AVISAN®SECURE AVISAN®SECURE

Inactivated vaccine, Avian salmonellosis, in injectable emulsion

COMPOSITION:
Inactivated Salmonella enteritidis; Inactivated Salmonella typhimurium. Adjuvant.
The main immunological property of this vaccine is the stimulation of the active immunity of
future layer and breeder chicks against Salmonella enteritidis and Salmonella typhimurium.
Hygienic and biosecurity measures, as well as good production practices and a proper or
suitable prophylaxis, are important in programmes for controlling the reduction of the
incidence of infection by Salmonella.
TARGET SPECIES:
Poultry (Hens: future layer and breeder chicks).
INDICATIONS FOR USE:
For active immunisation against Salmonella enteritidis and Salmonella typhimurium in future
layer and breeder chicks, for reducing the infection of internal organs by said microorganisms,
as well as the reduction of intestinal colonisation and of faecal excretion and reduction of
vertical transmission through ovaries.

d
Duration of immunity: As of 28-33 weeks after the second vaccination (when birds are 45-50
weeks of age) a reduction of the invasion of internal organs, and of intestinal colonisation,

e
and of lesions and symptoms was observed (in the case of S. typhimurium) as was a reduction
of vertical transmission through ovaries.

rv
DOSAGE:
Future layer and breeder chicks: 1 dose of 0.5 ml / bird.
ADMINISTRATION FORM AND ROUTE:

e
Intramuscular, in the breast.

s
It is recommended that the first dose be administered at the age of 10 weeks and a second
dose be administered at 17 weeks of age.

re
ADVERSE REACTIONS:
A slight decrease in the general activity of vaccinated birds associated with the administration
of the vaccine may appear; occasionally, moderate depression may occur (in about 7% of the
birds), which has a maximum duration of 2 days. In addition, because the vaccine contains an

s
adjuvant, a slight reaction may be seen at the inoculation site consisting of a swelling of less

t
than 1 cm in diameter. It will disappear totally by 7 weeks post-vaccination without any need
for treatment.

h
SPECIAL PRECAUTIONS FOR USE:
Use sterile material when administering.

i g
Administer the vaccine when it is at an ambient temperature of +15 to +25 °C.

r
Shake well before and during use.
Use the vaccine within 10 hours of opening the bottle.

ll
Do not administer other vaccines within 14 days before or after administering this product.
The use of this vaccine may interfere with programmes for controlling Salmonella
gallinarum/pullorum in that vaccinated birds may give false positive reactions in the

-A
agglutination tests used for detecting exposure to those infections.
OVERDOSE:
A slight decrease in the general activity of vaccinated birds associated with the administration
of the vaccine may appear; occasionally, moderate depression may occur (in about 24% of the
birds), which has a maximum duration of 3 days. In addition, because the vaccine contains an

A
adjuvant, birds vaccinated with an overdose may display a moderate reaction at the
inoculation site consisting of a swelling between 1 and 3 cm in diameter. It is no longer

R
detectable by 8 weeks, and will disappear completely by 12 weeks post-vaccination without
any need for treatment.

P
CONTRAINDICATIONS:

HI
The effects of administering this product once laying has started have not been investigated.
Therefore, do not administer to birds that are laying.
The rest period can be used, if believed convenient, in the case of moulting. This is the period
in which the poultry are not producing.
SPECIAL WARNINGS:
This product contains a mineral oil based compound. Accidental self-injection may result in

©
severe pain and swelling.
Clean and disinfect the wound immediately, see your doctor and show him or her this leaflet.
WITHDRAWAL PERIOD:
Zero days.
SPECIAL PRECAUTIONS FOR STORAGE:
Store between +2 and +8 °C; do not freeze.
SPECIAL PRECAUTIONS FOR THE DISPOSAL OF UNUSED MEDICINAL PRODUCTS AND/OR
CONTAINERS:
All unused veterinary medicaments, or wastes deriving from them, must be disposed of in
conformance with local guidelines.
PRESENTATION:
Bottle of 1,000 ds.
Reg. Nº 094774
Under veterinary prescription
FOR VETERINARY USE ONLY

LABORATORIOS HIPRA, S.A. Avda. la Selva, 135 . 17170 Amer (Girona) Spain LABORATORIOS HIPRA, S.A. Avda. la Selva, 135 . 17170 Amer (Girona) Spain

Tel. (34) 972 43 06 60. Fax (34) 972 43 06 61. hipra@hipra.com Tel. (34) 972 43 06 60. Fax (34) 972 43 06 61. hipra@hipra.com
713784-02.0 04-21 713784-02.0