemical reactions unique to each class or subclass of organic molecules
and their role in synthetic chemistry
2. Cognitive Skills
Upon successful completion of this course, students will be able to:
a. Write the different reaction mechanisms and their importance in organic synthesis.
b. Predict the possible major and minor products from a chemical reaction.
c. Explain the methods of preparation, reactions and reaction mechanisms of common
organic functional groups, their derivatives, and different aromatic systems
42
2. Communication, Information Technology, Numerical
Upon successful completion of this course, students will be able to:
a. Illustrate the chemical structures and organic reactions using chemistry software
programmes.
3. Psychomotor
Upon successful completion of this course, students will be able to:
a. Prepare organic/heterocyclic compounds of medicinal interest.
b. Examine the organic molecules using chemical reactions for the identification of the
functional groups.
Course Contents:
Aldehydes and ketones.
Carboxylic acids.
Carboxylic acid derivatives.
Aromatic compounds (aromaticity, el electrophilic substitution, nucleophilic
substitution, EAR and orientation)
Phenols.
Aromatic nitro and related compounds.
Heterocyclic chemistry. antibiotics, antiviral agents, antineoplastic agents,
immunotherapy)
Practical
Laboratory safety measures and precautions.
Criteria of purity (determination of mp, bp, crystallization and distillation).
Element tests for nitrogen, halogen and sulfur.
Identification of alcohols.
Identification of aldehydes and ketones.
Identification of phenols and naPHThols.
Identification of carboxylic acids and salts.
Identification of esters, amides and imides.
Preparation of aspirin.
Preparation of p-bromoacetanilide.
Preparation of phenolPHThalein.
Follow up the reactions of the prepared compounds by TLC and calculation of the
yields.
43
Contact 45 - - 30 - 75 hours
Hours
The following teaching strategies are used:
Class room lectures
Practical
Required Textbooks
T.W. Graham Solomon, Organic Chemistry, John Wiley & Sons, Inc,
Ralph J. Fessenden, Organic Chemistry, Brooks Cole.
I. L. Finar, Organic Chemistry: The Fundamental Principles, John Wiley & Sons
Recommended Textbooks and Reference Material
Jerry March & Michael B. Smith, Advanced Organic Chemistry, 6th Ed, John Wiley &
Sons
Electronic Materials
Online resources available at:
https://www.khanacademy.org/science/organic-chemistry
http://www.chemguide.co.uk/orgmenu.html
http://www.library.qu.edu.sa/Pages/default.aspx
44
Pharmaceutical Microbiology PHT123
Course Name: Pharmaceutical Microbiology األحياء الدقيقة الصيدلية :اسم المقرر
Course Code & No.: PHT123 صيد١٢٣ رقم المقرر
Credits: 3(2+1+0) 3(2+1+0) عدد الساعات
:المعتمدة
Prerequisite:106BIOL حين1٠٦ :المتطلب السابق
Level:2 2 :المستوى
Objectives
This course aims to introduce students to:
To describe basic medical microbiology focusing on biological properties of different
groups of microbes; their classification, nomenclature, structure,
nutrition,metabolism, cultivation, growth and genetics
To explain etiological agent(s), mode of infection, pathogenesis, laboratory diagnosis,
prevention, diseases surveillances, control, and treatment of the most medically
important infectious diseases.
Learning Outcomes
1. Knowledge:
a. List the names of classification systems used in microbiology, the name the shapes
and arrangement of different groups of microbes, and define the growth
characteristics, nutritional requirements, and cultivation methods of microorganisms.
b. Explain the differences among different groups of microorganisms (Bacteria
Rickettsiae, Mycoplasma, Chlamydiae, Viruses and Fungi).
45
d. Develop the necessary skills to differentiate, the nature of both endemic and epidemic
disease, their diagnosis, and the epidemiological and/or microbial surveillance studies.
3. Interpersonal Skills & Responsibility(minor)
a. Show continuing personal and professional development,
b. Demonstrate leadership effectively within groups when appropriate, - Ability to judge
reasonably and ethically with high moral standards in personal and public forums.
3. Psychomotor:
a. Examine different groups of microbes. Perform cultivation, prepare smears, and
examine them microscopically. Operate different types of microbiological equipment
in the lab. Perform work under aseptic conditions.
Course Contents:
History of Microbiology and the world of microorganisms.
Classification and fundamental characteristics of microbes, eukaryotic and
prokaryoticcells.
Nomenclature and structure of bacteria.
Growth characteristics of bacteria.
Cultivation methods.
Bacterial genetics.
Different groups of fungi (yeast, yeast-like fungi, filamentous and dimorphic fungi).
Gram-positive cocci:
Staphylococci.
Streptococci.
Pneumococci.
Gram-negative cocci:
Neisseria gonorrhea.
Neisseria meningitides.
Gram-positive spore forming bacilli:
Aerobic Gram-positive spore forming bacilli:
Bacillus anthracis and other Bacillus species.
Anaerobic Gram-positive spore forming bacilli:
Clostridium perfringens.
Clostridium tetani.
Clostridium botulinum.
Clostridium difficile.
Gram-positive non spore forming bacilli:
Corynebacterium diPHTheria and diPHTheria bacilli.
46
Listeria monocytogenes.
Fermentative Gram-negative rods
Enterobacteriaceae
Oxidative Gram-negative rods
Pseudomonas organisms.
Malta fever.
Bordetella and Haemophilus species.
Vibrio and Helicobacter.
Tuberculosis.
Spirochetes.
Rickettsia Diseases.
Superficial and systemic mycotic infections.
Laboratory Schedule:
Good Microbiological practice.
Distribution of microorganisms in different environments.
Microscopic examination of microorganisms:
Preparation and fixation of bacterial smear.
Bacterial staining.
Simple staining.
Negative stain.
Differential staining:
Gram stain.
Special staining:
Zeihl-Neelsen's acid-fast stain.
Spore stain.
Capsule stain.
Culture media:
Ordinary media.
Enrichment media.
Media for anaerobic bacteria.
Enriched media.
Selective and differential media
Media for fungi.
Isolation and purification of pure colonies (streaking method).
Bacterial count.
Motility techniques.
Antimicrobial susceptibility testing:
Minimum Inhibitory Concentration (MIC).
Disk diffusion method.
47
Antibiotic assay.
Collection, handling and processing of clinical specimens. Staphylococci and
streptococci
Spore forming and non-spore forming Gram-positive bacilli.
Bacillus and Clostridium species.
Corynebacterium and Listeria species.
Fermentative and Oxidative Gram-negative rods.
Enterobacteriaceae.
• Pseudomonas species.
• Acid-fast organisms.
48
Course Name: Pharmaceutical Analytical Chemistry الكيمياء التحليلية الصيدلية:اسم المقرر
CourseCode&No.:PHC124 كمص124:رقم المقرر ورمزه
Required Textbooks
Koneman, EW; Allen, SD and Janda, WM et al. "Color Atlas and Textbook of
Diagnostic
Microbiology", 5th. Ed., 1997, Lippincott Company, USA.
Murray, PR; Baron, EJ; Pfaller, MA et al. "Manual of Clinical Microbiology", 7th. Ed.,
1999, ASM Press USA.
Black, JG "Microbiology Principles and Explorations", 4th. Ed. 1999, John Wiley &
Sons, Inc., USA.
Colle, JG; Fraser, AG; Mannion, BP and Simmons, A "Mackie and McCartney,
Practical Medical Microbiology" 14th. Ed. 1996, Churchill Livingstone Inc., USA.
49
Credits:4(3+1+0) 4 (3+1+0) :عدد الساعات
Prerequisite: PHC103 كمص103 :المتطلب
Level:2 2 :المستوى
Course Description:
Analytical chemistry is a measurement science consisting of a set of power fluid as and,
methods that are useful in determining the composition of materials .The course will cover
both chemical methods of analysis with emphasis on volumetric category and,
physicochemical methods of analysis(spectro-analytical instrumental methods).The course
will cover the principle and, applications of each method, its laws ,calculation ,advantages
and, limitations of each method. More attention will be given to it application in thefield of
pharmaceutical analysis.
Objectives:
Understanding the theory and practical aspects of the titrimetry.
Understanding the spectroscopic methods of pharmaceutical materials analyses.
Understanding the chromatographic techniques for pharmaceutical materials
purification.
Learning Outcomes
1. Knowledge:
Upon successful completion of this course, students will be able to:
a. Describe the titrimetric techniques and, their use in sample analysis.
b. Recognize HPLC usefulness and, its applications in qualitative and, quantitative
analysis.
2. Cognitive Skills:
Upon successful completion of this course, students will be able to:
a. Estimate the chromatographic purity of a mixture of pharmaceutical compounds.
2. Communication, Information Technology, Numerical:
Upon successful completion of this course, students will be able to:
a. Evaluate spectra of drugs/organic-medicinal products for preliminary structure
information.
3. Psychomotor:
Upon successful completion of this course, students will be able to:
a. Employ the spectroscopic and/or, chromatographic techniques in sample's analysis.
Course Contents:
Introduction to analytical chemistry and, are view of elementary concepts.
Qualitative & quantitative analyses, evaluation of quantitative analytical data.
50
Acid base titrations in aqueous medium (pH of strong acids and bases, weak acids and
bases and salts, buffers solutions, titration curves ,acid-base indicators ,applications of
acid-base titrations)
Acid-base titrations in non-aqueous medium(types of solvents for non-aqueous
titration, end-point determination in non-aqueous titrations)
Precipitation titrations (titration curves for precipitation titrations ,applications of
precipitation titrations)
Complex-formation titration(titrations with amino poly carboxylic acid, applicationsof
Complexometric titrations)
Oxidation reduction titrations (Nernst equation and oxidation potential of redox
system, applications of standard oxidants ,applications of standard reductants)
Potentiometric methods (indicator electrodes ,instrument for cell potential
measurements ,direct potentiometric measurements, potentiometric titrations)
Introduction to spectroscopic methods of analysis (the electromagnetic spectrum
,emission and, absorption of electromagnetic radiation ,fluorescence and,
phosphorescence)
Applications of molecular spectroscopy (molecular absorption spectra ,applications of
absorption spectroscopy to qualitative analysis ,quantitative analysis by ultraviolet
and visible absorption measurement ,applications of infrared absorption ,molecular
fluorescence spectroscopy and its application, NMR spectrometry ,mass
spectrometry)
Introduction to chromatographic separation (general description of chromatography
,threat-theory of chromatography ,separation on column ,qualitative and quantitative
analysis by chromatography)
HPLC
GC
Laboratory Schedule:
Acid base titrations (preparation and standardization of 0.1NHCl,determination of
zinc oxide, determination of borax ,determination of boric and ,determination of
ammonium salts ,non-aqueous titration)
Precipitometric titrations (preparation and standardization of ammoniumthiocyanate,
determination of KCl by Mohr's method, determination ofNH4Cl by
Volhard'smethod, determination of KCl and KI and their mixture by Fajan method,
determination of sulfacetamide by Volhard's method)
Complexometric titrations (preparation and standardization of 0.05MEDTA,
determination of Ca++and Mg++and their mixture,determinationof ZnO)
Oxidation-reduction titrations (preparation and standardization of 0.1N potassium
permanganate ,assay of hydrogen-peroxide ,assay of ferrous sulfate in tablets
,bromometric determination of phenol ,analysis of tincture iodine ,determination of
calcium lactate)
51
Spectrophotometric analysis (absorption spectrum of potassium dichromate
,verification of Beer 'slaw, absorption spectrum of sulfacetamide in 0.1MHCl,analysis
of two-component mixtures
Infra- red spectrophotometry ,IR and Mass Spectrometry (Study of the spectrum of
some pharmaceutical compounds to show the different functional groups)
Fluorometric analysis (fluorescence spectra of ofloxacin and calibration graph and
analysis of its tablets)
Potentiometric analysis (potentiometric determination of isoniazid against standard
bromine sing Platinum/ calomelel ectrode system)
HPLC (inspection of atypical chromatogram and calculation of the resolution ,NTP
and HTEP)
Required TextBook(s):
DouglasA.Skoog&DonaldM.West.FundamentalsofAnalyticalChemistry.SandersCollege
52
Publishing,Philadelphia
Galen Ewing. Instrumental Methodsof ChemicalAnalysis,McGraw-Hill, NewYork
RobertdeLevie.PrinciplesofQuantitativeChemicalAnalysis.McGraw-Hill,New York
GaryD. Christianand, James EO'Reilly,InstrumentalAnalysis,PrenticeHall,New York J.
Baisett,R.C.Denney,G.H.JeffergandJ.Mendham,Vogel'sTextbookofQuantitativeInorganic
Analysis,Longman,Essex
Additional Suggested Readings:
Practical Pharmaceutical Chemistry, A.H. Beckell and J.B. Stenlake. The Athione Press,
London.
Pharmaceutical Drug Analysis, 2nd ed, Ashutosh Kar, New Age Publications, New
Delhi.
Pharmaceutical Analysis: A Textbook for Pharmacy Students and Pharmaceutical
Chemists, David G. Watson, Churchill Livingstone.
Modern Analytical Chemistry, David Harvey, McGraw-Hill.
Electronic Materials
e-Books (provided to students through Class/Course Representative)
Access Pharmacy
Pharmacy Library
http://www.library.qu.edu.sa/Pages/default.aspx
http://accesspharmacy.mhmedical.com.ezproxy.qu.edu.sa/ss/About.aspx
Biochemistry-I
Course Name: Biochemistry-I 1-الكيمياء الحيوية :اسم المقرر
Course Code & No.: PHG 210 210 دوى :رقم المقرر و رمزه
Credits:2(2 + 0 + 0) 2(2 + 0 + 0) :عدد الساعات
Prerequisite: PHC 103 103 كمص السا:المتطلب
:بق
Level:3 3 :المستوى
53
Course objectives:
Upon successful completion of this course, the following objectives should be covered:
Amino acids and proteins, enzymes, biological oxidation, porphyrins and nucleic
acids.
Clinical correlations and the action of certain therapeutic as well as toxic agents are
explained whenever possible.
Learning outcomes:
1. Knowledge:
Upon successful completion of this course, the student will be able to:
a. Recognize the structures of the 20 amino acids commonly found in proteins. Know
the properties of their side chains and how these properties affect protein structure.
b. Recognize the structure of peptide bond and to explain how its properties influence
protein folding.
c. List the four levels of protein structure and to describe the forces that determine how
protein folds.
d. Outline the structure and function of antibody molecules.
e. List the course and fate of acetyl-COA and pyruvate.
f. Describe role of the TCA cycle in metabolism.
g. Name inhibitors and uncouplers of oxidative phosphorylation.
h. Outline the pathway for heme synthesis and catabolism as well as related diseases.
i. Recognize the pyrimidine and purine bases and identify their precursors.
j. Outline nucleotide catabolism, urate formation, and purine salvage.
k. Describe DNA and RNA structure and function.
l. Outline the steps of protein synthesis.
2. Cognitive skills:
Upon successful completion of this course, the student will be able to:
a. Explain the mechanisms by which enzymes catalyze reactions and how the activity of
an enzyme can be regulated.
b. Differentiate between competitive & noncompetitive, and uncompetitive inhibition
and to explain the action of certain therapeutic agents.
c. Explain the mechanism by which hemoglobin and myoglobin reversibly bind oxygen
and to interpret the oxygen-binding curves.
d. Summarize electron transfer from NADH and succinate to oxygen.
e. Interpret serum enzyme and isozyme activities in the diagnosis of clinical conditions.
Course Contents:
Amino acids and proteins.
Chemistry of amino acids and their classification.
Acid-base, physical and chemical properties of amino acids.
54
Classification and function of proteins.
Structure of peptide bond.
Level of protein structure.
Protein unfolding (denaturation).
Hemoglobin and myoglobin.
Plasma proteins and antibody molecules.
Enzymes.
Enzyme classification and their mechanism of action.
Enzyme kinetics and inhibition of enzyme activity.
Regulation of enzyme activity.
Coenzymes.
Serum enzyme and isozyme activities in the diagnosis of clinical conditions.
Biological oxidation.
ATP cycle.
Source and fate of acetyl-COA and pyruvate.
Tricarboxylic acid cycle.
Mitochondrial electron transport chain and oxidative phosphorylation and their
inhibitors.
Porphyrins.
Heme biosynthesis and its regulation.
Heme catabolism and formation of bile pigments.
Porphyrias and jaundice.
Chemistry of nucleotides.
Metabolsim of purine and pyrimidine nucleotides.
Gout, Lysch-Nyhan syndrome and orotic aciduria
Chemistry of DNA and RNA.
The genetic code and protein synthesis.
55
Course outcomes and Assessment
Course outcome Method of Assessment
1 Outcome 1 W
2 Outcome 2 W
W: Written PB: Performance-Based AP: Assignment Project P:
Portfolio
Required Textbooks
Devlin, T.M. Biochemistry with Clinical Correlations. Latest edition. John Wiley and
Sons, Inc.
Marks, D.B. Biochemistry. Latest edition. Williams and Wilkins.
Champe, P.C., Harvey, RA. Biochemistry J.B. Latest edition. Lippincott Company.
Recommended Textbooks and Reference Material
Robert K. Murray et al. Harper's illustrated biochemistry. Twenty-sixth edition,
McGraw-Hill Companies
Electronic Materials
Online resources available at:
http://www.library.qu.edu.sa/Pages/default.aspx
http://www.pharmacylibrary.com.ezproxy.qu.edu.sa/public/about
http://www.pubmed.com
56
Physiology-I
Level: 3 3:المستوى
Course Description:
The course describes the Physiology of cell membrane, nerve and muscle, Physiology of
autonomic nervous system, Physiology of blood and cardiovascular system with emphasis on
the human body.
Objectives:
• Describe the importance and understanding of various physiological processes of the human
body.
• Describe the physiology of cell and various systems.
Perform various experiments relating to the various body system
Learning outcomes:
1. Knowledge:
Upon successful completion of this course, students will be able to:
a. Explain what is meant by active transport, Na+/K+ pumps and their role in
maintenance of the resting membrane potential and explain how an equilibrium
potential is produced.
b. Discuss the structure and general functions of the sympathetic and parasympathetic
divisions of the autonomic system and role of motor unit in control of muscle
contraction.
57
c. Describeblood composition, function of the heart, blood elements, blood vessels and
regulation of its function.
d. Explain the properties of action potentials and explain the significance of all-or-none
law and the refractory periods.
e. Explain the structure of smooth muscle and explain how its contraction is regulated.
Cognitive Skills:
Upon successful completion of this course, students will be able to:
a. Compare depolarization, repolarization and hyperpolarization.
b. •Distinguish between different types of muscles and contractions.
Psychomotor:
Upon successful completion of this course, students will be able to:
a. Perform various experiments relating to cardiovascular system, blood and respiratory
system.
Course Contents:
Transport through cell membrane.
Membrane potential.
Resting membrane potential.
Action potentials.
Peripheral neuron regeneration.
Structure of skeletal muscles.
Types of muscle contractions.
Mechanism of contraction.
Neural control of skeletal muscles.
Energy requirements of skeletal muscles.
Cardiac and smooth muscle.
Autonomic nervous system, introduction.
Somatic and autonomic motor reflex.
Divisions, functions and control of the autonomic nervous system.
Function of blood.
Composition of blood.
Plasma, erythrocytes, leukocytes and platelets.
Regulation of erythropoiesis.
Red blood cells antigens and blood typing.
Blood clotting and dissolution of clots.
Organization of cardiovascular system.
Arteries and veins.
Microcirculation.
Cardiac electrophysiology and electrocardiogram.
The heart as a pump.
58
Regulation of arterial pressure and cardiac output. Special circulations.
Practical Schedule:
Red blood cell count and hemoglobin determination.
White blood cell count.
White blood cell differential.
Blood groups, erythrocyte sedimentation rate and osmotic fragility of red blood cells.
Bleeding time, coagulation time.
Effect stannous ligatures, temperature and drugs on frog's heart in situ.
Effect of chemical mediators on isolated frog's heart.
Characterization of receptors in isolated frog's heart.
The electrocardiogram.
Measurement of arterial blood pressure.
Recording respiratory movements.
Nerve muscle preparation.
59
Text Book(s):
Guyton, A.C. and Hall, J.E. Textbook of Medical Physiology. Latest edition. W.B.
SaundersCompany, Philadelphia.
Additional suggested readings:
Fox, 8.1.Human Physiology.W.C. Brown Publlshers.Latest edition. Dubuque.
Ganong, W.F. Review of Medical Physiology. Latest edition. Appleton and Lange,
Norwalk.
Electronic Materials
Online resources available at:
http://www.library.qu.edu.sa/Pages/default.aspx
http://www.pharmacylibrary.com.ezproxy.qu.edu.sa/public/about
http://accesspharmacy.mhmedical.com/ss/About.aspx
http://accesspharmacy.mhmedical.com.ezproxy.qu.edu.sa/ss/About.aspx
http://search.proquest.com/
60
Pharmaceutics-I
Objectives:
This course aims to introduce students to:
Fundemnatales of measurment and calculation in pharmaceutices
Assessement of the physical and chemical data in order to evaluate the stability of a
given formulation.
The compounding of different liquid dosage forms
Learning outcome:
1. Knowledge
Upon successful completion of this course, students will be able to:
a. Record different types of solution dosage forms
b. Outline different types of concentration (Percentage strength, PPM etc…
c. List international systems of units
d. State methods ofisotonic preparations.
2. Cognitive skills:
Upon successful completion of this course, students will be able to:
a. Compare between ratio and proportion.
b. Differentiate between three states of matter.
c. Explain Phase rule and phenol water system
d. Estimate different methods of preparation aromatic water, syrups and elixirs
3.Numerical skills
e. Upon successful completion of this course, students will be able to:
f. Calculate ratio and proportion using different methods
g. Calculate different concentrations using alligation method
h. Evaluate isotonic solutions
61
3. Psychomotor skills
Upon successful completion of this course, students will be able to:
a. Perform solubility enhancement tests by co- solvent method
b. Draw miscibility of solvents in binary and ternary systems
c. Prepare different pharmaceutical solution dosage forms perform dilution and
alligation of alcoholic solution
Course Contents:
Fundamentals of Pharmaceutics.
Mathematics: basic pharmaceutical principles.
Fundamentals of measurement and calculation.
.Isotonicity
States of matter
Intrduction into pharmaceutical solution dosage form
syrups
Elixires
Stability of pharmaceuticals and basic chemical kinetics.
Partitioning, diffusion and dissolution.
Practical Schedule:
Introduction and general instructions:
Laboratory safety and chemical hazardous.
Dilution and alligation of alcoholic solutions
Isotonic Preparations
Solubility enhancement by co-solvent method
Phenol-water system
Miscibility of solvents
Preparation of iodine&ferrous sulphate syrup
Preparation of simple syrup & expectorant
Preparation of elixir
Chemical kinetics I.
Chemical kinetics II
62
The following teaching strategies are used:
Lectures
Lab.
63
Pharmacognosy
Course Name: Pharmacognosy علم العقاقير :اسم المقرر
Course Code & No.: PHC 215 كمص215 : ورمزه:رقم المقرر
Credits:3 (2+1+0) 3 (2+1+0) :عدد الساعات المعتمدة
Prerequisite: PHC 103, PHC 122 كمص122 ، كمص103 :المتطلب السابق
Level:3 3 :المستوى
Course Description (AIM):
Pharmacognosy course aims to provide the knowledge and understanding of the medicinal
plants and to encourage students to take a broad and continuing interest in medicinal plants
with emphasis to those available in the Saudi Arabia
Introduce the student to the different types of complementary and alternative medicine.
Course objectives:
This course aims to introduce students to:
Know the modern concept and scope of pharmacognosy
Understand the importance of natural products particularly medicinal plants as a
source of drugs.
Be able to apply their basic background in pharmacognosy to identify powdered drugs
by microscopical examination.
Learning outcomes:
1. Knowledge
Upon successful completion of this course, students will be able to:
a. Recognize and identify a wide range of medicinal plants, entire or dried
b. Know the active constituents of herbal drugs and understand their pharmacological
actions on the body
c. Know in detail the contraindications and incompatibilities of the studied medicinal
plants.
2. Cognitive skills
Upon successful completion of this course, students will be able to:
a. Identify any plant tissue under the microscope.
b. Interpersonal skills & responsibility
c. Upon successful completion of this course, students will be able to:
d. Apply the ethical and professional standard of ethics in the laboratory.
3. Communication, Information technology, Numerical
Upon successful completion of this course, students will be able to:
a. Know in detail the toxicity and dosage range of the medicinal plants studied.
b. Perform effective communication and positive relation with others and be able to
work as an effective member in a team.
4. Psychomotor
Upon successful completion of this course, students will be able to:
64
a. Aware of the influence of plant remedies on the psycho-social and spiritual aspects of
a patient's being.
Course Contents:
Introduction to Pharmacognosy and medicinal plants
Examines individual plant remedies and discusses their botanical, pharmacognostic
,pharmacological and therapeutic aspects, along with their indications in treatment,
contraindications and incompatibilities, including dosage for elderly patients and
children.
The plants are discussed from a traditional therapeutic aspect and modern scientific
research and clinical experience is used to supplement and/or extend the
understanding of the plant as a medicinal remedy. Specific indications are studied, as
herb combinations and synergy. Examples of Leaf, herb, flower, seed, fruit, bark,
subterranean and unorganized drugs
Complementary and Alternative systems of medical practice (CAM) [Introduction
,understanding how the body works, fields of practice and types].
Practical:
How to examine powdered drug
TLC profile of herbal drugs
Leaf and herb drugs: Morphological and microscopical characters leaves and testing
the active constituents (one example). Identification of powdered leaves by
microscopical examination and TLC profile.
Seed drugs: Morphological and microscopical characters seeds and testing the active
constituents (one example). Identification of powdered seeds by microscopical
examination and TLC profile.
Fruit drugs: Morphological and microscopical characters fruits and testing the active
constituents (one example). Identification of powdered fruits by microscopical
examination and TLC profile.
Bark drugs: Morphological and microscopical characters barks and testing the active
constituents (one example). Identification of powdered barks by microscopical
examination and TLC profile.
Subterranean drugs: Morphological and microscopical characters subterranean drugs
and testing the active constituents (one example). Identification of powdered leaves
by chemical testing and TLC profile.
65
Contact 32 - 24 - - 56
Hours
Text Book(s):
W.C. Evans, "Trease and Evans, PHARMACOGNOSY" 16th Edition, Bailliere
Tindall, London,Philadelphia, Toronto, Sydney, Tokyo (2009).
WHO monographs on selected medicinal plants, World Health Organization,
Paperback
Publisher, vol. 1, (1999)
WHO monographs on selected medicinal plants, World Health Organization,
Paperback
Publisher, vol. 2, (2002)
Additional suggested readings:
AshtoshKar, Pharmacognosy and Pharmacobiotechnology, 1st edition, 2008, New Age
International (P) Ltd., Publishers.
Gunnar Samuelsson. Drugs of Natural Origin. 4th. edition 1999. Swedish
Pharmaceutical press.
J. Higgins, D.J. Best, J. Jones, "Biotechnology, Principles and Applications",
Blackwell ScientificPublications (1985).
66
Harborne, J.B., "Phytochemical Methods", 3rd. ed., Chapma Hall, London, New York
(1998).
Electronic Materials:
http://www.pharmacylibrary.com.ezproxy.qu.edu.sa/public/about
http://accesspharmacy.mhmedical.com/ss/About.aspx
http://accesspharmacy.mhmedical.com.ezproxy.qu.edu.sa/ss/About.aspx
www.ncbi.nlm.nih.gov/SNP/
Encyclopedia of Medicinal Plants
Course Name: Computers for Health الحاسب اآللي للعلوم الصحية :أسم لمقرر
Sciences
Course Code & No.: 216 PHP مصد216 :رقم المقرر و رمزه
Credits:2(2+0+1) 2(2+0+1) :عد الساعات المعتمدة
Prerequisite:135 MATH ريض135 :المتطلب لسابق
Level: 3 3 :المستوى
67
Course Description (AIM):
This course is designed to provide the student with knowledge about advanced computer
technology and its application in the healthcare field. It will also introduce the student to
technological innovations in healthcare informatics as a discipline, clinical decision-support
systems, medical expert systems, telemedicine, telepharmacy and Internet health applications.
The course will emphasize the use of computerized health information retrieval systems, the
advanced features of the Internet information resources, patient-related programs and data
manipulation software for application in profession -related tasks.
Objectives:
This course aims to introduce students to:
Computer technology and its applications in the healthcare field
Online search in medical, Pharmaceutical and other literature through the World Wide
Web (WWW).
Technological advances in the healthcare and pharmaceutical field.
Learning Outcomes:
1. Knowledge
Upon successful completion of this course, students will be able to:
a. Recognize the advanced computer tecnology and its application in the healthcare
field.
b. Describe the online resources and perform online search in medical, Pharmaceutical
and other literature through internet
Course Contents:
Review of major software packages used in biomedical computing:
Types of Software packages and their use in healthcare.
Choosing and evaluating biomedical software.
Use of Microsoft Office programs to create:
Patient education materials (Brochures, pamphlets, etc)
A presentation about one drug or disease.
Create a health information website.
Graphical representation of data:
The use of plotting software (one or more of the following software can be used for
this purpose):
Stanford Graphics
68
Sigma Plot
Graph Pad Prism
Other free plotting software online.
The use of chemistry structure drawing software (one or more of the following
software can be used for this purpose):
ACDl ChemSketch
CambridgeSoft ChemDraw
Chemistry 3D Draw
MDLISIS
Substructure searchable chemical database software
Statistical Analysis, data mining and questionnaires analysis: (one or more of the
following software can be used for this purpose):
SPSS (must be used)
SAS
Systat
S-Plus
Microsoft Excel
Simple Healthcare programs:
Drug Interactions software
Total Parenteral Nutrition PN)
Pharmacokinetic modeling
Inventory Control
The Internet (advanced usage):
Internet resources:
Internet terminology.
Educational resources on the Internet
Medical, pharmaceutical and dental resources on the Internet
Free Medical textbooks (Merck Manual, Clinical Pharmacology, etc.)
Communication:
Professional communication:
E-mail, mailing lists, newsgroups.
Health-related Discussion groups and forums.
Inter-professional communication:
Intranet
Telemedicine and telepharmacy
Health Websites:
PubMed
Medscape
Health Information Retrieval and Digital Libraries
Indexing and abstracting services.
69
Factual databases.
Information Retrieval
Knowledge-based Information
Retrieval
Evaluation
Digital Libraries
Computerized Literature Search:
MEDLINE Search:
Major MEDLINE sites
Search Strategies.
Journals online.
Cybernetics, Medical informatics and pharmacoinformatics:
Artificial Intelligence (Al) programs (theory only).
Examples of such programs: MYCIN, ONCOCIN, etc.
Medical Expert Systems (MES) (theory and demonstration only).
Clinical Decision Support Systems (CDSS): CDSS Examples, Explain (demo)
Clinical simulations (demonstrations)
Experimental technologies, such as virtual reality systems (demonstrations)
Electronic patient record
Medical Imaging (Theory only + field visit + presentations)
Ultrasound
Radiology
CT Scan
Healthcare financial systems
MediSoft
Practisoft
Students' Presentations on selected topics of the course.
70
Required Textbooks Proportion of Total
Assessment method
Van Bemmel JH, Musen MA (editors). Handbook of Medical Assessment Informatics. 1997
1 Mid-term I exam 20%
Heidelberg, Germany. Springer. [Portions of the Handbook are available on the website
2 Mid-term II exam
at http://www.mihandbook.stanford.edu/handbook/home.html 20%
3Additional
Finalsuggested
exam readings: 60%
Shortliffe EH, Fagan LM, Wiederhold G, Perreault LE. Medical Informatics: Computer
applications in healthcare and biomedicine. 2000. Springer Verlag ISBN: 0387984720.
Course
Davis MW.
outcomeComputerizing healthcare information. 1St. edition. 1998.ofMcGraw-Hill
Method Assessment
1 Publishing
Outcome 1 Co. ISBN: 0070159467. W
2Recommended
Outcome 2Textbooks and Reference Material W
3 Outcome
Degoulet3P, Fieschi M. Introduction to Clinical lnformatics, 1997.
W ISBN: 0387946411
4Electronic Materials
Outcome 4 W
71
Online resources available at:
http://www.library.qu.edu.sa/Pages/default.aspx
http://www.pharmacylibrary.com.ezproxy.qu.edu.sa/public/about
http://accesspharmacy.mhmedical.com/ss/About.aspx
http://accesspharmacy.mhmedical.com.ezproxy.qu.edu.sa/ss/About.aspx
http://search.proquest.com/
Pharmacy Practice
72
system, etc). The course will emphasize the challenges that face pharmacy practice and the
Impact of automation in hospital and community pharmacies.
Objectives:
Concept of pharmaceutical care and role of a pharmacist working in any of the
specialist areas.
Processes of drug use evaluation and the various drugs information sources available
to the evaluation and comparison of therapies in individual patients.
Pharmacy policies and procedures in the healthcare settings and the principles and
procedures of drugs manufacture and supply.
Learning outcomes
1. Knowledge
Upon successful completion of this course, students will be able to:
a. Define the meaning of pharmaceutical care.
b. Describe the various drugs information sources available to the evaluation and
comparison of therapies.
c. Define the principles and procedures of drugs manufacture and supply as they apply
to pharmacy practice.
2. Cognitive Skills
Upon successful completion of this course, students will be able to:
a. Analyze pharmacy policies and procedures in the healthcare setting (e.g., the
formulary management system, clinical practice guidelines and the application of
technology innovation in drug distribution and drug information).
Course Contents:
73
Repacking of Pharmaceuticals
Inventory Control and Drug Supply
Medication Management (Pharmacy and Therapeutics Committee and Formulary
system)
Hospital Pharmacy practice standards. The policy and procedure manual
Intravenous Admixture systems and aseptic dispensing
Medication safety and Adverse Drug Reaction Monitoring
Pharmacist managed clinics + DPIC
Investigational Drugs in the hospital
74
Required Textbooks
Thomas R. Brown (Editor). Handbook of Institutional Pharmacy Practice. 3rd edition
(1992).AmerSoc of Health System Pharmacists.
Judith E. Thompson, Kroonm Thompson (Editors). A Practical Guide to Contemporary
Pharmacy Practice. 1st edition (1998). Lipplncott, Williams & Wilkins.
Lilian M. Azzopardi, Lilian M. Asuopardi. Validation Instruments for Community
Pharmacy: Pharmaceutical Care for the Third Millennium. (2000). Haworth Press.
Ben J Whalley, et al. (Editors). Foundation in Pharmacy Practice Practice. 1st edition
(2008). Pharmaceutical Press.
Recommended Textbooks and Reference Material
Robert J. Cipolle, Peter C. Moriey, Linda M. Strand (Editors) Pharmaceutical Care
Practice. (1998). McGraw-Hill Professional.
John P. Rovers (Editor), Harry P. Hagel, Jay D. Cume. Practical Guide to
Pharmaceutical Care. (2002). APhA Publications.
Best Practices for Heafth-System Pharmacy: Positions & Guidance Documents of
ASHP. 2003-2004.
American Society of Health-System Pharmacists.
Electronic Materials
http://www.library.qu.edu.sa/Pages/default.aspx
http://www.pharmacylibrary.com.ezproxy.qu.edu.sa/public/about
http://accesspharmacy.mhmedical.com/ss/About.aspx
75
http://accesspharmacy.mhmedical.com.ezproxy.qu.edu.sa/ss/About.aspx
http://search.proquest.com/
General Immunology
Objectives:
To provide knowledge based curriculum for understanding of immune system
To specify the role of immune system in infection and inflammation
To relate and apply knowledge gained for understanding selected immuno-
pathological disorders
Learning outcomes:
1. Knowledge:
Upon successful completion of this course, students will be able to:
a. Gain perspective on immunology's historical foundations.
b. Understand the basic structural and functional components of the immune system
76
c. Acquire knowledge on the immunological role of vaccines
d. Gain the basic knowledge necessary to understand the three pathways of complement
activationand MHC classes.
e. Understand the role of cytokines in immune response.
f. Identify different classes of immunoglobulins and its individual function.
2. Cognitive Skills:
Upon successful completion of this course, students will be able to:
a. Apply basic principles of immune system for understanding of different
immunological disorders; autoimmunity, hypersensitivity and immunodeficiency
b. Relate the role of immunoglobulins, complement system and cytokines in
transplantation immunology and immunosuppression therapy.
Course Contents:
Introduction and overview of the immune system
Lymphoid system and cells of the immune system
Innate and Adaptive Immunity
Immune response and control mechanisms
Immunoglobulin structure and function
Antigen-Antibody interaction
MHC classes and HLA System
Complement System
Cytokines
Transplantation Immunology and Immunosuppression therapy
Immunological disorders:
Hypersensitivity
Autoimmunity
Immunodeficiency
Immunity to Infection
Vaccines (manipulation of the immune response)
77
Assessment and grading plan:
Required Textbooks
R.A. Goldsby, T. J. Kindt, BA. Osborne, Kuby Immunology, Fourth edition, 2003. W.
H. Freeman & Co., New York.
Janeway, C., Travers, P. Walport, M., and Capra, J., ImmunoBiology, Eight edition,
2012. Garland Publishing, Inc., NY.
Coico, R., G. Sunshine and E. Benjamini. Immunology: A Short Course. Fifth edition.
2003. Wiley-Uss Pubs.
Abul K. Abbas, Andrew H. Lichtman and Shiv Pillai, Cellular and Molecular
Immunology, Seventh Edition, 2012. Elsevier Saunders.
Recommended textbooks and Reference material
Morgan B.P. Complement Clinical Aspects and Relevance to Disease. 1991.
Academic Press, London.
Ravetch J.V. & Bolland S. lgG Fc receptors. Annual Review of Immunology 19,
275.2001.
Amigorena S. & Bonnerot C. Fc receptor signaling and trafficking: a connection for
antigen processing. Immunological Reviews 172, 279.1999.
Hennecke J. & Wiley D.C. T-cell receptor-MHC interactions up close. Cell 104,
1.2001.
Cyster J.G., Chemokines and cell migration in secondary lymphoid organs. Science
286, 2098.1999.
Jenkins M.K., Khoruts A., Ingulli E. et al In-vivo activation of antigen-specific CD4
T-cells. Annual Review of Immunology 19, 23.2001.
Buckley R.H. Advances in immunology: primary immunodeficiency diseases due to
defects in lymphocytes. New England Journal of Medicine 343, 1313.2000.
Electronic Materials
78
Online resources available at:
http://www.library.qu.edu.sa/Pages/default.aspx
http://www.pharmacylibrary.com.ezproxy.qu.edu.sa/public/about
http://accesspharmacy.mhmedical.com/ss/About.aspx
http://accesspharmacy.mhmedical.com.ezproxy.qu.edu.sa/ss/About.aspx
http://search.proquest.com/
Biochemistry-II
Objectives:
Upon successful completion of this course, the following objectives should be covered:
The metabolism of carbohydrates, lipids, proteins and minerals.
Clinical correlations and the action of certain therapeutic as well as toxic agents are
explained, whenever possible.
Much of the laboratory is devoted to the determination of blood biochemical
parameters.
Learning outcomes:
1. Knowledge:
Upon successful completion of this course, the student will be able to:
a. Outline the process of digestion and absorption of carbohydrates, lipids and proteins.
Describe the Embden-Myerhof glycolytic pathway, its regulation and the pathway of
glycogen biosynthesis and degradation. State the main functions of the pentose
phosphate pathway.
b. Describe the structures of fatty acids, fatty acid activation and β-oxidation, fatty acid
biosynthesis by fatty acid syntheses multienzyme complex and the pathways for
triglyceride biosynthesis.
79
c. Recognize ketone body metabolism, the pathways for glycerolipid, sphingolipid,
cholesterol and bile salt biosynthesis. Describe pathways for chylomicrons, VLDL,
LDL and HDL metabolism.
d. List the five classes of steroid hormones, ten non-essential amino acid and describe
their biosynthesis. Describe the reactions of urea cycle, the elements found in humans
and their functions.
2. Cognitive skills:
Upon successful completion of this course, the student will be able to:
a. Summarize the glycolytic bypass reactions of gluconeogenesis and its regulation, the
enzyme defects that produce glycogen storage diseases.
b. Explain how blood glucose level is regulated.
c. Summarize the fate of carbon skeleton of amino acids. Interpret the inborn errors of
amino add metabolism.
3. Psychomotor and communication skills:
Upon successful completion of this course, the student will be able to:
80
Abundant minerals found in humans.
Trace minerals found in humans.
Practical sessions:
Introduction
Safety procedures and sampling
Basic instrumentation
Standard solutions for biochemistry
Qualitative estimation of chemical constituents
Quantitative estimation of plasma glucose
Quantitative estimation of plasma cholesterol
Quantitative estimation of plasma protein
Quantitative estimation of blood hemoglobin
Quantitative estimation of plasma glutamate pyruvate transaminase (GPT)
Quantitative estimation of plasma glutamate oxaloacetate transaminase (GOT)
Quantitative estimation of plasma alkaline phosphatase (ALP)
Quantitative estimation of plasma glucose in different samples
Quantitative estimation of plasma total protein in different samples
81
Required Textbooks
Devlin, T.M. Biochemistry with Clinical Correlations. Latest edition. John Wiley and
Sons, Inc.
Marks, D.B. Biochemistry. Latest edition. Williams and Wilkins.
Champe, P.C., Harvey, RA. Biochemistry J.B. Latest edition. Lippincott Company.
Recommended Textbooks and Reference Material
Robert K. Murray et al. Harper's illustrated biochemistry. Twenty-sixth edition,
McGraw-Hill Companies
Electronic Materials
Online resources available at:
http://www.library.qu.edu.sa/Pages/default.aspx
http://www.pharmacylibrary.com.ezproxy.qu.edu.sa/public/about
http://www.pubmed.com
Physiology-II
82
Course Name: Physiology-Il 2 -علم وظائف األعضاء: إسم المقرر
Course Code & No.: 222 PHG دوي٢٢٢رقمالمقرر
Course Description:
This course is designed to build upon the concepts and principles taught in pathophyiosolgy-
I. This course includes the pathophysiological basis of electrolyte disturbances, calcium
metabolic disorders, diseases of the endocrine, reproductive and central nervous systems.
Objectives:
This course describes the physiological aspects of respiratory,renal, digestive and
central nervous systems
Learning Outcomes:
1. Knowledge:
Upon successful completion of this course, students will be able to:
a. Describe the functions of different organs of respiratory system and their regulation of
function.
b. Describe the functions of different organs of digestive system and regulation of its
functions.
c. Describe the functions of different organs of renal system and regulation of its
functions.
d. Describe the functions of different organs of nervous system and regulation of its
functions.
2. Cognitive skills:
Upon successful completion of this course, students will be able to:
Course Contents:
The respiratory system (structure and function).
Lung volumes and capacities.
Mechanism of respiration.
Regulation of respiration.
83
Oxygen transport in the blood.
Carbon dioxide transport in the blood.
Hypoxia and cyanosis.
The urinary system (structure and function).
Mechanism of urine production and clearance.
The renal glomeruli and glomerular filtration rate.
The proximal convoluted tubules.
The loops of Henle.
Distal convoluted tubules and collecting ducts.
Regulation of acid-base balance.
Micturition.
Clinical applications (use of diuretics, renal function tests and kidney disease).
Introduction to the digestive system (functions, structure and innervations of the
gastrointestinal tract).
Mouth and esophagus.
Stomach.
Small intestine.
Large intestine.
The pancreas.
Bile and gallbladder.
The liver function.
Neural and endocrine regulation of the digestive system.
Digestion and absorption of carbohydrates, lipids and proteins.
Structural organization of the brain.
Cerebrum
Diencephalon.
Midbrain and hindbrain.
Spinal cord tracts.
Cranial and spinal nerves
.
Teaching/learning methods and Contact hours
Lecture Tutorial Laboratory Practical Other: Total
Contact Hours 30 30
Credit 2 2
84
Lectures
Labs
Assessment and grading plan:
S.No. Assessment method Proportion of Total Assessment
1 Mid-term I 20%
2 Mid-term II 20%
3 Final Exam 60%
Text Book(s):
Guyton, A.C. and Hall, J.E. Textbook of Medical Physiology. Latest edition. W.B.
SaundersCompany. Philadelphia.
Electronic Materials
Online resources available at:
http://www.library.qu.edu.sa/Pages/default.aspx
http://www.pharmacylibrary.com.ezproxy.qu.edu.sa/public/about
http://accesspharmacy.mhmedical.com/ss/About.aspx
http://accesspharmacy.mhmedical.com.ezproxy.qu.edu.sa/ss/About.aspx
http://search.proquest.com/
85
Medicinal Chemistry-I
This course will handle the relationship of chemical structure to biological activity and the
general structural features required for a specific mechanism of action. Topics of discussion
will include the effects of molecular modifications on receptor binding, distribution and
metabolism as they relate to clinical response. Although the course outline reflects a
pharmacological classification, the material covered will deal principally with the chemical,
structure and biophysical properties as related to drug action at the molecular level and will
relate to therapeutic use.
Objectives:
1. Knowledge:
Upon successful completion of this course, students will be able to:
a. Describe how drug functions at the molecular level.
b. Demonstarte ability to know how to carry out a rational approch to drug design.
c. Describe and, corelate the structure activity & quantitative structure activity
relationships (SAR & QSAR)
2. Cognitive Skills
Upon successful completion of this course, students will be able to:
a. Estimate the metabolic process and, factors involved in metabolism of a drug and,
their implication in retro-metabolic drug design.
b. Explain the relationships between physicochemical properties of drug, prodrug and,
their biological activity.
86
Upon successful completion of this course, students will be able to:
a. Calculate the active ingredient in pharmaceutical forms.
4. Psychomoter
Upon successful completion of this course, students will be able to:
a. Perform preparation, identification of some important medicinal agents.
Course Contents:
Introduction (sources of drugs, nomenclature of drugs, and classification of drugs).
Drug action (pharmaceutical phase which includes cell membrane structure, transfer
of drugs through membrane , pharmacokinetic phase which includes ADME,
pharmacodynamic phase which includes receptors and drug receptor interactions)
Physicochemical principle of drug action (drug solubility and distribution, partition
coefficient, ionization, pH, pKa, the Hansch approach, Hammett equation, Taft
equation (QSAR)).
Metabolic changes of drugs (phase I, Phase II). Drug latentiation and prodrugs
(carrier-linked and bioprecursor prodrugs). Chemical delivery system. Receptors
and drug action (historic perspectives, receptor locations, receptor subtypes, affinity:
the role of chemical bonding, rationale for the receptor site concept, interaction
between drugs and receptor site, biologic response to drug-receptor interactions).
Structural features and pharmacologic activity (optical isomerism and pharmacologic
activity, geometric isomerism and pharmacologic activity, conformational isomerism
and pharmacologic activity, isosterism and pharmacological activity).
Drug development & drug discovery (search for a lead compound, optimization of a
lead compound, preclinical trials, clinical trials,
Combinatorial chemistry and solid-phase synthesis, computer –aided drug design).
Practicals
To Run TLC (Thin Layer Chromatography) of an Organic Compound’s Sample.
To Use Chemistry Software ChemDraw/ACD for Structure Drawing & Molecular
Properties Estimation
To Synthesize Benzoic Acid.
To Estimate the Partition Coefficient of an Organic Compound/Drug Sample.
To Measure Optical Rotation [α ]D of a Known Organic Compound’s Sample.
To Measure the Optical Rotation [α ]D of an Unknown Sample.
To Determine Calcium Ions Content in a Pharmaceutical Formulation by
Chelometric Estimation.
To DetermineMagnesium Ions Content in an Antacid Formulation by
Complexometric Analysis.
To Synthesize of Boric Acid from Borax.
To Determine the Contents of Boric Acid in Eye Drop Sample.
87
To Synthesize Hexamine.
To Synthesis Fluorescein from Resorcinol and, PHThalic Anhydride
To Synthesize Tetra-Bromo Fluorescein.
To Synthesize a Chalcone Derivative.
To Determine the Rate of Hydrolysis of Sucrose Sample Catalyzed by a DiluteHCl
Solution
88
Required Textbooks
G. Thomas: Medicinal Chemistry: An introduction. John Wiley & Sons, Ltd
Jaime N. Delgado,G.Patrick, An introduction to Medicinal Chemistry.
Wilson and Gisvold's Textbook of Organic, Medicinal and Pharmaceutical Chemistry,
Lippincott-Raven Publishers, Philadelphia- New York
Casebooks:
Greta K. Gourley, James M. Holt (Editors) Casebook for Textbook of Therapeutics:
Drug and disease management. 7th edition (2000). Lippincott Williams & Wilkins
Publishers.
Terry L. Schwlnghammer1 Joseph Dipiro, Robert Talbert, Gary Yee, Gary Matzke1
Barbara G. Wells, L. Michael Posey (Editors). Pharmacotherapy Casebook. 5th
edition (2002). McGraw Hil Appleton & Lange.
Recommended Textbooks and Reference Material
Remington's Pharmaceutical Sciences, A. Gennaro, Mack Publishing Co: Eaton,
Pennsylvania. Drug Action, E Mutscher, CRC press
Foye's Principles of Medicinal chemistry, David A. Williams, Lippincott: New York
Burger's Medicinal Chemistry and Drug Discovery: Drug Discovery and Drug
Development, Donald J. Abraham, John Wiley & Sons, Inc
Electronic Materials
Online resources available at:
www.ncbi.nlm.nih.gov/SNP/
Advanced Chemistry Development, ACD labs, Canada
ChemDraw
HyperChem, Gainesville, FL, USA.
Discovery Software by Accelrys Inc., CA, USA
Spartan Software, USA
Lexicomp Online Acaemic W/ AHFS.
Facts & Comparison Bundle including Trissel"s.
Martindail: The Complete Drug Reference.
Access Pharmacy.
89
Pharmacology I
Objectives:
The course aims to introduce students to: the basic principles of pharmacology, definition of
drugs and sources of drugs the process of the development of drugs, from preclinical to clinical
trials stages and the approval process by regulatory agencies various terminologies used in the
development and uses of drugs, such as agonist and antagonist and how drugs act with
macromolecules (receptors) in the body to produce effects the pharmacokinetic and
pharmacodynamics aspects of drugs in the body introduce to the autonomic nervous system, its
divisions, cholinergic and adrenergic receptors, cholinergic and adrenergic agonists and
antagonists, and their uses in different diseases with hands-on experience in the lab to reinforce
the theoretical concepts of the course
Learning outcomes:
1. Knowledge
Upon successful completion of this course, students will be able to:
90
a. Discuss the scientific meanings of various pharmacological terms such as potency,
efficacy, ED50, tachyphylaxis, tolerance, agonists, antagonists, idiosyncrasy... etc.
b. State the factors that influence the variability of drugs actions.
c. Describe the medical uses of drugs that stimulate or inhibit various cholinoceptors and
adrenoceptors.
2. Cognition
Upon successful completion of this course, students will be able to:
a. Defend selective and judicious use of drugs in diseases involving muscarinic and
nicotinic receptors
b. Infer the differences between drugs acting as competitive and non-competitive; reversible
and irreversible autonomic receptors blockers.
c. Develop the clinical use of drugs acting as agonists and antagonists on cholinergic and
adrenergic receptors to treat various diseases.
3. Interpersonal Skills
a. Be able to interact amicably with peers, pay attention, participate and discuss the nuances
of the experiments conducted in the lab
4. Psychomotor Skills
a. Demonstrate skills to conduct an experiment on isolated tissues and intact animals, and
be able to evaluate and interpret the results obtained from such experiments
Course Contents:
Introduction to pharmacology
Sources of drugs.
Definitions of pharmacological terms.
Drug development, Safety, Adverse Drug Reactions, ED50, LD50 and Therapeutic index
Drug-drug interactions
Pharmacokinetics: Absorption, Distribution, Metabolism and Excretion
Pharmacodynamics: Drug-receptor interaction, Signal transduction, dose-response
relationship, graded and quantal dose response, efficacy and potency
Autonomic Nervous System (ANS)
Cholinergic agonists (Cholinomimetic drugs)
Cholinergic antagonists
Adrenergic agonists
Adrenergic antagonists
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Experiments in lab
Basic instruments used in experimental pharmacology
Introduction to powerlab data acquisition system
D.R.C. Of ach on rat smooth muscle using cummulative doses
D.R.C. Of ach on rat smooth muscle using arithmetic doses
D.R.C. Of ach on rat smooth muscle using logarithmic doses
Study of muscarinic antagonist on ach d.r.c. Using rat colon
Study of indirect agonist on ach d.r.c. Using rat colon
Study the effect of unknown drug on ach d.r.c. Using rat colon
Study of drugs on the ciliary motility on frog oesophagus
Study of drugs on rabbits eye
Teaching/learning methods and Contact hours
Lecture Tutorial Laboratory Practical Other Total
Contact Hours 45 30 75
Credit 3 1 4
92
Required Textbooks
Laurence L.Brunton (eds.): Goodman and Gilman's Pharmacological Basis of
Therapeutics, 12th. Edition, 2011, McGraw-Hill, New York.ISBN-13: 978-
0071624428 ISBN-10:0071624422
Bertram G. Katzung, Susan B. Masters and Anthony J. Trevor (eds). Basic and Clinical
Pharmacology, 12th Edition, 2012, McGraw Hill Lang, New York.
Recommended textbooks and Reference material
Lippincott Illustrated Reviews: Pharmacology (Lippincott Illustrated Reviews Series). 6th
Ed. 2014. Williams and Wilkins Publisher Co., N.Y.
Pelletier, Catherine: Lange Smart Charts Pharmacology 2/E Paperback,August 5, 2015.
Electronic Materials
http://www.library.qu.edu.sa/Pages/default.aspx
http://www.pharmacylibrary.com.ezproxy.qu.edu.sa/public/about
http://accesspharmacy.mhmedical.com/ss/About.aspx
http://accesspharmacy.mhmedical.com.ezproxy.qu.edu.sa/ss/About.aspx
http://search.proquest.com/
93
Molecular Pharmacology
Objectives:
Upon successful completion of this course, the following objectives should be covered:
The molecular assembly of biological membranes and cell walls and the passage of
molecules and ions across them. Study the molecular nature of ion channels as drug
targets.
The molecular aspects of the action of neurotransmitters and other endogenous
molecules.
The different types and subtypes of the receptors of these neurotransmitters.
The role of neurotransmitters in health and disease states and the basis behind drug
treatment and to appreciate the diversity of chemical classes of drugs used to treat a
particular disease state.
Learning outcomes:
1. Knowledge:
Upon successful completion of this course, students will be able to:
a. Outline the molecular aspects of biological membranes, organic cation and anion
transport through them and how it is affected by the drugs.
94
b. Outline the pharmacological aspects of neurotransmitters and other endogenous
substances, their interactions with their respective receptors and the resulting effects in
the body.
c. Describe the dynamic nature of receptors during health and disease.
d. Describe the effect of drugs resulting in up-regulation or down-regulation of their
targeted receptors.
2. Cognitive skills:
Upon successful completion of this course, students will be able to:
a. Differentiate between the dynamic nature of receptors during health and disease.
b. Explain the pharmacological aspects of neurotransmitters and other endogenous
substances, their interactions with their respective receptors and the resulting effects in
the body.
c. Compare the effect of drugs resulting in up-regulation or down-regulation of their
targeted receptors
Course Contents:
Introduction: General concepts and functions of biological membranes.
General concepts of receptors and their classifications.
Cholinergic receptors, their natural ligands and their synthesis.
Adrenergic receptors, their natural ligands and their synthesis.
Dopaminergic receptors, their natural ligands and their synthesis.
Serotoninergic receptors, their natural ligands and their synthesis.
Gamma Aminobutyric Acid receptors, their natural ligands and their synthesis
Histamine receptors, their natural ligands and their synthesis.
MAO enzymes, their natural substrates and their synthesis.
Sodium ion channels and drugs affecting them.
Calcium ion channels and drugs affecting them.
Chloride ion channels and Coupled sodium/chloride ion channels and drugs affecting
them.
Membrane-bound ATPases: Such as Na+,K+- ATPase (Cardiac glycosides), H+,K+-
ATPase.
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Teaching/learning methods and Contact hours
Lecture Tutorial Laboratory Practical Other: Total
Contact
30 30
Hours
Credit 2 2
Required Textbooks
Williams and Lemke, Foye's Principles of Medicinal Chemistry 15th. Edition, 2002.
Lippincott Williams & Wilkins.
Wilson and Gisvold's. Textbook Of Medicinal and Pharmaceutical Chemistry, Latest
edition. Lippincott Company.
G. Thomas. Medicinal Chemistry: An Introduction, 2000. John Wiley & Sons Ltd.,
England.
Wingard, Brady, Lamer & Schwartz, Human Pharmacology: Molecular to Clinical, 1991
.Mosby Yearbook.
Graham L. Patrick. An Introduction to Medicinal Chemistry, 1995. Oxford University
Press.
Rang and Dale. Pharmacology 7th edition. 2012. Elsevier.
Lippincott's illustrated Reviews: Pharmacology, 4th Ed. 2008. Williams and Wilkins
Publisher Co., N.Y
Recommended textbooks and Reference material
Stone, T.W. CNS Neurotransmitters and Neuromodulators, Neuroactive steroids. 1996,
96
Barnes and Noble.
Rang and Dale. Pharmacology 7th edition. 2012. Elsevier.
Lippincott's illustrated Reviews: Pharmacology, 4th Ed. 2008. Williams and Wilkins
Publisher Co., N.Y
Electronic Materials
Online resources available at:
http://www.library.qu.edu.sa/Pages/default.aspx
http://www.pharmacylibrary.com.ezproxy.qu.edu.sa/public/about
http://accesspharmacy.mhmedical.com/ss/About.aspx
http://accesspharmacy.mhmedical.com.ezproxy.qu.edu.sa/ss/About.aspx
http://search.proquest.com/
97
Pharmaceutics-II
Course Name: Pharmaceutics-II 2-الصيدالنيات :اسم المقرر
Course Code & No.: 223 PHT صيد223 :رقم المقرر ورمزه
Credits:3(2+1+0) 3(2+1+0) :عدد الساعات المعتمدة
Prerequisite:212PHT, 135MATH ريض135 ، صيد212 :المتطلب السابق
Level:4 4 :المستوى
Objectives:
This course aims to introduce students to:
Components and technologies involved in the development, manufacture and evaluation
of various dosage forms.
The principles to design the appropriate dosage forms.
The applications of pharmaceutical polymers and excipients.
Learning outcome:
1. Knowledge
Upon successful completion of this course, students will be able to:
a. Record different types of suspensions and emulsions
b. List different types of flows (Newtonian &non-Newtonian systems)
c. State different applications of Thixotropy
d. Name different types of semisolid dosages forms (creams, ointments. pastes, etc…..)
e. List different types of suppository bases
f. Recognize different types of respiratory dosage forms
2. Cognitive skills
Upon successful completion of this course, students will be able to:
a. Differentiate between different types of suspensions
b. Compare between different types of emulsions
c. Explain different types of semisolid dosages forms (creams, ointments. Pasts, etc…..)
d. Evaluate different types of suppository bases
e. Differentiate between respiratory dosage forms.
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3. Numerical skills
Upon successful completion of this course, students will be able to:
a. Calculate the displacement value in molded suppository preparation
b. Calculate of viscosity parameters
4. Psychomotor skills
Upon successful completion of this course, students will be able to:
a. Prepare different types of suspensions (magnesium trisilicate).
b. Prepare different types of emulsions
c. Show surface tension and viscosity on certain solutions.
d. Perform of suppositories (plain and medicated).
Course Contents:
Surface and interfacial phenomena.
Colloidal systems and coarse dispersion.
Rheology.
Oral suspensions and emulsions.
Semisolids dosage forms (topical ointments, creams and gels).
Rectal drug delvery system
Aerosols, inhalants and sprays
Practical Schedule:
Preparation of magnesium trisilicate oral suspension.
Preparation of calamine lotion.
Preparation of pharmaceutical emulsions.
Determination of Viscosity
Determination of surface tension
Preparation of castor oil emulsion
Preparation of cold cream.
Preparation of simple ointement
Preparation of suppositories.
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Assessment and grading plan:
Assessment method Proportion of Total
Assessment
1 Midterm I exam 15%
2 Mid-term II exam 15%
3 Practical exam 20%
4 Final exam 50%
Course outcomes and Assessment
Required Textbooks
Howard Ansel, Nicholas Popvich and Lloyd Allen, Pharmaceutical Dosage Forms and
Drug Delivery Systems. Edition 9 (2010).
Lea &Febiger, Philadelphia, PA. Alfonso Gennaro Remington: The Science and Practice
of Pharmacy. Edition 22 (2012).
Williams & Wilkins, Baltimore, MD. L. Lachman, H. A. Lieberman and J. L. Kanig. The
Theory and Practice of Industrial Pharmacy.Edition 3 (2013).
Lea &Febiger, PA. G.S. Banker and C.T. Rhodes Modern Pharmaceutics, Marcel
Dekker, Inc., New York, NY, edition 4 (2002).
M.E. Aulton: Pharmaceutics: The Science of Dosage Form Design, Churchill Livingston,
St Louis, MO. Edition 4 (2013).
Electronic Materials
Lexicomp Online Acaemic W/ AHFS .
Facts& compersion bundle including trissels
Martindie; the complete drug reference
Access pharmacy
https://www.dropbox.com/s/sxsjit1cih1yx2k/British%20National%20Formulary.pdf?dl
https://www.dropbox.com/s/x7b3scj66yfwp50/BNF%20for%20Children%202014-
2015%5bNewMedicalBooks%5d.pdf?dl
100
Medicinal Chemistry-II
Description:
This course will handle the relationship of chemical structure to biological activity and the
general structural features required for a specific mechanism of action. Topics of discussion will
include the effects of molecular modifications on receptor binding, distribution and metabolism
as they relate to clinical response. Although the course outline reflects a pharmacological
classification, the material covered will deal principally with the chemical, structure and
biophysical properties as related to drug action at the molecular level and will relate to
therapeutic use.
Objectives:
To provide students with knowledge and understanding of the chemistry of basic classes
of medicinal agents.
To develop the student’s ability to understand mechanism of action, metabolism of
medicinal drugs.
To develop student’s ability to understand the relation between structure and biological
activity (SARs) of medicinal agents acting on specific target and producing
pharmacological response.
Learning outcomes:
1. Knowledge
Upon successful completion of this course, students will be able to:
a. Recognize the nomeclature, physicochemical properties, chemical classification and
chemical structure of medicinal agents.
b. Describe the drug mechanism of action based on its chemical structure.
2. Cognitive Skills
Upon successful completion of this course, students will be able to:
a. Predict the effect of vaious substituents in a particular drug molecule with respect to
biological response.
101
b. Write the single and multistep synthesis of drug molecules from a simple chemical
compound.
3. Communication, Information Technology, Numerical
Upon successful completion of this course, students will be able to:
a. Calculate the yield in a chemical synthesis.
b. Calculate amount of active ingredient in pharmaceutical dosage forms.
4. Psychomotor
Upon successful completion of this course, students will be able to:
a. Perform preparation, identification, assay for some important medicinal agents.
Contents:
Adrenergic drugs (biosynthesis and metabolism of catecholamines, stereochemistry of
interaction with adrenergic receptor, -adrenergic receptors, -adrenergic receptors, SAR
of direct-acting sympathomimetics including catecholamines and imidazolines, -
adrenergic agonists, -adrenergic agonists, indirect-acting sympathomimetics, mixed-
acting sympathomimetics, -adrenergic antagonists, -adrenergic antagonists)
Cholinergic drugs (cholinergic receptors, biosynthesis and metabolism of ACh,
stereochemistry and interaction with the receptor, SAR of cholinergic drugs,
cholinesterase inhibitors, anticholinergic drugs, antimuscarinic drugs, ganglionic
blockers, neuromuscular blockers)
Cardiovascular drugs (antianginal and vasodilators, calcium antagonists, anti-arrhythmic
drugs, antihypertensive drugs, diuretics, antihyperlipidemics, anticoagulants, cardiac
inotropics)
Diagnostic drugs (X-ray contrast agents, MRI, radiopharmaceuticals, US)
Chemotherapeutic agents (local anti-infective agents, antifungal agents, antiscabious and
antipedicular agents, anthelmintics, antiprotozoal agents, antileishmanial and
antitrypanosomal drugs, antimalarial drugs, sulfonamides, antimycobacterial drugs
(antitubercular drugs and antilepral drugs), synthetic antibacterial agents, antibacterial
antibiotics, antiviral agents, antineoplastic agents, immunotherapy)
Practical
Introduction of different methods of assay of drugs in dosage forms, calculations of
percentage recovery of the drug, concentration representation, pharmacopoeial
requirements, and limit of degradation products.
Preparation of benzimidazole, benztriazole, benzil, benzilic acid, 2,3-diphenylquinoxaline
Assay of calamine powder
Assay of methylene blue solution
Assay of hydrogen peroxide solution
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Assay of povidone iodine solution
Assay of ampicillin capsules
Assay of cephalexin capsules
assay of trimethoprim tablets
Assay of acetylcholine chloride
Assay of epinephrine injection
Assay of phenylepherine eye drops
Assay of methyldopa tablets
Assay of pilocarpine nitrate eye drops
Assay of phenindione tablets
Assay of resorcinol solution
Assay of gallaminetriethiodide ampoules
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Course outcome Method of Assessment
1 Outcome 1 W
2 Outcome 2 W
3 Outcome 3 W, PB
4 Outcome 4 W, PB
Required Textbooks
Remington's Pharmaceutical Sciences, A. Gennaro, Mack Publishing Co: Eaton,
Pennsylvania.
Drug Action, E Mutscher, CRC press, New York.
Wilson and Gisvold's Textbook of Organic, Medicinal and Pharmaceutical Chemistry,
Jaime N. Delgado, Lippincott-Raven Publishers: Philadelphia-New York
Foye's Principles of Medicinal chemistry, David A. Williams, Lippincott: New York
Recommended Textbooks and Reference Material
Burger's Medicinal Chemistry and Drug Discovery: Drug Discovery and Drug
Development, Donald J. Abraham, John Wiley & Sons, Inc
Electronic Materials
Online resources available at:
http://www.library.qu.edu.sa/Pages/default.aspx
http://www.phc.vcu.edu/310/
http://www.kubinyi.de/lectures.html
http://www.chemlin.net/chemistry/medicinal_chemistry.htm
104
Pathophysiology-I
Course Description:
This course is designed to promote the understanding and application of fundamental disease
processes in clinical settings, including etiology, pathogenesis, and clinical significance. The aim
of the course is to teach students the pathogenesis of various symptoms and diseases affecting
the human body. Altered physiological functions of human organs are explained on molecular,
cellular, organ and systemic levels. The framework of this course is to represent the general
concept of the diseases and basic pathophysiology of cardiovascular, hematopoietic,
gastrointestinal and respiratory systems.
Objectives:
The following objectives will be covered
Pathogenesis of various symptoms and diseases affecting the human body.
Altered physiological functions of human organs are explained on molecular, cellular,
organ and systemic levels.
The general concept of the diseases and basic pathophysiology of cardiovascular,
haemopoetic, gastrointestinal and respiratory systems.
Learning Outcomes:
1. Knowledge:
Upon the successful completion of this course, students will be able to
a. Discuss the etiology, pathogenesis, local and systemic effects of cell injury.
b. Explain the phenomenon of inflammation and its relationship to disease process.
c. Discuss the implication of different patterns of wound healing.
d. Discuss the etiology, pathogenesis and clinical significance of selected disorders of the
cardiovascular, hemopoeitic, gastrointestinal and respiratory systems.
2. Cognitive Skills
Upon the successful completion of this course, students will be able to
a. Distinguish the various types of cancer and their characteristic features.
105
b. Understanding the concepts of selected diseses.
Course Contents:
Introduction to pathophysiology
General concepts of disease
Cell injury: Etiology, pathogenesis of cell injury, adaptation, cell death, ischemia,
necrosis and gangrene.
Inflammation: Classification, causes, mediators of inflammation, signs of inflammation,
consequences of inflammation, congestion, edema etiology, pathogenesis and
complications.
Tissue repair and regeneration: Healing by repair, scar formation and fibrosis.
Neoplasia (Cancer): Classification, characteristic features of benign and malignant
tumors, differentiation, carcinogenesis (molecular basis of cancer)
Cardiovascular Disorders: Hypertension, atherosclerosis, ischemic heart disease, heart
failure, cardiac arrhythmias, rheumatic heart disease, pulmonary edema, shock
(cardiogenic, hemorrhagic, etc.)
Hemopoietic Disorders: Anemia, leucocytosis, leucopenia, thrombocytopenia,
thrombosis, embolism, leukemias, lymphomas, hemophilia.
Gastrointestinal and Hepatobiliary Disorders: Peptic ulcer disease (PUD), gastro-
esophageal reflux disease (GERD), nausea/vomiting, diarrhea, inflammatory bowel
disease, jaundice, hepatitis, cirrhosis of liver,
Respiratory disorders: Pulmonary tuberculosis, bronchial asthma, chronic bronchitis,
chronic obstructive pulmonary disease (COPD), emphysema, bronchiectasis.
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Course outcomes and Assessment
Course outcome Method of Assessment
1 Outcome 1 W
2 Outcome 2 W
W: Written
Required Textbooks
Price B. and Wilson L. Pathophysiology: Clinical Concepts of Disease Processes. 6th.
edition, 2002. Mosby.
Zdanowicz MM. Essentials of Pathophysiology for Pharmacy. 2002. CRC Press.
Porth C. Pathophysiology. 9th. edition, 2014. Llppincott Williams & Wilkins,
Additional suggested readings:
Kumar P, Clark M. Clinical Medicine. 8th. edition, 2012. WB Saunders.
Forbes CD, Jackson WF. Color Atlas and Text of Clinical Medicine. 4th. edition, 2003.
Elsevier Science.
Electronic Materials
Online resources available at:
http://www.library.qu.edu.sa/Pages/default.aspx
http://www.pharmacylibrary.com.ezproxy.qu.edu.sa/public/about
http://accesspharmacy.mhmedical.com/ss/About.aspx
http://accesspharmacy.mhmedical.com.ezproxy.qu.edu.sa/ss/About.aspx
http://search.proquest.com/
107
Pharmacology II
Objectives:
This course is intended to achieve the following objectives:
The students are introduced to drugs that are used to treat various diseases affecting the
cardiovascular system, including the blood coagulation process
The students should learn the mechanisms of action of drugs, and how they modify the
pathophysiology of diseases like hypertension, congestive heart failure, angina pectoris
cardiac arrhythmias,dyslipidemiaand broncho-spastic diseases
The students should understand the mechanisms of actions of drugs affecting
haemopoetic system and blood coagulation system to understand their appropriate uses
under different circumstances
The students are also expected to comprehend the adverse effects of these drugs and any
potential drug-drug interactions, as patients with cardiovascular diseases use several
drugs simultaneously
108
Learning outcomes:
1. Knowledge
Upon successful completion of this course, students will be able to:
a. State specific drugs and their mechanisms of action to treat hypertension, congestive
heart failure, cardiac arrhythmias, angina pectoris and dyslipidemia
b. Define the differences among the pharmacological profile of various anti-dyslipidemic
drugs and the limitations of their uses
c. Summarize the causes of thrombosis and atherosclerosis and the logical choices of drugs
in the management of each of them.
2. Cognitive skills
Upon successful completion of this course, students will be able to:
a. Distinguish among specific drugs used to treat hypertension, angina pectoris and cardiac
arrhythmias.
b. Interpret the differences between the anticoagulants, anti-platelets and thrombolytic drugs
and the use of appropriate drugs under various circumstances.
c. Understand the mechanisms of action and other features of the drugs used to treat
bronchial asthma and chronic obstructive pulmonary disease.
3. Interpersonal Skills
a. Pay attention, participate and discuss the nuances of the experiments conducted in the lab
4. Psychomotor Skills
Upon successful completion of this course, students will be able to:
a. Demonstrate skills to conduct an experiment on isolated tissues and intact animals, and
be able to evaluate and interpret the results obtained from such experiments
Course Contents:
Antihypertensive drugs
Antianginal drugs
Antiarrhythmic drugs
Antihyperlipidemic drugs
Anticoagulants, Antiplatelet and Thrombolytic drugs
Drugs used for congestive heart failure
Diuretics
Drugs used for anemia and hematopoiesis
Drugs used for bronchial asthma and COPD
Autacoids: Antihistamines
109
Experiments in lab
Basic instruments used in experimental pharmacology-2
2.mouse handling and manual restraint
injection methods for mice
electrocardiogram in mice non invasive
study of adrenaline on mice ecg
effect of dobutamine on mice ecg
effect of unknown drug on mice ecg
demonstrationof langendorff isolated rat heart
effect of drugs on b.p. of anesthetized dog simulation
effects of drugs on the isolated heart of frog simulation
110
Required Textbooks
Laurence L.Brunton (eds.): Goodman and Gilman's Pharmacological Basis of
Therapeutics, 12th. Ed., 2011, McGraw-Hill, New York.ISBN-13: 978-
0071624428, ISBN-10:0071624422
Bertram G. Katzung, Susan B. Masters and Anthony J. Trevor (eds). Basic and Clinical
Pharmacology, 12th Edition, 2012, McGraw Hill Lang, New York. ISBN-13: 978-
0071764018ISBN-10: 0071764011
Recommended textbooks and Reference material
Lippincott Illustrated Reviews: Pharmacology (Lippincott Illustrated Reviews Series). 6th
Ed. 2014. Williams and Wilkins Publisher Co., N.Y.ISBN-13: 978-1451191776 ISBN-
10:1451191774
Paul Vanhoutte (Editor): Cardiovascular Pharmacology: Heart and circulation, Volume 59
(Advances in Pharmacology) Hardcover – November 4, 2010, ISBN-13: 978-
0123849038ISBN-10: 9780123849038
Electronic Materials
Online resources available at:
http://www.library.qu.edu.sa/Pages/default.aspx
http://www.pharmacylibrary.com.ezproxy.qu.edu.sa/public/about
http://accesspharmacy.mhmedical.com/ss/About.aspx
http://accesspharmacy.mhmedical.com.ezproxy.qu.edu.sa/ss/About.aspx
http://search.proquest.com/
111
Chemotherapy
Description:
This course is designed to provide students - the general principles of antimicrobial andanti-
parasitic therapy. It also deals with the study of anti-neoplastic drugs and pharmacological
aspects of those chemotherapeutic agents that are produced naturally,synthetically or semi-
synthetically. It also deals with their spectrum of activity, mechanisms, andside effects when
used for treatment of bacterial, fungal or viral infections. Part of thecourse also deals with those
chemotherapeutic agents that are currently used for treatment ofmalaria, schistosomiasis,
amoebiasis, filariasis, ascariasis, and oxyuriasis.
Objectives:
The course aims to:
Develop knowledge and understanding of anti-microbial, anti-parasitic and anti-
neoplastic drugs.
Develop pharmacological aspects of chemotherapeutic agents that are produced naturally,
synthetically and semi-synthetically.
Learning outcomes:
1. Knowledge:
Upon successful completion of this course, students will be able to:
a. Describe the general principles of chemotherapy.
b. Discuss the various mechanisms, side effects and limitations of the available anticancer
drugs.
c. State the differences in the spectrum of action of the synthetic, semi-synthetic and
thenatural antibacterial agents.
2. Cognitive skills:
Upon successful completion of this course, students will be able to:
a. Explain the major differences in the mechanisms of action of the naturally derived
antibiotics and the synthetically produced antibacterial agents.
b. Compare the advantages and limitations of the various natural antibiotics and their semi-
syntheticderivatives.
112
c. Judge the factors that influence the choice of a certain chemical in the treatment of
certain infections that are caused by bacteria, fungi or viruses.
d. Assess the molecular mechanisms of the chemotherapeutic agents used in thetreatment of
various parasitic diseases
Contents:
Principles of antimicrobial therapy.
Spectra, mechanisms of action, doses and side effects of the antibacterial, sulphonamide,
trimethoprim and fluoroquinolones.
Spectra, mechanisms of action, doses and side effects of the natural and semi-
syntheticantibiotics such as:
Penicillins
Cephalosporins
Aminoglycosides
Tetracyclines
Chloramphenicols
Systemic antifungal agents
Antivirals
Drugs for the treatment of Malaria
Drugs for the treatment ofSchistosomiasis
Drugs for the treatment ofAmebiasis
Drugs for the treatment of Filariasis
Drugs for the treatment of Ascariasis
Drugs for the treatment of Oxyuriasis
Drugs for the treatment of Tape worm infections.
Drugs for the treatment of Anti-neoplastics
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Assessment and grading plan:
Assessment method Proportion of Total
Assessment
1 Mid-term II exam 20%
2 Mid-term I exam 20%
3 Final exam 60%
Required Textbooks
Meyers, Burt R.. Antimicrobial Therapy Guide. 2002 Ba mes and Noble.Skeel, Roland,
T.
Handbook of Cancer Chemotherapy. 2003. Barnes and Noble.
Additional suggested readings:
O'Grady, F. (ed.) Antibiotics and Chemotherapy: Anti-infective Agents and Their Use
in Therapy, 1997. Barnes and Noble.
Yakoub A. Abdi, Gustafsson, L.L., Erickson, O. Hellgren, U. Handbook of Drugs for
TropicalParasitic Infections. 2000. Barnes and Noble.
Bogitsh, B.J, Cheng, T.C. Human Parasitology. 1999. Barnes and Noble.A
Electronic Materials
Online resources available at:
http://www.library.qu.edu.sa/Pages/default.aspx
http://www.pharmacylibrary.com.ezproxy.qu.edu.sa/public/about
http://accesspharmacy.mhmedical.com/ss/About.aspx
http://accesspharmacy.mhmedical.com.ezproxy.qu.edu.sa/ss/About.aspx
http://search.proquest.com/
114
Natural Products Chemistry
Objectives:
To know the chemical structure of different classes of natural compounds.
To know the extraction, isolation and identification of active compounds from natural
sources and their physiological activity.
Learning outcomes:
1. Knowledge
Upon successful completion of this course, students will be able to
a. Acquire basic knowledge of different classes of natural products.
b. State the pharmacological activity, toxicity and uses of natural compounds.
c. Know in detail the contraindications and incompatibilities of the studied medicinal plants.
2. Cognitive skills
Upon successful completion of this course, students will be able to
a. Illustrate the methods of identification and assay of active compounds.
b. Interpersonal skills & responsibility
c. Upon successful completion of this course, students will be able to:
d. Apply the ethical and professional standard of ethics in the laboratory.
e. Prepare extracts and isolates from natural sources.
3. Communication, Information technology, Numerical
Upon successful completion of this course, students will be able to:
a. Gain an appreciation of how to deal with and to apply the given information to evaluate
phytochemicals.
b. Perform effective communication and positive relation with others and be able to work as
an effective member in a team.
115
4. Psychomotor
Upon successful completion of this course, students will be able to:
a. Aware of the influence of natural products remedies on the psycho-social and spiritual
aspects of a patient's being.
Course Contents:
Volatile oils:
“Methods of preparation, composition of volatile oils and classification of the volatile oil
components, Qualitative testing, pharmacological activity”
Alkaloids:
“Definition, classification, extraction, separation, qualitative testing, assaying,
pharmacological activity”
Carbohydrates
“Classification, qualitative testing, uses”
Glycosides
“Definition, classification, extraction, separation, qualitative testing, assaying,
pharmacological activity”
Bitter principles, tannins & resins
The course content is good but you have to give some more details about subjects that
you feel are important such as opium alkaloids, ergot alkaloids, flavovoid and
anthraquinone glycosides, saponins, tannins, etc…
Practical:
Phytochemical screening of medicinal plants
Qualitative tests for alkaloids
Microchemical test for alkaloids
Alkaloidal assays
Assay of some volatile oil components
Isolation of some natural compounds from their natural sources
116
Practical sessions
Text Book(s):
W.C. Evans, "Trease and Evans, PHARMACOGNOSY" 16th Edition,
BailliereTindal, London,Philadelphia, Toronto, Sydney, Tokyo (2009).
Michael Heinrich, Fundamentals of Pharmacognosy and Phytotherapy, 1st edition,
Churchill Livingstone, 2004, an imprint on Elsevier Limited, 2007.
WHO monographs on selected medicinal plants, World Health Organization,
PaperbackPublisher, vol. 1, (1999)
WHO monographs on selected medicinal plants, World Health Organization,
Paperback
Publisher, vol. 2, (2002)
Richard J. P. Cannell. Natural Products Isolation. 1998. Humana Press Inc.
Raphael Ikan. Natural Products; a Laboratory Guide. 2nd edition1 1991. Academic
Press.
Kurt B.G. Torssell, "Natural Product Chemistry, Mechanestic Biosynthetic and
Ecological Approai Apotekarsocieteten- Swedish. Pharmaceutical Pr Sweden (1997).
Additional suggested readings:
AshtoshKar, Pharmacognosy and Pharmacobiotechnology, 1st edition, 2008, New
Age International (P) Ltd., Publishers.
James E. Robbers, Marilyn Speedie, Varo E. Tyler, Pharmacognosy and
pharmacobiotechnology Williams & Wilkins, Baltimore.1996.
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Pengelly, Andrew, The constituents of medicinal plants: an introduction to
the chemistry and therapeutics of herbal medicine. ALLEN & UNWIN. This edition
first published in 2004.
Paul M Dewick, Medicinal Natural Products, A Biosynthetic Approach, 1st edition,
1997, John Wiley and Sons Ltd. England. Reprinted 1998.
Gunnar Samuelsson. Drugs of Natural Origin. 4th. edition 1999. Swedish
Pharmaceutical press.
J. Higgins, D.J. Best, J. Jones, "Biotechnology, Principles and Applications",
Blackwell Scientific Publications (1985).
Harborne, J.B., "Phytochemical Methods", 3rd. ed., Chapman Hall, London, New
York (1998).
David H. Attaway and Oskar R. Zaborsky. Modern Biotechnology. Volume 1, 1993.
Plenum Press.
Melanie J. C. Toxicology and Clinical pharmacology of Herbal Products. 2000
Humana Press Inc. James E. R. Marilyn K. S. and Varro E. T. Pharmacognosy and
Pharmacobiotechnology.
S. Grabley and R. Thiericke. Drug Discovery from Nature. 1999. Springer
Electronic Materials:
http://www.pharmacylibrary.com.ezproxy.qu.edu.sa/public/about
http://accesspharmacy.mhmedical.com/ss/About.aspx
http://accesspharmacy.mhmedical.com.ezproxy.qu.edu.sa/ss/About.aspx
https://www.dropbox.com/s/sxsjit1cih1yx2k/British%20National%20Formulary.pdf?
dl=0
118
Pharmacopial Analysis
Description:
The course is designed to teach the student how to use the pharmacopoeia, specially USP, BP
and, EP. First, the student is entitled to know how to know the purity and, identify a
pharmaceutical compound based on its physico-chemical properties in relation to different
pharmacopoeial standards. Second, to check the trace elements presence in these compounds by
applying limit tests. Third, how to assay the composition of a pharmaceutical compound per se
or, in pharmaceutical preparation and, in a heterogeneous mixture. The course will also include
introduction to statistical evaluation of data.
Objectives:
To give pharmacy students an understanding of the pharmacopoeial requirements which
governs drug analysis.
Equip students with analytical techniques required for pharmacopeia-based analyses.
Learning Outcomes:
1. Knowledge:
Upon successful completion of this course, students will be able to:
a. Describe the identity of pharmaceutical compounds through their physical and/or
physicochemical properties.
2. Cognitive Skills:
Upon successful completion of this course, students will be able to:
a. Estimate the assay of pharmaceutical compounds in their pure and, mixture forms.
b. Analyze multi-component mixture using different chromatographic & spectral methods.
3. Psychomotor:
Upon successful completion of this course, students will be able to:
a. Examine the purity of pharmaceutical compounds.
119
b. Ability to employ HPLC methods and, evaluate chromatograms.
Contents:
Introduction to the pharmacopoeias (definitions, abbreviation terms and history of
pharmacopoeias)
How to use the pharmacopoeia?
Methods of analysis: (refractive index, optical rotation, absorption spectrophotometry,
infrared, ultraviolet and visible, nuclear magnetic resonance, circular dichroism, thin
layer chromatography, gas chromatography, liquid chromatography, size-exclusion
chromatography, super critical fluid chromatography, density of solids, capillary
electrophoresis).
Limit tests (limit tests for anions (chloride, sulfate, phosphate), limit tests for cations
(heavy metals, iron, calcium, potassium, ammonium, aluminum)
Limit tests for related compounds (HPLC methods for identification and determination of
related compounds, potentiometric and amperometric determination of related
compounds, spectrophotometric methods for the determination of related compounds).
Statistical evaluation of data (introduction, randomization and independence of individual
treatment, assay depending upon quantitative responses, assay depending upon quantal
responses, combination of assay results)
Miscellaneous methods of analysis (Karl-Fischer method for the determination of water
content in pharmaceutical compounds, Oxygen-flask method for the determination of
organically-combined elements (halogens, sulfur, phosphorous, zinc, mercury, etc),
Kjeldal method for the determination of organically-combined nitrogen in vaccines,
diazometric determination of pharmaceutical compounds containing primary amino
group, e.g., sulfonamides
Practical Schedule:
How to use the pharmacopoeia? How to read the pharmacopoeial monograph?
Limit tests for acid radicals.
Limit tests for basic radicals and, heavy metals.
Limit for related substances in pharmaceutical compounds using HPLC (limit of 2-
chloroethylamine in ifosfamide).
Limit of related substances in pharmaceutical compounds using potentiometery (chloride
ion in melphalan, chloride ion in ifosfamide).
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Limit of related compounds in pharmaceutical compounds using spectrophotometery
(limit of salicylic acid in aspirin, limit of phenolic compounds in aspirin, limit of
metaproterenone in metaproterenol)
Diazometric determination of sulfonamides.
Determination of water-content in pharmaceutical compounds using Karl-Fischer
method.
Analysis of cycloserine capsules, analysis of captopril tablets.
Atomic absorption spectroscopic determination of zinc in insulin
Polarimetric analysis and identification of pharmaceutical compounds.
121
Required Textbook(s):
The United States Pharmacopoeia. The US Pharmaceutical Convention, Rockville.
The British Pharmacopoeia. The Pharmaceutical Press, London.
The European Pharmacopoeia. Council of Europe, Strasbourg.
Practical Pharmaceutical Chemistry, A.H. Beckell and J.B. Stenlake. The Athione Press,
London.
Vogel's Textbook of Quantitative Chemical Analysis, A I Vogel, Revised by G H
Jeffery,
GaryD.Christianand, JamesEO'Reilly,InstrumentalAnalysis,PrenticeHall,NewYork
Additional Suggested Readings:
Pharmaceutical Drug Analysis, 2nd ed, Ashutosh Kar, New Age Publications, New
Delhi.
Pharmaceutical Analysis: A Textbook for Pharmacy Students and Pharmaceutical
Chemists,
David G. Watson, Churchill Livingstone.
Modern Analytical Chemistry, David Harvey, McGraw-Hill.
J Bassett, J Mendham & R C Denney, Longman Scientific & Technical and, John-Wiley
& Sons
DouglasA.Skoog&DonaldM.West.FundamentalsofAnalyticalChemistry.SandersCollege
Publishing,Philadelphia
GalenEwing.InstrumentalMethodsofChemicalAnalysis,McGraw-Hill, NewYork
RobertdeLevie.PrinciplesofQuantitativeChemicalAnalysis.McGraw-Hill,New York
Electronic Materials
Access Pharmacy, Digital library at QU
Pharmacy Library
http://www.library.qu.edu.sa/Pages/default.aspx
http://accesspharmacy.mhmedical.com.ezproxy.qu.edu.sa/ss/About.aspx
122
Medicinal Chemistry-III
Course Name: Medicinal Chemistry-III 3-الكيمياء الدوائية إسم
:المقرر
Course Code & No.: PHC 320 كمص320 رقم المقرر
:ورمزه
Credits: 3 (2+1+0) 3(2+1+0) :عدد الساعات
Prerequisite: 315 PHC كمص315 :المتطلب السابق
Level: 6 6 :المستوى
Description:
This course will handle the relationship of chemical structure to biological activity and the
general structural features required for a specific mechanism of action. Topics of discussion will
include the effects of molecular modifications on receptor binding, distribution and metabolism
as they relate to clinical response. Although the course outline reflects a pharmacological
classification, the material covered will deal principally with the chemical, structure and
biophysical properties as related to drug action at the molecular level and will relate to
therapeutic use.
Objectives:
To provide students with knowledge and understanding of the chemistry of basic classes
of medicinal agents.
To develop the student’s ability to understand mechanism of action, metabolism of
medicinal drugs.
To develop student’s ability to understand the relation between structure and biological
activity (SARs) of medicinal agents acting on specific target and producing
pharmacological response.
Learning outcomes:
1. Knowledge:
Upon successful completion of this course, students will be able to:
a. Recognize the nomeclature , physicochemical properties, chemical classification,
synthesis, identification of medicinal agents.
b. Describe the drug mechanism, drug target interaction at molecular level.
2. Cognitive skills
Upon successful completion of this course, students will be able to:
a. Explain the metabolism of xenobiotics, and drugs depending on their chemical structure,
and its role in pharmacological and toxicological effect.
b. Predict the biological response and mechanism of action , if any, from a chemical
structure of compounds affecting various receptors, enzymes and/or systems.
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3. Communication, Information Technology, Numerical
Upon successful completion of this course, students will be able to:
a. Calculate the active ingredient in pharmaceutical forms.
4. Psychomoter
Upon successful completion of this course, students will be able to:
a. Perform preparation, identification of some important medicinal agents.
Contents:
CNS stimulants (analeptics, methyl xanthines, central sympathomimetic agents, MAO
inhibitors, tricyclic and mechanistically related antidepressants).
CNS depressants (general anesthetics, anxiolytic, sedative and hypnotics, antipsychotics,
antimanic, anticonvulsants or antiepileptic drugs, narcotic analgesics, narcotic
antagonists, antitussive agents, NSAIDs).
Local anesthetics
H1-antagonists and antiallergenic agents
Gastrointestinal drugs.
Drugs used to manage peptic ulcer (gastric antacids, H2 receptor antagonists, proton
pump inhibitors, chemical complexation, cytoprotective drugs, selective muscarinic (M1)
antagonists)
Laxatives, Antidiarrheal drugs, Emetics, Antiemetics, Adsorbents, Digestant,
Miscellaneous GI drugs
Hormones
Steroidal hormones (nomenclature and stereochemistry, estrogens and antiestrogens,
progestins, chemical contraceptive agents, androgens and anabolic drugs, antiandrogens
and 5-reductase inhibitors, adrenal cortex hormones)
Pancreatic hormones, Oral hypoglycemics
Thyroid hormones, Anti-thyroid hormones, Parathyroid hormones
Polypeptide hormones, Pituitary hormones, Placental hormones, Substance P
Practical course
Functional Group Analysis
Assay of aspirin (spectro)
Assay of theophylline
Assay of indomethacine
Titremetric determination of beta-lactam antibiotic
Assay of sulphonamides
Assay of ibuprofen
Synthesis of Aspirin
Synthesis of paracetamol
124
Synthesis of Phenacetin (1st Step)
Synthesis of Phenacetin (2nd Step)
Synthesis of Antipyrine
Synthesis of Phenytoin
1st Step: Synthesis of Benzil
Synthesis of Phenytoin
2nd Step: Condensation of Benzil
Synthesis of Thiobarbituric Acid
Assay of Steroids
125
Required Textbooks
Wilson and Gisvold's Textbook of Organic, Medicinal and Pharmaceutical
Chemistry, Lippincott-Raven Publishers, Philadelphia- New York
Foye's Principles of Medicinal chemistry, David A. Williams, Lippincott: New York
Recommended Textbooks and Reference Material
Remington's Pharmaceutical Sciences, A. Gennaro, Mack Publishing Co: Eaton,
Pennsylvania.
Drug Action, E Mutscher, CRC press
Burger's Medicinal Chemistry and Drug Discovery: Drug Discovery and Drug
Development, Donald J. Abraham, John Wiley & Sons, Inc
Electronic Materials
Online resources available at:
-www.ncbi.nlm.nih.gov/SNP/
-Advanced Chemistry Development, ACD labs, Canada
-ChemDraw
-HyperChem, Gainesville, FL, USA.
-Discovery Software by Accelrys Inc., CA, USA
-Spartan Software, USA
-Lexi comp Online Acaemic W/ AHFS.
-Facts & Comparison Bundle including Trissel"s.
-Martindale: The Complete Drug Reference.
-Access Pharmacy
126
Pathophysiology-Il
Description:
This course is designed to build upon the concepts and principles taught in pathophyiosolgy-I.
This course includes the pathophysiological basis of electrolyte disturbances, calcium metabolic
disorders, diseases of the endocrine, reproductive and central nervous systems.
Objectives:
Learning Outcomes:
1. Knowledge
Upon the successful completion of this course, students will be able to gain
a. Discuss the etiology, pathogenesis and clinical significance of selected disorders of renal,
reproductive, musculoskeletal and connective tissue.
b. Determine the basic pathophysiological processes electrolyte disturbances, calcium
metabolic disorders, diseases of endocrine system, diseases of reproductive system and
central nervous system.
c. Interpret the etiology, pathogenesis and clinical correlations to central nervous system
disorders.
2. Cognitive skills
Upon the successful completion of this course, students will be able to gain
127
a. Analyze the relationship between normal physiology and pathological phenomena in
endocrine disorders.
b. Understanding the concepts of selected electolyte, calcium metabolism, endocrine,
reporductive, and central nervous system disorders.
Contents:
Renal disorders: Fluid and electrolyte disturbances, urinary tract infections (UTI),
urolithiasis (renal calculi), glomerulonephritis, nephrotic syndrome, renal failure, renal
cell carcinoma.
Endocrine disorders: Pituitary disorders (hypo and hyper secretions), thyroid disorders
(hypo and hyper secretions), diabetes mellitus, adrenal gland disorders (Cushing’s
syndrome)
Calcium metabolism disorders: Osteoporosis, osteomalacia, musculoskeletal system and
connective tissue disorders, rheumatoid arthritis, osteoarthritis, gout, systemic lupus
erythromatosis.
Central nervous system disorders: Epilepsy, migraine headaches, meningitis,
parkinsonism.
Reproductive Disorders: Infertility / sterility, dysmenorrhea, menorrhagia.
128
Required Textbook
Text Book(s):
Price S. and Wilson L. Pathophysiology: Clinical Concepts of Disease Processes. 6th.
edition, 2002. Mosby.
Zdanowicz MM. Essentials of Pathophysiology tor Pharmacy. 2002. CRC Press.
Porth C. Pathophysiology. 9th. Edition, 2014. Lippincott Williams & Wilkins.
Additional suggested readings:
Kumar P, Clark M. Clinical Medicine. 8th. edition, 2012. WB Saunders.
Forbes C.D., Jackson W.F. Color Atlas and Text of Clinical Medicine. 3rd. edition,
2002. Elsevier Science
Electronic Materials
Online resources available at:
http://www.library.qu.edu.sa/Pages/default.aspx
http://www.pharmacylibrary.com.ezproxy.qu.edu.sa/public/about
http://accesspharmacy.mhmedical.com/ss/About.aspx
http://accesspharmacy.mhmedical.com.ezproxy.qu.edu.sa/ss/About.aspx
http://search.proquest.com/
129
Pharmaceutics-III
Course Name: Pharmaceutics-III 3-الصيدالنيات :اسم المقرر
Course Code & No.: 323 PHT صيد323 :رقم المقرر ورمزه
Credits: 3(2+1+0) 3(2+1+0) :عدد الساعات المعتمدة
Prerequisite:223PHT صيد223 : السابق:المتطلب
Level: 6 6 :المستوى
Description:
This course covers the principles and techniques involved in the formulation, preparation and
evaluation of solid dosage forms and sterile dosage forms. Methods of sterilization and
applications of aseptic techniques will also be studied.
Objectives:
This course aims to introduce students to
Formulation methods of powder, granules and solid dosage forms (tablets and capsules).
Principles for sterile products.
Learning Outcome:
1. Knowledge
Upon successful completion of this course, students will be able to:
a. List different methods for measuring the flow of powder.
b. Outline different types of tablets and excipients.
c. Name different types capsules and excipients
d. List different types of sterile products forms
e. Describe the manufacturing of Parenteral products
2. Cognitive skills
Upon successful completion of this course, students will be able to:
a. Estimate different methods used for evaluation of tablets
b. Analyze different methods used for evaluation of capsules.
c. Differentiate between different types of ophthalmic products
d. Summarize different methods used for evaluation of parenteral dosage form.
3. Psychomotor skills
Upon successful completion of this course, students will be able to:
a. Preparation of effervescent granules
b. Preparation of tablet using different methods.
c. Perform dissolution tests.
130
d. Perform quality control tests for tablets and capsules
Contents:
Powder and granules.
Tablets .
capsules.
Introduction into sterial products.
Sterile products: Parenterals.
OPHThalmic products.
Sterilization principles
GMP and clean room
Laboratory schedule:
Flowability of Powder and Porosity
Preparation of Effervescent Granules.
Tablet press & Dissolution testing.
Quality Control Test for Tablets.
Capsule Filling and Quality Control of Capsule.
Isotonic preparations
Preparation of opthalmic product
Preparation of Nasal and Ear Products.
Preparation of a Parenteral Products.
Sterilizations methods and Autoclave
131
Course outcomes and Assessment
Course outcome Method of Assessment
1 Outcome 1 W
2 Outcome 2 W
3 Outcome 3 W
4 Outcome 4 W
W: Written PB: Performance-Based AP: Assignment Project P: Portfolio
Required Textbooks
A.J. Winfleld and R.M. Richards: Pharmaceutical Practice, edition 2 (2008).
Churchill Livingston, St. Louis, MO, USA. Salvatore Turco, Sterile Dosage Forms Their
Preparation and Clinical Application. Williams & Wilkins, Baltimore, MD. Edition 2
(2008).
Aulton’s Pharmaceutics: The design and manufacture of medicines – 2007 – 3rd edition
(Edited by Michael E. Aulton)
Martin’s physical pharmacy and pharmaceutical sciences – 2006 - 5th edition (P. J.
Sinko)
A.J. Winfield and R.M. Richards: Pharmaceutical Practice, Churchill Livingston, St.
Louis, MO, USA, 3rd Edition, 2004
Ansel’s Pharmaceutical dosage forms and drug delivery systems: 2005 – 8th edition –
Loyd Allen, Nicholas Popovich and Howard Ansel
Electronic Materials
Lexicomp Online Acaemic W/ AHFS
Facts& compersion bundle including trissels
Marttidie; the complete drug reference
Access pharmacy
https://www.dropbox.com/s/sxsjit1cih1yx2k/British%20National%20Formulary.pdf?dl
https://www.dropbox.com/s/x7b3scj66yfwp50/BNF%20for%20Children%202014-
2015%5bNewMedicalBooks%5d.pdf?dl
132
Pharmacology-III
Description:
This course is concerned with the study of drugs that primarily affect the central nervous system.
An overview of the central nervous system and the functions of neurotransmitters will precede
the introduction of drugs that are used to treat depression, psychosis, epilepsy, Parkinson’s
disease, Alzheimer’s disease or as sedatives/ hypnotics. Drugs used as local and general
anesthetics and skeletal muscle relaxants will also be covered in this course. Pharmacological
profiles of analgesics, such as NSAIDs and opioids, drugs used for migraine headaches and
substances of abuse, including CNS stimulants will also be discussed.
Objectives:
Upon successful completion of this course, the following objectives should be covered:
The pharmacological profiles of the drugs that are used to treat different diseases
affecting the central nervous system.
The phrmacology of the drugs used as local and general anesthetics and skeletal muscle
relaxants.
Discussion of the pharmacological profiles of analgesics and CNS stimulants.
Learning Outcomes:
1. Knowledge:
Upon successful completion of this course, the student will be able to:
a. Describe the physiological roles of neurotransmitters in behavior and their relevance to
specific neurological and psychiatric disorders.
b. Discuss pharmacology of drugs used for the treatment of anti-psychotic drugs,
Parkinson’s disease, Alzheimer’s disease and migraine headaches
c. Describe various local and general anesthetics , analgesics and skeletal muscle
relaxants.
d. Describe and understand the deleterious effects of substances of abuse.
133
2. Cognitive skills:
Upon successful completion of this course, the student will be able to:
a. Deffrentiate between the causes and symptoms of diseases affecting the central nervous
system .
b. Compare between the mechanisms of actions and uses of barbiturates and
benzodiazepines as sedative/hypnotics and their role in general anesthesia.
c. Differentiate between various classes of antidepressant drugs and justify their selective
use under different circumstances.
Contents:
CNS Overview
Sedatives/Hypnotics: Benzodiazepines, Barbiturates, Atypicals
Antidepressants: TCAs, SSRIs, MAOIs
Antipsychotics: Phenothiazines, Thioxanthenes, Butyrophenones, Azepines,
Miscellaneous
Antiepileptics: Drugs for generalized tonic/clonic seizures, drugs for partial seizures,
adjunct drugs
Antiparkinsons drugs
Anti-Alzheimer drugs
Nonsteroidal anti-inflammatory drugs (NSAIDs)
Opioid analgesics
Drugs for migraine headaches
Substances of abuse
Local anesthetics
General anesthetics
Skeletal muscle relaxants
Experiments in lab
Instruments used in experimental pharmacology-3
Study of hypnotic activity in mice by righting reflex
Antidepressant activity in mice using f.s.t.
Anxiolytic effect in mice using elevated plus maze
Muscle relaxant activity of diazepam in mice using rota rod
Anti-convulsant activity of diazepam in ptz induced convulsions in mice
Study of anti parkinsonian effect in mice
134
Study of local anesthetic effect of xylocaine on rabbit's eye
Study of analgesic effect in mice using hot plate method
Study of anti-nociceptive effect of diclofenac on acetic acid
Induced writhing in mice.
135
Barnes and Noble.
Wells, B.G., Hamilton, C.W., Dipiro, J.T. (ed.) Pharmacothempy Handbook. 2002.
Barnes and Noble..Y
Rang H.P., Dale M.M. and Ritter J.M. Pharmacology. Churchill Livingstone, New York.
Latest Edition.
Lippincott's illustrated Reviews: Pharmacology, 4th Ed. 2008. Williams and Wilkins
Publisher Co., N.Y
Electronic Materials
Online resources available at:
http://www.library.qu.edu.sa/Pages/default.aspx
http://www.pharmacylibrary.com.ezproxy.qu.edu.sa/public/about
http://accesspharmacy.mhmedical.com/ss/About.aspx
http://accesspharmacy.mhmedical.com.ezproxy.qu.edu.sa/ss/About.aspx
http://search.proquest.com/
136
Scientific writing and Seminars-I
Course Name: Scientific Writing and Seminar-I 1-الكتابة العلمية وحلقة نقاش :اسم المقرر
Course Code & No.: 325 PHP مصد325 :رقم المقرر ورمزه
Credits:1(1+0+0) 1(1+0+0) : المعتمدة:عدد الساعات
Prerequisite: 216 PHP مصد216 :المتطلب السابق
Level: 8 8 :المستوى
Description:
The purpose of this course is to introduce basics of scientific presentation and discussions of
current issues in the profession of clinical pharmacy. Emphasis will be on general evaluation of
drug literature, articles for proper research, design and data interpretation including use of
multimedia, slides, overheads, handouts and other visual aids as well as methods of answering
questions from the audience
Objectives
This course aims to introduce students the:
Importance of the scientific article, presentation and technologies used for presentation
Beneficial aspects of various software used for presentation in seminars.
Evaluation of scientific articles.
Learning Outcomes:
1. Knowledge
By the end of the course, students will be able to:
a. Describe the methods how to make presentation and how to present them in class
State the methods of writing the scientific articles
2. Cognitive Skills
a. Illustrate the articles writing.
b. Prepare their presentation to present in the seminars
3. Interpersonal Skills & Responsibility
a. Communication skills of the students should be improved
4. Communication, Information Technology, Numerical
a. Student’s effective participations in the discussion of subjects.
b. They will made presentation relating to clinical topics and present them in the class.
Contents:
Introduction to scientific presentation
Overview of available audiovisual presentation aids
137
Basics of scientific writing
Basics of scientific discussion
Scientific presentation techniques
Scientific and clinical paper evaluation
Types of scientific and clinical research
Interactive presentation
Clinical pharmacy topics presentations
138
Required Textbooks
How to Run Seminars and Workshops: Presentation Skills for Consultants, Trainers
and
Teachers, Robert Jolles.
How to Develop and Promote Successful Seminars and Workshops
by Howard L. Shenson
Additional suggested readings:
Marketing and Promoting Your Own Seminars and Workshops, Fred Gleeck.
Profitable Seminars by Len Wood.
Electronic Materials
Online resources available at:
http://www.library.qu.edu.sa/Pages/default.aspx
http://www.pharmacylibrary.com.ezproxy.qu.edu.sa/public/about
http://accesspharmacy.mhmedical.com/ss/About.aspx
http://accesspharmacy.mhmedical.com.ezproxy.qu.edu.sa/ss/About.aspx
http://search.proquest.com/
139
Pharmacotherapy-I
Description:
The purpose of this course is to integrate the pathophysiologic abnormalities of disease states
(Cardiovascular, Pulmonary, and respirotary system Diseases) with concepts of drug action and
therapy. State-of-the-art pharmacotherapy will be reviewed with pertinent pathophysiology and
pharmacology. Emphasis will be placed on drug selection, dosing regimen design, and
therapeutic drug monitoring to assess the attainment of therapeutic efficacy and avoidance of
adverse reactions
Objectives:
This course aims to introduce students to:
Selection of appropriate pharmacologic and non-pharmacologic therapies of selected
diseases.
Relationship between the pathophysiology of selected diseases and the mechanism(s) of
action, rationale, reasonable and practical solution to drug related problems in patient
with selected diseases.
A plan for a desired outcomes, monitoring drug efficacy, adverse effects, compliance,
and drug interactions for patient drug therapy.
Team based learning and effective communication skills.
Learning outcomes:
1. Knowledge:
Upon successful completion of this course, students will be able to:
a. Describe the pathophysiology, complications and risk factors of Dyslipidemias,
Hypertension, chronic stable angina, Acute coronary syndromes, Ambulatory Heart
failure, Acute Heart failure & Cardiogenic shock, Cardiac Arrhythmias, Endocarditis,
Thrombosis & Peripheral Vascular Disorders, Bronchial asthma, COPD, Pneumonia, and
Tuberculosis.
140
b. Recognise the therapeutic goals, drug and nondrug therapy used in management
ofDyslipidemias, Hypertension, chronic stable angina, Acute coronary syndromes,
Ambulatory Heart failure, Acute Heart failure & Cardiogenic shock, Cardiac
Arrhythmias, Endocarditis, Thrombosis & Peripheral Vascular Disorders, Bronchial
asthma, COPD, Pneumonia, and Tuberculosis.
2. Cognitive Skills:
Upon successful completion of this course, students will be able to:
a. Design appropriate care plan for management of patient with Dyslipidemias,
Hypertension, chronic stable angina, Acute coronary syndromes, Ambulatory Heart
failure, Acute Heart failure & Cardiogenic shock, Cardiac Arrhythmias, Endocarditis,
Thrombosis & Peripheral Vascular Disorders, Bronchial asthma, COPD, Pneumonia, and
Tuberculosis.
b. Identify and prioritize therapeutic alternatives to individualize patient specific regimens.
c. Identify the drug-related problems associated with management of patient with
Dyslipidemias, Hypertension, chronic stable angina, Acute coronary syndromes,
Ambulatory Heart failure, Acute Heart failure & Cardiogenic shock, Cardiac
Arrhythmias, Endocarditis, Thrombosis & Peripheral Vascular Disorders, Bronchial
asthma, COPD, Pneumonia, and Tuberculosis, and solve them with evidence-based
therapy.
d. Monitor therapeutic outcomes and adverse effects of drug therapy used in management of
patient with Dyslipidemias, Hypertension, chronic stable angina, Acute coronary
syndromes, Ambulatory Heart failure, Acute Heart failure & Cardiogenic shock, Cardiac
Arrhythmias, Endocarditis, Thrombosis & Peripheral Vascular Disorders, Bronchial
asthma, COPD, Pneumonia, and Tuberculosis.
141
Contents:
Dyslipldemias
Hypertension
Acute Heart failure&Cardiogenic shock
Chronic Heart failure
Thromboembolic disorders
Coronary artery disease: (chronic stable angina)
Acute coronary syndromes: (unstable angina & acute myocardial infarction)
Arrhythmias
Asthma
Chronic obstructive pulmonary diseases
Peripheral Vascular Disorders
Community acquired pneumonia/nosocomial pneumonia
Mycobacterium tuberculosis
Endocarditis
Tutorial (small group discussion) Schedule:
Dyslipldemias
Hypertension
Acute Heart failure &Cardiogenic shock
Chronic Heart failure
Thromboembolic disorders
Coronary artery disease: (chronic stable angina)
Acute coronary syndromes: (unstable angina & acute myocardial infarction)
Arrhythmias
Asthma
Chronic obstructive pulmonary diseases
Peripheral Vascular Disorders
Community acquired pneumonia/nosocomial pneumonia
Mycobacterium tuberculosis
Endocarditis
142
The following teaching strategies are used:
Team Based Learning (TBL)
Lectures
Case presentations
143
Required Textbooks
Mary Anne Koda-Kimble1 Lloyd Yee Young1 Wayne A. Kradjan1 B. Joseph
Guglielmo. Applied Therapeutics. The Clinical Use of Drugs. 10th edition (2013).
Lippincott Williams & Wilkins Publishers.
Joseph T. Dipiro, Robert L. Talbert, Gary C. Yee, Gary R. Matzke1 Barbara G. Wells,
L. Michael Posey. Pharmacotherapy: A Pathophysiologlc Approach. 5th edition
(2002). McGrawHill/Appleton & Lange.
In Schwinghammer, T. L., In Koehler, J. M., In Borchert, J. S., & In Slain, D. (2014).
Pharmacotherapy casebook: A patient-focused approach.
Eric T. Q. Herfindal and Dick R. Gourley ~ditors), Greta K. Gourley (Editor), James
M. Holt (Editors).Textbook of Therapeutics: Drug and Disease Management. 7th
edition (2000).
Casebooks:
Greta K. Gourley, James M. Holt (Editors) Casebook for Textbook of Therapeutics:
Drug and disease management. 7th edition (2000). Lippincott Williams & Wilkins
Publishers.
Terry L. Schwlnghammer1 Joseph Dipiro, Robert Talbert, Gary Yee, Gary Matzke1
Barbara G. Wells, L. Michael Posey (Editors). Pharmacotherapy Casebook. 5th
edition (2002). McGrawHilvAppleton & Lange.
144
Pharmacology-IV
Level: 7 7 :المستوى
Description:
This course is designed to teach about drugs related to endocrine hormonal system, including
drugs for diabetes mellitus, pituitary, adrenal and thyroid hormone disorders. Various drugs
involving gonads and benign prostate hyperplasia will be dealt in this course. This course will
also educate about for various gastrointestinal disorders, such peptic ulcer disease, diarrhea,
vomiting and constipation. Immune system modifying drugs will also be a part of this course and
general concepts of gene therapy and its future potential will be discussed. General
pharmacological profiles of drugs used in common skin disorders will also be covered.
Objectives:
Learning Outcomes:
1. Knowledge:
Upon successful completion of this course, students will be able to:
a. Describe the diseases resulting from disturbances of various endocrine hormones and
their treatment.
b. Outline the rationale for hormone replacement therapy.
c. Describe various strategies available for treatment of diabetes mellitus common
gastrointestinal disorders, such as peptic ulcer disease, diarrhea, constipation
d. Discuss the mechanisms through which drugs stimulate or suppress the immune system.
e. List the common skin diseases and name the drugs used for their treatment.
145
2. Cognitive skills:
Upon successful completion of this course, students will be able to:
a. Explain the regulatory control of hormonal actions
b. Explain the principles that underlie disorders, such as erectile dysfunction and benign
prostate hyperplasia, and the drugs used to treat them.
Contents:
Endocrine hormones: Hypothalamic hormones
Pituitary hormones
Adrenal hormones
Thyroid hormones
Parathyroid hormones: Calcium and Bone homeostasis
Gonads
Drugs used for benign prostate hyperplasia (BPH)
Drugs used for erectile dysfunction (ED)
Antidiabetic drugs
Insulins
Hypoglycemic drugs
Antihyperglycemic drugs
G.I. Drugs:
Anti-ulcer: H2-receptor antagonists, Proton pump inhibitors (PPIs), Cytoprotective drugs,
Antacids
Anti-emetics
Antidiarrheals
Laxatives
Immune system modifying drugs
Drugs used for dermatological conditions
146
Assessment and grading plan:
Required Textbooks
Hadley, Mace E.: Endocrinology. 1999. Barnes and Noble.
Brody, T.M.: Human Pharmacology: Molecular to Clinical 2003. Mosby - Year Book,
Inc.
Struck Medical Office Pharmacology. 2002. Pearson Professional Education, Prentice
Hall, Blackwell Publishing Co.
Recommended textbooks and Reference material:
Rang H.P., Dale M.M. and Ritter J.M. Pharmacology. Churchill Livingstone, New York.
Latest Edition.
Lippincott's illustrated Reviews: Pharmacology, 4th Ed. 2008. Williams and Wilkins
Publisher Co., N.YRuth, Wood row Essentials of Pharmacology for Health Occupations,
2002. Academic Press.
Electronic Materials
Online resources available at:
http://www.library.qu.edu.sa/Pages/default.aspx
http://www.pharmacylibrary.com.ezproxy.qu.edu.sa/public/about
http://accesspharmacy.mhmedical.com/ss/About.aspx
http://accesspharmacy.mhmedical.com.ezproxy.qu.edu.sa/ss/About.aspx
http://search.proquest.com/
147
Toxicology
Course Name: Toxicology علم السموم :اسم المقرر
Course Code & No.: 333 PHG دوي333 : ورمزه:رقم المقرر
Credits: 2(2+0+0) 2(2+0+0) :عدد الساعات المعتمدة
Prerequisite: 224PHG دوي224 :المتطلب السابق
Level: 7 7 :المستوى
Description:
This course is concerned with the basic principle of toxicology and different disciplines of
toxicology, the mechanisms of toxicity and management of the common toxicities. Also, it
concerned with serious consequences of exposure to drugs and chemicals with especial
considerations with maternal, fetal and neonatal health.
Objectives
This course aims to introduce students to:
General principles of toxicology
Non-organ-directed toxicity (carcinogenicity, mutagenicity, and teratogenicity)
The target organ toxicity
The environmental toxicology
Course learning outcomes:
Learning Outcomes
1. Knowledge
Upon successful completion of this course, students will be able to:
a. State the general procedures for management of poisoning
b. Outline the general mechanisms of the common poisons
c. List the common drugs which have toxic effects on the heart, liver, kidneys, lungs and
brain
d. Indicate the mechanism of toxicity of the common drugs on the heart, liver, kidneys,
lungs and brain
e. Outline the toxicity of the environmental pollutants.
f. Outline the toxicity of the common heavy metals poisoning
148
2. Cognitive Skills
Upon successful completion of this course, students will be able to:
a. Explain the biochemical and cellular mechanisms that underlie the common toxicities of
drugs and chemicals
b. Differentiate between the mechanisms involved in drug-induced tetratogenicity,
mutagenicity or carcinogenicity
c. Explain the drug-Drug, drug-food interactions of commonly used drugs
d. Describe the mechanism of drug-induced allergies
Course Contents:
General principles of management of poisoning.
General mechanisms of toxicity.
Roles of free radicals in induction of diseases.
Environmental pollutants.
Drug-Drug interactions.
Drug-food interactions.
Drug-induced allergies. Iatrogenic diseases.
Heavy metals poisoning.
Groups of drugs that are toxic to:
Heart
Liver
Kidneys
Lungs
Brain
Teratogenic agents
Mutagenic agents
Carcinogenic agents
149
The following teaching strategies are used:
Lectures
Required Textbooks
Casarite and Doulls Toxicity, The Basic Science of Poisoning. 8 edition. 2013. McGraw-
Hill.
Hodgson, E., Smart, Robert, C., Introduction to Biochemical Toxicology. 2001. Barnes
and Noble.
Greenberg, M.l. (2003). Occupational, Industrial and Environmental Toxicology. Elsevier
Science. N.Y.
Casebooks:
Fenton JJ. (2012): TOXICOLOGY: A Case-Oriented Approach. CRC Press LLC
Recommended Textbooks and Reference Material
Shannon MW, Borron SW, Burns MJ. Haddad and Winchester’s Clinical Management of
Poisoning and Drug Overdose. 4th ed. 2007. Elsevier’s Health Sciences.
Olson KR. Poisoning and Drug Overdose. 5th ed. . McGraw-Hill. 2006
Electronic Materials
Online resources available at:
http://www.library.qu.edu.sa/Pages/default.aspx
http://www.pharmacylibrary.com.ezproxy.qu.edu.sa/public/about
http://accesspharmacy.mhmedical.com/ss/About.aspx
http://accesspharmacy.mhmedical.com.ezproxy.qu.edu.sa/ss/About.aspx
http://search.proquest.com/
150
Pharmaceutical Biotechnology
Course Name: Pharmaceutical Biotechnology التقنية الحيوية الصيدالنية اسم
:المقرر
Course Code & No.: 335 PHT صيد33٥ رقم المقرر
:ورمزه
Credits:2 (2+0+0) 2(2+0+0) عدد
Prerequisite: 212 PHT دوي212
::الساعات
المتطلب
:المعتمدة
Level:7 :السابق
7 :المستوى
Description:
The student's basic biochemistry and pharmacy education will be expanded with current
concepts in biochemistry, molecular biology, analytical techniques, drug development, delivery
and formulation relevant to the use and development of biotechnology-derived products,
including protein and nucleic-based pharmaceuticals. The course provides extensive coverage of
both basic science and applications of biotechnology-produced pharmaceutical, with special
emphasis on their clinical use and applications.
Objectives:
This course aims to introduce students to:
To describe the current concepts in biochemistry, molecular biology, analytical
techniques, drug development, delivery and formulation relevant to the use and
development of biotechnology-derived products, including protein and nucleic-based
pharmaceuticals.
To explain extensively both basic science and applications of biotechnology-produced
pharmaceutical, with special emphasis on their clinical use and applications.
Learning Outcomes
1. Knowledge
Upon successful completion of this course, students will be able to:
a. Record, label, or dispense (knowledge of how) of protein based products.
2. Cognitive skills
Upon successful completion of this course, students will be able
a. Prepare, explain, and interpret the clinical applications of biotechnology and
biotechnology related products, including biopharmaceutical considerations.
b. Predict gene therapy outcomes recombinant vaccine applications and outcomes
c. Comparethe pharmacokinetic and pharmacodynamic of peptides and proteins drugs with
that of other chemical compounds.
151
3. Interpersonal Skills & Responsibility
Judge and justify responsibly while communicating with healthcare teams on problems and
issues related to use of recombinant protein as medicines
Course Contents:
Overview, Biotechnology
Background, Cell and Molecular Biology
Tools for Molecular Analysis
Cloning, Combining Molecular Tools for Recombinant Product Development Production
ofBiotech Compounds
Formulation of Biotech Products including Biopharmaceutical Considerations Genetics in
Drug Therapy
Treatment Options Protein Drug Development Related Products Antibodies,
Immunotherapy and Vaccines
Insulin and Growth Hormones
The impact of Biotechnology on Drug Discovery
152
Assessment and grading plan:
Assessment method Proportion of Total
Assessment
1 Mid-term I exam 20%
2 Mid-term II exam 20%
3 Final exam 60%
Required Textbooks
Daan J.A. Crommelin and Robert D. Sindelar (editors), Pharmaceutical Biotechnology:
An Introduction to Pharmacists and Pharmaceutical Scientists, 1St. edition, 1997.
Haiwood AcademicPublisher, Amsterdam, the Netherlands.
Rodney J.Y. Ho and Milo Gibaldi, Biotechnology and Biopharmaceuticals: Transforming
Proteinsand Genes into Drugs, 1st. edition, 2003. John Wiley & Sons, Inc., Hoboken, NJ.
Gary Walsh, Biopharmaceuticals: Biochemistry and Biotechnology, 1st. edition, 2002,
John Wiley& Sons, Inc., West Sussex, England, ISBN: 0471977896
Susanna Wu-Pong and Yongyut Rojanasakul (editors), Biopharmaceutical Drug Design
and Development, 1st. edition, 1999, Humana Press, Totowa, NJ, ISBN: 089603891x
Recommended Textbooks and Reference Material
Pharmaceutical Biotechnology: fundamentals and applications, 3rd edition, Informa
Healthcare.
153
Basic Pharmacokinetics
Course Name: Basic Pharmacokinetics أسس حركية الدواء :اسم المقرر
Course Code & No.: 336 PHT مصد336 : ورمزه:رقم المقرر
Credits:2(2+0+1) 2(2+0+1) : المعتمدة:عدد الساعات
Prerequisite:135MATH 135 ريض : السابق:المتطلب
Level:7 7 :المستوى
Description:
This course is designed to acquaint the student with the fundamental concepts that determine the
time course of drug concentrations in the body, during single and chronic dosing. The course will
cover the basic principles and concepts of pharmacokinetics and pharmacodynamics that affect
the absorption, distribution, metabolism, excretion and action of drugs in the body.
Course objectives:
The fundamental concepts that determine elimination, distribution, absorption and time
course of drug concentrations in the body, during single and chronic dosing.
Principles for the design of dosage regimen for an individual patient for different routes
of drug administration
Learning outcomes:
1. Knowledge:
a. Define the different pharmacokinetic models and parameters.
b. Describe the characteristics of linear and non-linear pharmacokinetics.
c. Describe the rout of drug administration and define drug clearance
d. Memorize the basic equations used in pharmacokinetic
2. Cognitive Skills:
a. Calculation of maintenance and loading dose for different rout of administration
b. Calculation of drug concentration at any given time after drug administration for different
rout of administration
154
a. Calculate slope and intercept by using scientific calculator
5- Psychomotor:
b. Draw data on semi log and ordinary paper to estimate pharmacokinetic parameters.
Course Contents:
Introduction in Pharmacokinetics
Pharmacokinetics models and methods of determination of drug concentration
Compartmental pharmacokinetics model
One compartment mode IV bolus injection
Two compartment mode IV bolus injection
Single orally administration
Intravenous infusion (IV infusion)
I.V infusion plus loading dose
Multiple IV administration
Multiple orally administration
Non- linear pharmacokinetics
Tutorial schedule:
Comparing between zero order and first order reaction..
Plotting of data on rectangular and semi-logarithmic scales.
Calculation of pharmacokinetic parameters using one compartment model: IV bolus.
Calculation of pharmacokinetic parameters using urine sample after IV bolus by using the
Rate method
Calculation of pharmacokinetic parameters using urine sample after IV bolus by using the
Sigma minus method
Calculation of pharmacokinetic parameters using two compartment model: IV
bolus.(Residual method)
Calculation area under the plasma drug concentration curve [AUC} after IV bolus and
after single orally administration.
Calculation of pharmacokinetic parameters after single orally administration (Residual
method).
Calculation of Cssand infusion rate from IV infusion data (slow infusion)
Calculation of Cssand infusion rate from IV infusion data (rapid and slow infusion)
Calculation of loading dose in combination with IV infusion
Calculation of drug concentration at any given time during multiple IV administration
Calculation of drug concentration at any given time during multiple orally administration
Dose design regimen for multiple IV (time interval, maintenance dose and loading dose).
155
Dose design regimen for multiple oral administrations (time interval, maintenance dose
and loading dose).
Teaching/learning methods and Contact Hours
Lecture Tutorial Laboratory Practical Other: Total
Contact Hours 30 - 15 - 45 hours
W: Written
156
M. Gibaldi and D. Perrier, Pharmacokinetics, Marcel Dekker, Inc., NY, USA. 2nd
Edition, 1982.
L. Shargel and A.B.C. Yu, Applied Biopharmaceutics and Pharmacokinetics, Appleton &
Lange, Stanford, CT, USA. 5th edition, 2005.
WA. Ritschel and G.L. Keams, Handbook of Basic Pharmacokinetics Including Clinical
Applications, American Pharmaceutical Association, Washington, DC, USA.
A.R. Gennaro, Remington: The Science and Practice of Pharmacy, Mack Publishing Co.,
Easton, PA, USA.7th edition, 2009.
Electronic Materials
Online resources available at:
http://www.library.qu.edu.sa/Pages/default.aspx
http://www.pharmacylibrary.com.ezproxy.qu.edu.sa/public/about
http://accesspharmacy.mhmedical.com/ss/About.aspx
http://accesspharmacy.mhmedical.com.ezproxy.qu.edu.sa/ss/About.aspx
http://search.proquest.com/
Radiopharmacy
Course Name: Radiopharmacy المستحضرات الصيدالنية المشعة:إسم المقرر
Course Code & No.: 332 PHC كمص332 :رقم المقرر ورمزه
Credits:1(1+0+0) 1(1+0+0) :عدد الساعات المعتمدة
Prerequisite: 320 PHC كمص320 :المتطلب السابق
Level:7 7 :المستوى
Description:
This course will deal with the atomic & nuclear structure and, the reasons that lead to
phenomenon of radioactivity. This also includes the radioactivity detectors, production of
radioisotopes, preparation and, quality control of radiopharmaceuticals anlong with their
specific use in different physiological conditions. The radiation hazards involved with radiation
exposure and, protection from them will also be imparted.
Objectives:
Understanding the radioactivity, radionuclide decay and, half-life of radioisotopes.
Outline the identity of different radioisotopes.
Acquire the knowledge and, skills to produce and, appropriately use radioisotopes &
radiopharmaceuticals in research and/or, in clinical applications.
Learning Outcomes:
Knowledge:
157
Upon successful completion of this course, students will be able to:
a. Describe radiation and, types of particles emitted from radionuclide.
b. Recognize the hazards involved with radiation exposure and, recommend precautionary
measures.
c. Describe different techniques to produce and identify different radioisotopes and,
radiopharmaceuticals.
d. Recognize radionuclides bio-applications in therapy and diagnostics
Cognitive Skills:
Upon successful completion of this course, students will be able to:
a. Differentiate different types of radioactivity detectors & counters and, judge their
applicability.
Communication, Information Technology, Numerical:
Upon successful completion of this course, students will be able to:
a. Calculate the half-life of radionuclide and, decipher the labels on radiopharmaceuticals.
Course Contents:
Atomic structure (electronic structure of the atom, nuclear structure, the difference
between chemical reactions and nuclear reactions)
Isotopes (stable and radioactive isotopes, naturally occurring and artificially produced
isotopes)
Radioactive decay (decay mechanisms, radioactivity, definition, units and calculations,
decay equations (transmutations, half-life and its significant, 14C Dating).
Instruments and detectors for measuring radioactivity (Gas-filled detectors, liquid
scintillators, solid scintillators, gamma counters and cameras).
Production of radionuclides (reactors, cyclotron, generators)
Radiolabeling
Pharmacopoeial Monographs (British Pharmacopoea”BP”, European Pharmacopoea
“EP”, United States Pharmacopoea “USP”)
Identification tests
(99mTc and 123I human serum albumin by electrophoresis, 14C Urea by
chromatography)
Quality control of radiopharmaceuticals (radiochemical purity systems for
radiopharmaceuticals, TLC for technetium radiopharmaceuticals, TLC for other
radiopharmaceuticals, solid phase extraction cartridge methods
Formulary Section (non-radioactive reagents and diluents, radiopharmaceuticals,
Technetium labeled denatured RBCs, Technetium in vitro labeling of RBCs,
radiopharmaceuticals for gastric emptying, methods for concentrating 99mTC generator
eluate)
158
Adverse reactions and effects (adverse reactions and symptoms following administration,
Unanticipated biodistribution of radiopharmaceuticals
Required TextBook(s):
Textbook of Radiopharmacy. Theory and Practice. Ed CB Sampson.
Radiopharmaceutical in Nuclear Pharmacy and Nuclear Medicine, Amazon, 2nd
edition
Additional Suggested Readings:
Fundamentals of Nuclear Pharmacy, 6th Ed. Gopal B Saha, Springer, New York.
The Radiopharmacy, A Technologist's Guide, EANM (European Association of
159
NucleaMedicine), Lantheus Medical Imaging, USA
Electronic Materials
Access Pharmacy
Pharmacy Library
http://www.library.qu.edu.sa/Pages/default.aspx
Pharmacogenomics
Course Name: Pharmacogenomics الصيدلة الجينية :اسم المقرر
Course Code & No.: 338 PHG دوي٨ :رقم المقرر ورمزه
Credits:2 (2+0+0) 2(2+0+0) :عدد الساعات المعتمدة
Prerequisite: 324PHG دوي٤ :المتطلب السابق
Level:7 7 :المستوى
Description:
This course provided pharmacy students with an understanding of pharmacogenetics ranging
from genetic principles and the inheritance of complex traits to specific examples of
pharmacogenomics in drug therapy.
Objectives
This course aims to introduce students to:
Explain the principles of pharmacogenomics ranging from genetic principles and the inheritance
of complex traits to specific examples of pharmacogenomics in drug therapy.
Understand the principles and applications of human genetics and genomics in drug therapy
optimization, patient care, and genetic counseling.
160
Understand environmental and genetic factors in disease and therapy, and predictive testing in
genetic disorders.
Learning Outcomes
Knowledge:
Upon successful completion of this course, students will be able to:
a. Describe the principles and applications of human genetics and genomics in drug therapy
optimization, patient care, and counseling.
Cognitive skills
Upon successful completion of this course, students will be able to:
a. Predict how alleles segregate and analyze different types of environmental and genetic
factors that affect development of the allele phenotype, including drug response and
explain the multifactorial nature of most human traits, including drug response
b. Interpret how human genetic variation affects drug metabolism, activation, and
disposition and how polymorphisms and linkage are used to identify candidate genes.
c. Predict and estimate the advantages, limitations, and dangers of predictive testing for
genetic disease and drug response and analyze legal and ethical issues in genetic testing
and patient stratification in clinical trials.
Course Contents:
• Introduction
• The case for Pharmacogenomics
• The history of genetics and Pharmacogenetics
• Information flow in biological systems
• Gene Expression – transcription and translation
• Genes in Pedigrees – Information Transmission/Inheritance
• Mendelian Transmission Patterns
• Dominance/Recessive expression patterns
• Sex-linkage
161
• Factors Affecting Gene Frequencies
• Selection
• Race/ethnicity and ancestral or geographic origin of alleles
• Population Genetics and Evolution
• Gene and allele frequencies
• Hardy-Weinberg Equilibria
• Population Structure/admixture
• Genes in Pedigrees – Information Transmission/Inheritance
• Genetic Mapping
• Pedigree Analysis
• Locus and Allelic Heterogeneity
• Quantitative Genetics and Multifactorial Inheritance
• Polygenic traits and environmental factors
• Genetic markers and linkage mapping
• The Human Genome - the organization and structure of genomes
• Genetic Data and the Internet
• Navigating the National Center for Biotechnology Information (NCBI)
• Navigating the Pharmacogenetics and Pharmacogenomics Knowledge Base (PharmGKB)
• Genome Evolution
• Mechanisms of gene duplication and development of gene families
• Paralogs versus Orthologues
• The Human Genome - Organization and structure of genomes
• Genomes – Diversity, Size and Structure
• Genomic Technologies: Microarrays and Quantitative PCR
• Drug Target Pharmacogenomics
• Drug transporters
• Drug metabolizing enzymes
• Cellular signaling pathways
• Guest Lecture: Pharmacogenomics: Oncology and Hematology
• Guest Lecture: Pharmacogenetics: Cardiovascular Diseases
• Guest Lecture: Pharmacogenetics: Transplantation
• Guest Lecture: Central Nervous System and Psychiatry Pharmacogenetics
162
The following teaching strategies are used:
Required References
Pharmacogenomics. Applications to Patient Care. American College Clinical Pharmacy,
KansasCity, MO. 2004.
Didactic lecture
Group discussions
163
Pharmacogenomics. Applications to Patient Care. American College Clinical Pharmacy,
Kansas.
Recommended Textbooks and Reference Material
Motulsky AG. Drug reactions, enzymes, and biochemical genetics. JAMA. 1957;
165:835-7.
Sansgiry SS, Kulkarni AS. The Human Genome Project: assessing confidence in
knowledge andtraining requirements for community pharmacists. Am J Pharm Educ.
2003; 67(2): Article 39.
AACP Final Report of the 2001-02 Academic Affairs Committee. Pharmacogenomics: a
scientific revolution in pharmaceutical sciences and pharmacy practice. Available at:
http://www.aacp.org/
Docs/AACPFunctions/Governance/6103_AcademicAffrsfinalreport.pdf
Latif DA, McKay AB. Pharmacogenetics and Pharmacogenomics Instruction in colleges
andschools of Pharmacy in the United States. Am J Pharm Educ. 2005; 69(2): Article 23.
Wilson JF, Weale ME, Smith AC, et al. Population genetic structure of variable drug
response.Nat Genetics. 2001; 29:265-29.
Korf BR. Integration of genetics into clinical teaching in medical school education. Genet
Med.2002; 4:S33-38.
Wilson JF, Weale ME, Smith AC, et al. Population genetic structure of variable drug
response.Nat Genetics. 2001; 29:265-29.
Electronic Materials
Motulsky AG. Drug reactions, enzymes, and biochemical genetics. JAMA. 1957;
165:835-7.
Sansgiry SS, Kulkarni AS. The Human Genome Project: assessing confidence in
knowledge andtraining requirements for community pharmacists. Am J Pharm Educ.
2003; 67(2): Article 39.
AACP Final Report of the 2001-02 Academic Affairs Committee. Pharmacogenomics: a
scientific revolution in pharmaceutical sciences and pharmacy practice. Available at:
http://www.aacp.org/
Docs/AACPFunctions/Governance/6103_AcademicAffrsfinalreport.pdf
Latif DA, McKay AB. Pharmacogenetics and Pharmacogenomics Instruction in colleges
andschools of Pharmacy in the United States. Am J Pharm Educ. 2005; 69(2): Article 23.
Wilson JF, Weale ME, Smith AC, et al. Population genetic structure of variable drug
response.Nat Genetics. 2001; 29:265-29.
Korf BR. Integration of genetics into clinical teaching in medical school education. Genet
Med.2002; 4:S33-38.
Wilson JF, Weale ME, Smith AC, et al. Population genetic structure of variable drug
164
response.Nat Genetics. 2001; 29:265-29.
Course Name: Dispensing of Medications تجهيز الوصفات الصيدلية :اسم المقرر
Dispensing of Medications
165
Course Code & No.: 337 PHT صيد337 :رقم المقرر ورمزه
Credits:3(2+1+0) 3(2+1+0) :عدد الساعات المعتمدة
Prerequisite:323PHT صيد323 :المتطلب السابق
Level:7 7 :المستوى
Description:
In this course, students will apply previously acquired knowledge to the practice of dispensing
medications. Comparative evaluation of commonly prescribed and some non-prescribed drugs
will be discussed. Different criteria used for selection of drugs and pharmaceutical products will
be emphasized. Drug interactions and prescriptions for different groups of patients will be
discussed.
Objectives:
Knowledge of medical prescription,drug interactions and drug dispensing in different
types of patients.
Criteria used for selection of drugs and pharmaceutical products and appropriate
recommendations on the use of commonly prescribed pharmaceutical products.
How to process prescriptions and dispense medications
How to perform calculations in dispensing of medication.
Learning outcomes
Knowledge
Upon successful completion of this course, students will be able to:
a. Define different types of drug interactions.
b. List theprescription abbreviations, error-prone abbreviations, Symbols, and Dose
Designations.
c. Outline the appropriate procedure used in dispensing prescriped pharmaceutical products.
d. Describe the appropriate extemporaneous compounding of Rifampin suspension as a
prescribed preparations.
Cognitive Skills
Upon successful completion of this course, students will be able to:
a. Convert the units of Metric System from one to another (e.g. grams to kilograms or vice
versa)
b. Demonstrate the appropriate procedure used for dispensing prescriped pharmaceutical
products including controlled medications
c. Perform the extemporaneous compounding of prescribed medication.
d. Familiarity with unit dose system
166
e. Demonstrate the techniques to use various Inhalers (metered dose inhaler, dry powder
inhaler), Insulin pens, aero chambers, skin patches.
f. Identify medication errors (prescription errors and dispensing errors).
g. Labelling the prescribed product and learn the use of various auxiliary labels for different
prescribed products.
h. Preparing, handling, reading, reviewing and understanding the prescriptions
Contents:
Apply previously taught knowledge in the practice of dispensing.
Reviewing, Understanding and Evaluating Prescription and Medication orders
Processing Prescriptions and Patient Counseling
Identify Drug interactions (Drug-Drug, Drug-Food)
Learn the different criteria used for selection of drugs and pharmaceutical products.
Controlled Medication prescriptions and dispensing
Comparative study between prescription of various age groups (Pediatrics, Geriatrics,
Pregnancy and Breast Feeding)
Identify medication errors (prescription errors and dispensing errors)
Learn how to provide the appropriate recommendations on the use of commonly
prescribed drugs.
Learn how to provide the appropriate recommendations on the use of some non-
prescription pharmaceutical products.
Appreciate the differences between normal adults and some other groups of patients (e.g.
pediatrics) and learn the basic knowledge of prescriptions for such groups.
Learn the basic knowledge of pharmacokinetic drug interactions and be able to detect
drug interactions in medical prescriptions.
Learn how to perform the appropriate extemporaneous compounding of selected
commonly prescribed preparations.
Teaching/learning methods and Contact Hours
Lecture Tutorial Laboratory Practical Other: Total
167
Contact 25 hours 18
Hours 43
Credit 3
45
Required Textbooks
Remington: The Science and Practice of Pharmacy / Edition 21 by Lippincott Williams &
Wilkins.
168
L. Shargel, A. Mutnick, L. Swanson. Comprehensive Pharmacy Review.
Essential References Materials
American Hospital Formulary Service Drug Information. Latest Edition. American
Society of Health System.
The Pharmaceutical Press. W. Lund.
Recommended Textbooks and Reference Material
Remington: The Science and Practice of Pharmacy / Edition 21 by Lippincott Williams &
Wilkins
Comprehensive Pharmacy Review by Leon Shargel PhD RPh, Alan H.
Drug Facts and Comparisons, Latest Edition, Facts and Comparison.
Facts and Comparison Drug Interactions, Latest Edition, Facts and Comparison. A.R.
Gennaro, ed., Remington. The Science and Practice or Pharmacy, Latest edition. Mack
Publishing Co.
American Hospital Formulary Service Drug Information. Latest Edition. American
Society of Health System.
The Pharmaceutical Codex: Principles and Practice of Pharmaceutics. Latest Edition.
Rittenhouse Book Distributors.
Handbook of Non-prescription Drug. Latest Edition. American Pharmaceutical
Association.
Electronic Materials
http://www.library.qu.edu.sa/Pages/default.aspx
http://www.pharmacylibrary.com.ezproxy.qu.edu.sa/public/about
http://accesspharmacy.mhmedical.com/ss/About.aspx
http://accesspharmacy.mhmedical.com.ezproxy.qu.edu.sa/ss/About.aspx
http://search.proquest.com/
Biopharmaceutics
Course Name: Biopharmaceutics صيدلة حيوية :اسم المقرر
Course Code & No.: 345 PHT مصد345 :رقم المقرر
:ورمزه
169
Credits:2 (2+0+0) 2(2+0+0) :عدد الساعات
335مصد :المعتمدة
Prerequisite: 335 PHT :المتطلب
Level: 8 :السابق
8 :المستوى
Description:
This course will deal with the effects of the physicochemical properties of the drug, the
formulation factors, the dosage form, the route of administration and the physiological factors on
the rate and extent of systemic drug absorption. Also in vitro methods and the application of
different equations used to study the dissolution from dosage forms will be discussed. The
concept of clearance and the mathematical relationships that describe drug – protein binding and
methods used for study and calculation of dissolution parameters from dosage forms.
Objectives:
1. The concepts of biopharmaceutics terminology and principles of drug transfer from the dosage
form to the gastrointestinal fluids as well as the arrival of drug at the systemic circulation after
oral administration.
2. Principles and applications of formulation factors affecting oral absorption.
3- Mathematical relationships that describe drug – protein binding and methods used for
estimating of dissolution parameters for dosage forms.
Learning outcomes:
1- Knowledge:
a. Define the concepts of bioavailability and bioequivalence.
b. Describe the mechanisms of drug transport and drug release from dosage forms
c. List formulation factors affecting oral absorption
d. Memorize the basic equations used in protein binding and drug dissolution
2- Cognitive Skills:
a. Explain the relationship among physicochemical and biological factors, dosage forms,
routes of administration and therapeutic outcomes
b. Estimate the absolute and relative drug bioavailability using plasma and urinary data.
c. Calculation of protein binding parameters
d. Compare between different dosage forms.
e. Explain how formulation additives affect drug absorption and drug bioavailability
170
b.. Illustrate the principles of pharmaceutics and biopharmaceutics in dosage form design and
development.
4- Communication, information Technology, Numerical:
a. Evaluate biopharmaceutics studies involving drug product equivalency
b. Calculate slope and intercept by using scientific calculator
5- Psychomotor:
a. Draw data on semi log and ordinary paper to estimate protein binding parameters
Course Contents:
Introduction in Biopharmaceutics
Rate parameters and physical processes relevant to drug absorption
Relative &absolute bioavailability
Supply of the gastrointestinal fluids with drug
Delivery of the drug to and removal of drug from uptake sites
physicochemical factors effecting the oral drug absorption
Dissolution from immediate release tablets
Dissolution from powders and hard gelatin capsules
Similarity and dissimilarity factors
Protein binding and Volume of distribution
Renal and hepatic clearance
Modified release drug products, osmotic extended release products. Drug release from
matrix, polymeric matrix tablets
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1 Mid-term I exam 20%
2 Mid-term II exam 20%
3 Final exam 60%
W: Written
Required Textbooks
L. Shargel and A.B.C. YU, Applied Biopharmaceutics and Pharmacokinetics, Appleton
&Langel McGraw-Hill, NY, USA. 5th edition, 2005
M. Gibaldi, Biopharmaceutics and Clinical pharmacokinetics, Latest edition, Lea and
Febiger,Philadelphia, USA. 4th edition, 1991
Electronic Materials
Online resources available at:
http://www.library.qu.edu.sa/Pages/default.aspx
http://www.pharmacylibrary.com.ezproxy.qu.edu.sa/public/about
http://accesspharmacy.mhmedical.com/ss/About.aspx
http://accesspharmacy.mhmedical.com.ezproxy.qu.edu.sa/ss/About.aspx
http://search.proquest.com/
172
Course Name: Clinical Communication Skills مهارات التواصل اإلكلينيكية اسم
:المقرر
Course Code & No.: 342 PHP مصد342 رقم المقرر
:ورمزه
Credits:2(2+0+0) 2(2+0+0) عدد
:الساعات
Prerequisite: None بدون :المتطلب
:المعتمدة
Level: 8 8 :السابق
المستوى
Description:
This course emphasize on specific tools and techniques for improving effective listening and
responding skills in clinical communication with different communication styles with patients.
Through interactive lectures, class discussions, simulation and role playing by students to apply
clinical communication tools and strategies
Objectives:
This course aims to introduce students to
Basic skills of clinical communication in patient centered care through verbal and non-verbal
communication of patients with good questioning, active listening and patient interviewing skills
and removing of potential barriers for patient counseling to achieve the therapeutic outcome
Attitudes, behavior and strategies to communicate effectively with different type of patients and
tools to counsel patients beyond stereotyping and build rapport, improve quality of interpersonal
relationships and overall healthcare team performance.
Electronic method of communications.
Learning Outcomes:
1. Knowledge
Upon successful completion of the course students will be able to:
a. Describe importance of communication in meeting patient care responsibilities.
b. State different barriers in communication skills
c. Summarize listening, responding and explaining skills in communication
d. Discuss effective communication skills with children, elderly, people with mental
problems, low health literacy and with disabilities.
2. Cognitive skills
a. Apply motivational interviewing principles and strategies to improve patient compliance
b. Identify types of errors in communicating with healthcare providers and its potential
solutions
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Interpersonal skills and responsibility
a. Show interest in interviewing the patients using communication skills.
Course Contents:
Introduction to the basics of interpersonal communication.
Tools and types of communication
The basics of verbal & non - verbal cues. The questioning skills.
The listening skills.
The responding skills.
The expressing & explaining skills.
How to handle differences-conflict effectively.
Gathering and presenting information.
Rapport: How to strengthen it and how to respond when you lose it.
Ten Common Errors - and how to avoid them - in communication, leadership and
negotiation.
Dealing with negative communication.
The sender-receiver relationship.
Effective meetings.
Effective presentation skills.
Teaching/learning methods and Contact Hours
Lecture Tutorial Laboratory Practical Other: Total
Contact 30 - - - - 30 hours
Hours
The following teaching strategies are used:
Lectures
Class discussions
Assessment and grading plan:
Assessment method Proportion of Total Assessment
1 Mid Term 1 15%
2 Mid Term 2 15%
3 Role Playing (Mock Pharmacy) 10%
4 Final Exam 60%
174
Course outcomes and Assessment
Course outcome Method of Assessment
1 Outcome 1 W
2 Outcome 2 W
3 Outcome 3 W
4 Outcome 4 W
Required Textbook
Tindall WN, Beardsley RS, Kimberlin CL. Communication Skills in pharmacy practice.
4th. Edition, 2002. Lippincott Williams & Wilkins.
Electronic Materials
Online resources available at:
http://www.library.qu.edu.sa/Pages/default.aspx
http://www.pharmacylibrary.com.ezproxy.qu.edu.sa/public/about
http://accesspharmacy.mhmedical.com/ss/About.aspx
http://accesspharmacy.mhmedical.com.ezproxy.qu.edu.sa/ss/About.aspx
http://search.proquest.com/
175
Ethics in Pharmacy
Course Name: Ethics in Pharmacy أخالقيات الصيدلة :اسم المقرر
Course Code & No.: 341 PHP مصد341 :رقم المقرر ورمزه
Credits:2(2+0+0) 2(2+0+0) :عدد الساعات المعتمدة
Prerequisite:102 IC سلم102 :المتطلب السابق
Level:8 8 :المستوى
Description:
This course introduces the basic principles of professional ethics to the students pertaining to
healthcare in general and pharmacy practice in particular. This course makes the pharmacists to
use their ethical knowledge and skills for the benefit of patients and other healthcare providers to
be just and fair in their services to the public.
Objectives:
This course aims to introduce students to:
Basic principles of professional ethics in pharmacy practice and ethical requirements in
preserving patient’s rights, confidentiality and autonomy and taking decisions for their benefit.
Ethical requirements and criteria in community pharmacy, research, therapeutic drug selection
and interchange, drug promotion and use of drugs in sports
Ethical cases and pharmacist’s decision based on professional ethical values.
Learning outcomes
1. Knowledge
By the end of this course, students will be able to:
a. Describe basic ethical principles, theories and liabilities and practices in pharmacy
profession
b. Discuss patient’s quality of life issues, their confidentiality, autonomy and rights
c. Define ethics in community pharmacy and research
2. Cognitive skills
a. Classify different criteria for ethical therapeutic drug selection and interchange
b. Assess ethical cases of contraception and abortion
c. Distinguish between ethical cases of euthanasia and mercy killings
Course Contents:
Ethics and Pharmacy Law and other Drug Acts in Saudi Arabia - Legislative positions on
ethical issues.
The concept of the pharmacy profession.
Ethical theories.
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Bioethical principles. Conflict of interest.
Patient's quality of life and Patients' rights (prejudice, stereotyping, and racism).
Patient confidentiality and autonomy.
Codes of ethics:
Code of Ethics for Pharmacists - American Pharmaceutical Association (APhA).
Code of Ethics - American Association of Pharmaceutical Scientists (MPS).
Ethics in the community pharmacy.
A pharmacist's liabilities.
Commercialism In the pharmacy field.
Drugs and sport - The role of the pharmacist.
Therapeutic Drug product selection, interchange and substitution.
Ethics in research.
World Health Organization (WHO) criteria for drug promotion.
Ethics Cases (contraception and abortion)
Ethic Cases (euthanasia - assisted and mercy killings).
177
Required Textbook
Ethics In Pharmacy Practice by Hisham S Abou Auda, 2004. King Saud University.
Recommended Books
Ethics in pharmacy practice by Remington's Pharmaceutical Sciences. (20th. edition).
Genarro A. editor. Easton, PA. 2000. ISBN: 0683306472.
Buerki RA, Vottero LD, Ethical responsibility in pharmacy practice. 2nd. edition. 2002
Smith M, Strauss S, Baldwin HJ, Alberts Kr. (editors). Pharmacy Ethics. 1991.
Pharmaceutical Products Press. New York, NY. IS BN: 1560241721
Electronic Materials
Online resources available at:
http://www.library.qu.edu.sa/Pages/default.aspx
http://www.pharmacylibrary.com.ezproxy.qu.edu.sa/public/about
http://accesspharmacy.mhmedical.com/ss/About.aspx
http://accesspharmacy.mhmedical.com.ezproxy.qu.edu.sa/ss/About.aspx
http://search.proquest.com/
178
Pharmacotherapy II
Course Name: Pharmacotherapy-II 2-العالجيات :إسم المقرر
Course Code & No.: PHP 340 مصد340 :رقم المقرر ورمزه
Credits:3(3+0+1) 3(3+0+1) :عدد الساعات المعتمدة
Prerequisite: PHP 330 مصد330 :المتطلب السابق
Level:8 10 :المستوى
Description:
The purpose of this course is to integrate the pathophysiologic abnormalities of disease states
(Gastroenterology, Nephrology and Hepatology) with concepts of drug action and therapy. State-
of-the-art pharmacotherapy will be reviewed with pertinent pathophysiology and pharmacology.
Emphasis will be placed on drug selection, dosing regimen design, and therapeutic drug
monitoring to assess the attainment of therapeutic efficacy and avoidance of adverse reactions.
Objectives:
This course aims to introduce students to:
Therapeutic knowledge and appropriate pharmacologic and non-pharmacologic therapies
of selected diseases.
Rationale, reasonable and practical solution to drug related problems in patient with
selected diseases.
Plan for monitoring drug efficacy, adverse effects, compliance, drug interactions and
desired outcome for patient drug therapy of the selected diseases.
Learning Outcomes:
1. Knowledge:
Upon successful completion of this course, students will be able to:
a. Describe the pathophysiology, complications and risk factors of upper and lower
gastrointestinal infections, viral hepatitis, kidney and liver diseases, urinary tract
infections, gout, and arthritic diseases.
b. Recognise the therapeutic goals, drug and nondrug therapies used in management of
upper and lower gastrointestinal infections, viral hepatitis, kidney and liver diseases,
urinary tract infections, gout, and arthritic diseases.
2. Cognitive Skills:
Upon successful completion of this course, students will be able to:
a. Design appropriate care plan for management of patient with upper and lower
gastrointestinal infections, viral hepatitis, kidney and liver diseases, urinary tract
infections, gout, and arthritic diseases.
b. Identify and prioritize therapeutic alternatives to individualize patient specific regimens.
179
c. Identify the drug-related problems associated with management of patient with upper and
lower gastrointestinal infections, viral hepatitis, kidney and liver diseases, urinary tract
infections, gout, and arthritic diseases, and solve them with evidence-based therapy.
d. Monitor therapeutic outcomes and adverse effects of drug therapy used in management of
patient with upper and lower gastrointestinal infections, viral hepatitis, kidney and liver
diseases, urinary tract infections, gout, and arthritic diseases.
3. Interpersonal Skills & Responsibility:
Upon successful completion of this course, students will be able to:
a. Demonstrate ability to work in group and take the responsibility for self-learning.
4. Communication, Information Technology, Numerical
Upon successful completion of this course, students will be able to:
a. Effectively communicate care plan and other related medical information to patient and
health care professionals.
b. Effectively use computer technologies that help in designing an individualized care plan
regimen
Contents:
Gastroenterology Pharmacotherapy:
Peptic ulcer diseases
Liver cirrhosis
Hepatitis
Intra-abdominal infections
Inflammatory bowel diseases
Gastroenteritis, diarrhea and constipation
Pancreatitis
Drug-induced hepatotoxicity
Renal and UroPharmacotherapy
Acute and chronic renal failure
Dialysis and other renal replacement therapies
Drug-induced nephrotoxicity
Urinary tract infections
STDs
Ortho+rheumatic
Osteoporosis & osteomalacia
Gout and hyperuricemia
Osteoarthritis
Rheumatoid arthritis
Systemic lupus erythromatosis
180
Teaching/learning methods and Contact Hours
Lecture Tutorial Laboratory Practical Other: Total
Contact 42 14 - - - 56 hours
Hours
181
Required Textbooks
Mary Anne Koda-Kimble1 Lloyd Yee Young1 Wayne A. Kradjan1 B. Joseph Guglielmo.
Applied Therapeutics. The Clinical Use of Drugs. 10th edition (2013). Lippincott
Williams & Wilkins Publishers.
Joseph T. Dipiro, Robert L. Talbert, Gary C. Yee, Gary R. Matzke1 Barbara G. Wells, L.
Michael Posey. Pharmacotherapy: A Pathophysiologlc Approach. 5th edition (2002).
McGrawHill/Appleton & Lange.
In Schwinghammer, T. L., In Koehler, J. M., In Borchert, J. S., & In Slain, D. (2014).
Pharmacotherapy casebook: A patient-focused approach.
Eric T. Q. Herfindal and Dick R. Gourley ~ditors), Greta K. Gourley (Editor), James M.
Holt (Editors).Textbook of Therapeutics: Drug and Disease Management. 7th edition
(2000).
Casebooks:
Greta K. Gourley, James M. Holt (Editors) Casebook for Textbook of Therapeutics: Drug
and disease management. 7th edition (2000). Lippincott Williams & Wilkins Publishers.
Terry L. Schwlnghammer1 Joseph Dipiro, Robert Talbert, Gary Yee, Gary Matzke1
Barbara G. Wells, L. Michael Posey (Editors). Pharmacotherapy Casebook. 5th edition
(2002). McGrawHilvAppleton & Lange.
182
Drug and Poison Information Services and literature Evaluation
Course Name: Drug and Poison Information خدمات معلومات األدوية والسموم وتقويم :اسم المقرر
Services and literature evaluation الدراسات
Description:
The theoretical part is designed to introduce the students to the concept of drug Information,
functions, and how to establish drug information centers. In addition this part will expose the
students to the theoretical background required to locate, evaluate and communicate drug
information using mainly secondary and tertiary resources. In this case the student will be taught
types of literatures, classification of requests, and how to prepare, formulate, and communicate
an answer.
In the practical part, the students will also be exposed to the various types of drug and poison
information requests, and be involved in preparation of written response to each using the
official request form used by the center. In addition, the student will learn how to write drug
monograph. Furthermore the student will be taught and exposed to the various types of
secondary and tertiary resources and to the searching technique required for each type.
Objectives:
This course aims to introduce students to:
Drug & poison information services and profession and their roles and responsibilities
Skills, knowledge and facilities required to carry on services and perform tasks
Standards, ethics and quality requirements needed for offering drug and poison
information services and for the professionals
Varieties and options in providing drug and poison information services
Application of basic concepts and principles on some practical scenarios and cases
provided as examples
183
Learning outcomes:
1. Knowledge
Upon successful completion of this course, students will be able to:
a. Define the principle of drug and poison information center
b. Describe the role of a pharmacist as drug information provider
c. Describe the required processes and materials to establish drug Information center or
service
2. Cognitive Skills
Upon successful completion of this course, students will be able to:
a. Differentiate between primary, secondary and tertiary literature that are usually used in
answering drug and poison information request.
b. Recognize various types of requests and the required background information that should
be extracted for each type of question
184
n. Evaluating and using various types of tertiary literatures.
o. Handling the various types of requests
p. Preparing drug monographs, writing drug information in newsletters
q. Searching secondary literature Including IDIS (IOWA system), MICROMEDEX,
Medline, and Internet.
r. Communicating responses to drug and poison information requests verbally and in a
written format.
185
Required Textbooks
Patrick M. Malone (Editor), Kristen W. Mosdell, Karen Kier, John Stanovich. Drug
Information: A Guide for Pharmacists. 2nd. edition (2000). McGraw-Hill/Appleton &
Lange.
Casebooks:
Ascione, F.J., Manifold, C.C., Parenti, M.A. (1997). Principles of drug information and
scientific literature evaluation. Washington, D.C.: American Pharmaceutical Association
Robson, A.S., Bawden, D., Judd, A.(2001). Pharmaceutical and medicines information
management: principles and practice. Edinburgh, London, New York, Philadelphia, St
Louis, Sydney, Toronto: Churchill Livingstone.
Winfield, A.J. & Richards, R.M.E. (2004). Pharmaceutical practice, 3rd edition.
Edinburgh, London, New York, Oxford, Philadelphia, St Louis, Sydney, Toronto:
Churchill Livingstone
Electronic Materials
Online resources available at:
http://www.library.qu.edu.sa/Pages/default.aspx
http://www.pharmacylibrary.com.ezproxy.qu.edu.sa/public/about
http://accesspharmacy.mhmedical.com/ss/About.aspx
http://accesspharmacy.mhmedical.com.ezproxy.qu.edu.sa/ss/About.aspx
http://search.proquest.com/
186
Over The Counter Drugs
Course Name: Over The Counter Drugs األدوية غير الوصفية :اسم المقرر
Course Code & No.: 344PHT صيد344 :رقم المقرر
Credits:2(2+0+0) 2(2+0+0) :ورمزه
:الساعات عدد
Prerequisite:335 PHT صيد335 :المعتمدة
:المتطلب
Level:8 :السابق
8 :المستوى
Description:
This course enables pharmacy students to follow health care practitioners, and consumers by
making available comprehensive, convenient and easy-to-use compilation of information on
nonprescription drugs and drug products. Students practice interviewing and counseling skills,
and continue to develop their skills in over the counter drugs (OTC) counseling with new topics,
including some alternative medicine. Emphasis will be placed on mechanism(s) of action of the
various drug classes, body system(s) affected, clinical manifestations of problems and the
resulting adverse effects.
Objectives:
This course aims to introduce students to:
Acquire and demonstrate knowledge about over the counter drugs including legal
requirement, drug classification, storage and the role of the pharmacist in the health
information.
Role and action of non-prescription drugs including treatment, mechanism of action,
dosage, side effects, and contraindications in selected minor ailments affecting
gastrointestinal, eye, ear, dermatology, upper respiratory system in different type of
patient.
Demonstrate responding to signs/symptoms and selection of non-prescription drugs for
treatment and expected outcomes in selected minor ailments.
Learning outcomes:
1. Knowledge
Upon successful completion of this course, students will be able to:
a. Outline the pharmacist's role in management the over the counter medications and
legal requirements. State how nonprescription medicines are supplied in accordance
with legal and professional requirements.
b. Describe the self-care movements
187
c. Identify monitoring and referral criteria and explain the treatment choices for minor
ailments include; with common gastrointestinal tract, upper respiratory system, skin,
eye and ear minor ailments.
2. Cognitive Skills
Upon successful completion of this course, students will be able to:
a. Select the appropriate nonprescription drug therapy for each patient
b. Recognize the regulations govern the non-prescription medications.
c. Apply monitoring and referral criteria and explain the treatment choices for minor
ailments include;with common gastrointestinal tract, upper respiratory system, skin,
eye and ear minor ailments
d. Evaluate the appropriateness of nonprescription drug therapy, including the choice of
the drug, Dosage, route, frequency, and duration of therapy in patient with common
gastrointestinal tract, upper respiratory system, skin, Eye and ear minor ailments
Contents:
Introduction
The self-care movements
Patient Assessment and consultation
The pharmacist's role
The FDA's OTC review
Drug classification
Drug abuse
OTC drug interactions
Drug combinations
Health information act
Nutrition (special requirements)
Nutrition(a health diet)
Nutrition (obesity)
Infant nutrition
188
Eating disorders
Internal supplement
Total parenteral nutrition
Products for Oral Cavity and Gastrointestinal Tract; digestion and related conditions
Diarrhea and antidiarrheal agents
Constipation and laxatives
Hemorrhoidal and antihemorrhoidal products
Oral hygiene; problems and products
Upper respiratory tract infections and their symptoms products
Common cold and allergy products
Hay fever products for their alleviation
Ophthalmic products and common eye problems and products for their relief
Contact lens care solutions
Otic products and ommon ear problems and products for their relief
Pregnancy and Lactation; Pregnancy tests and products during pregnancy and lactation
Contraceptives
Skin Products; acne, dandruff, psoriasis, foot care and parasitic skin diseases
189
Learning outcomes and Assessment:
Required Textbooks:
Handbook or Non Prescription Drugs; American Pharmaceutical Association I The
National Professional Society of Pharmacists, 2009.
Comprehensive pharmacy review. SHARGEL, L. Philadelphia, Wolters Kluwer.
Lippincott Williams & Wilkins, (2007).
Recommended Textbooks and Reference Material
Pharmaceutics: the science of dosage form design. Aulton, Michael E.. Edinburgh ; New
York: Churchill Livingstone, 2002.
Goodman & Gilman's the pharmacological basis of therapeutics. GOODMAN, L. S.,
GILMAN, A., HARDMAN, J. G., GILMAN, A. G., & LIMBIRD, L. E. New York,
McGraw-Hill, Health Professions Division (1996).
Principles of Medical Pharmacology; H. Kalant, W.H.E. Roschlau and E.M. Sellers,
University of Toronto Press, 1985.
Clinical pharmacy and therapeutics. Walker, Roger, and Clive Edwards. Edinburgh:
Churchill Livingstone, 2003.
Electronic Materials
Online resources available at:
http://www.library.qu.edu.sa/Pages/default.aspx
http://www.pharmacylibrary.com.ezproxy.qu.edu.sa/public/about
http://accesspharmacy.mhmedical.com/ss/About.aspx
http://accesspharmacy.mhmedical.com.ezproxy.qu.edu.sa/ss/About.aspx
http://search.proquest.com/
190
Patient Assessment and First Aid
Course Name: Patient Assessment and First Aid الفحص السريري واإلسعاف األولي :اسم المقرر
Course Code & No.: 346 PHP مصد346 رقم المقرر
:ورمزه
Credits:1(0+1+1) 1(0+1+1) :عدد الساعات
Prerequisite:222PHG دوي222 :المعتمدة
:المتطلب
Level:8 :السابق
8 :المستوى
Description:
This course focuses mainly on patient assessment and development of medical skills within
pharmacy practice. Also, it educates the students to collect physical examination data which play
a limited role as compared with the information gathered through the health and medication
history.
Objectives:
This course aims to introduce students to:
Assessment of common complaints that may be experienced in the delivery of
pharmaceutical care
Physical assessment techniques and tools necessary to monitor drug therapy
Equipment and techniques necessary to conduct a physical examination
Care of patients in remote environments, lacking typical health care facility resources for
dealing with life-threatening situations and emergencies
Learning outcomes:
1. Knowledge
Upon successful completion of this course, students will be able to:
a. Learn the method of taking a basic medical history
b. Record, in an appropriate format, the necessary patient information.
c. Discuss the common medical problems presenting in primary health care setting at
the hospital and community centers.
d. Recognize the difference between quantitative and qualitative testing.
e. Outline the clinical emergencies and basic lifesaving techniques.
f. Identify risk factors for common diseases
2. Cognitive Skills
Upon successful completion of this course, students will be able to:
a. Analyze symptoms and signs
b. Construct a differential diagnosis for commonly presented patient complaints.
191
c. Interpret the results of commonly used diagnostic procedures.
d. Evaluate the significance of laboratory findings of common disease conditions
e. Select certain laboratory parameters to monitor drug therapy and clinical outcomes.
4. Practical:
a. Physical examination of different organs of the body
b. Introduction to first aid for all ages and all systems of the body, aims and priorities of
first aid
c. Management of the injured patient and shock
d. Maintenance of airway passages and intravenous line
e. Cardiovascular resuscitation
192
f. Management of bleeding, open wounds, fractures, epilepsy, coma, sunstroke, animal
bites, high grade fever, burns, poisoning, drowning, head injuries
g. Emergency procedures at home, work, or leisure.
193
Required Textbooks
Rhonda M. Jones, Raylene M. Rospond, Lynn Walton Hall. Patient Assessment in
Pharmacy Practice. (2003). Lippincott Williams & Wilkins Publishers.
Scott L. Traub (Editor). Basic Skills in Interpreting Laboratory Data: Illustrated With
Case Studies. 2nd. edition (1996). American Society of Health-System Pharmacists.
First Aid Manual, St Andrews' Ambulance Association and the British Red Cross
Society, St John Ambulance.
Casebooks:
Terry L. Schwlnghammer1 Joseph Dipiro, Robert Talbert, Gary Yee, Gary Matzke1
Barbara G. Wells, L. Michael Posey (Editors). Pharmacotherapy Casebook. 5th edition
(2002). McGrawHilvAppleton& Lange.
Recommended Textbooks and Reference Material
Bickley, L.S. Bates' Guide to Physical Examination and History Taking. Philadelphia:
J.B. Lippincott Williams & Wilkins.
James Thomas, Tanya Monaghan. Oxford Handbook of Clinical Examination and
Practical Skills. Oxford University Press.
Kathleen DeskaPagana, Timothy James Pagana (Editors). Mosby's Manual of Diagnostic
and Laboratory Tesss. 2nd. edition (2002). Mosby.
Jarvis C. Physical Examination L Health Assessment: Lab Manual 4th. Edition, (2003).
W B Saunders.
Electronic Materials
Online resources available at:
http://www.library.qu.edu.sa/Pages/default.aspx
http://www.pharmacylibrary.com.ezproxy.qu.edu.sa/public/about
http://accesspharmacy.mhmedical.com/ss/About.aspx
http://accesspharmacy.mhmedical.com.ezproxy.qu.edu.sa/ss/About.aspx
http://search.proquest.com/
194
Pharmacotherapy-IlI
Description:
This course is formulated to integrate the pathophysiologic abnormalities of disease states
(Endocrinology, Neurology, Psychiatry, and Reproductive system) with concepts of drug action
and therapy. State-of-the-art pharmacotherapy will be reviewed with pertinent pathophysiology
and pharmacology. Emphasis will be placed on drug selection, dosing regimen design and
therapeutic drug monitoring to assess the attainment of therapeutic efficacy and avoidance of
adverse reactions.
Objectives:
This course aims to introduce students to:
Therapeutic knowledge necessary to manage patients with selected diseases
Appropriate pharmacologic and non-pharmacologic therapies of selected diseases
Relationship between the pathophysiology of selected diseases and the mechanism(s) of
action of drugs used to treat these diseases
Rationale, reasonable and practical solution to drug related problems in patient with
selected diseases
Desired outcomes of pharmacotherapy of selected diseases
A plan for monitoring drug efficacy, adverse effects, compliance, and drug interactions
for patient drug therapy
Learning outcomes:
1. Knowledge
Upon successful completion of this course, students will be able to:
a. Write the therapeutic goals for treatment of patient with (e.g. Endocrine, Neurologic,
Psychiatric, and Reproductive system) disease
b. Discuss the role of non-pharmacological therapies for the treatment of patient with (e.g.
Endocrine, Neurologic, Psychiatric, and Reproductive system) disease
c. Outline the risk factors for each of the following disease; Endocrine, Neurologic,
Psychiatric, and Reproductive system
195
d. Describe the rationale, benefits, and appropriate use of combination drug therapy for
managing (e.g. Endocrine, Neurologic, Psychiatric, and Reproductive system) disease
2. Cognitive Skills
Upon successful completion of this course, students will be able to:
a. Identify the drug therapy problems associated with treatment of patient with (e.g.
Endocrine, Neurologic, Psychiatric, and Reproductive system) disease
b. Recommend the most appropriate drug therapy for patient with (e.g. Endocrine,
Neurologic, Psychiatric, and Reproductive system) disease among different alternative
drug therapy
c. Create a care plan for treatment of patient with (e.g. Endocrine, Neurologic, Psychiatric,
and Reproductive system) disease
Contents:
Endocrinology Pharmacotherapy:
Diabetes mellitus
Thyroid disorders
Neurology Pharmacothempy:
Cerebrovascular diseases
Headache disorders
Parkinson's disease
Epilepsy
Psychiatry Pharmacotherapy:
Mood disorder I: major depressive disorders
Mood disorder II: bipolar affective dls9rders
Anxiety disorders
Schizophrenia
Reproductive Pharmacotherapy:
Premenstrual syndrome
196
Hormone replacement therapy
Contraception
Drugs in pregnancy and lactation
Tutorial (small group discussion) Schedule:
Diabetes mellitus type I
Diabetes mellitus type II
Thyrotoxicosis
Stroke
Migraine and tension headache
Parkinson's disease
Epilepsy
Depression
Bipolar affective disorders
Anxiety disorders
Schizophrenia
Premenstrual syndrome and hormone replacement therapy
197
Course outcomes and Assessment
Course outcome Method of Assessment
1 Outcome 1 W, PB
2 Outcome 2 W, PB
3 Outcome 3 W, PB,
4 Outcome 4 W, PB
W: Written PB: Performance-Based AP: Assignment Project P: Portfolio
Required Textbooks
Mary Anne Koda-Kimble1 Lloyd Yee Young1 Wayne A. Kradjan1 B. Joseph
Guglielmo. Applied Therapeutics. The Clinical Use of Drugs. 10th edition (2013).
Lippincott Williams & Wilkins Publishers.
Joseph T. Dipiro, Robert L. Talbert, Gary C. Yee, Gary R. Matzke1 Barbara G. Wells,
L. Michael Posey. Pharmacotherapy: A Pathophysiologlc Approach. 5th edition (2002).
McGrawHill/Appleton & Lange.
In Schwinghammer, T. L., In Koehler, J. M., In Borchert, J. S., & In Slain, D. (2014).
Pharmacotherapy casebook: A patient-focused approach.
Eric T. Q. Herfindal and Dick R. Gourley ~ditors), Greta K. Gourley (Editor), James M.
Holt (Editors).Textbook of Therapeutics: Drug and Disease Management. 7th edition
(2000).
Casebooks:
Greta K. Gourley, James M. Holt (Editors) Casebook for Textbook of Therapeutics:
Drug and disease management. 7th edition (2000). Lippincott Williams & Wilkins
Publishers.
Terry L. Schwlnghammer1 Joseph Dipiro, Robert Talbert, Gary Yee, Gary Matzke1
Barbara G. Wells, L. Michael Posey (Editors). Pharmacotherapy Casebook. 5th edition
(2002). Mc GrawHilvAppleton& Lange.
Recommended Textbooks and Reference Material
Walker, R., & Edwards, C. (2003). Clinical pharmacy and therapeutics. Edinburgh:
Churchill Livingstone.
Electronic Materials
Online resources available at:
http://www.library.qu.edu.sa/Pages/default.aspx
http://www.pharmacylibrary.com.ezproxy.qu.edu.sa/public/about
http://accesspharmacy.mhmedical.com/ss/About.aspx
http://accesspharmacy.mhmedical.com.ezproxy.qu.edu.sa/ss/About.aspx
http://search.proquest.com/
198
Pharmacoeconomics and Pharmacoepidemiology
Course Name: Pharmacoeconomics and إقتصاديات الدواء واإلحصاء الصيدلي :اسم المقرر
Pharmacoepidemiology
Course Code & No.: PHP 411 مصد411 المقرر رقم
:ورمزه
Credits: 3 (3+0+0) 3(3+0+0) :عدد الساعات
Prerequisite: PHP 343 :المعتمدة
مصد343 المتطلب
:السابق
Level: 9 9 المستوى
Description:
This course is designed to provide a framework for the understanding and application of the
concepts and techniques of pharmacoeconomics and pharmacoepidemology. The course also
emphasizes the importance of utilizing Pharmacoeconomic and Pharmacoepidemiology results
when evaluating drug safety. It also enables students to explore and assess vital topics and trends
regarding spontaneous reporting systems, adverse drug reactions, and post marketing
surveillance (PMS).
Objectives:
This course aims to introduce students to:
Basic concepts and theoretical aspects in pharmacoeconomics and
pharmacoepidemiology
Roles and responsibilities of pharmacoeconomists and pharmacoepidemiologists
Basic requirements and steps needed to conduct a pharmacoeconomic or a
pharmacoepidemiology-related procedures and actions
Common study designs used for pharmacoeconomic and pharmacoepidemiologic
evaluations
Strength and limitations of the study designs used in pharmacoeconomics and
pharmacoepidemiology
Rules and formulae used for pharmacoeconomic and pharmacoepidemiological
calculations
Application of concepts and theories of pharmacoeconomics and pharmacoepidemiology
on some practical scenarios and cases provided as examples
Learning outcomes:
1. Knowledge
a. Upon successful completion of this course, students will be able to:
199
b. Explain the role of outcome research and pharmacoeconomics
c. Describe different types of economic and humanistic evaluations
d. Describe the methods, steps, and techniques used to conduct pharmacoeconomic
evaluations
e. Describe the concept of pharmacoepidemology and its application in pharmacy practice
f. Describe the concept of postmarketing surveillance, their limitations and ethical
considerations
2. Cognitive Skills
Upon successful completion of this course, students will be able to:
a. Evaluate published pharmacoeconomic studies.
b. Apply Pharmacoeconomics concepts to clinical practice
c. Differentiate various types of pharmacoepidemiological methods
d. Apply the concepts of pharmacoepidemology in monitoring, evaluation, and approval
of new drugs
e. Communication, Information Technology, Numerical
f. Upon successful completion of this course, students will be able to:
g. Communicate the risk associated with adverse drug reactions to drug regulatory
authority
h. Conduct pharmacoeconomic research and analyses
Contents:
Pharmacoeconomics
Introduction to pharmacoeconomics
Describe main types of economic evaluation
Cost determination
Evaluating outcomes-effectiveness
Methods of data collection and analysis (decision analysis modeling)
Cost benefit analysis
Cost utility analysis (quality of life)
Pharmacoepidemology
Principles of pharmacoepidemology
Study designs available for pharmacoepidemiology
Meta-analysis of the pharmacoepidemiology literature
Regulatory agencies and pharmacoepidemiology
Safety profiles of new drugs at the time of initial marketing
The spontaneous reporting systems
The drug approval process and the information it provides
200
Drug safety, pharmacoepidemiology and regulatory decision making
Risk analysis and pharmaceuticals
Standards of postmarketting surveillance (PMS)
201
Required Textbooks
Bungay, K, Osterhaus, J, Paladino, J, Sanchez, L. Pharmacoeconomics and Outcomes:
Application for Patient Care. (1997). The American College of Clinical Pharmacy.
F. Randy, Phd Vogenberg, Randy Vogenberg. Introduction to Appiled
Pharmacoeconomics. (2000). McGraw-Hill; 1st. edition.
Brian L. Strom. pharmacoepidemiology. 3rd. edition (2000). John Wiley & Sons.
Casebooks:
Recommended Textbooks and Reference Material
Joyce A. Cramer, Bert, Ph.D. Spilker. Quality of Life and Pharmacoeconomics, An
introduction. 2nd. edition (1998). Lippincott Williams & Wilkins Publishers.
Brenda Waning, Michael Montagne, William W. McCloskey, Rebecca A. Maki.
pharmacoepidemiology: Principles & Practice. (2000). McGraw-Hill/Appleton & Lange
Electronic Materials
Online resources available at:
http://www.library.qu.edu.sa/Pages/default.aspx
http://www.pharmacylibrary.com.ezproxy.qu.edu.sa/public/about
http://accesspharmacy.mhmedical.com/ss/About.aspx
http://accesspharmacy.mhmedical.com.ezproxy.qu.edu.sa/ss/About.aspx
http://search.proquest.com/
202
Pharmacy Management
Description:
This course is designed to introduce the principles of management as they applied to professional
pharmacy practice. The course is intended to provide pharmacy students with a basic
understanding of the practical aspects of managing a pharmacy operation. This Includes the basic
functions of planning, organizing, directing, coordinating, and controlling as they relate to fiscal,
personnel, and merchandize management. In addition, the course will Introduce the student to the
principles and methods of human resources management by teaching topics such as recruitment,
selection, orientation, training, motivation, management by objectives, and performance
evaluation. It will also introduce the student to principles and methods of financial and
operational management such as principles of accounting, financial statements, purchasing, and
inventory control.
Objectives:
Upon successful completion of this course, students will be able to:
Discuss principles of effective management.
Understand the principles of developing a motivating environment and how to deal
effectively with personal conflicts.
Prepare pharmacy budget for the coming financial years.
Understand the principles of using budget in planning, controlling and evaluation of
employee performance.
Discuss the principles and tools that should be followed for effective, practical, accurate
and less time consuming inventory control.
Read both income and financial position statements, and understand their uses in
management.
Discuss various steps and processes required for preparation of financial statements.
Understand the principals of purchasing and how to handle each stage of the various
purchasing functions.
Recognize the meaning and scope of marketing, and at the same time be able to Identify
the marketing variables that would influence product and service decision.
203
Contents:
Management by objectives
Pharmacy manager functions
Planning, organizing, directing, coordinating and controlling
Human resources management:
Recruitments
Orientation and training
Performance evaluation
Employee motivation
Conflict management
Disciplining the employee
Accounting principals
Financial statements
Budgeting
Purchasing functions
Inventory control
Marketing for the pharmacist
Text Book(s):
Effective pharmacy management: A comprehensive presentation of practical
management techniques for pharmacists. Seventh edition. Marion Merrell Inc.
Norman V. Carroll. Financial management for pharmacists: A decision-making approach.
1991. Lea & Febiger.
204
Evidence Based Pharmacy
Course Name: Evidence-Based Pharmacy الصيدلة المبنية على البراهين :اسم المقرر
Course Code & No.: 413 PHP مصد413 رقم المقرر
:ورمزه
Credits:2(1+1+0) 2(1+1+0) عدد الساعات:
Prerequisite:343PHP :المعتمدة
مصد343 المتطلب :
Level:9 :السابق
9 المستوى:
Description:
The course is designed to provide the understanding of the concept and skills required to practice
evidence--based pharmacy (EBP) and pharmacotherapy. Hand-on-experience will include use of
evidence--based databases, critical appraisal and how to calculate and interpret statistical
indicators used in pharmaceutical and medical literature.
Objectives:
This course aims to introduce students to:
Clinical skill necessary to formulate a focused clinical question.
Necessary skills to perform critical appraisal and determine the appropriateness of
various biostatistical analyses.
How to develop a practice guideline for the best use of medicine.
The principle of the evaluation criteria on how to add a new medicine in the hospital drug
formulary
Learning outcomes:
Upon successful completion of this course, students will be able to:
1. Knowledge
a. Recognize the basic concept of evidence-based pharmacy and pharmacotherapy.
b. Recognize how to use evidence-based pharmacy and pharmacotherapy in the activity
of Pharmacy and Therapeutic (P&T) committee
2. Cognitive Skills
a. Explain how to use evidence-based pharmacy and pharmacotherapy data-bases (e.g.
Medline, Cochrane Library, etc.) in searching for the evidence.
b. Develop practice guidelines for drug therapy and rational drug use
3. Interpersonal skills and responsibility
a. Evaluate and rephrase issues arising in patient care as correct clinical questions
(PICO questions)
4. Communication, Information technology and numerical skills
205
a. Demonstrate an effective communication skills with drug representative and other
health professionals to improve the best use of medicine, patient safety and quality of
care.
Contents:
Evidence--based pharmacy: concepts and principles
Evidence--based databases
Asking answerable clinical questions
How to find current best evidence
Evaluating literatures on pharmaceutical products information
How to evaluate pharmaceutical and medical literature on drug therapy
Appraising pharmaceutical and medical literature on medical interventions
Use of Evidence--based pharmacy principles to develop practice guidelines
Evidence-based Pharmacy and Pharmacy and Therapeutic (P&T) committee.
206
Course outcomes and Assessment
Required Textbook
Christine Bond (Editor). Evidence-Based Pharmacy. 1st edition (2000). Pharmaceutical
Press.
David L. Sackett1 Sharon E. Straus, W. Scott Richardson1 William Rosenberg, R. Brian
Haynes, Evidence-Based Medicine: How to Practice and Teach EBM. 2nd edition
(2000). Wolfe Pub Ltd
Recommended Textbook
Martin Dawes (Editor), Alastair M. Gray, Philip T. Davies. Evidence-Based Practice: A
Primer for Health Care Professionals. (December 1999). Churchill Livingstone
Electronic Materials
Online resources available at:
http://www.library.qu.edu.sa/Pages/default.aspx
http://www.pharmacylibrary.com.ezproxy.qu.edu.sa/public/about
http://accesspharmacy.mhmedical.com/ss/About.aspx
http://accesspharmacy.mhmedical.com.ezproxy.qu.edu.sa/ss/About.aspx
http://search.proquest.com/
207
Pharmaceutical care
Description:
To introduce students to the comprehensive process of pharmaceutical care including collection,
organizing, maintaining and evaluation of patient’s specific medical information.Each student
must understand the professional practice of pharmaceutical care and its components, to be able
to identify, resolve or prevent patient drug therapy problems, and to work with the patient and
other healthcare providers to recommend effective solutions for those problems
Objectives:
This course aims to introduce students to:
Knowledge necessary to provide pharmaceutical care to patients
Skills necessary to work in team-based practices
Philosophies that underline pharmaceutical care
The meaning of pharmaceutical care
An overview of patient information assessment
Learning Outcomes
1 Knowledge
a. Upon successful completion of this course, students will be able to:
b. Define pharmaceutical care
c. List the main steps in the pharmaceutical care process and cycle
d. Outline the main components of a pharmaceutical care plan
e. Describe the concept of pharmaceutical car
2. Cognitive Skills
Upon successful completion of this course, students will be able to:
a. Create a pharmaceutical care plan for a given patient case include one or more
medical conditions
b. Prepare the practice site to support pharmaceutical care practice
c. Discuss actual and potential drug therapy problems
208
d. Apply pharmaceutical care to a given patient case
e. Discuss strategies to establish collaborative working relationship with other
healthcare providers
3. Interpersonal Skills & Responsibility
a. Upon successful completion of this course, students will be able to:
b. Evaluate patient specific medical information in a given patient case
c. Communication, Information Technology, Numerical
d. Upon successful completion of this course, students will be able to:
e. Discuss the rationale for the identification and resolution of drug related problems in
a given patient case
Contents:
Practice Skills
The case for pharmaceutical care
Identifying drug therapy problems
Patient data collection
Patient data evaluation
Patient care plan development
Documentation
Drug information skills for pharmaceutical care
Professional Practice Development
Developing collaborative relationships
Pharmaceutical care for patients’ specific disease
Self-care as pharmaceutical care practice
Wellness and health promotion
Practice Site Development
Marketing pharmaceutical care
Reimbursement
Measuring change and outcomes in your practice
Staffing modification for pharmaceutical care
Re-engineering the pharmacy lay out
Obstacles to pharmaceutical care
Creating the infrastructure to pharmaceutical care
Developing a practice implementation plan
209
Teaching/learning methods and Contact Hours
Lecture Tutorial Laboratory Practical Other: Total
Contact 2 - - - 2 hours
Hours
Required Textbooks
John P. Rovers and Jay D. Currie (Editors). A Practical Guide to Pharmaceutical Care,
2rd Edition. 2003
210
Applied Pharmacokinetics
Course Name: Applied Pharmacokinetics حركية الدواء التطبيقية :اسم المقرر
Course Code & No.: PHP 416 مصد416 رقم المقرر
:ورمزه
Credits: 2(2+0+1) 2(2+0+1) عدد الساعات:
Prerequisite: 336 PHT :المعتمدة
صيد336 المتطلب :
Level: 9 :السابق
9 المستوى :
Description:
This course introduces the student to principles of monitoring drug therapy for those involved in
the interpretation of drug levels in a patient care setting. Pharmacokinetics of commonly used
and low-therapeutic-index drugs are emphasized in this course.
Objectives
This course aims to introduce students to:
Concepts of Clinical Pharmacokinetics and Therapeutic Drug Monitoring (TDM)
Learning outcomes:
1. Knowledge
a. Upon successful completion of this course, students will be able to:
b. Recognize the rationality of Therapeutic Drug Monitoring (TDM).
c. Describe the principles of clinical pharmacokinetics & its parameters and TDM.
d. List the types of narrow therapeutic-index drugs.
e. Describe the initial dosage determination methods of narrow therapeutic-index drugs.
2. Cognitive Skills
a. Upon successful completion of this course, students will be able to:
b. Summarize the effects of disease states and conditions on pharmacokinetics and
dosing of narrow therapeutic-index drugs.
c. Evaluate the drug interactions and its effect on pharmacokinetics and dosing of
narrow therapeutic-index drugs.
3. Interpersonal Skills & Responsibility
a. Upon successful completion of this course, students will be able to:
b. Demonstrate ability to work and communicate effectively (Verbal and written) health
care professionals as well as with peers during group discussion and group readiness
assurance test (gRAT).
c. Demonstrate ability to take responsibility towards their learning when preparing to
the Team Based Learning (TBL).
211
d. Use the principles of pharmacokinetics and dosage determination methods in
calculate the dose and optimizing the drug therapy in special situations
Contents:
Therapeutic drug monitoring of clinically used drugs:
Aminoglycosides
Vancomycin
Digoxin
Theophylline
Lidocaine
Procainamide
Quinidine
Phenytoin
Carbamazepine
Valproicadd
Phenobarbital
Cyclosporine
Tacrolimus (FK506)
Lithium
Computer programs in Therapeutic drug monitoring
212
Assessment and grading plan:
Required Textbooks
Larry A. Bauer. Applied Clinical Pharmacokinetics. (2008). McGraw-Hilll/Appleton &
Lange
List Essential References Materials
Clinical Pharmacokinetics Journal
List Recommended Textbooks and Reference Material
Malcolm Rowland, Thomas N. Tozer, Randy Rowland (Editors). Clinical
Phannacokinetics:Concepts and Applications. 3rd edition (1995). Lippincott1 Williams
& Wilkins.
William E. Evans, Jerome J. Schentag, William J. Jusko (Editors). Applied
Phamiacokinetics: Principles of Therapeutic Drug Monitoring. 3rd edition (1992).
Applied Therapeutics.
Michael E. Winter. Basic Clinical Pharmacokinetics. 3rd edition (1994). Applied
Therapeutics.
Joseph T. Dipiro, William J. Spruill, Robert A. Bloum, Jane M. Pruemer, American
Cancer Society, (Joan Heimann editors). Concepts in Clinical Pharmacokinetics. 3rd.
edition (2002). American Hospital Association
Electronic Materials
http://www.library.qu.edu.sa/Pages/default.aspx
http://www.pharmacylibrary.com.ezproxy.qu.edu.sa/public/about
213
Clinical Nutrition and IV Admixture
Course Name: Clinical Nutrition& IV admix. التغذية العالجية والمحاليل الوريدية :إسم المقرر
Course Code & No.: PHP 423 مصد423 رقم المقرر
:ورمزه
Credits: 4 (3+1+1) 4(3+1+1) عدد الساعات:
Prerequisite:135 MATH :المعتمدة
ريض135 المتطلب :
Level:10 :السابق
10 المستوى:
Description:
This course will cover principles of enteral & parenteral nutrition, Intravenous admixture and a
septic technique.
Objectives:
This course aims to introduce students to:
Principles of Enteral, &parenteral nutrition and Intravenous admixture & Aseptic
techniques.
Learning outcomes:
1. Knowledge
Upon successful completion of this course, students will be able to:
a. Describe the different routes and methods of nutrition, the advantages, disadvantages
& limitations of each route.
b. Describe the basic concepts and principles of parenteral nutrition.
c. Describe the principles of aseptic technique, IV admixture and incompatibilities
2. Cognitive Skills
a. Upon successful completion of this course, students will be able to:
b. Justify the nutritional needs for individualized patiens.
c. Explain the rationality of nutritional supplements and its routes.
d. Apply critical thinking to identify and solve the nurtion relate dproblems.
e. Justify the nutritional needs for individualized patiens.
f. Identify and explain the type of supplies and equipments and their proper use for the
preparations of IV admixtures and cytotoxic drugs
g. Demonstrate proper hand washing, gowning and garbing procedures use before
preparation of sterile products
h. Demonstrate working under laminar flow hood to prepare sterile preparations
according to aseptic techniques.
214
i. Describe and analyze physician’s order of total parenteral nutrition and IV
admixtures.
j. Calculate the nutritional requirements according to patients’ need.
215
Assessment and grading plan:
Assessment method Proportion of Total
Assessment
1 Mid-term I exam 15%
2 Mid-term II exam 15%
3 Practical Exam (Mock Pharmacy) 20%
5 Final exam 60%
Required Textbooks
Mary Anne Koda-Kimble1 Lloyd Yee Young1 Wayne A. Kradjan1 B. Joseph Guglielmo.
Applied Therapeutics. The Clinical Use of Drugs. 10th edition (2013). Lippincott
Williams & Wilkins Publishers.
Guidelines for the use of parenteral and enteral nutrition in adults and pediatric patients,
David August et al, 26(1), Jan-Feb 2002.
The Training Module for Intravenous Admixture Personnel (sixth edition) by Max L.
Hunt et al
Essential References Materials (Journals, Reports, etc.)
Casebooks:
Joseph T. Dipiro, Robert L. Talbert, Gary C. Yee, Gary R. Matzke1 Barbara G. Wells, L.
Michael Posey. Pharmacotherapy: A Pathophysiologlc Approach. 5th edition (2002).
McGrawHill/Appleton & Lange.
ADA Pocket Guide to Parenteral Nutrition by Pamela Charney PhD, RD, and Ainsley
Malone MS, RD
Recommended Textbooks and Reference Material (Journals, Reports, etc)
The American Journal of Clinical Nutrition.
Clinical Nutrition Journal.
Electronic Materials (eg. Web Sites, Social Media, Blackboard, etc.)
http://www.library.qu.edu.sa/Pages/default.aspx
http://www.pharmacylibrary.com.ezproxy.qu.edu.sa/public/about
216
Pharmacy Law
Course Name: Pharmacy Law نظام الصيدلة إسم المقرر:
Course Code & No.: 426 PHP 426مصد رقم المقرر
ورمزه:
)Credits:1(1+0+0 :عدد الساعات )1(1+0+0
Prerequisite:None المعتمدة:
المتطلب بدون :
Level:10 السابق:
:المستوى 10
Description:
The course deals with the materials of the pharmacy law, which deals with the regulations of
pharmacy practice and trading in medicinal and pharmaceutical products issued by the Council
of Ministers letter number 335 and dated 7/3/1398 H and Its various explanations. The course is
one hour, delivered by lecture through which the followings will be discussed: pharmacy practice
including registration of pharmacists and their assistants, pharmacies, wholesale drug distribution
warehouses, pharmaceutical companies and industries, medicines registration, pharmaceutical
companies registration and their scientific offices, transitional provisional rules, penalties, and
regulations of poisons, narcotics, and psychiatric medications under control.
Objectives:
Upon successful completion of this course, students will be able to:
معرفة النظم واللوائح والقواعد المنظمة لمزاولة مهنة الصيدلة واالتجار باألدوية تمهيدا لتطبيقها أثناء ممارسة الصيدلة .
إدراك أهمية بتطبيق مواد ولوائح وقواعد هذا النظام وتأثيره على مزاولة مهنة الصيدلة .
إظهار وإبراز أخالقيات مهنة الصيدلة من خالل بنود مواد ولوائح هذا النظام
Contents:
أوال :مواد النظام :
فيه يتم التعرض للمواد التي تنظم الجوانب التالية :مزاولة المهنة ــ الصيدليات ــ مستودعات بيع األدوية بالجملة ــ مصانع
المستحضرات الصيدلية ــ تسجيل األدوية ــ األحكام االنتقالية لتطبيق هذا النظام ــ العقوبات التي تترتب على اإلخالل بمواد
ولوائح النظام .
ثانيا :اللوائح المفسرة لهذا النظام وتتكون من األتي :
الباب األول :مزاولة مهنة الصيدلة والشروط واإلجراءات الواجب إتباعها وتوفرها .
217
الهيئة السعودية للتخصصات الصحية وتسجيل الصيادلة .
الئحة مصانع األدوية والمستحضرات الطبية والشروط الواجب توفرها في المصنع .
الئحة المكاتب العلمية لشركات ومصانع األدوية وتضم الشروط الواجب توفرها في المكاتب العلمية والتعريف بمهام المكتب
العلمي ورئيسه .
الئحة تسجيل شركات األدوية ومنتجاتها وتضم لجنة تسجيل األدوية ــ شروط تسجيل الشركات وفروعها ــ شروط تسجيل
المستحضرات وتسعيرتها ــ األحكام العامة والخاصة ــ تعليمات متطلبات التسجيل .
الئحة السموم والعقاقير المخدرة ــ واألدوية النفسية الخاضعة للرقابة .
القواعد المنظمة لألدوية التي يتم صرفها بدون وصفة طبية .
قواعد وإجراءات األدوية المخدرة :وتظم ما يلي :تحديد االحتياج السنوي ــ عهدة األدوية المخدرة ــ إجراءات صرف وقيد
األدوية المخدرة ــ األصناف الراكدة والتالفة ــ فقد أو نقص أصناف األدوية المخدرة ــ األصناف الراكدة والتالفة ــ فقد أو نقص
أصناف األدوية المخدرة ــ متابعة ومراقبة المخزون .
Evaluation methods:
) 40-(2 Midterm exams
60-Final Exam
Text Book(s):
نظام مزاولة المهن الصحية ،وزارة الصحة
نظام المنشآت الصيدلية ،وزارة الصحة
218
Scientific Writing and Seminar-II
Course Name: Scientific Writing and Seminar-II 2-الكتابة العلمية وحلقة نقاش :إسم المقرر
Course Code & No.: 421 PHP مصد421 رقم المقرر
:ورمزه
Credits:2(1+1+0) 2(1+1+0) عدد الساعات:
Prerequisite:325PHP :المعتمدة
مصد325 المتطلب :
Level:10 :السابق
10 المستوى:
Description:
This course is designed to provide the student with an overview of the current conventions and
practices used in scientific and technical writing in the field of pharmacy and other health-related
disciplines. This course is considered as an intensive introduction on how to prepare, write, edit
and review pharmacy research communications, pharmacy reports, and patient education
materials. The student will also learn how to present and convey his ideas with conviction, poise
and style. A limited questionnaire-type field research project will be conducted by students as a
part of the course requirements. Students will apply their acquired knowledge in coding,
recoding and analyzing collected data to formulate, write, and present the results.
Objectives:
This course aims to introduce students to:
Effective writing skills in scientific materials related to pharmacy and other health-related
disciplines.
Skills on presentation and the use of audiovisual media to enhance presentation.
Research-writing steps and get an opportunity to analyze and present results by providing
a practical hand-on experience in conducting small research projects.
Learning Outcomes:
Upon successful completion of this course, students will be able to:
Reproduce the knowledge as to how to write scientific publications and report using an
effective and scientific writing style.
Develop scientific knowledge and skills to collect scientific data in a research project and
to analyse and interpret the data.
Demonstrate effective presentation skills by presenting the report of their research
projects.
Course Contents:
Types of research manuscripts: original research articles, review articles, editorials, case
reports, short communications, and letters to editor.
219
Vancouver style of writing research papers (The unified requirements for biomedical
research articles).
Structure of a scientific paper.
Developing an effective writing style.
Language and sentence construction (choice of words, passive/active tense, punctuation,
grammar).
Paragraph construction (different types of arguments)
Plagiarism.
Successful report writing.
Types of oral presentations: persuasive.
Oral presentations: the difference between oral and written presentations, preparation,
technique, and common problems.
Scientific conventions (taxonomy, measures, numbers, units, abbreviations, acronyms,
symbols)
Oral presentation skills.
Lab Sessions:
The course will emphasize on practical exercises to practice the ideas and methods. The
student will work on his/her own material and the group work will concentrate on one
case study selected from the group.
A research project in questionnaire format to be conducted by the students in this course.
Each student is required to distribute the questionnaire, collect and analyze the data using
the appropriate software program (SPSS) and write a report. The students will also
prepare professional slides to present their results independently. Several suggested
topics dealing with one of the following research titles, as an example, can be offered:
Job satisfaction for pharmacists.
Patients' attitude toward hospital pharmacy services.
The effect of patient counseling on patient compliance.
Community pharmacy services.
Patient education in various disease areas.
Preparation of patient education materials in both Arabic and English.
Preparation of drug Package Inserts about selected drugs.
Promotional drug presentations.
220
Teaching/learning methods and Contact Hours
Lecture Tutorial Laboratory Practical Other: Total
Contact 15 - - - 30 45 hours
Hours
221
Text Book(s):
Matthews JR, Bowen JM, Matthews RW. Successful Scientific Writing: A Step-by-step
Guide for the Biological & Medical Sciences. 2000. CambridgeUniversity Press. ISBN:
0521789621.
Bell J. Doing Your Research Project: A Guide for First time Researchers in Education and
Social Science. 1987. Open University Press. ISBN: 0335159877.
Bell L. Doing Your Research Project: & Good Research Guide. 2003. Open University
Press. ISBN: 0335215335
Letendre. Fundamentals of Writing for the Biomedical Sciences. 1991.
MichiganStateUniversity Press. ISBN: 0888647697.
Casebooks:
None
Recommended Textbooks and Reference Materials:
Day RA. How to Write & Publish a Scientific Paper. 1998. Greenwood Press,
ISBN:1573561657.
BraceI. Questionnaire Design. 2004. Kogan Page, ISBN: 074944181X.
Zeiger M. Essentials of writing biomedical research papers. 2nd ed. 2000. McGraw-Hill.
Pechenik JA. A short guide to writing about biology. 3rd ed. 1997. Longman.
Iverson C, Dan BB, Glitman P et al. American Medical Association manual of style. 8th
ed. 1989. Chicago: American Medical Association;
Electronic Materials
Online resources available at:
http://www.library.qu.edu.sa/Pages/default.aspx
http://www.pharmacylibrary.com.ezproxy.qu.edu.sa/public/about
http://accesspharmacy.mhmedical.com/ss/About.aspx
http://accesspharmacy.mhmedical.com.ezproxy.qu.edu.sa/ss/About.aspx
http://search.proquest.com/
222
Drugs of Abuse
Course Name: Drugs of Abuse األدوية المدمنة :اسم المقرر
Course Code & No.: 424 PHG دوي424 رقم المقرر
:ورمزه
Credits:2(2+0+0) 2(2+0+0) عدد الساعات:
Prerequisite:334PHG :المعتمدة
دوي334 المتطلب :
Level:10 :السابق:
10 المستوى
Description:
This course is intended to provide the student with knowledge regarding the different cases of
drugs of abuse, whether they are used by legal or illegal methods. The major part of the course
will be directed for discussion of the pharmacological action, mechanisms and adverse reactions
of the drugs of abuse. Furthermore, the discussions will include the various methods available for
treatment of addiction and prevention of precipitation of the withdrawal symptoms.
Objectives:
This course aims to introduce students to:
General principle of drugs of abuse.
Pharmacology of drugs of abuse.
Management of various types of the abused drugs.
Learning outcomes:
1. Knowledge
Upon successful completion of this course, students will be able to:
a. List and define various medical terms in the field of drugs of abuse such as addiction,
tolerance, dependence and abstinence syndrome.
b. Discuss the different types of tolerance and dependence.
c. State the various types of the abused drugs and their alternative names used in different
countries.
d. Summarize the factors that predispose to the abuse of drugs.
e. Explain the different scientific strategies that can be followed for prophylactic youth from
indulging in the habit of drug abuse.
f. Discuss the various pharmacological actions of the abused drugs, their mechanisms of
action and adverse reactions.
2. Cognitive Skills
Upon successful completion of this course, students will be able to:
a. Differentiate between different types of tolerance and dependence.
223
b. Compare between pharmacological actions of the various drugs of abuse.
c. Distinguish between withdrawal symptoms of the various drugs of abuse.
d. Choose the available and appropriate therapeutic regimen for treatment of addicts.
3. Interpersonal Skills & Responsibility
a. Upon successful completion of this course, students will be able to:
b. Pay attention to narcotic schedule
c. Recommend the appropriate treatment for drug dependence.
d. Communication, Information Technology, Numerical
e. Upon successful completion of this course, students will be able to:
f. Formulate a plan for prevention of youth from indulging in the habit of drug abuse.
Contents:
Definition of the terms: abused drugs, habituation1 tolerance, dependence, addiction and
abstinence syndrome.
Types of tolerance and dependence.
Factors that predispose for drug abuse.
Scientific strategies to prevent youth from indulging in the habit of drug abuse.
The discussion of the pharmacological actions, mechanisms, adverse reactions and types
of tolerances and dependence that accompany the abuse of the following drugs:
Alcohols
Tobacco
Cocaine
Khat
Amphetamines
Opioids e.g. Heroin
Cannabis (hashish - Marijuana)
Benzodiazepines
Barbiturates
The Hallucinogens: LSD, Psilocybin, Psilocin, mescaline, Phencyclidine
Inhalants: Benzene, toluene, gasoline
Treatment of withdrawal symptoms and addiction
224
The following teaching strategies are used:
Lectures
Scientific discussions
Case presentations
Required Textbooks
American Psychiatric Association. (2013). Diagnostic and statistical manual of mental
disorders: DSM-5. Washington, D.C: American Psychiatric Association.
Brunton L L, Blumenthal D K, Murri N, Dandan R H, Knollmann B C. Goodman &
Gilman's The Pharmacological Basis of Therapeutics. 12th ed. New York: McGraw-Hill,
2011
Tasman A, Kay J, Lieberman JA, First MB, Maj M. Psychiatry, 3rd ed. USA. John Wiley
& Sons, Ltd, 2008.
Case books
Recommended Textbooks and references Materials
El-Tahir, Kamal E.H. Narcotics and Mind Manifesting Drugs. 2002. Dar AI-Iloom,
225
Riyadh, Saudi Arabia.
Hogan, J.A., Gabrielsen, K. and Luna, N. Substance Abuse Prevention: The Intersection
of Science and Practice. 2002. Barnes and Noble
Keltner, N.L. and Folkds, D.G. Psychotropic Drugs. 2001. Barnes and Noble.
Journal of Addiction
Journal of psychopharmacology
Electronic Materials
Online resources available at:
http://www.library.qu.edu.sa/Pages/default.aspx
http://www.pharmacylibrary.com.ezproxy.qu.edu.sa/public/about
http://accesspharmacy.mhmedical.com/ss/About.aspx
http://accesspharmacy.mhmedical.com.ezproxy.qu.edu.sa/ss/About.aspx
http://search.proquest.com/
226
Pharmacotherapy-lV
Description:
The purpose of this course is to integrate the pathophysiologic abnormalities of disease states
(Oncology, Hematology, Dermatology, Transplantation, ID,and Pediatrics)with concepts of drug
action and therapy. State-of-the-art pharmacotherapy will be reviewed with pertinent
pathophysiology and pharmacology. Emphasis will be placed on drug selection, dosing regimen
design, and therapeutic drug monitoring to assess the attainment of therapeutic efficacy and
avoidance of adverse reactions.
Objectives
This course aims to introduce students to:
Necessary therapeutic knowledge to manage patients with selected diseases based on
evidence based medicine.
Llearning outcomes:
1. Knowledge
Upon successful completion of this course, students will be able to:
a. Describe the goals of treatment for diseases included in the course (eg: Anemia,
sepsis, leukemia....etc).
b. Write the given clinical case of diseases included in the course in SOAP (Subjective,
Objective, Assessment and Plan) and FARM (Findings, Assessment,
Recommendations, and Monitoring) Format.
2. Cognitive Skills
a. Upon successful completion of this course, students will be able to:
b. Select and recommend appropriate patient treatment plans for diseases included in the
course based on evidence based medicine.
c. Explain the rationale for the proposed treatment of diseases included in the course
(eg: Anemia, sepsis, leukemia....etc).
d. Evaluate the appropriateness of patient specific drug therapy regimen and treatment
plans.
227
e. Apply critical thinking to identify and solve the Drug Related Problems (DRPs) as
well as prevent the actual DRPs.
Contents:
Anemia.
Sepsis
Leukemia
Pediatric Pharmacotherapy.
Dermatologic Disorders.
Transplantation pharmacotherapy
Solid tumors
OPHThalmology pharmacotherapy
Pain and it’s Management
HIV.
ENT
Tutorial (small group discussion) Schedule:
Anemia.
Sepsis
Leukemia
Pediatric Pharmacotherapy.
Dermatologic Disorders.
Transplantation pharmacotherapy
Solid tumors
OPHThalmology pharmacotherapy
228
Pain and it’s Management
HIV.
ENT
Learning Resources
Required Textbooks
Mary Anne Koda-Kimble1 Lloyd Yee Young1 Wayne A. Kradjan1 B. Joseph Guglielmo.
Applied Therapeutics. The Clinical Use of Drugs. 10th edition (2013). Lippincott
229
Williams & Wilkins Publishers.
Joseph T. Dipiro, Robert L. Talbert, Gary C. Yee, Gary R. Matzke1 Barbara G. Wells, L.
Michael Posey. Pharmacotherapy: A Pathophysiologlc Approach. 5th edition (2002).
McGrawHill/Appleton & Lange
In Schwinghammer, T. L., In Koehler, J. M., In Borchert, J. S., & In Slain, D.
(2014).Pharmacotherapy casebook: A patient-focused approach.
Eric T. Q. Herfindal and Dick R. Gourley ~ditors), Greta K. Gourley (Editor), James M.
Holt (Editors).Textbook of Therapeutics: Drug and Disease Management. 7th edition
(2000).
Essential References Materials (Journals, Reports, etc.)
Casebooks:
Greta K. Gourley, James M. Holt (Editors) Casebook for Textbook of Therapeutics: Drug
and disease management. 7th edition (2000). Lippincott Williams & Wilkins Publishers.
Terry L. Schwlnghammer1 Joseph Dipiro, Robert Talbert, Gary Yee, Gary Matzke1
Barbara G. Wells, L. Michael Posey (Editors). Pharmacotherapy Casebook. 5th edition
(2002). McGrawHilvAppleton & Lange.
Recommended Textbooks and Reference Material (Journals, Reports, etc)
Walker, R., & Edwards, C. (2003). Clinical pharmacy and therapeutics. Edinburgh:
Churchill Livingstone.
Electronic Materials (eg. Web Sites, Social Media, Blackboard, etc.)
http://www.library.qu.edu.sa/Pages/default.aspx
http://www.pharmacylibrary.com.ezproxy.qu.edu.sa/public/about
230
Graduation Project
Course Name: Graduation Project مشروع تخرج :إسم المقرر
Course Code & No.: 425 PHP مصد425 رقم المقرر
:ورمزه
Credits:2(1+1+0) 2(1+1+0) عدد الساعات:
Prerequisite:343PHP :المعتمدة
مصد343 المتطلب :
:السابق
Description:
Topics will include research design, data collection, analysis, and interpretation and
formulation of research results and describe their process in oral session presentation.
Objectives:
The course aims to:
Provide an opportunity for students to work on projects of variable scope.
Introduce students to the method used to conduct research and to provide them
with the opportunity to give a formal presentation on the final project report.
Learning Outcomes:
Upon successful completion of this course students will be able to:
Reproduce the knowledge as to how to write Research Proposals and Report.
Develop scientific knowledge and skills to collect scientific data in their research project
and to analyse and interpret the data
Develop qualities of team player and learning from others while working in a research
project as a team.
Demonstrate effective presentation skills by presenting the report of their research
projects in front of fellow students and faculty members.
Perform effective psychomotor skills in laboratory and technical tasks during the
execution of their research projects.
Contents:
Meetings with advisor to select projects
Research planning
Research conduction
Project presentation
Project report
231
Teaching/learning methods and Contact Hours
Lecture Tutorial Laboratory Practical Other: Total
Contact 5 - 30 - 10 45 hours
Hours
232
Required Textbooks
NONE
Casebooks:
None
Recommended Textbooks and Reference Material
Pub Med
Electronic Materials
Online resources available at:
http://www.library.qu.edu.sa/Pages/default.aspx
http://www.pharmacylibrary.com.ezproxy.qu.edu.sa/public/about
http://accesspharmacy.mhmedical.com/ss/About.aspx
http://accesspharmacy.mhmedical.com.ezproxy.qu.edu.sa/ss/About.aspx
http://search.proquest.com/
233
Distribution of learning outcomes in each course
Pharmacy Practice
Course Name Knowledge Cognitive Interpersonal Communication, Psychomotor Total
and Code Skills skills & Information (in
Responsibility Technology & %)
Numerical
Applied 50 30 10 10 100
Pharmacokinetics
PHP 416
Biostatistics 50 25 25 100
PHP 121
Clinical 60 10 10 20 100
Communication
Skills PHP 342
Medical 60 40 100
Terminology
PHP 102
234
Patient Assessment 50 30 5 15 100
& First Aid
PHP 346
Pathophysiology-I 70 30 100
PHP 310
Pathophysiology-II 70 30 100
PHP 322
Pharmacoeconomics 50 20 15 15 100
& Epidemiology
PHP 411
Pharmacotherapy-I 50 30 10 10 100
PHP 330
Pharmacotherapy II 50 30 10 10 100
PHP 340
Pharmacotherapy 50 30 10 10 100
III
PHP 410
Pharmacotherapy- 50 30 10 10 100
IV
PHP 420
Pharmacy Law 90 10 100
PHP 426
Pharmacy 55 20 15 10 100
Management
PHP 412
Pharmacy Practice 70 10 10 10 100
PHP 217
Psychology & 40 40 10 10 100
Health
PHP 414
Scientific Writing & 20 20 60 100
Seminar-I
PHP 325
Scientific Writing & 20 20 60 100
Seminar-II
PHP 421
235
Pharmacology and Toxicology
Course Name Knowledge Cognitive Interpersonal Communication, Psychomotor Total
and Code Skills skills & Information (in%)
Responsibility Technology &
Numerical
Biochemistry-I 60 40 100
PHG 210
Biochemistry-II 45 40 15 100
PHG 220
Chemotherapy 60 40 100
PHG 315
General 70 30 100
Immunology
PHG 218
Molecular 70 30 100
Pharmacology
PHG 225
Pharmacogenomics 20 70 10 100
PHG 338
Pharmacology-I 40 40 5 5 10 100
PHG 224
236
Pharmacology-II 40 40 5 5 10 100
PHG 314
Pharmacology-III 30 30 10 10 20 100
PHG 324
Pharmacology-IV 50 50 100
PHG 334
Physiology I 60 20 10 10 100
PHG 211
Physiology II 70 30 100
PHG 222
Toxicology 60 35 5 100
PHG 333
Medicinal 60 20 5 15 100
Chemistry-II
PHC 315
237
Medicinal 60 20 5 15 100
Chemistry-III
PHC 320
Organic 80 20 100
Chemistry
PHC 103
Pharm. 60 20 5 15 100
Analytical
Chemistry
PHC 124
Phamacognosy 60 20 10 5 5 100
PHC 215
Pharmacopeal 60 20 20 100
Analysis
PHC 327
Radiopharmacy 70 20 10 100
PHC 332
Pharmaceutics
Course Name Knowledge Cognitive Interpersonal Communication, Psychomotor Total
and Code Skills skills & Information (in%)
Responsibility Technology
&Numerical
Pharmaceutical 30 40 15 15 100
Biotechnology
PHT 335
Pharmaceutical 20 40 10 10 20 100
Microbiology
PHT 123
Pharmaceutics-I 40 20 20 20 100
PHT 212
238
Pharmaceutics-II 40 40 20 100
PHT 223
Pharmaceutics-III 40 40 20 100
PHT 323
Basic 30 20 10 20 20
Pharmacokinetics
PHT 336
Dispensing of 60 10 10 10 10 100
Medication
PHT 337
Biopharmaceutics 30 20 10 20 20 100
PHT 345
239
List of courses, course coordinators and teaching faculty
First Year - First Semester
Teaching
Course Code Name of the Course Course Coordinator
Instructors
Dr. Salman Afroze Azmi Dr. Salman Afroze
102 PHP Medical Terminology
Mohammed Azmi Mohammed
Dr. Salman Afroze Azmi Dr. Salman Afroze
106BIOL Human Biology
Mohammed Azmi Mohammed
103PHC Organic Chemistry Dr. Salah Alnaeem Dr. Salah Alnaeem
Human Anatomy and
111ANAT Ahmed alkasaby Ahmed alkasaby
Histology
240
Sciences Saleem Saleem
Dr. Salman Afroze
Azmi Mohammed
Dr. Hamid Mustafa
217PHP Pharmacy Practice Dr. Hamid Mustafa
Dr. Nahid Eisa
Dr. Salah Abdalla Dr. Salah Abdalla
218PHG General Immunology
Dr. Sarah Ali
241
Dr. Syed Emam Rabbani
315PHG Chemotherapy Dr. Syed Emam Rabbani
Dr. Azza El Sherbini
Natural Products Dr. Mohsen Al Omar
316PHC Dr. Mohsen Al Omar
Chemistry Dr. Nadia Hashish
242
336PHT Basic Pharmacokinetics Dr. HamzahMaswadeh Dr. HamzahMaswadeh
Dr. Ahmer Mirza
337PHT Dispensing of Medication Dr. Ahmer Mirza
Dr. Salwa Salim
332PHC Radiopharmacy Dr. Riaz Khan Dr. Riaz Khan
338PHG Pharmacogenomics Dr. Arif Khan Dr. Arif Khan
243
Hassan Hassan
Dr. Nuha Awwad
Dr. Rami Faraj
414PHP Pharmaceutical care Dr. Rami Faraj
Dr. Nuha Awwad
Dr. Mustafa Saleh
416PHP Applied Pharmacokinetics Dr. Mustafa Saleh Dr. Salwa
Abougalambou
244
Mapping of the courses in the curriculum to the expected competencies for graduates of the
program
Pharmacy Practice
No. CODE COURSE NAME Professional Competencies
Patient System Public
Care Management Health
1 PHP 102 Medical Tterminology √
2 PHP 120 Introduction to Pharmacy Profession √ √
3 PHP 121 Biostatistics √ √ √
4 PHP 216 Computer for Health Sciences √ √ √
5 PHP 217 Pharmacy Practice √ √
6 PHP 310 Pathophysiology-1 √ √
7 PHP 322 Pathophysiology-2 √ √
8 PHP 325 Scientific Writing & Seminar-1 √
9 PHP 330 Pharmacotherapy-1 √ √
10 PHP 342 Clinical Communication Skills √ √ √
11 PHP 341 Ethics in Pharmacy √
12 PHP 340 Pharmacotherapy-2 √ √
13 PHP 343 Drug and Poison information services √ √ √
14 PHP 346 Patient Assessment & First Aid √
15 PHP 410 Pharmacotherapy-3 √ √
16 PHP 411 Pharmacoeconomics & Epidemiology √ √ √
17 PHP 412 Pharmacy Management √
18 PHP 413 Evidence Based Pharmacy √ √
19 PHP 414 Pharmaceutical Care √ √ √
20 PHP 416 Applied Pharmacokinetics √ √
21 PHP 423 Clinical Nutrition & IV. Administration √
22 PHP 426 Pharmacy Law √
23 PHP 421 Scientific Writing & Seminar-2 √
24 PHP 420 Pharmacotherapy-4 √ √
25 PHP 425 Graduation Project √
245
Pharmacology & Toxicology
No. CODE COURSE NAME Professional Competencies
Patient System Public
Care Management Health
1 ANAT Human Anatomy and Histology √
111
2 BIOL 106 Human Biology √
3 PHG 210 Biochemistry-1 √ √
4 PHG 211 Physiology-1 √
5 PHG 218 General Immunology √
6 PHG 220 Biochemistry-2 √
7 PHG 222 Physiology-2 √
8 PHG 224 Pharmacology-1 √ √
9 PHG 225 Molecular Pharmacology √
10 PHG 314 Pharmacology-2 √ √
11 PHG 315 Chemotherapy √ √
12 PHG 324 Pharmacology-3 √ √
13 PHG 333 Toxicology √ √
14 PHG 334 Pharmacology-4 √ √
15 PHG 338 Pharmacogenomics √
16 PHG 424 Drug of Abuse √ √
246
6 PHC 315 Medicinal Chemistry-2 √
7 PHC 316 Natural Products Chemistry √ √ √
8 PHC 327 Pharmacopeial Analysis √
9 PHC 320 Medicinal Chemistry-3 √
10 PHC 332 Radiopharmacy √ √
Pharmaceutics
No. CODE COURSE NAME Professional Competencies
Patient System Public
Care Management Health
1 PHT 123 Pharmaceutical Microbiology √ √
2 PHT 212 Pharmaceuitics-1 √ √
3 PHT 223 Pharmaceuitics-2 √ √
4 PHT 323 Pharmaceuitics-3 √ √
5 PHT 335 Pharmaceutical Biotechnology √ √
6 PHT 336 Basic Pharmacokinetics √ √
7 PHT 337 Dispensing of Medication √ √ √
8 PHT 344 Over the Counter Drugs √ √
9 PHT 345 Biopharmaceutics √
Course a b c d a b c a b a b c a
1 PHP 102
2 PHP 120
3 PHP 121
4 PHP 216
5 PHP 217
6 PHP 310
7 PHP 322
247
8 PHP 325
9 PHP 330
10 PHP 342
11 PHP 341
12 PHP 340
13 PHP 343
14 PHP 346
15 PHP 410
16 PHP 411
17 PHP 412
18 PHP 413
19 PHP 414
20 PHP 416
21 PHP 423
22 PHP 426
23 PHP 421
24 PHP 420
25 PHP 425
26 PHT 337
27 PHT 344
28 ANAT 111
29 BIOL 106
30 PHG 210
31 PHG 211
32 PHG 218
33 PHG 220
34 PHG 222
35 PHG 224
36 PHG 225
37 PHG 314
38 PHG 315
39 PHG 324
40 PHG 333
41 PHG 334
42 PHG 338
43 PHG 424
44 PHC 103
248
45 PHC 122
46 PHC 124
47 PHC 215
48 PHC 225
49 PHC 315
50 PHC 316
51 PHC 327
52 PHC 320
53 PHC 332
54 PHT 123
55 PHT 212
56 PHT 223
57 PHT 323
58 PHT 335
59 PHT 336
60 PHT 345
249
Relationship between program courses, goals, objectives and assessment tools of Pharm D
program
250
218
PHG ✓ ✓ ✓ ✓ ✓ 1, 2, 5, 7
220
PHG ✓ ✓ ✓ ✓ ✓ ✓ ✓ 1,2,5
222
PHC ✓ ✓ ✓ ✓ ✓ 1, 2, 5, 7
225
PHG ✓ ✓ ✓ ✓ ✓ ✓ ✓ ✓ ✓ 1,2,5,7
224
PHG ✓ ✓ ✓ ✓ ✓ ✓ ✓ 1,2,5
225
PHT ✓ ✓ ✓ ✓ ✓ ✓ ✓ ✓ 1,2,5
223
PHC ✓ ✓ ✓ ✓ ✓ 1, 2, 5, 7
315
PHP ✓ ✓ ✓ 1,2,5
310
PHG ✓ ✓ ✓ ✓ ✓ ✓ ✓ ✓ ✓ ✓ 1,2,5,7
314
PHG ✓ ✓ ✓ ✓ ✓ ✓ ✓ ✓ 1,2,5
315
PHC ✓ ✓ ✓ ✓ ✓ 1, 2, 5, 7
316
PHC ✓ ✓ ✓ ✓ ✓ 1, 2, 5, 7
327
PHC ✓ ✓ ✓ ✓ ✓ 1, 2, 5, 7
320
PHP ✓ ✓ ✓ 1,2,5
322
PHT ✓ ✓ ✓ ✓ ✓ ✓ ✓ ✓ 1,2,5
323
PHG ✓ ✓ ✓ ✓ ✓ ✓ ✓ ✓ ✓ ✓ 1,2,5,7
324
PHP ✓ ✓ ✓ ✓ ✓ ✓ ✓ ✓ ✓ 1,2,4,5
325
PHP ✓ ✓ ✓ ✓ ✓ ✓ ✓ ✓ ✓ ✓ 1,2,6,8,9
330
PHG ✓ ✓ ✓ ✓ ✓ ✓ ✓ ✓ 1,2,5
251
334
PHG ✓ ✓ ✓ ✓ ✓ ✓ ✓ ✓ 1,2,5
333
PHT ✓ ✓ ✓ ✓ ✓ ✓ ✓ ✓ 1,2,5
335
PHT ✓ ✓ ✓ ✓ ✓ ✓ ✓ ✓ 1,2,5
336
PHT ✓ ✓ ✓ ✓ ✓ ✓ ✓ ✓ 1,2,4,6
337
PHC ✓ ✓ ✓ ✓ ✓ 1, 2, 5, 7
332
PHG ✓ ✓ ✓ ✓ ✓ 1,2,5
338
PHT ✓ ✓ ✓ ✓ ✓ ✓ ✓ ✓ 1,2,5
345
PHP ✓ ✓ 1,2,5
342
PHP ✓ ✓ 1,2,5
341
PHP ✓ ✓ ✓ ✓ ✓ ✓ ✓ ✓ ✓ ✓ 1,2,6,8,9
340
PHP ✓ ✓ ✓ 1,2,7
343
PHT ✓ ✓ ✓ ✓ ✓ ✓ 1,2,7
344
PHP ✓ ✓ ✓ ✓ ✓ ✓ 1,2,6,9
346
PHP ✓ ✓ ✓ ✓ ✓ ✓ ✓ ✓ ✓ ✓ 1,2,6,8,9
410
PHP ✓ ✓ 1,2,7
411
PHP ✓ ✓ ✓ 1,2,5
412
PHP ✓ ✓ ✓ ✓ ✓ ✓ 1,2,5
413
PHP ✓ ✓ ✓ ✓ ✓ ✓ ✓ ✓ 1,2,5
414
PHP ✓ ✓ ✓ ✓ ✓ ✓ ✓ ✓ 1,2,8
252
416
PHP ✓ ✓ ✓ ✓ ✓ ✓ ✓ ✓ 1,2,5
423
PHP ✓ ✓ 1,2
426
PHP ✓ ✓ 1,2,7
421
PHG ✓ ✓ ✓ ✓ ✓ ✓ ✓ ✓ 1,2,5
424
PHP ✓ ✓ ✓ ✓ ✓ ✓ ✓ ✓ ✓ ✓ 1,2,6,8,9
420
PHP ✓ ✓ 5,6
425
253
Program Learning Outcome Mapping Matrix
The table below indicate the courses and levels that are required for each:
I = Introduction P = Proficient A = Advanced
PHARMACY PRACTICE
Courses Names Course Knowledge Cognitive Interpersonal Communication, Psychomotor
Code Skills Skills & Information
Responsibility Technology,
Numerical
Medical terminology 102PHP I I
Introduction to 120PHP I I I I
Pharmacy Profession
Biostatistics 121PHP I I I
Computer for Health 216PHP I I
Sciences
Pharmacy Practice 217PHP P P P P
Pathophysiology-1 310PHP P I
Pathophysiology-2 322PHP P I
Scientific Writing & 325PHP I P P
Seminar-1
Pharmacotherapy-1 330PHP A P P P
Clinical 342PHP P P P P
Communication
Skills
Ethics in Pharmacy 341PHP P P
Pharmacotherapy-2 340PHP A P P P
Drug and Poison 343PHP P P P P
information services
& Literature
Evaluation
Patient Assessment & 346PHP P P P P
First Aid
Pharmacotherapy-3 410PHP A A A A
Pharmacoeconomics 411PHP P P P
& Epidemiology
Pharmacy 412PHP P P A A
Management
Evidence Based 413PHP A P P P
Pharmacy
Psychology and 414PHP A P P P
Health
Applied 416PHP A A A A
Pharmacokinetics
Clinical Nutrition & 423PHP A A A A
254
IV. Adm
Pharmacy Law 426PHP A I
Scientific Writing 421PHP A A
&Seminar-2
Pharmacotherapy-4 420PHP A A A A
Graduation Project 425PHP A A A
255
Chemistry
Pharmacopeial Analysi 327PHC I A P
s
Medicinal Chemistry-3 320PHC A A P A
Radiopharmacy 332PHC A A P
PHARMACEUTICS
Courses Names Course Code Knowledge Cognitive Interpersonal Communication, Psychomotor
Skills Skills & Information
Responsibility Technology,
Numerical
Pharmaceutical 123PHT I I I I P
Microbiology
Pharmaceuitics-1 212PHT I I I P
Pharmaceuitics-2 223PHT I I P
Pharmaceuitics-3 323PHT I I P
Pharmaceutical 335PHT A P P P
Biotechnology
Basic 336PHT I A A A P
Pharmacokinetics
Dispensing of 337PHT P A P A A
Medication
Over the Counter 344PHT A P A A
Drugs
Biopharmaceutics 345PHT I A A A P
256