The genetic code is the instruction manual that cells
use to translate the information stored in DNA into
proteins. It's like a complex dictionary where sequences of DNA nucleotides (building blocks) are matched to specific amino acids (protein building blocks). Here's a breakdown of the key points: The Players: o DNA: Deoxyribonucleic acid, the genetic
material that stores the instructions for
building and maintaining an organism. DNA uses four nucleotide bases: Adenine (A), Thymine (T), Cytosine (C), and Guanine (G). o RNA: Ribonucleic acid, a molecule involved
in protein synthesis. There are a few types
of RNA, but messenger RNA (mRNA) is key in this process. mRNA uses the same bases as DNA except for Uracil (U) instead of Thymine (T). o Amino Acids: The building blocks of
proteins. There are 20 different standard
amino acids used to build proteins in humans. o Codons: Three-base sequences of nucleotides in DNA or RNA. Each codon codes for a specific amino acid (with some exceptions). o Ribosomes: Cellular machines that translate
the genetic code by linking amino acids
together to form proteins. The Process: 1. Transcription: DNA is unwound, and a
complementary mRNA strand is copied from
a specific DNA gene segment. 2. Transport: mRNA carries the genetic code
from the nucleus to the cytoplasm (cellular
fluid). 3. Translation: Ribosomes read the mRNA
codon by codon. Transfer RNA (tRNA)
molecules, each carrying a specific amino acid, match their anticodons (complementary base sequences) to the mRNA codons. The ribosome links the amino acids together in the order specified by the mRNA codons, forming a protein. Key Characteristics: o Triplet Code: The genetic code is a triplet code, meaning that a sequence of three nucleotides (codon) specifies a single amino acid. o Degeneracy: Most amino acids are coded for by more than one codon (except methionine and tryptophan). This redundancy helps ensure protein synthesis can still occur even if there are occasional errors during copying DNA or RNA. o Universality: The genetic code is nearly universal, meaning that the same codons generally specify the same amino acids in all living organisms. This allows for the transfer of genetic information across species. Understanding the genetic code is fundamental to genetics, medicine, and biotechnology. It allows scientists to study how genes control the development and function of organisms, diagnose genetic diseases, and develop new therapies.