Oval yeasts 2x4 Histoplasmosis

Spherules 10-80 Coccidioidomycosis

Thick-walled 8-15 Blastomycosis

Large, multiple 15-30 Paracoccidioidomycosis

Amphotericin B This drug binds to ergosterol in the cell membrane.

This interaction alters the membrane fluidity and
perhaps produces pores in the membrane through
which ions and small molecules are lost.

Fluconazole This drug interferes with the synthesis of ergosterol.

They block the cytochrome P450- dependent 14α-
demethylation of lanosterol, which is a precursor of
ergosterol in fungi and cholesterol in mammalian
cells.

Caspofungin Perturbs the synthesis of the pervasive cell wall

polysaccharide β-glucan by inhibiting 1,3-β- glucan
synthase and disrupting cell wall integrity

Flucocytosine interferes with the activity of thymidylate synthetase

and DNA synthesis.

Griseofulvin an orally administered antibiotic derived from a interacts with microtubules and disrupts mitotic
species of penicillium. It is used to treat spindle function, resulting in inhibition of
dermatophytosis and must be given for long periods growth. Only actively growing hyphae are affected.