description

field
gene
asthma
hypertension
both
Familial Forms
HPO
With associated codi
eQTL regulated
targets of indicated d
targets of contraindic
Differentially express
Text mining (HuGE)
is_connected
module1-module6
in_modules
novel

Page 1
 description
Supplementary Table 1. 330 genes associated with asthma and hypertension according to various evidence sources.

description
gene name
The number of evidence sources supporting gene association with asthma.
The number of evidence sources supporting gene association with hypertension.
The total number of evidence sources supporting gene association with asthma and hypertension.
Whether a gene has variants causing familial disorders characterized by asthma or hypertension. Here and below: 2- if the
Whether a gene was associated with HPO terms relevant to asthma or hypertension.
Whether a gene has coding GWAS variants.
Whether a gene is regulated by an eQTL associated with asthma or hypertension.
Whether a gene is a target of a drug indicated in asthma or hypertension.
Whether a gene is a target of a drug contraindicated in asthma or hypertension.
Whether a gene is differentially expressed in asthma or hypertension.
Whether a gene co-occurs in texts with asthma or hypertension.
Whether a gene is connected in the network.
1 if a gene belongs to a module; otherwise 0.
Comma-separated list of modules each gene belongs to.
Whether a gene seems to be novel, i.e. not fund in a simple search in TargetMine and DisGeNET with query terms asthm

Page 2
 description

ailable for both diseases; 1- if the evidence is available only for one disease; 0 – no evidence

Page 3
 Supplementary Table 1
gene both asthma hypertension Have variants causing Familial Forms HPO
VEGFA 4 2 2 0 0
AGT 3 1 2 0 0
ANXA1 3 1 2 0 0
ARG1 3 2 1 0 0
CAT 3 2 1 0 0
CCL11 3 2 1 0 0
CCL2 3 2 1 0 0
CCL5 4 3 1 0 0
COL4A3 2 1 1 0 1
CSF2 3 2 1 0 0
CTGF 2 1 1 0 0
CXCL8 5 3 2 0 0
FAS 3 2 1 0 0
FOS 3 2 1 0 0
FOXP3 3 2 1 0 0
GSTP1 3 2 1 0 0
HP 2 1 1 0 0
ICAM1 3 2 1 0 0
IFNG 3 2 1 0 0
IL13 4 3 1 0 0
IL17A 3 2 1 0 0
IL18 3 2 1 0 0
IL4 3 2 1 0 0
IL5 5 4 1 0 0
LEP 3 2 1 0 0
MAPK1 3 2 1 0 0
MYLK 3 2 1 0 1
NFKB1 2 1 1 0 0
NR3C1 6 3 3 0 1
PTGS2 5 2 3 0 0
TGFB1 3 2 1 0 0
TIMP1 3 2 1 0 0
TLR4 3 2 1 0 0
TNF 3 2 1 0 0
VCAM1 3 2 1 0 0
ABCB1 2 1 1 0 0
ABCC2 2 1 1 0 0
ABO 2 1 1 0 0
ACE 3 1 2 0 0
ACTN4 3 1 2 0 1
ADA 3 2 1 0 1
ADH1B 2 1 1 0 0
ADH1C 2 1 1 0 0
ADORA1 3 2 1 0 0
ADORA2A 2 1 1 0 0
ADRA1B 4 1 3 0 0
ADRB1 6 3 3 0 0
ADRB2 6 3 3 0 0
ADRB3 3 1 2 0 0
AGER 4 2 2 0 0
AIF1 2 1 1 0 0
ALDH2 4 2 2 0 0

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 Supplementary Table 1
ALMS1 2 1 1 0 2
ALOX5AP 2 1 1 0 0
APOA2 2 1 1 0 0
ARHGEF40 2 1 1 0 0
ATF6B 2 1 1 0 0
ATM 2 1 1 0 0
ATP2A2 2 1 1 0 0
ATP2B1 3 1 2 0 0
ATP6V1G2 2 1 1 0 0
BAG6 2 1 1 0 0
BBS1 2 1 1 0 2
BBS4 2 1 1 0 2
BDKRB2 2 1 1 0 0
BDNF 2 1 1 0 0
BTN2A1 2 1 1 0 0
BTN3A1 2 1 1 0 0
BTN3A2 2 1 1 0 0
C3 2 1 1 0 0
C4A 3 1 2 0 0
C4B 2 1 1 0 0
C5 2 1 1 0 0
C6orf48 2 1 1 0 0
CACNB4 2 1 1 0 0
CCHCR1 3 1 2 0 0
CCR2 2 1 1 0 0
CCR5 2 1 1 0 0
CD14 2 1 1 0 0
CD40 2 1 1 0 0
CFTR 3 2 1 0 1
CHI3L1 3 2 1 0 0
CHIT1 3 2 1 0 0
CHUK 2 1 1 0 0
CIITA 2 1 1 0 0
CLEC16A 2 1 1 0 0
CMA1 2 1 1 0 0
COMT 2 1 1 0 1
CRIP1 2 1 1 0 0
CRP 2 1 1 0 0
CSK 3 1 2 0 0
CSNK2B 2 1 1 0 0
CTLA4 3 1 2 0 1
CTSB 2 1 1 0 0
CX3CR1 2 1 1 0 0
CXCL12 2 1 1 0 0
CYBA 2 1 1 0 0
CYP1A1 2 1 1 0 0
CYP1A2 2 1 1 0 0
CYP21A2 4 1 3 0 1
CYP24A1 2 1 1 0 0
CYP2C19 2 1 1 0 0
CYP2C9 2 1 1 0 0
CYP2D6 2 1 1 0 0
CYP2E1 2 1 1 0 0

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 Supplementary Table 1
CYP2R1 2 1 1 0 0
CYP3A4 2 1 1 0 0
DDX39B 2 1 1 0 0
DOM3Z 2 1 1 0 0
EDN1 2 1 1 0 0
EDNRA 2 1 1 0 0
EGFR 3 1 2 0 1
EPHX1 2 1 1 0 0
ERAP1 2 1 1 0 0
ERBB2 2 1 1 0 0
ERCC2 2 1 1 0 1
ESR1 2 1 1 0 0
FADS1 2 1 1 0 0
FADS2 2 1 1 0 0
FAM216A 2 1 1 0 0
FCGR1A 3 2 1 0 0
FCGR1B 3 2 1 0 0
FCGR1C 2 1 1 0 0
FLOT1 2 1 1 0 0
FTO 2 1 1 0 0
FUT2 2 1 1 0 0
GATA2 2 1 1 0 0
GBP1 2 1 1 0 0
GBP2 2 1 1 0 0
GBP3 2 1 1 0 0
GBP4 2 1 1 0 0
GBP5 2 1 1 0 0
GBP7 2 1 1 0 0
GC 2 1 1 0 0
GCKR 2 1 1 0 0
GLS 2 1 1 0 0
GNPDA2 2 1 1 0 0
GPANK1 2 1 1 0 0
GPN3 2 1 1 0 0
GPX1 2 1 1 0 0
GSTA1 2 1 1 0 0
GSTM1 2 1 1 0 0
GSTM3 2 1 1 0 0
GSTO1 2 1 1 0 0
GSTT1 2 1 1 0 0
HCG27 2 1 1 0 0
HCP5 2 1 1 0 0
HECTD4 2 1 1 0 0
HIST1H2BC 2 1 1 0 0
HIST1H2BE 2 1 1 0 0
HIST1H2BF 2 1 1 0 0
HIST1H2BG 2 1 1 0 0
HIST1H2BI 2 1 1 0 0
HIST1H4A 2 1 1 0 0
HIST1H4B 2 1 1 0 0
HIST1H4C 2 1 1 0 0
HIST1H4D 2 1 1 0 0
HIST1H4E 2 1 1 0 0

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 Supplementary Table 1
HIST1H4F 2 1 1 0 0
HIST1H4H 2 1 1 0 0
HIST1H4I 2 1 1 0 0
HIST1H4J 2 1 1 0 0
HIST1H4K 2 1 1 0 0
HIST1H4L 2 1 1 0 0
HIST2H2BF 2 1 1 0 0
HIST2H4A 2 1 1 0 0
HIST2H4B 2 1 1 0 0
HIST4H4 2 1 1 0 0
HLA-A 2 1 1 0 0
HLA-B 4 2 2 0 0
HLA-C 4 2 2 0 0
HLA-DPB1 5 3 2 0 1
HLA-DQA1 3 2 1 0 0
HLA-DQB1 3 2 1 0 0
HLA-DRB1 4 2 2 0 0
HLA-DRB5 2 1 1 0 0
HLA-DRB6 2 1 1 0 0
HLA-E 3 2 1 0 0
HLA-G 2 1 1 0 0
HMOX1 2 1 1 0 0
HSPA1B 3 1 2 0 0
IDS 3 2 1 0 1
IER3 2 1 1 0 0
IL10 2 1 1 0 0
IL10RA 2 1 1 0 0
IL12B 2 1 1 0 0
IL15 2 1 1 0 0
IL16 2 1 1 0 0
IL1A 2 1 1 0 0
IL1B 2 1 1 0 0
IL1R1 2 1 1 0 0
IL1RN 2 1 1 0 0
IL22 2 1 1 0 0
IL23R 2 1 1 0 0
IL2RA 2 1 1 0 0
IL3 2 1 1 0 0
IL4R 2 1 1 0 0
IL5RA 2 1 1 0 0
IL6 2 1 1 0 0
IL6R 3 2 1 0 0
INS 2 1 1 0 0
INSIG2 2 1 1 0 0
IRAK1 2 1 1 0 0
IRF5 2 1 1 0 0
ITGB3 3 1 2 0 0
ITPR2 2 1 1 0 0
JAK2 3 1 2 0 1
KIF1B 2 1 1 0 1
KIT 2 1 1 0 0
LOC100131190 2 1 1 0 0
LOC100293534 2 1 1 0 0

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 Supplementary Table 1
LOC100294307 2 1 1 0 0
LOC100507709 2 1 1 0 0
LOC100507714 2 1 1 0 0
LST1 2 1 1 0 0
LTA 3 1 2 0 0
LTC4S 2 1 1 0 0
LY6G5B 2 1 1 0 0
LY6G6C 2 1 1 0 0
MBL2 2 1 1 0 0
MC4R 3 1 2 0 1
MEFV 2 1 1 0 0
MICB 3 2 1 0 0
MIF 3 2 1 0 0
MIR146A 2 1 1 0 0
MKKS 3 1 2 0 2
MMP1 2 1 1 0 0
MMP12 2 1 1 0 0
MMP9 2 1 1 0 0
MPO 2 1 1 0 0
MS4A2 2 1 1 0 0
MSH5 2 1 1 0 0
MSH5-SAPCD1 2 1 1 0 0
MTHFR 2 1 1 0 0
MUC1 2 1 1 0 1
MX2 2 1 1 0 0
MYADM 2 1 1 0 0
NAT2 2 1 1 0 0
NFKBIA 2 1 1 0 0
NLRP12 2 1 1 0 0
NLRP3 2 1 1 0 0
NOD2 3 1 2 0 1
NOS1 2 1 1 0 0
NOS2 2 1 1 0 0
NOS2A 2 1 1 0 0
NOS3 3 1 2 1 0
NOTCH4 3 2 1 0 0
NPPA 2 1 1 0 0
NQO1 2 1 1 0 0
OAS2 3 2 1 0 0
OBFC1 3 1 2 0 0
P2RY12 2 1 1 0 0
PARD3B 2 1 1 0 0
PDE3A 3 1 2 1 1
PDE4D 3 2 1 0 0
PDGFRA 2 1 1 0 0
PECAM1 2 1 1 0 0
PLA2G7 2 1 1 0 0
PLAUR 2 1 1 0 0
PON1 2 1 1 0 0
PON2 2 1 1 0 0
PPARA 2 1 1 0 0
PPARG 4 2 2 0 1
PPP1R15A 2 1 1 0 0

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 Supplementary Table 1
PRKCA 2 1 1 0 0
PRRC2A 2 1 1 0 0
PSORS1C1 3 2 1 0 0
PSTPIP2 2 1 1 0 0
PTGDR 2 1 1 0 0
PTGER4 2 1 1 0 0
PTGES 2 1 1 0 0
PTGS1 2 1 1 0 0
PTPN22 3 1 2 0 1
PTPRD 2 1 1 0 0
RICTOR 2 1 1 0 0
RNF5 2 1 1 0 0
RREB1 2 1 1 0 1
RUNX1 2 1 1 0 0
RXRA 2 1 1 0 0
S100A10 2 1 1 0 0
SAPCD1 2 1 1 0 0
SCAMP2 2 1 1 0 0
SCAMP5 2 1 1 0 0
SCGB1A1 2 1 1 0 0
SDCCAG8 2 1 1 0 2
SDHA 2 1 1 1 0
SDHD 4 1 3 1 2
SELL 2 1 1 0 0
SELP 2 1 1 0 0
SERPINA1 2 1 1 0 0
SERPINA3 2 1 1 0 0
SERPINE1 3 1 2 0 0
SH2B3 6 2 4 0 1
SKIV2L 2 1 1 0 0
SLC22A5 2 1 1 0 0
SLC44A4 2 1 1 0 0
SLC6A4 3 1 2 0 0
SMAD3 4 2 2 0 1
SNORD84 2 1 1 0 0
SOCS3 2 1 1 0 0
SOD2 2 1 1 0 0
SOD3 2 1 1 0 0
SPP1 2 1 1 0 0
STAT1 3 2 1 0 0
STAT4 2 1 1 0 0
TAGAP 2 1 1 0 0
TAP1 2 1 1 0 0
TBXA2R 2 1 1 0 0
TGFB2 2 1 1 0 1
TGFBR1 2 1 1 0 1
TGFBR2 3 1 2 0 1
TIRAP 2 1 1 0 0
TLR2 2 1 1 0 0
TLR9 2 1 1 0 0
TMEM18 2 1 1 0 0
TNFRSF1B 2 1 1 0 0
TNFRSF4 2 1 1 0 0

Page 6
 Supplementary Table 1
TNFSF4 3 2 1 0 0
TP53 3 1 2 0 1
TRPM8 2 1 1 0 0
TRPV4 2 1 1 0 0
TUBB 2 1 1 0 0
UBE2L6 2 1 1 0 0
UGT1A1 2 1 1 0 0
UPP1 2 1 1 0 0
USF1 2 1 1 0 0
USP4 2 1 1 0 0
UTP18 2 1 1 0 0
VDR 2 1 1 0 0
ZNF219 2 1 1 0 0

Page 7
 Supplementary Table 1
With associated coding variants (GWAS)eQTL regulated targets of indicated drugs
0 0 0
0 0 0
0 0 1
0 0 0
0 0 0
0 0 0
0 0 0
0 1 0
0 0 0
0 0 0
0 0 0
0 2 0
0 0 0
0 2 0
0 0 0
0 0 0
0 0 0
0 0 0
0 0 0
0 1 0
0 0 0
0 0 0
0 0 0
0 1 1
0 0 0
0 0 0
0 0 0
0 0 0
0 0 1
0 0 0
0 0 0
0 0 0
0 0 0
0 0 0
0 0 0
0 0 0
0 0 0
0 0 0
0 0 1
0 1 0
0 0 0
0 0 0
0 0 0
0 1 1
0 0 1
0 0 1
0 0 2
0 0 2
0 0 1
0 2 0
0 2 0
0 2 0

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 Supplementary Table 1
0 0 0
0 0 0
0 1 0
0 2 0
0 2 0
0 0 0
0 0 0
0 2 0
0 2 0
0 2 0
0 0 0
0 0 0
0 0 0
0 0 0
0 1 0
0 2 0
0 2 0
0 0 0
0 2 0
0 2 0
0 0 0
0 2 0
0 1 1
0 2 0
0 0 0
0 0 0
0 0 0
0 0 0
0 0 0
0 1 0
0 1 0
0 0 0
0 0 0
0 1 0
0 0 0
0 0 0
0 2 0
0 0 0
0 2 0
0 2 0
0 0 0
0 2 0
0 0 0
0 0 0
0 0 0
0 0 0
0 0 0
0 2 0
0 0 0
0 0 0
0 0 0
0 0 0
0 0 0

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 Supplementary Table 1
0 0 0
0 0 0
0 2 0
0 2 0
0 0 0
0 0 0
0 0 0
0 0 0
0 0 0
0 1 0
0 0 0
0 0 0
0 0 0
0 0 0
0 2 0
0 2 0
0 2 0
0 2 0
0 2 0
0 0 0
0 0 0
0 1 0
0 2 0
0 2 0
0 2 0
0 2 0
0 2 0
0 2 0
0 0 0
0 0 0
0 2 0
0 0 0
0 2 0
0 2 0
0 0 0
0 0 0
0 0 0
0 0 0
0 0 0
0 0 0
0 2 0
0 2 0
0 2 0
0 2 0
0 2 0
0 2 0
0 2 0
0 2 0
0 2 0
0 2 0
0 2 0
0 2 0
0 2 0

Page 10
 Supplementary Table 1
0 2 0
0 2 0
0 2 0
0 2 0
0 2 0
0 2 0
0 2 0
0 2 0
0 2 0
0 2 0
0 0 0
0 2 0
0 2 0
1 1 0
0 1 0
0 1 0
0 2 0
0 2 0
0 2 0
0 2 0
0 0 0
0 0 0
0 2 0
0 2 0
0 2 0
0 0 0
0 0 0
0 0 0
0 0 0
0 0 0
0 0 0
0 0 0
0 0 0
0 0 0
0 0 0
0 0 0
0 0 0
0 0 0
0 0 0
0 0 0
0 0 0
0 1 0
0 0 0
0 0 0
0 0 0
0 0 0
0 0 0
0 0 0
0 0 0
0 1 0
0 0 0
0 2 0
0 2 0

Page 11
 Supplementary Table 1
0 2 0
0 2 0
0 2 0
0 2 0
0 1 0
0 0 0
0 2 0
0 2 0
0 0 0
0 0 0
0 0 0
0 2 0
0 1 0
0 0 0
0 0 0
0 0 0
0 0 0
0 0 0
0 0 0
0 0 0
0 2 0
0 2 0
0 0 0
0 0 0
0 2 0
0 2 0
0 0 0
0 0 0
0 2 0
0 0 0
0 0 0
0 0 0
0 0 0
0 0 0
0 0 0
1 2 0
0 0 0
0 0 0
1 2 0
0 2 0
0 0 0
1 0 0
0 0 1
0 1 0
0 0 0
0 0 0
0 0 0
0 0 0
0 0 0
0 0 0
0 0 0
0 0 0
0 2 0

Page 12
 Supplementary Table 1
0 0 0
0 2 0
1 2 0
0 2 0
0 0 0
0 0 0
0 1 0
0 0 0
0 0 0
0 0 0
0 2 0
0 2 0
0 0 0
0 0 0
0 0 0
0 2 0
0 2 0
0 2 0
0 2 0
0 0 0
0 0 0
0 1 0
0 0 0
0 0 0
0 0 0
0 0 0
0 0 0
0 0 0
2 2 0
0 2 0
0 1 0
0 2 0
0 0 0
0 1 0
0 2 0
0 0 0
0 0 0
0 0 0
0 0 0
0 2 0
0 0 0
0 2 0
0 0 0
0 0 0
0 0 0
0 0 0
0 0 0
0 0 0
0 0 0
0 0 0
0 0 0
0 0 0
0 0 0

Page 13
 Supplementary Table 1
0 1 0
0 0 0
1 0 0
0 0 0
0 2 0
0 2 0
0 0 0
0 2 0
0 1 0
0 2 0
0 2 0
0 0 0
0 2 0

Page 14
 Supplementary Table 1
targets of contraindicated drugs Differentially expressed Text mining (HuGE) is_connected module1
0 2 2 1 0
0 1 2 1 0
1 1 0 1 0
0 1 2 1 1
0 1 2 1 0
0 1 2 1 0
0 1 2 1 1
0 1 2 1 0
0 1 0 1 0
0 1 2 1 1
0 1 1 1 0
0 1 2 1 0
0 1 2 1 1
0 1 0 1 1
0 1 2 1 1
0 1 2 1 0
0 1 1 1 0
0 1 2 1 0
0 1 2 1 1
0 1 2 1 1
0 1 2 1 1
0 1 2 1 1
0 1 2 1 1
0 1 2 1 1
0 1 2 1 1
0 1 2 1 1
0 1 1 1 0
0 1 1 1 1
1 1 2 1 0
2 1 2 1 1
0 1 2 1 0
0 1 2 0 0
0 1 2 1 1
0 1 2 1 1
0 1 2 1 0
0 0 2 1 1
1 0 1 0 0
0 0 2 0 0
0 0 2 1 0
0 0 1 1 0
0 0 2 1 0
0 0 2 1 0
0 0 2 0 0
0 0 1 1 0
0 0 1 1 0
1 0 2 1 0
2 0 2 1 0
2 0 2 1 0
1 0 1 1 0
0 0 2 1 1
0 0 0 1 0
0 0 2 1 0

Page 15
 Supplementary Table 1
0 0 0 1 0
0 0 2 1 1
0 0 1 1 0
0 0 0 0 0
0 0 0 0 0
0 0 2 1 0
0 0 2 1 0
0 0 1 1 0
0 0 0 1 0
0 0 0 0 0
0 0 0 1 0
0 0 0 1 0
0 0 2 1 0
0 0 2 1 1
0 0 1 0 0
0 0 0 1 0
0 0 0 1 0
0 0 2 1 0
0 0 1 1 0
0 0 0 1 0
0 0 2 1 0
0 0 0 0 0
0 0 0 0 0
0 0 1 0 0
0 0 2 1 0
0 0 2 1 0
0 0 2 1 1
0 0 2 1 1
0 0 2 1 0
0 0 2 0 0
0 0 2 0 0
0 0 2 1 1
0 0 2 1 0
0 0 1 1 1
0 0 2 1 0
0 0 1 1 0
0 0 0 1 0
0 0 2 1 0
0 0 1 1 0
0 0 0 1 1
0 0 2 1 1
0 0 0 1 0
0 0 2 0 0
0 0 2 1 0
0 0 2 1 0
0 0 2 1 0
0 0 2 1 0
0 0 1 0 0
0 0 2 1 0
0 0 2 1 0
0 0 2 1 0
0 0 2 1 0
0 0 2 1 0

Page 16
 Supplementary Table 1
0 0 2 1 0
0 0 2 1 0
0 0 0 1 0
0 0 0 0 0
0 0 2 1 1
0 0 2 1 0
0 0 2 1 1
0 0 2 1 0
0 0 2 0 0
0 0 1 1 1
0 0 1 1 0
0 0 2 1 0
0 0 2 1 0
0 0 2 1 0
0 0 0 1 0
0 0 1 1 0
0 0 1 1 0
0 0 0 0 0
0 0 0 1 0
0 0 2 0 0
0 0 2 0 0
0 0 1 1 1
0 0 0 1 0
0 0 0 1 0
0 0 0 1 0
0 0 0 1 0
0 0 0 1 0
0 0 0 1 0
0 0 2 1 0
0 0 2 0 0
0 0 0 0 0
0 0 2 0 0
0 0 0 0 0
0 0 0 1 0
0 0 2 1 0
0 0 2 1 0
0 0 2 1 0
0 0 2 1 0
0 0 2 1 0
0 0 2 1 0
0 0 0 1 0
0 0 0 0 0
0 0 0 0 0
0 0 0 1 0
0 0 0 1 0
0 0 0 1 0
0 0 0 1 0
0 0 0 1 0
0 0 0 1 0
0 0 0 1 0
0 0 0 1 0
0 0 0 1 0
0 0 0 1 0

Page 17
 Supplementary Table 1
0 0 0 1 0
0 0 0 1 0
0 0 0 1 0
0 0 0 1 0
0 0 0 1 0
0 0 0 1 0
0 0 0 1 0
0 0 0 1 0
0 0 0 1 0
0 0 0 1 0
0 0 2 1 0
0 0 2 1 0
0 0 2 1 0
0 0 2 1 0
0 0 2 1 0
0 0 2 1 0
0 0 2 1 0
0 0 0 1 0
0 0 0 0 0
0 0 1 1 0
0 0 2 1 0
0 0 2 1 1
0 0 1 1 1
0 0 0 0 0
0 0 0 1 0
0 0 2 1 0
0 0 2 1 1
0 0 2 1 1
0 0 2 0 0
0 0 2 0 0
0 0 2 1 1
0 0 2 1 1
0 0 2 1 1
0 0 2 1 1
0 0 2 1 1
0 0 2 1 1
0 0 2 1 1
0 0 2 1 1
0 0 2 1 1
0 0 2 1 1
0 0 2 1 1
0 0 2 1 1
0 0 2 1 0
0 0 2 1 0
0 0 2 1 1
0 0 2 1 0
1 0 2 1 0
0 0 2 1 0
0 0 2 1 1
0 0 0 0 0
0 0 2 1 1
0 0 0 0 0
0 0 0 0 0

Page 18
 Supplementary Table 1
0 0 0 0 0
0 0 0 0 0
0 0 0 0 0
0 0 0 1 0
0 0 2 1 1
0 0 2 1 1
0 0 0 0 0
0 0 0 0 0
0 0 2 1 0
0 0 2 1 0
0 0 2 1 0
0 0 1 0 0
0 0 2 1 0
0 0 2 0 0
0 0 1 1 0
0 0 2 1 0
0 0 2 1 0
0 0 2 1 0
0 0 2 1 1
0 0 2 1 1
0 0 0 1 0
0 0 0 0 0
0 0 2 0 0
0 0 1 0 0
0 0 0 1 0
0 0 0 0 0
0 0 2 1 0
0 0 2 1 1
0 0 0 1 1
0 0 2 1 1
0 0 2 1 1
0 0 2 1 1
0 0 2 1 1
0 0 2 0 0
0 0 2 1 0
0 0 0 1 0
0 0 2 1 1
0 0 2 0 0
0 0 0 1 0
0 0 1 0 0
0 0 2 1 0
0 0 1 0 0
0 0 0 0 0
0 0 2 0 0
0 0 2 1 0
0 0 2 0 0
0 0 2 1 0
1 0 1 1 1
0 0 2 1 0
0 0 2 0 0
1 0 1 0 0
1 0 2 1 1
0 0 0 1 0

Page 19
 Supplementary Table 1
0 0 2 1 1
0 0 0 0 0
0 0 0 0 0
0 0 0 0 0
0 0 2 1 0
0 0 2 1 0
0 0 1 1 0
1 0 1 1 0
0 0 2 1 0
0 0 2 0 0
0 0 0 1 0
0 0 0 1 0
0 0 1 0 0
0 0 2 1 0
0 0 2 1 0
0 0 0 1 0
0 0 0 0 0
0 0 0 0 0
0 0 0 0 0
0 0 2 0 0
0 0 0 1 0
0 0 0 1 0
0 0 1 1 0
0 0 2 1 0
0 0 2 1 0
0 0 2 1 0
0 0 2 1 0
1 0 2 1 0
0 0 1 1 1
0 0 0 1 0
0 0 1 0 0
0 0 0 0 0
1 0 2 0 0
0 0 2 1 0
0 0 0 0 0
0 0 2 1 1
0 0 2 1 0
0 0 2 1 0
0 0 2 1 0
0 0 1 1 1
0 0 2 1 1
0 0 0 1 1
0 0 2 1 0
0 0 2 1 0
0 0 1 1 0
0 0 1 1 0
0 0 2 1 0
0 0 2 1 1
0 0 2 1 1
0 0 2 0 0
0 0 2 0 0
0 0 2 1 1
0 0 2 1 1

Page 20
 Supplementary Table 1
0 0 2 1 1
0 0 2 1 1
0 0 1 0 0
0 0 2 0 0
0 0 0 1 0
0 0 0 1 0
0 0 2 1 0
0 0 0 1 0
0 0 1 0 0
0 0 0 1 1
0 0 0 1 0
0 0 2 1 0
0 0 0 0 0

Page 21
 Supplementary Table 1
module2 module3 module4 module5 module6 novel in_modules
0 1 0 0 0 0 3
0 0 1 0 0 0 4
0 0 0 0 0 0 0
0 0 0 0 0 0 1
1 0 0 0 0 0 2
0 0 1 0 0 0 4
0 0 0 0 0 0 1
0 0 1 0 0 0 4
0 1 0 0 0 1 3
0 0 0 0 0 0 1
0 1 0 0 0 0 3
0 0 1 0 0 0 4
0 0 0 0 0 1 1
0 0 0 0 0 0 1
0 0 0 0 0 0 1
1 0 0 0 0 0 2
1 0 0 0 0 0 2
0 0 0 1 0 0 5
0 0 0 0 0 0 1
0 0 0 0 0 0 1
0 0 0 0 0 0 1
0 0 0 0 0 0 1
0 0 0 0 0 0 1
0 0 0 0 0 0 1
0 0 0 0 0 0 1
0 0 1 0 0 0 1,4
0 0 1 0 0 0 4
0 0 0 0 0 1 1
0 1 0 0 0 0 3
0 0 0 0 0 0 1
0 1 0 0 0 0 3
0 0 0 0 0 0 0
0 0 0 0 0 0 1
0 0 0 0 0 0 1
0 0 0 1 0 0 5
0 0 0 0 0 0 1
0 0 0 0 0 1 0
0 0 0 0 0 0 0
0 0 1 0 0 0 4
0 1 0 0 0 1 3
1 0 0 0 0 0 2
1 0 0 0 0 0 2
0 0 0 0 0 1 0
0 0 1 0 0 0 4
0 0 1 0 0 0 4
0 0 1 0 0 0 4
0 0 1 0 0 0 4
0 0 1 0 0 0 4
0 0 1 0 0 0 4
0 0 0 0 0 0 1
0 0 0 0 0 1 0
1 0 0 0 0 0 2

Page 22
 Supplementary Table 1
0 0 0 0 0 1 0
0 0 0 0 0 0 1
1 0 0 0 0 0 2
0 0 0 0 0 1 0
0 0 0 0 0 0 0
0 0 0 0 0 0 0
0 1 0 0 0 0 3
0 0 0 0 0 1 0
0 0 0 0 0 1 0
0 0 0 0 0 1 0
1 0 0 0 0 1 2
1 0 0 0 0 1 2
0 0 1 0 0 0 4
0 0 0 0 0 0 1
0 0 0 0 0 1 0
0 0 0 0 0 1 0
0 0 0 0 0 1 0
1 0 1 0 0 0 2,4
1 0 0 0 0 0 2
1 0 0 0 0 1 2
1 0 1 0 0 0 2,4
0 0 0 0 0 1 0
0 0 0 0 0 1 0
0 0 0 0 0 1 0
0 0 1 0 0 0 4
0 0 1 0 0 0 4
0 0 0 0 0 0 1
0 0 0 0 0 0 1
0 0 1 0 0 0 4
0 0 0 0 0 0 0
0 0 0 0 0 0 0
0 0 0 0 0 0 1
0 0 0 1 0 1 5
0 0 0 0 0 0 1
0 1 0 0 0 0 3
1 0 0 0 0 0 2
1 0 0 0 0 1 2
0 0 1 0 0 0 4
0 0 0 1 0 0 5
0 0 0 0 0 1 1
0 0 0 0 0 0 1
0 0 0 1 0 0 5
0 0 0 0 0 0 0
0 0 1 0 0 0 4
0 1 0 0 0 0 3
1 0 0 0 0 0 2
1 0 0 0 0 0 2
0 0 0 0 0 1 0
0 0 0 0 0 0 0
1 0 0 0 0 0 2
1 0 0 0 0 0 2
1 0 0 0 0 0 2
1 0 0 0 0 0 2

Page 23
 Supplementary Table 1
0 0 0 0 0 1 0
1 0 0 0 0 0 2
1 0 0 0 0 1 2
0 0 0 0 0 1 0
0 0 1 0 0 0 1,4
0 0 1 0 0 0 4
0 0 0 0 0 0 1
1 0 0 0 0 0 2
0 0 0 0 0 1 0
0 0 0 0 0 0 1
0 0 0 0 0 1 0
0 0 1 0 0 0 4
0 1 0 0 0 0 3
0 1 0 0 0 0 3
0 1 0 0 0 1 3
0 0 0 1 0 0 5
0 0 0 1 0 1 5
0 0 0 0 0 1 0
0 0 0 0 0 1 0
0 0 0 0 0 0 0
0 0 0 0 0 1 0
0 0 0 0 0 1 1
0 0 0 1 0 1 5
0 0 0 1 0 1 5
0 0 0 1 0 1 5
0 0 0 1 0 1 5
0 0 0 1 0 1 5
0 0 0 1 0 1 5
1 0 0 0 0 0 2
0 0 0 0 0 0 0
0 0 0 0 0 1 0
0 0 0 0 0 0 0
0 0 0 0 0 1 0
0 1 0 0 0 1 3
1 0 0 0 0 0 2
1 0 0 0 0 0 2
1 0 0 0 0 0 2
1 0 0 0 0 0 2
1 0 0 0 0 0 2
1 0 0 0 0 0 2
0 0 0 0 0 1 0
0 0 0 0 0 1 0
0 0 0 0 0 1 0
0 0 0 0 1 1 6
0 0 0 0 1 1 6
0 0 0 0 1 1 6
0 0 0 0 1 1 6
0 0 0 0 1 1 6
0 0 0 0 1 1 6
0 0 0 0 1 1 6
0 0 0 0 1 1 6
0 0 0 0 1 1 6
0 0 0 0 1 1 6

Page 24
 Supplementary Table 1
0 0 0 0 1 1 6
0 0 0 0 1 1 6
0 0 0 0 1 1 6
0 0 0 0 1 1 6
0 0 0 0 1 1 6
0 0 0 0 1 1 6
0 0 0 0 1 1 6
0 0 0 0 1 1 6
0 0 0 0 1 1 6
0 0 0 0 1 1 6
0 0 0 1 0 0 5
0 0 0 1 0 0 5
0 0 0 1 0 1 5
0 0 0 1 0 0 5
0 0 0 1 0 1 5
0 0 0 1 0 0 5
0 0 0 1 0 0 5
0 0 0 1 0 1 5
0 0 0 0 0 1 0
0 0 0 1 0 1 5
0 0 0 1 0 0 5
0 0 0 0 0 0 1
0 0 0 0 0 0 1
0 0 0 0 0 0 0
0 0 1 0 0 1 4
0 1 0 0 0 0 3
0 0 0 0 0 0 1
0 0 0 0 0 0 1
0 0 0 0 0 0 0
0 0 0 0 0 1 0
0 0 0 0 0 0 1
0 0 0 0 0 0 1
0 0 0 0 0 0 1
0 0 0 0 0 0 1
0 0 0 0 0 0 1
0 0 0 0 0 0 1
0 0 0 0 0 0 1
0 0 0 0 0 0 1
0 0 0 0 0 0 1
0 0 0 0 0 0 1
0 0 0 0 0 0 1
0 0 0 0 0 0 1
0 0 0 0 0 0 0
0 0 1 0 0 0 4
0 0 0 0 0 0 1
0 0 0 1 0 0 5
0 1 0 0 0 0 3
0 0 0 0 0 1 0
0 0 0 0 0 0 1
0 0 0 0 0 1 0
0 0 0 0 0 0 1
0 0 0 0 0 1 0
0 0 0 0 0 1 0

Page 25
 Supplementary Table 1
0 0 0 0 0 1 0
0 0 0 0 0 1 0
0 0 0 0 0 1 0
0 0 0 0 0 1 0
0 0 0 0 0 0 1
0 0 0 0 0 0 1
0 0 0 0 0 1 0
0 0 0 0 0 1 0
1 0 0 0 0 0 2
0 0 1 0 0 0 4
0 0 0 0 0 0 0
0 0 0 0 0 0 0
1 0 0 0 0 0 2
0 0 0 0 0 1 0
1 0 0 0 0 1 2
0 1 0 0 0 0 3
0 1 0 0 0 0 3
0 1 0 0 0 0 3
0 0 0 0 0 0 1
0 0 0 0 0 1 1
0 0 0 0 0 1 0
0 0 0 0 0 1 0
0 0 0 0 0 0 0
0 0 0 0 0 0 0
0 0 0 1 0 1 5
0 0 0 0 0 1 0
1 0 0 0 0 0 2
0 0 0 0 0 0 1
0 0 0 0 0 1 1
0 0 0 0 0 0 1
0 0 0 0 0 0 1
0 0 0 0 0 0 1
0 0 0 0 0 0 1
0 0 0 0 0 1 0
0 0 1 0 0 0 4
0 1 0 0 0 1 3
0 0 0 0 0 0 1
0 0 0 0 0 0 0
0 0 0 1 0 1 5
0 0 0 0 0 1 0
0 0 1 0 0 0 4
0 0 0 0 0 1 0
0 0 0 0 0 0 0
0 0 0 0 0 0 0
0 1 0 0 0 0 3
0 0 0 0 0 0 0
0 1 0 0 0 0 3
0 0 0 0 0 0 1
1 0 0 0 0 0 2
0 0 0 0 0 0 0
0 0 0 0 0 0 0
0 0 0 0 0 0 1
0 1 0 0 0 1 3

Page 26
 Supplementary Table 1
0 0 0 0 0 0 1
0 0 0 0 0 0 0
0 0 0 0 0 1 0
0 0 0 0 0 1 0
0 0 1 0 0 1 4
0 0 1 0 0 0 4
1 0 0 0 0 0 2
1 0 0 0 0 0 2
0 0 0 1 0 0 5
0 0 0 0 0 0 0
0 0 0 0 0 1 0
0 0 1 0 0 1 4
0 0 0 0 0 1 0
0 1 0 0 0 0 3
0 1 0 0 0 0 3
0 0 0 0 0 1 0
0 0 0 0 0 1 0
0 0 0 0 0 1 0
0 0 0 0 0 1 0
0 0 0 0 0 0 0
0 0 0 0 0 1 0
0 0 0 1 0 1 5
0 0 0 1 0 1 5
0 0 0 0 0 0 0
0 1 0 0 0 0 3
1 1 0 0 0 0 2,3
0 1 0 0 0 0 3
0 1 0 0 0 0 3
0 0 0 0 0 1 1
0 1 0 0 0 1 3
0 0 0 0 0 0 0
0 0 0 0 0 1 0
0 0 0 0 0 0 0
0 1 0 0 0 0 3
0 0 0 0 0 1 0
0 0 0 0 0 0 1
1 0 0 0 0 0 2
1 0 0 0 0 0 2
0 1 0 0 0 0 3
0 0 0 1 0 0 1,5
0 0 0 0 0 0 1
0 0 0 0 0 1 1
0 0 0 1 0 0 5
0 0 1 0 0 0 4
0 1 0 0 0 0 3
0 1 0 0 0 0 3
0 1 0 0 0 0 3
0 0 0 0 0 1 1
0 0 0 0 0 0 1
0 0 0 0 0 0 0
0 0 0 0 0 0 0
0 0 0 0 0 0 1
0 0 0 0 0 0 1

Page 27
 Supplementary Table 1
0 0 0 0 0 0 1
0 0 0 0 0 0 1
0 0 0 0 0 0 0
0 0 0 0 0 0 0
0 0 0 0 0 1 0
0 0 0 1 0 1 5
1 0 0 0 0 0 2
1 0 0 0 0 1 2
0 0 0 0 0 1 0
0 0 0 0 0 1 1
0 1 0 0 0 1 3
0 1 0 0 0 0 3
0 0 0 0 0 1 0

Page 28