Antimalarials

These are the drugs that are basically used in treatment of malaria.

Malaria: Most widespread serious life-threatening disease caused by Plasmodium parasite (protozoa).
It is transmitted to humans through bites of female Anopheles mosquitoes or infected mosquitoes.

Etiology of Malaria

It starts when female Anopheles mosquito bites & release Plasmodium species in human body.
Classification of Antimalarials

Cinchona alkaloids: Quinine sulphate

7-chloro-4-amino quinolines
NHR

Cl N

Chloroquine: R= -CH(CH3)-(CH2)3-N(C2H5)2

Amodiaquine: R=

6-methoxy-8-amino quinolines

Pamaquine: R= -CH(CH3)-(CH2)3-N(C2H5)2

Primaquine: R= -CH(CH3)-(CH2)3-NH2

Mefloquine

9-amino acridines: Quinacrine

Biguanides

Proguanil Cycloguanil