ulhcopa

wo wpatko opa hede (tV Blus

K12 Drshibuia phac.

erprin Hama

iminah m
Puoan

KE tima

tV Bolys of 2 compaotment kin eice

dug
decine. in plasma CoMc" 2 biexponentia
indiahng PLuAna o 2 disposj Hon pavCOAes
distubuiou eliminaha

(2)
dis tubuien
phae ( iniial xapid dockuna)

c gd a u
elimna o (Slaw leunina decline)
PRi
pexad

ewthal compammenf
-
neAupr-ljk
Hme

Cankal
Compasctment hMada o hignly pautused hamus,
exaceula fid & bland with kapid
unifoam drug disteu buti on.
Priphoal
COpasntment =oup d HBAUOA WiHh laies bload
penkusiau & dbhNk ahhini ty foy
he daug uhSlouw daug distsubuhon
 &eugial PpoJsible 2 toupanmen} models 8

ModelA
Wtd ofleu
disaihe plame

Centual Ka Psiphuol
keKo
Madel 6

ke Kzo

Model c
Cba
Penga

Kg dud K 94apoent Aust-oado. gale a n sfen consants

KiO K20 &KE pUent HaJe elimuAadion cOuan
 FmM gdph 2)
m untal Compastmant &
nc"
Rale chanae uA S
uuen as: Gc dug Conc"
Caal cmphrun
dt pediphenal np
K Hus+-Oider sale
couwtanthoM
Cauba
X= Va C. x= o n h t ot dug eupaL
aom

C a Uolumw disibulhn ke elimuhale atk

Cmanem

Ve Ve
Ve

n C*2
K2 Xp = amt 9dung
el C& C2
Ve 2 Vp= appant
 men Knetig of Mulhiple Dohing
takin
Manna. in which a diung
pOsaa Kegimen =

admuuistouai O
Juat H h o
is no dsug un tha
aAume
dase^ w e
Heo Single. oe u aig to
endminislaad & that no
u
bady kketa daug
be admiisleud
n ae omuthpla doA oe aso expecled
Lowenw also subsaquonF doses heaa 3
to uLe d dosaq
scomplukely elimnaed
shoulol bo. AMajdaiad.
hus acCumytati on do.te a dauas

adminustahion h a plasma CQne l

Qu ep2at, dug
Foi each dole inleawal giving a plaleau
be added pod
Stalle ith Ma plaua Oye ucahng b/w
Sleady
uin ax h
opant han Conc uiu
doSe a a reM nough ur

haua Men to opproX

0 befors hext d0se
acurmulaion dang n bg.dy.
be
Thora uU wo

Accumulahng Dosa
Xo at T=0
Afles 1S dose adminiShubion.,
auuLaunt of daug u bedy is X =
Xo

At naxt dosing iver) X =/2%o

auuount e daug sanauiug tha bady cantent to

X- o+/2o
Accumulaiou bcoz dRug
occus hum prous doses has nof
been renauad Complerely.
 As amaunt of cdug bady AiLes 9adually
due to accumulahidn

when t2
dcqec Q gecumMlahon greateA Uia vrsa.
Thus, exlent to wi dh a daug accumuulales in Hha. bady
duuiug muliple deng s a funchan a dosing inleya
eliminaian halt+ UeXu mdepandent a doue size

s max

Plasm
Seady shale

AAA Ccs mun

me
 sleady Shade. Douug leuols (ss

lime aeauisued to suaach sleady slale. depeuds paómarily upa

half ife el duug
Pashdad Ka >>ke tme plateaut paiciple
Tauo means 4hat the 0take at wlich mulliple dose Sady
Ste s utaced is dekexmumnd @uly by kE

Tme takew to geach steady sBale u indapandont o dosa

ize dosing inesual &ruumbe o oloses'

Accumulaion Tndex (R)

R =
-eReE
I- 0 63/ba)T

AVEA amount D g at Skadu shale

Aveage ale u =
Auwag uale Qt

Aunage ae n =F XDo
Ass ay = aug amount
aaqe Aae-out
=
K. As av
Udkug PHa
bady ole dosing
inlesual at plaleku

o F DOse = X. Ass ay.

inel eguaion Css aw = AUC Auc aRad uudon

7
awg awaunt o daug un biady daponds upon uale o administtah3n,
CuuuR

bioaumilakitt hal uepasma daug conc dponds

a also duaran apast ben dose, bioarailabi
k doung ntewa
 Lo adiug ef aud Maintaudy a Dotel

Loadinag Doses
Ti4ha dae Trilial hight dnse oh a dsug that i gnon n
Hu beqinuing 4heaBment bahoAe dsopping to lawe dosa

DoLug Dese daes not shaw honapaufic achuiy mlas

cacies desisad sleady stale
T akts abeu- u-5 half Ges

calulathau s
av va
o,L ss 9

Wheu u t Ruown,
Loadiang cose a y be. alculaked by
Xo,L
Xo 1-e)1-et)
in quaiau applies wen ka> Ke Ldsuq ls dishibuod
wkau da s mn by IV o4 absapio4 i ekhemey sapid
apiduy1
Hon absphan phaNe s aquLted abaua 2quah on amduas
to accumulah on DAdex

-Ket
(1-e
aintainua DO
Nataineua Rale o dsg odministsai on equal to gale
elimiun adi 0n o skady skake
MD Cp CL MD Maintaineuca,don
Cp DeuAsd Paak cotc
CL = deashna eLdaug n
FD6 IV, Bpovulobjühy F= ad
F Bioauailabiüky