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19F + recent travel through southern US + stayed at dodgy AF motel on the side of the highway next

to a Denny’s and a Sonic + itchy lesions on arm as shown in image below; Q asks for organism:

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o Answer on NBME = bed bugs; caused by an insect called Cimex.


- 6M + family recently immigrated to US from Albania + diffuse maculopapular rash + photograph of

buccal mucosa is shown below; Dx + Tx?

o Dx = measles (rubeola); Tx is supportive; image shows Koplik spots (pathognomonic whiteish lesions on buccal
mucosa); immigrant Hx on USMLE sometimes implies unvaccinated status.

 - 6M + diffuse maculopapular rash + tenderness at base of occiput and behind the ears; Dx + Tx?àDx

is rubella (German measles); Tx is supportive; suboccipital and post-auricular lymphadenopathy are

characteristic.

 - 4M + fever + image shown below; what is the most likely causal organism (DNA vs RNA; enveloped vs

non-enveloped; segmented vs non-segmented)?


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o Dx is mumpsàcauses POMàParotitis, Orchitis, Meningitis; virus is RNA, enveloped, non- segmented.

- Neonate + intracranial calcifications + hepatomegaly + rash as shown in image below; no murmurs; Q asks most
likely causal organism:

o Answer = congenital cytomegalovirus (CMV); image shows blueberry muffin rash; no murmurs implies not rubella
(causes patent ductus arteriosus).

- 5M + fever 2-3 days ago + brought in by mother to emergency with appearance as shown below; the most likely
causal organism can also cause what?

o Answer = aplastic anemia; Dx = Parvovirus B19 (Fifth disease); image shows classic “slapped cheek” appearance;
next best step in Dx = Parvovirus B19 IgM titers; if IgM titers are not listed, choose bone marrow biopsy; increased
risk of aplastic anemia in sickle cell. Once child has developed the red cheeks, he/she has immunologically cleared
the illness (i.e., if they turn it into a communications style Q, tell parents to chill the fuck out / Relax because the
child has cleared the virus).

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