Q1.

Discuss in detail:[5x3]
(a) Digestion and absorption of lipids
(b) Composition of chylomicron
(c) Exogenous lipid transport pathway
 2. Describe the steps of β-Oxidation of fatty acids. Calculate the energy production from the complete oxidation
of one molecule of palmitic acid. 7+3
3. Describe the long-chain fatty acids synthesis. How chain elongation takes place? 10+5=15
 4. Give an account of the synthesis of Cholesterol in our body. How is it regulated? State some
important functions of Cholesterol. [7+3+5]
5. Explain the stages of Cholesterol synthesis. How it is regulated? How the statin group of drugs act?
[15]
6. What is the fate of cholesterol in the body? Elaborate. Write about the normal lipid profile. 15
 7. What are ketone bodies? Explain the reactions leading to the formation of them. How they are
utilized in the body? 3+7+5=15
 8. Name the different lipoproteins present in blood and give their general structural features. Write the
metabolism of triglyceride-rich lipoprotein. 1+2+7
9. Discuss various lipoprotein and altered metabolism of them. (15)
10. An obese patient has presented with palmar xantoma & xanthesma in the medial corners of the eye.
(4+3+3)
(a) What is the most common cause of such a finding? What are the other types of
hyperlipoproteinemias?
(b) Why HDL is called good cholesterol?
(c) From which molecule cholesterol is synthesized? Which is the rate limiting step of cholesterol
synthesis?
11. Describe briefly the various ways of utilization of Acetyl CoA in our body. (15)
SQ
1. Briefly describe the components and applied aspects of the serum lipid profile. (5)
2. Low-density lipoprotein (LDL) (5)
3. Refsum disease (5)
4. VLDL (3)
5. HDL (3)
6. Carnitine (2.5)
7. Fatty liver (2.5)
8. Lipid storage diseases (2.5) SMBPU 16
9. Hypercholesterolemia (2)
10. Reverse cholesterol transport (2)
11. Use of Prostaglandins in medicine (2)
12. Lipotropic factors (2)
13. Lipoprotein (A) (2)
14. Carnitine transporters (2)
15. Synthesis and utilization of ketone bodies (2)
16. Aspirin is used as a blood thinner in patients with coronary artery disease. (2)
17. Which lipoprotein contains the maximum amount of cholesterol? (1)
18. Which ketone body is not detected by Rothera’s test? (1)
19. Name the apolipoprotein associated with chylomicron (1)
20. Name the rate-limiting enzyme in Fatty acid synthesis. (1)
21. Which apoprotein activates LCAT? (1)
22. Normal serum level of cholesterol (0.5)
23. Name the cofactor for lipoprotein lipase. (0.5)
24. What is the effect of insulin on lipogenesis? (1)
25. Which fatty acid is required for ceramide synthesis? (1)
26. Which enzyme deficiency causes Gaucher disease? (1)
27. B48 is an apoprotein of VLDL cholesterol. (T/F)
28. Nicotinic acid increases serum Lp(a) levels. (T/F)
29. The liver cannot utilize ketone bodies due to absence of _______enzyme. (1)
30. Deficiency of sphingomyelinase causes ______ disease. (1)
31. Acyl carrier protein contains vitamin _______. (1)
32. Serum cholesterol is _______ in hypothyroidism. (1)
33. Lipoprotein______ takes part in reverse cholesterol transport (0.5)
34. Normal serum HDL level in male is_______. (1)
35. _______ is accumulated in Refsum disease (1)
36. β-oxidation of stearic acid forms_______ amount of ATP.
37______ is a lipotropic factor. (0.5)
38. Lightest lipoprotein circulating in blood is ______ (1)
39. Hormone-sensitive lipase is inhibited by ______ (1)
40. ______carries dietary and ______ carries endogenous Triglycerides? (2)
41. A rare inherited absence of peroxisomes in all tissues causes______ syndrome (1)