Stomach Disorders

Peptic Ulcer Disease

UGIB Gastric Cancer
Hematemesis
Atrophic
Gastritis Weight loss
Anorexia
Chronic Inflammation
+
Artery Erosion
Malt Lymphoma
Worst
case Adenocarcinoma
+ scenario

Melena Hypovolemic
+ Antral
Shock
Edema
and
+ Fibrosis
Serosal
Erosion

Perforation Gastric Outlet

Obstruction
Vomiting

Gastric
Dilation
Air leak
Bacteria,
Acid Pain
Pneumoperitoneum Succussion
Peritonitis Splash +
 Stomach Disorders
Gastritis
Stomach Involvement Pathophysiology
Thin Mucus Layer Shallow Stress Ulcers
+
+ Erosions
NSAIDS/Ethanol H. pylori
Curling’s Cushing’s
Ulcers Ulcers
+
Burns ICP
Inflammation - COX Urease +
Hypovolemia Vagus Nerve
Prostaglandins NH3
Gastrin +
Activity
Antrum H. pylori survival Sepsis
M/C Location Acetylcholine
Autoimmune Alkaline
Epigastric pain Mucus Cytotoxicity
HCl Perfusion
Parietal HCl
HCl
Atrophy Cells Ischemia
Intrinsic Factor
(mucosal)
Inflammation/Erosions Inflammation/Erosions HCl

Peptic Ulcer Disease

Stomach Involvement Pathophysiology

Thin Mucus Submucosal and NSAIDS/Ethanol H. pylori (M/C) Gastrinoma

+
Layer + Beyond Ulcer

+ Pancreas
Urease
- COX
Inflammation Gastrin
NH3
Gastrin
Antral PG
H. pylori HCl
Location HCl
Duodenum survival
HCl Mucus Refractory
Location
Cytotoxicity Duodenal
(M/C)
Gastric ulcer Greater Ulcers/Inflammation
Ulcers/Inflammation Zollinger-Ellison Syndrome
Epigastric Pain Food Ulcers/Inflammation
(ZES)
Duodenal ulcer Decrease