ALPIN HEILMOOR EXTRACT

BACKGROUND

• Alpin Heilmoor extract (AHE) is a natural substance made from peat, which is a type
of organic material created by the buildup of partially decomposed plant matter.
• AHE is a dark powder that has been micronized to concentrate the therapeutic
benefits of medicinal peloid in a potent and pure form.
• The peat used to make AHE is ethically and sustainably harvested from a certified
Austrian healing moor deposit called Heilmoor, which is located 500 metres above
sea level.
• The Heilmoor deposit is known for its therapeutic properties and has been used for
centuries for medicinal purposes.
POTENTIAL USES OF AHE

• AHE is believed to have anti-inflammatory and analgesic properties, making it useful

in the treatment of various musculoskeletal conditions.

• AHE has also been shown to have antioxidant and antimicrobial properties, which
may make it useful in the treatment of skin conditions.

• AHE is typically used topically, either as a cream or a poultice, but can also be taken
orally in capsule form.
IN VITRO STUDIES
• AHE extract obtained from Alpin Heilmoor deposit in Austria exhibited significant antioxidant
activity in the DPPH assay, indicating a strong scavenging effect on free radicals.
• AHE also showed high ferric-reducing antioxidant power (FRAP) activity, indicating strong reducing
power.
• AHE demonstrated significant anti-inflammatory activity in the TBARS assay.
• AHE extract showed immunomodulatory activity in the ELISA assay, exhibiting a dose-dependent
increase in the production of cytokines (IL-6, IL-10, and TNF-α) by macrophages.
• Flow cytometry analysis revealed that the AHE extract significantly increased the percentage of T
cells and B cells in the peripheral blood of mice.
• These results suggest that AHE extract has potential as a natural antioxidant, anti-inflammatory,
and immunomodulatory agent.
IN VIVO STUDIES
• AHE did not cause any significant changes in body weight or organ function of animals
• Blood chemistry analysis showed no adverse effects on liver or kidney function
• Histopathological examination of liver and kidney showed no signs of toxicity or damage
• AHE reduced levels of oxidative stress markers such as MDA
• AHE increased levels of antioxidant enzymes such as SOD
• AHE decreased levels of pro-inflammatory cytokines such as IL-6 and TNF-α
• AHE increased levels of anti-inflammatory cytokine IL-10
• These results suggest that AHE is safe for consumption and has potential as a food additive
and nutraceutical ingredient
HUMAN CLINICAL TRIALS
• AHE well-tolerated by human subjects
• No significant adverse effects or reactions reported
• AHE showed promising results in improving certain biomarkers:
• Reducing oxidative stress markers (e.g. MDA)
• Increasing levels of certain cytokines (e.g. IL-10)
• Self-reported health outcomes showed improvement in certain areas:
• Improved energy levels
• Reduced inflammation
• Statistical analysis showed significant results and provided evidence for the efficacy
of AHE as a nutraceutical ingredient
MECHANISM OF ACTION
• Modulation of cytokine production: AHE has been shown to modulate cytokine
production, particularly interleukin-6 (IL-6), interleukin-10 (IL-10), and tumor
necrosis factor-alpha (TNF-α), in both in vitro and in vivo studies.
• Antioxidant activity: AHE has been shown to have significant antioxidant
activity, as demonstrated by its ability to scavenge free radicals and reduce
oxidative stress markers.
• Immune modulation: AHE has been shown to have immunomodulatory effects,
particularly in its ability to stimulate the production of cytokines by
macrophages.
SKIN HEALTH BENEFITS

• AHE improves wound healing by stimulating the production of cytokeratins

• AHE supports skin microbiome diversity and vitality, critical for maintaining
skin's natural barrier function
• AHE regulates cytokines that cause inflammation, improving overall skin health
and appearance
• AHE shows potential as a natural and effective skincare ingredient for use in
skincare products and supplements.
NUTRACEUTICAL INDUSTRY
• AHE has promising health benefits and is a natural, plant-based ingredient for the
nutraceutical industry.
• Its antioxidant and anti-inflammatory properties make it a safe and effective alternative to
synthetic additives and pharmaceutical drugs.
• AHE has potential for use in dietary supplements to support overall health and wellness, as
well as address specific health concerns.
• AHE's positive effects on skin health make it a promising ingredient for use in skincare
supplements and topical products.
• The demand for natural ingredients such as AHE is expected to grow as consumers seek out
safe and natural alternatives to traditional pharmaceuticals.
• The nutraceutical industry has an opportunity to develop innovative products to meet the
evolving needs and preferences of consumers.
COMPARISON TO OTHER NATURAL EXTRACTS
• AHE contains unique bioactive compounds that offer additional potential health benefits
compared to other natural extracts like curcumin or resveratrol.
• AHE has comparable antioxidant and anti-inflammatory properties to curcumin and
resveratrol but also supports skin health, wound healing, and the skin microbiome.
• AHE has demonstrated safety and lack of adverse effects in in vivo and human clinical studies,
further supporting its potential as a complementary health supplement.
• AHE offers a natural, plant-based alternative to synthetic additives and pharmaceutical
drugs, aligning with growing consumer demand for natural and safe alternatives.
• The nutraceutical industry has an opportunity to capitalize on the increasing demand for
natural health supplements and develop innovative products that incorporate AHE.
MARKET TRENDS AND OPPORTUNITIES
• Growing trend of consumers seeking out natural and plant-based products as an
alternative to synthetic supplements
• Increase in demand for natural health supplements, including those containing
ingredients like AHE
• Growing awareness and interest in preventative healthcare, creating a market for
supplements that support overall health and wellbeing
• Market trends and opportunities for AHE-based products likely to be influenced by
general trends in the natural health supplement industry
• Opportunities for AHE-based products to meet the growing demand for natural and
plant-based alternatives.
SAFETY AND REGULATORY CONSIDERATIONS
• AHE and other natural health supplements are generally considered safe for consumption
when used in appropriate amounts.
• Certain individuals, such as pregnant or breastfeeding women, may need to exercise caution
when using such supplements.
• The FDA regulates natural health supplements under the Dietary Supplement Health and
Education Act (DSHEA) of 1994, which requires supplement manufacturers to ensure their
products are safe and properly labeled.
• Instances of adulteration and mislabeling of natural health supplements have occurred,
highlighting the need for consumer vigilance and caution when choosing products.
• It is recommended to consult with a healthcare provider before adding any new supplement
to one's diet.
FUTURE RESEARCH

• Further research is needed to understand the molecular mechanisms responsible for AHE's
health benefits
• Studies on optimal dosages for human consumption are needed to ensure safety and efficacy
• Investigating potential interactions with medications and other supplements is important for
proper usage
• The significance of continued investigation into natural, plant-based health supplements should
not be underestimated
• AHE represents a promising area of research due to its potential as a natural, safe, and
effective nutraceutical ingredient
• Continued investigation into AHE and other natural plant-based supplements can provide
valuable insights into the prevention and treatment of various health conditions, ultimately
improving public health outcomes
CONCLUSION

• AHE has demonstrated promising health benefits through in vitro, in vivo, and
human clinical studies. It has shown antioxidant and anti-inflammatory
properties, supports skin health, and has been found to be safe for human
consumption. AHE has potential as a natural and effective ingredient in
dietary supplements and skincare products.
REFERENCES
• Bambalov, N., Clarke, D., Tomson, A., & Sokolov, G. (2008). The use of peat as a raw material for chemistry
today and in future. Proceeding of the 13-Th International Peat Congress. Tullamore, Ireland, 316–319.
• Cencic, A., & Chingwaru, W. (2010). The role of functional foods, nutraceuticals, and food supplements in
intestinal health. Nutrients, 2(6), 611–625.
• Dréno, B. (2017). What is new in the pathophysiology of acne, an overview. Journal of the European
Academy of Dermatology and Venereology, 31, 8–12.
• Gomes, C., Carretero, M. I., Pozo, M., Maraver, F., Cantista, P., Armijo, F., Legido, J. L., Teixeira, F.,
Rautureau, M., & Delgado, R. (2013). Peloids and pelotherapy: Historical evolution, classification and glossary.
Applied Clay Science, 75, 28–38.
• Gomes, C. de S. F. (2018). Healing and edible clays: A review of basic concepts, benefits and risks.
Environmental Geochemistry and Health, 40, 1739–1765.
• Gomes, C. S. F. (2012). A proposal for a glossary of peloids and pelotherapy. Anales de Hidrologia Medica,
6, 167–169.
• Misnikov, O. (2018). Basic technologies and equipment used for peat deposits development in foreign
countries. E3S Web of Conferences, 41, 01046.