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Mendelian Law of Inheritance
Mendelian Law of Inheritance
Mendelian Law of Inheritance
2
3
4
Inheritance
5
How did the experiments of
Gregor Mendel lay the foundation
for the study of transmission
genetics?
6
Introduction to Inheritance
Looking at
yourself in the
mirror...
7
Introduction to Inheritance
8
Introduction to Inheritance
9
Introduction to Inheritance
Genetics answers
most of our
inquiries about how
traits are
transmitted from
parents to their
children.
10
Introduction to Inheritance
Genetics
Heredity Variation
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Introduction to Inheritance
Genetics
Heredity Variation
12
Introduction to Inheritance
Genetics
Heredity Variation
13
Introduction to Inheritance
Genetics
Heredity Variation
14
Introduction to Inheritance
Branches
of
Genetics
Branches
of
Genetics
Transmission genetics
deals with different
patterns of inheritance. Population genetics
18
Introduction to Inheritance
Branches
of
Genetics Population genetics
deals with how
forces of evolution
influence genes in
Transmission genetics populations.
19
Introduction to Inheritance
Farm Father of
Tender Genetics
Augustinian
Beekeeper Academicia
Monk
n
21
Brief Background of Gregor Mendel
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Pea Plant Hybridization
Mendel chose
the legumes
garden peas or
Pisum sativum
for his
hybridization
experiments.
23
Pea Plant Hybridization
24
Pea Plant Hybridization
What makes
peas ideal
for genetic
studies?
25
Pea Plant Hybridization
They
What makes exhibit
peas ideal
for genetic vigorous
studies? growth.
26
Pea Plant Hybridization
They can
self-
fertilize.
They
What makes exhibit
peas ideal
for genetic vigorous
studies? growth.
27
Pea Plant Hybridization
They can
self-
fertilize.
They
What makes exhibit They can
peas ideal
for genetic vigorous cross-
studies? growth. fertilize.
28
Challenges faced by Mendel
Pangenesis
Blending
theory
29
Challenges faced by Mendel
Previous
Notions of
Inheritance
Pangenesis
Homunculus
theory
Blending
theory
30
Challenges faced by Mendel
Previous
Notions of
Inheritance
Pangenesis
Homunculus
theory
Blending
theory Pangenesis was the belief that seeds are
produced in different organs and will later
on gather to form the offspring. 31
Challenges faced by Mendel
Previous
Notions of
Inheritance
Pangenesis
Homunculus
theory
Blending
theory The invention of the microscope made
people believe that sperm cells bear a
homunculus or little man. 32
Challenges faced by Mendel
Previous
Notions of
Inheritance
Pangenesis
Homunculus
theory
Blending
theory The blending theory of inheritance
states that traits of parents blend every
generation of offspring. 33
Rediscovery of Mendel’s Work
35
Review of Genetic Terminologies
A chromosome consists of
a DNA molecule, which serve
as the repository of genetic
information in cells.
Review of Genetic Terminologies
A characteristic is a heritable
feature of an organism.
Review of Genetic Terminologies
Alleles are
the alternative
forms of a
gene.
Review of Genetic Terminologies
The genotype is
homozygous if
the alleles are
identical.
Review of Genetic Terminologies
The genotype is
heterozygous if
the alleles are
different.
Review of Genetic Terminologies
Tall Round-
seeded
Review of Genetic Terminologies
Tall Round-
seeded
Phenotypes refer to the actual
manifestation of genotypes into observable
Review of Genetic Terminologies
55
Monohybrid Cross
57
Monohybrid Cross
58
Monohybrid Cross
59
Monohybrid Cross
P generation
F1 generation
F2 generation
60
Monohybrid Cross
The parental
P generation generation consists of
the true- breeding initial
parents.
F1 generation
F2 generation
61
Monohybrid Cross
P generation
F2 generation
62
Monohybrid Cross
P generation
F1 generation
Result 1:
The dwarf trait
disappeared in the F1
generation.
64
Monohybrid Cross
P
generation
Result 1:
The dwarf trait
disappeared in the F1
generation.
F1
generation
65
Monohybrid Cross
P
generation
Result 1:
The dwarf trait
disappeared in the F1
generation.
F1
Explanation: generation
Tall trait must be
dominant over the
dwarf trait.
66
Monohybrid Cross
Principle of
Dominance
Principle of
Dominance
If we assign letters to each allele :
68
Monohybrid Cross
Principle of
Dominance
If we assign letters to each allele :
T - tall
69
Monohybrid Cross
Principle of
Dominance
If we assign letters to each allele :
T - tall
t - dwarf
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Monohybrid Cross
Principle of
Dominance
If we assign letters to each allele :
T - tall
t - dwarf
Thus, we will have the corresponding genotypes and
phenotypes :
71
Monohybrid Cross
Principle of
Dominance
If we assign letters to each allele :
T - tall
t - dwarf
Thus, we will have the corresponding genotypes and
phenotypes :
TT - tall
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Monohybrid Cross
Principle of
Dominance
If we assign letters to each allele :
T - tall
t - dwarf
Thus, we will have the corresponding genotypes and
phenotypes :
TT - tall Tt - tall
73
Monohybrid Cross
Principle of
Dominance
If we assign letters to each allele :
T - tall
t - dwarf
Thus, we will have the corresponding genotypes and
phenotypes :
TT - tall Tt - tall tt - dwarf
74
Monohybrid Cross
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Monohybrid Cross
Phenotypes Genotypes
P generation
F1 generation
F2 generation
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Monohybrid Cross
Phenotypes Genotypes
F1 generation
F2 generation
77
Monohybrid Cross
Phenotypes Genotypes
F1 generation
F2 generation
78
Monohybrid Cross
Phenotypes Genotypes
F2 generation
79
Monohybrid Cross
Phenotypes Genotypes
F2 generation
80
Monohybrid Cross
Phenotypes Genotypes
F2 generation
81
Monohybrid Cross
Phenotypes Genotypes
Phenotypes Genotypes
F2 generation 3/4 Tall: 1/4 Dwarf 1/4 TT: 2/4 Tt: 1/4 tt
83
Monohybrid Cross
Result 2:
The phenotypes in
the F2 generation
occur in a ratio of 3:1.
84
Monohybrid Cross
F1
generation
Result 2:
The phenotypes in
the F2 generation
occur in a ratio of 3:1.
F2
generation
85
Monohybrid Cross
F1
generation
Result 2:
The phenotypes in
the F2 generation
occur in a ratio of 3:1.
F2
generation
86
Monohybrid Cross
F1
generation
Result 2:
The phenotypes in
the F2 generation
occur in a ratio of 3:1.
F2
Explanation: generation
The alleles are
segregating during
gamete formation.
87
Monohybrid Cross
Law of
Segregation
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Monohybrid Cross
Law of Segregation
P generation cross F1 generation cross
89
Monohybrid Cross
Law of Segregation
P generation cross F1 generation cross
TT × tt Tt × Tt
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Monohybrid Cross
Law of Segregation
P generation cross F1 generation cross
TT × tt Tt × Tt
alleles
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Monohybrid Cross
Law of Segregation
P generation cross F1 generation cross
TT × tt Tt × Tt
alleles T T t t
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Monohybrid Cross
Law of Segregation
P generation cross F1 generation cross
TT × tt Tt × Tt
alleles T T t t
progeny
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Monohybrid Cross
Law of Segregation
P generation cross F1 generation cross
TT × tt Tt × Tt
alleles T T t t
progeny Tt Tt
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Monohybrid Cross
Law of Segregation
P generation cross F1 generation cross
TT × tt Tt × Tt
alleles T T t t
progeny Tt Tt Tt Tt
95
Monohybrid Cross
Law of Segregation
P generation cross F1 generation cross
TT × tt Tt × Tt
alleles T T t t
progeny Tt Tt Tt Tt
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Monohybrid Cross
Law of Segregation
P generation cross F1 generation cross
TT × tt Tt × Tt
alleles T T t t T t T t
progeny Tt Tt Tt Tt
97
Monohybrid Cross
Law of Segregation
P generation cross F1 generation cross
TT × tt Tt × Tt
alleles T T t t T t T t
progeny Tt Tt Tt Tt TT Tt
98
Monohybrid Cross
Law of Segregation
P generation cross F1 generation cross
TT × tt Tt × Tt
alleles T T t t T t T t
progeny Tt Tt Tt Tt TT Tt Tt tt
99
Punnett Square
5. Distribute alleles.
6. Combine alleles.
7. Determine
phenotypes.
8. Determine ratios. 100
Punnett Square
5. Distribute alleles.
6. Combine alleles.
7. Determine
phenotypes.
8. Determine ratios. 101
Punnett Square
5. Distribute alleles.
6. Combine alleles.
7. Determine
phenotypes.
8. Determine ratios. 102
Punnett Square
5. Distribute alleles.
6. Combine alleles.
7. Determine
phenotypes.
8. Determine ratios. 103
Punnett Square
5. Distribute alleles.
6. Combine alleles.
7. Determine
phenotypes.
8. Determine ratios. 104
Punnett Square
6. Combine gametes. t
7. Determine
phenotypes. t
8. Determine ratios. 105
Punnett Square
6. Combine alleles. t Tt Tt
7. Determine
phenotypes. t Tt Tt
8. Determine ratios. 106
Punnett Square
6. Combine alleles. t Tt Tt
(Tall) (Tall)
7. Determine
phenotypes. t Tt Tt
8. Determine ratios. (Tall) (Tall) 107
Punnett Square
6. Combine alleles. t Tt Tt
(Tall) (Tall) GR: 100% Tt
7. Determine PR: 100% Tall
phenotypes. t Tt Tt
8. Determine ratios. (Tall) (Tall) 108
Punnett Square
5. Distribute alleles.
6. Combine alleles.
7. Determine
phenotypes.
8. Determine ratios. 109
Punnett Square
5. Distribute alleles.
6. Combine alleles.
7. Determine
phenotypes.
8. Determine ratios. 110
Punnett Square
5. Distribute alleles.
6. Combine alleles.
7. Determine
phenotypes.
8. Determine ratios. 111
Punnett Square
5. Distribute alleles.
6. Combine alleles.
7. Determine
phenotypes.
8. Determine ratios. 112
Punnett Square
5. Distribute alleles.
6. Combine alleles.
7. Determine
phenotypes.
8. Determine ratios. 113
Punnett Square
6. Combine alleles. T
7. Determine
phenotypes. t
8. Determine ratios. 114
Punnett Square
6. Combine alleles. T TT Tt
7. Determine
phenotypes. t Tt tt
8. Determine ratios. 115
Punnett Square
6. Combine alleles. T TT Tt
(Tall) (Tall)
7. Determine
phenotypes. t Tt tt
8. Determine ratios. (Tall) (Dwarf) 116
Punnett Square
119
Dihybrid Cross
120
Dihybrid Cross
121
Dihybrid Cross
122
Dihybrid Cross
6. Combine alleles.
7. Determine
phenotypes.
8. Determine ratios. 124
Punnett Square
6. Combine alleles.
7. Determine
phenotypes.
8. Determine ratios. 125
Punnett Square
6. Combine alleles.
7. Determine
phenotypes.
8. Determine ratios. 126
Punnett Square
6. Combine alleles.
7. Determine
phenotypes.
8. Determine ratios. 127
Punnett Square
6. Combine alleles.
7. Determine
phenotypes.
8. Determine ratios. 128
Punnett Square
6. Combine alleles.
7. Determine
phenotypes.
8. Determine ratios.
Punnett Square
6. Combine alleles.
7. Determine
phenotypes.
8. Determine ratios.
Punnett Square
6. Combine alleles.
7. Determine
phenotypes.
8. Determine ratios.
Punnett Square
6. Combine alleles.
7. Determine
phenotypes.
8. Determine ratios.
Punnett Square
6. Combine alleles.
7. Determine
phenotypes.
8. Determine ratios.
Punnett Square
6. Combine alleles.
7. Determine
phenotypes.
8. Determine ratios.
Punnett Square
7. Determine
phenotypes. r
8. Determine ratios.
Punnett Square
6. Combine alleles.
7. Determine
phenotypes.
8. Determine ratios.
Punnett Square
7. Determine r
phenotypes. y
8. Determine ratios.
Punnett Square
Result 2:
The phenotypes in the F2
generation occur in a ratio
of 9:3:3:1
153
Dihybrid Cross
Result 2:
The phenotypes in the F2
generation occur in a ratio
of 9:3:3:1
154
Dihybrid Cross
Result 2:
The phenotypes in the F2
generation occur in a ratio
of 9:3:3:1
Explanation:
The genes for seed shape
and color are
independently assorting.
155
Dihybrid Cross
Law of Independent
Assortment
The alleles from different genes are
sorted into the gametes independently of
each other. Thus, the inheritance of
these two genes become independent.
156
Is the law of segregation still
applicable when two genes are
already involved? Why do you
think so?
157
Laws of Inheritance and Gametogenesis
Both laws of
inheritance operate
during the
Anaphase I of
meiosis during
gamete formation.
158
How is the separation of
homologous chromosomes
relevant to the laws of
inheritance?
159
Brylle is fond of growing crops in his garden. One of the
crops that he cultivates is the garden pea (Pisum sativum).
One strain of his pea plants is heterozygous for flower
colors, with genotype Mm. Another strain of his peas has
smooth pods and axial flowers with genotype AaBB. What
are the alleles produced by each of these two plants with
respect to the indicated characteristics?
160
Brylle is fond of growing crops in his garden. One of the
crops that he cultivates is the garden pea (Pisum sativum).
One strain of his pea plants is heterozygous for flower
colors, with genotype Mm. Another strain of his peas has
smooth pods and axial flowers with genotype AaBB. What
are the alleles produced by each of these two plants with
respect to the indicated characteristics?
162
In pea plants, axial inflorescence is dominant over terminal
inflorescence. If Laiza crossed a parent plant that is
heterozygous for inflorescence to another plant with
terminal inflorescence, what are the genotypic and
phenotypic ratios of the offspring?
163
In pea plants, axial inflorescence is dominant over terminal
inflorescence. If Laiza crossed a parent plant that is
heterozygous for inflorescence to another plant with
terminal inflorescence, what are the genotypic and
phenotypic ratios of the offspring?
The genotypic ratio of the cross is 1/2 AA: 1/2 aa. The
phenotypic ratio is 1/2 axial: 1/2 terminal.
164
If a parent pea plant that is hybrid for
flower color is crossed with a plant that is
true-breeding for violet flowers, what are
the genotypic and phenotypic ratios of the
F1 generation? Note that having violet
flowers is dominant over having white
flowers.
165
In pea plants, round seeds are dominant over wrinkled
seeds, while the tall trait is dominant over the dwarf trait. If
you cross two plants that are both heterozygous for seed
shape but homozygous dominant for height, what are the
expected genotypic and phenotypic ratios of the offspring?
166
In pea plants, round seeds are dominant over wrinkled
seeds, while the tall trait is dominant over the dwarf trait. If
you cross two plants that are both heterozygous for seed
shape but homozygous dominant for height, what are the
expected genotypic and phenotypic ratios of the offspring?
170
● Genetics is the study of inheritance and variation in
organisms. It has various subdisciplines.
Transmission genetics is the one that is
particularly concerned about the mechanisms or
patterns of inheritance.
171
● Gregor Mendel is the father of genetics. He
performed experiments on garden pea or Pisum
sativum. This led him to formulate the laws of
inheritance in his publication, Experiments on Plant
Hybrids.
172
● Different genes control the expression of the
characteristics of organisms. Each gene exists in
alternative forms called alleles.
174
● Mendel’s dihybrid cross reveals the law of
independent assortment. According to this law,
allele pairs from different genes separate
independently during gamete formation. This
explains the characteristics ratio of 9:3:3:1 of F2 of
dihybrid crosses.
175
Transmission genetics serves as the pioneer field in genetics.
176
You crossed two true-breeding lines of
violet-flowered and white-flowered
peas. Is it possible to establish a true-
breeding line of the genotype found in
the offspring of your cross? Why or
why not?
177