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ORIGINAL ARTICLE

Psychosocial Stress, Social Support, and the


Escalation of Schizotypal Symptoms
Michael A. Juan, PhD* and Irwin Ford Rosenfarb, PhD*†

Little is known, however, about either the factors that are associ-
Abstract: Although research suggests that psychosocial stress is associated with ated with increases in schizotypy or the factors that lead to the develop-
an increase in schizotypal symptoms, the type of stressor associated with increased ment of a psychotic disorder in individuals who score highly on schizotypy
symptomatology is unclear, and no study has examined whether social support scales. According to vulnerability-stress models of schizophrenia
might mitigate the effects of stress on symptom change. In this study, 131 young (Nuechterlein and Dawson, 1984; Zubin and Spring, 1977), individuals
adults completed measures of schizotypal symptoms, major life events, daily has- with a genetic or biological vulnerability to develop schizophrenia
sles, and perceptions of social support at baseline, and measures of stress and develop symptoms when psychosocial stressors exceed a certain thresh-
symptoms again 4 to 6 weeks later. Results indicated, after controlling for base- old. According to model, stress leads to an activation of the hypothalamic-
line measures, that for those scoring low on schizotypal measures at baseline, pituitary-adrenocortical (HPA) axis, which in turn increases dopamine and
only low levels of social support were associated with increased symptoms. serotonin levels in the brain (Walker et al., 2004). Cognitively, stress
For those scoring high on the schizotypal scales at baseline, however, both major also increases negative cognitive schemas, which may lead to a decrease
life events and daily hassles were associated with increased symptomatology, but in feelings of personal control and an increase in psychotic symptoms
only when perceptions of social support at baseline were low. The results suggest such as being suspicious and paranoia (Mayo et al., 2017).
that it is important to assess both perceptions of social support and baseline Two types of psychosocial stressors have been identified in the
symptomatology when examining whether major life events and daily stress literature: major stressors, also known as major life events, and minor
are associated with increased psychotic symptoms. Both types of psychosocial stressors, also known as daily hassles (DeVylder et al., 2013; Tessner
stress are associated with an increase in symptoms, but only for those who are al- et al., 2011), and both types have been found to be associated with in-
ready showing above average symptoms and only when social support is low. creases in schizotypy and psychotic symptoms. Beards et al. (2013),
Key Words: Schizotypal symptoms, life events, daily stressors, social support for example, in a meta-analytic review, found over a threefold increase
in major life events before psychosis onset, and several studies have
(J Nerv Ment Dis 2022;210: 61–67)
found that daily stressors were predictive of an increase in psychotic
symptoms (DeVylder et al., 2013; Norman and Malla, 1994; Tessner
he term “schizotypy,” first coined by Meehl (1962), refers to a broad,
T multidimensional range of personality traits that include unusual
perceptual experiences, paranoid thinking, social anhedonia, and odd
et al., 2011; Yung et al., 2005). Yet, research in this area has been incon-
sistent. At least two studies (DeVylder et al., 2013; Tessner et al., 2011)
found that major life stressors were not associated with an increase in
or disorganized behavior and speech (Barrantes-Vidal et al., 2015; Kwapil
psychotic symptoms in individuals at risk for psychosis and Mason
and Barrantes-Vidal, 2015). Schizotypy is often viewed as a latent person-
et al. (2004) reported that major life events were not associated with
ality dimension, and schizotypal symptoms are seen as the phenotypic or
conversion to psychosis in a high-risk sample.
clinical indicators of that dimension (Debbané et al., 2015; Fonseca-
Research examining the relationship between psychosocial stress
Pedrero et al., 2018; Velikonja et al., 2015). Moreover, although schizotypy
and the escalation of psychotic symptoms may be inconsistent, in part be-
is usually viewed as a stable personality trait, research suggests that
cause few studies have assessed the role that social support might play in
scores on schizotypy scales fluctuate based on environmental stressors.
mitigating the effects of stress on the escalation of symptoms. According
Kocsis-Bogár et al. (2013), for example, found that the number and
to vulnerability-stress models, social support should play a critical role in
severity of stressful life events were significantly associated with schizotypy
buffering the effects of stress on psychotic symptom exacerbation. Social
scores, and Cohen et al. (2008) reported, over a 20-year period, that
support might mitigate the effects of stress by reducing HPA activation
schizotypal personality scores increased based on the number of adverse
and by increasing self-efficacy and decreasing suspiciousness and para-
life events experienced.
noia. Much empirical research has also found that social support plays
Research also suggests that individuals who score highly on
a critical role in buffering the effects of psychosocial stress on psychiatric
schizotypy scales, even if they do not meet criteria for a psychotic dis-
symptom exacerbation. Hultman et al. (1997), for example, found that af-
order at the time of assessment, are at increased risk of developing
ter a significant life event, patients with schizophrenia with close social
schizophrenia and other psychotic disorders in the future. Both Mason
attachments were significantly less likely to have a relapse episode than
et al. (2004) and Miller et al. (2002), for example, in prospective studies,
individuals without close social attachments, and Avcıoğlu et al. (2019)
found that the best predictor of developing a psychotic disorder over a 1-
recently reported that siblings of patients with schizophrenia with high
to 3-year period was the presence of schizotypal personality characteris-
levels of caregiver burden were significantly more likely to score high
tics. In addition, Kwapil et al. (2013) reported that, over a 10-year period,
on a measure of subjective well-being when their perceptions of social
schizotypy uniquely predicted the development of a schizophrenia
support were also high.
spectrum disorder.
To our knowledge, however, no study has directly examined how
social support may interact with life stress to reduce the probability that
*California School of Professional Psychology, Alliant International University, San
Diego; and †Department of Psychiatry, University of California, La Jolla,
schizotypal symptoms emerge. The purpose of the present study, there-
California. fore, was to examine, among young adults, whether major life events
Send reprint requests to Irwin Ford Rosenfarb, PhD, California School of Professional and daily stressors would be associated with the escalation of schizotypal
Psychology, Alliant International University, 10455 Pomerado Road, San Diego, symptoms over a 4- to 6-week period, and whether perceptions of social
CA 92131. E‐mail: ifrosenfarb@alliant.edu.
Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.
support would mitigate the effects of psychosocial stress on the escalation
ISSN: 0022-3018/22/21001–0061 of symptoms. We hypothesized that the escalation of both major life
DOI: 10.1097/NMD.0000000000001416 events and daily hassles would be associated with an escalation of

The Journal of Nervous and Mental Disease • Volume 210, Number 1, January 2022 www.jonmd.com 61

Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.


Juan and Rosenfarb The Journal of Nervous and Mental Disease • Volume 210, Number 1, January 2022

schizotypal symptoms. We also hypothesized, however, that high levels and means, standard deviations, and ranges for the study measures, and
of social support would mitigate the effects of both types of stressors on Table 2 shows the correlation matrix for the variables. Forty-three percent
the escalation of symptoms. of the sample was Latinx (n = 56), 30% was White (n = 39), 20% were
Asian (n = 27), and 4% were African-American (n = 5). In addition, ap-
METHODS proximately 25% had a high school degree (n = 33), 62% had completed
some college (n = 81), and 13% had a graduate school education (n = 17).
Participants None of the demographic variables correlated significantly with the
outcome measures.
Participants were recruited through advertisements posted on
Craiglist.com and Backpage.com, through a schizotypal personality
web forum, and via flyers posted in coffee houses. Undergraduate col- Assessment of Schizotypal Symptoms
lege students from local community colleges and universities were also Two questionnaires have typically been used to assess schizotypy:
approached in class, and print advertisements were placed in a local weekly the Wisconsin Schizotypy Scales and the Schizotypal Personality Ques-
publication. Potential participants were told, “Stress can lead to a number of tionnaire (Cohen and Fonseca-Pedrero, 2017; Gross et al., 2014). The
unusual experiences. If you are between the ages of 18 to 35 and would like scales have been shown to be highly correlated. Wuthrich and Bates
to participate in a research study examining how stress and certain person- (2006), for example, found that the Schizotypal Personality Question-
ality characteristics are related, contact the first author by phone or email to naire correlated 0.70 with the Perceptual Aberration scale and 0.72 with
obtain access to the study.” the Magical Ideation Scale. The latter two scales are components of the
Upon contacting the researcher, potential participants were screened Wisconsin Schizotypy Scales. In this study, we used both the Schizotypal
to ensure they were between 18 and 35. Individuals indicating a current di- Personality Questionnaire–Brief (SPQ-B; Raine and Benishay, 1995) and
agnosis of schizophrenia, schizoaffective disorder, schizophreniform, or bi- Perceptual Aberration/Magical Ideation Scales (PER-MAG; Chapman
polar disorder were also excluded. A total of 163 individuals completed the et al., 1994) to assess schizotypal symptoms. Raine and Benishay (1995)
time 1 measures. Of those, 132 (81%) also completed the time 2 measures. created the SPQ-B as an attenuated but psychometrically sound version
One participant, however, was omitted from the analyses because he en- of the longer Schizotypal Personality Questionnaire (Raine, 1991). This
dorsed every item across a number of measures, and his data proved to instrument assesses the presence of schizotypal personality disorder by
be an outlier. Participants who completed time 1 measures only (n = 32) way of self-report of symptoms as defined by the Diagnostic and Statistical
did not differ significantly from those who completed the study on any Manual of Mental Disorders, 4th Edition criteria. The PER-MAG scales
demographic variable. have been shown, at a 10-year follow-up, to be strong predictors of psycho-
Participants who completed the study ranged in age from 18 to sis in respondents and in their close relatives (Chapman et al., 1994). Be-
35 (mean, 23.3; SD, 4.5), and 64.1% of the sample was female (n = 84). cause the SPQ-B and the PER-MAG scales both assess schizotypy and
Sixty-five participants (50%) were recruited from local community col- were highly correlated in prior studies and in this study (Table 2), they were
leges and universities; the remainder were recruited from advertisements. standardized and combined to create one measure of schizotypal symptoms.
Table 1 provides a summary of the sample's demographic characteristics Before standardization, however, square root transformations were conducted
on both variables at time 1 and time 2 to adjust for a moderate positive skew.

TABLE 1. Demographics, Time 1, and Time 2 Measures Assessment of Psychosocial Stress


Mean SD Range n % Hassles Scale (HAS; Kanner et al., 1981) and Life Experiences
Survey (LES; Sarason et al., 1978). The HAS assesses daily stressors
Age, yrs 23.3 4.5 18 to 35 and contains 117 items descriptive of the stressors that may befall a per-
Sex (female) 84 64 son on a daily basis. Items include concerns about one's health, the use
Ethnicity of alcohol or drugs, and feeling prejudice and discrimination from
White 39 30 others. Items are first endorsed by the respondent and then rated on a
Latinx 56 43 3-point Likert scale for severity. The LES is a 57-item, self-report scale
Asian/Pacific Islander 27 20
that asks respondents to endorse specific life events that they have re-
cently experienced. Items include the death of a family member, change
African-American 5 4
of residence, and major personal injury or illness. As with the HAS, the
Other 4 3 subjective impact of these events is then determined using a 7-point
Education Likert scale. A square root transformation was conducted on the HAS
High school 33 25 at time 1 to adjust for a moderate positive skew, and a logarithmic trans-
College 81 62 formation was performed on the HAS at time 2 due to a substantial pos-
Graduate school 17 13 itive skew. LES data were normally distributed at both time points.
SPQ-B T1 7.3 5.4 0 to 22
PER-MAG T1 11.5 9.4 0 to 59 Assessment of Social Support
HAS T1 56.9 38.9 0 to 181 Perceived Social Support Scale (PSS; Procidano and Heller, 1983).
LES T1 −1.7 7.4 −34 to 21 The PSS is divided into two components—perceived social support from
PSS 22.4 5.8 0 to 35 family members and perceived social support from friends. Scores are ag-
SPQ-B T2 7.1 5.6 0 to 22 gregated, with higher totals indicating higher levels of perceived support.
PER-MAG T2 10.5 8.7 0 to 56 Studies of internal consistency for the PSS have yielded Cronbach alpha
HAS T2 49.8 43.2 2 to 280 scores of .84 to .92 (Lyons et al., 1988). PSS scores were reflected and
LES T2 −1.7 6.6 −39 to 17
square roots were obtained to adjust for a moderate negative skew.

HAS indicates Hassles Scale, severity rating (higher numbers indicate greater Procedure
severity); LES, Life Events Scales, severity rating (lower numbers indicate
greater negative impact); T1, time 1; T2, time 2. Those who met the screening criteria were provided access to a
website with the informed consent. Participants then completed the

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The Journal of Nervous and Mental Disease • Volume 210, Number 1, January 2022 Stress and Schizotypal Symptoms

TABLE 2. Correlations Among Study Variables

1 2 3 4 5 6 7 8
1. SPQ-B 1
2. SPQ-B 2 0.86**
3. PAMI 1 0.63** 0.61**
4. PAMI 2 0.64** 0.63** 0.89**
5. Soc support −0.35** −0.32* −0.20* −0.20*
6. Hassles 1 0.48** 0.38** 0.34** 0.34** −0.19*
7. Hassles 2 0.37** 0.37** 0.32** 0.30** −0.16 0.60**
8. Life events 1 −0.15 −0.18* −0.27** −0.27** 0.26** −0.28** −0.22*
9. Life events 2 −0.08 −0.11 −0.19* −0.14 0.15 −0.16 −0.22* 0.59**
N = 131.
Hassles 1 indicates Hassles Scale, time 1; Hassles 2, Hassles Scale, time 2; Life events 1, LES time 1; Life events 2, LES time 2; PAMI 1, Perceptual Aberration/
Magical Ideation Scales time 1; PAMI 2, Perceptual Aberration/Magical Ideation Scales time 2; SPQ-B 1, SPQ-B time 1; SPQ-B 2, SPQ-B time 2; Soc support, PSSS
(administered at time 1).
*p < 0.05.
**p < 0.01.

measures online. At baseline, participants completed the SPQ-B, the PER- 2 hassles  social support (β = 0.155, p = 0.001), time 2 life events 
MAG, the HAS, the LES, and the PSS. They were told to complete the social support (β = 0.174, p = 0.003), time 1 schizotypy  time 2 has-
HAS and LES while focusing solely on the prior 4-week period. sles (β = 0.123, p = 0.01), time 1 schizotypy  time 2 life events
Four weeks later, participants were sent an email and asked to (β = 0.125, p = 0.02), and time 1 schizotypy  time 2 life events  so-
again respond to the same measures except the PSS, which was com- cial support (β = −0.145, p = 0.02). The complete regression model is
pleted only at time 1. Participants who failed to complete the time 2 shown in Table 3.
measures were sent two follow-up emails asking them to participate
in the study. Instructions at time 2 also asked participants to limit their
responses to the stress measures to the prior 4-week period. Participants Daily Stressors
earned either a $5 gift certificate to Amazon.com or class credit for To understand the significant time 1 schizotypy  time 2 hassles
completing the measures at time 1 and time 2. At completion of time interaction, we created high and low groups for each measure based on
2 measures, participants were also entered into a $100 lottery. median splits. As can be seen in Figure 1, results indicated that for in-
dividuals low in baseline schizotypal symptoms, daily stress did not sig-
Data Analysis nificantly influence time 2 schizotypal symptom scores, (t[62] = 0.06,
The purpose of the study was to determine whether an increase p = 0.95). For individuals with high baseline schizotypal symptoms,
in psychosocial stress would be associated with an increase in schizotypy however, those with a greater severity of daily stress had significantly
scores. We also hypothesized that if social support was high at baseline, higher time 2 schizotypal scores (mean, 0.90; SD, 0.78) than those with
even if there was an increase in stress, schizotypy scores would not in- a lower severity of daily stress (mean, 0.38; SD, 0.70; t[65] = 2.73, p = 0.008).
crease significantly. A linear regression analysis was computed. The The next set of analyses examined the time 2 hassles  social
dependent variable was the time 2 schizotypy score. Predictor variables support interaction. These results indicated, as can be seen in Figure 2,
included all the time 1 predictors (schizotypy score, hassles, life events, that for those with high levels of social support, daily stress did not sig-
and social support), time 2 hassles and life events scores, all two-way nificantly influence time 2 schizotypal symptom scores, (t[62] = 1.32,
interactions of time 1 schizotypy, social support, time 2 hassles, time p = 0.19). For individuals with low levels of social support, however,
2 life events, and the three-way interactions of time 1 schizotypy  social those with greater daily stress had significantly higher time 2 schizotypal
support  time 2 hassles, and time 1 schizotypy  social support  time scores (mean, 0.63; SD, 1.03) than those with a lower levels of daily stress
2 life events. To understand interaction effects, following Tabachnick and (mean, −0.08; SD, 0.87; t[65] = 3.00, p = 0.004).
Fidell (2007), high and low groups for each measure were created based
on median splits, and groups were compared using two-tailed t-tests. To
Life Events
assess for outliers, Cook's and Mahalanobis distances were determined
(Tabachnick and Fidell, 2007). Cook's assessment revealed no major out- To understand the three-way time 1 schizotypy  time 2 life events
liers in the data (Cook's >1.0), whereas Mahalanobis did reveal six out-  social support interaction, we created high and low groups for each mea-
liers (χ2 = 22.458, p < 0.001). These were examined and retained in sure based on median splits. As can be seen in Figure 3, results indicated
the analyses because of the expectation that some of those responding that for individuals low in time 1 schizotypal symptoms, there was a
to the study advertisements would endorse high scores on some of significant main effect for social support. Those with high levels of so-
the measures (e.g., schizotypy). cial support had lower time 2 schizotypal scores (mean, −0.86; SD,
0.51) than those with low social support (mean, −0.53; SD, 0.64; t
[62] = 2.23, p = 0.02). A different pattern emerged, however, for those
RESULTS with high time 1 schizotypal symptoms. For those individuals, for those
Results indicated that the overall model was significant (F high in social support, time 2 life events did not significantly affect time
[13,117] = 48.1, p < 0.0001); the R2 was 0.842. Significant predictors 2 schizotypal symptom scores (t[23] = 1.11, p = 0.28). For individuals
included time 1 schizotypy (β = 0.942, p < 0.001), time 1 hassles with low social support, however, those with more negative life events
(β = −0.113, p = 0.02), time 1 life events (β = −0.114, p = 0.02), time at time 2 had significantly higher time 2 schizotypal scores (mean,

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Juan and Rosenfarb The Journal of Nervous and Mental Disease • Volume 210, Number 1, January 2022

TABLE 3. Regression Model to Predict Time 2 Schizotypy Scores

Predictor b SE b t p
Intercept −0.049 0.041 −1.17 0.241
Time 1 schizotypy 0.942 0.048 19.74 0.000
Time 1 hassles −0.113 0.051 −2.20 0.029
Time 1 life events −0.114 0.051 −2.21 0.029
Social support 0.026 0.043 0.60 0.548
Time 2 hassles 0.065 0.053 1.23 0.219
Time 2 life events −0.052 0.054 −0.96 0.337
Time 1 schizotypy  time 2 hassles 0.126 0.048 2.62 0.010
Time 1 schizotypy  time 2 life events 0.163 0.070 2.34 0.021
Time 1 schizotypy  social support −0.089 0.049 −1.84 0.068
Time 2 hassles  social support 0.149 0.045 3.32 0.001
Time 2 life events  social support 0.177 0.058 3.05 0.003
Time 1 schizotypy  time 2 hassles  social support 0.018 0.051 −0.34 0.728
Time 1 schizotypy  time 2 life events  social support −0.168 0.072 −2.33 0.021
N = 131. Bolded text indicates significant relationships. schizotypy indicates combined SPQ-B and Perceptual Aberration/Magical Ideation Scales; hassles, Hassles
Scale; life events, LES; Social support, PSSS (administered at time 1).

1.05; SD, 0.84) than those with fewer negative life events at time 2 Malla, 1994; Tessner et al., 2011; Yung et al., 2005) are associated with
(mean, 0.47; SD, 0.80; t[40] = 2.33, p = 0.03). increases in psychotic symptoms.
The results also suggest that social support might mitigate the
effects of stress on symptom escalation, replicating similar findings
DISCUSSION with patients with schizophrenia (Hultman et al., 1997) and siblings
The results indicated that for those scoring low on schizotypal of individuals with schizophrenia (Avcıoğlu et al., 2019). It is unclear,
measures at baseline, only low levels of social support were associated however, why social support buffered the effects of stress on symptom
with increased symptoms. For those scoring high on the schizotypal scales exacerbation. Previous research found that social support was associ-
at baseline, however, both major life events and daily hassles were ated with decreased paranoia in a nonclinical sample (Freeman et al.,
associated with increased symptomatology, but only when perceptions 2011) and increased problem-focused coping in those at high risk for
of social support at baseline were low. The results thus extend previous developing psychosis (Kang et al., 2018). Support thus might lead to
research that found that both major life events (see Beards et al., 2013 decreased feelings of suspiciousness and paranoia and may help indi-
for a review) and daily stressors (DeVylder et al., 2013; Norman and viduals cope more effectively with psychosocial stressors.

FIGURE 1. The effects of daily stress on schizotypal symptoms based on baseline schizotypal symptom score.

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The Journal of Nervous and Mental Disease • Volume 210, Number 1, January 2022 Stress and Schizotypal Symptoms

FIGURE 2. The effects of social support on schizotypal symptoms based on level of daily stress.

The results also indicated that stressors were only associated psychosis. This interpretation, however, should be viewed cautiously
with increased symptomatology at time 2 for individuals scoring above because, in this study, high scorers on the schizotypy scales simply
the median on the schizotypal questionnaires at baseline. Thus, stress scored above the median on the scales, and the taxon, or the genetic vulner-
seems to exacerbate psychotic symptoms only for individuals with ability to develop psychosis, is usually viewed as being present for only ap-
above average levels of symptomatology. The data give further support proximately 10% of the population (Kwapil and Barrantes-Vidal, 2015).
to the view that schizotypy, the personality organization underlying The results also have important treatment implications. The results
schizotypal symptoms, is taxonic in nature, and there may be qualitative dif- suggest that for those scoring high on schizotypy scales, both major life
ferences between those scoring high and low on schizotypy questionnaires stressors and minor, daily hassles should be monitored by clinicians to
(see Kwapil and Barrantes-Vidal, 2015 for a further discussion of this issue). help prevent increased symptomatology. Attempts to increase social sup-
According to this view, the genetic vulnerability to develop schizophre- port may also help decrease symptom escalation. Recent treatments
nia is present in only a small percentage of the population, and stress aimed at improving social skills and family relationships in individuals
should exacerbate symptoms only for those with the taxon to develop at risk for developing psychosis may be important ways to increase social

FIGURE 3. The interaction of severity of major life events and perceived social support on schizotypal symptoms based on baseline schizotypal symptom score.

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Juan and Rosenfarb The Journal of Nervous and Mental Disease • Volume 210, Number 1, January 2022

support in this vulnerable population (see Lecomte et al., 2019 for DeVylder JE, Ben-David S, Schobel SA, Kimhy D, Malaspina D, Corcoran CM
a review). (2013) Temporal association of stress sensitivity and symptoms in individuals at
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ent outcomes (e.g., Kwapil et al., 2012, 2013). Thus, the results in this Cohen A, Raine A, Compton MT, Tone EB, Suhr J, Bobes J, Fumero A, Giakoumaki
study may have been different had each of the schizotypy dimensions S, Tsaousis I, Preti A, Chmielewski M, Laloyaux J, Mechri A, Lahmar MA,
been examined separately. There is, however, a lack of consensus as to Wuthrich V, Larøi F, Badcock JC, Jablensky A, Barron D, Swami V, Tran US,
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