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Review Science. 2022 Nov 4;378(6619):505-510. doi: 10.1126/science.abq2591.

Epub 2022 Nov 3.

The emergent properties of the connected brain

Michel Thiebaut de Schotten 1 2, Stephanie J Forkel 2 3 4 5
Cite
Affiliations expand
PMID: 36378968 DOI: 10.1126/science.abq2591 Collections

Abstract
There is more to brain connections than the mere transfer of signals between brain regions. Behavior
and cognition emerge through cortical area interaction. This requires integration between local and
distant areas orchestrated by densely connected networks. Brain connections determine the brain's
functional organization. The imaging of connections in the living brain has provided an opportunity to
identify the driving factors behind the neurobiology of cognition. Connectivity differences between
species and among humans have furthered the understanding of brain evolution and of diverging
cognitive profiles. Brain pathologies amplify this variability through disconnections and, consequently, Title & authors
the disintegration of cognitive functions. The prediction of long-term symptoms is now preferentially
based on brain disconnections. This paradigm shift will reshape our brain maps and challenge current Abstract
brain models.

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Publication types
Research Support, Non-U.S. Gov't
Review

MeSH terms
Brain* / physiology
Brain* / ultrastructure
Cognition*
Connectome*
Humans
Magnetic Resonance Imaging / methods
Nerve Net* / ultrastructure

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