KWARA STATE UNIVERSITY, MALETE

FACULTY OF PURE AND APPLIED SCIENCE

DEPARTMENT OF BIOCHEMISTRY

2022/2023 RAIN SEMESTER EXAMINATIONS (STREAM II)

HBCH409 – Introductory Bioinformatics

(2 Credit Units)

Attempt question three (3) questions.

Question 1 (23 marks)

a. Define Bioinformatics. State the goal of Bioinformatics. (7 marks)
b. Describe the application of Bioinformatics. (6 marks)
c. Describe biological data. Highlight the type of biological data with examples. (10 marks)

Question 2 (23 marks)

a. Write short notes on
i. GenBank ii. EBI iii. DDBJ iv. Swiss-Prot (10 marks)
b. Differentiate between Pairing alignment and Multiple sequence alignment. (6 marks)
c Write short note on the following:
i. Basic Local Alignment Search Tools (BLAST) (3½ marks)
ii. Hidden Marker Models (HMMs) (3½ marks)

Question 3 (23 marks)

a. Differentiate between Sequence Similarity and Sequence Identity (6 marks)

b. Write short note on the following
i. TCoffee ii. Kalign iii. Cluster Omega iv. ClustalW (10 marks)
c. Describe the installation of WINDOWS operating system (7 marks)

Question 4 (23 marks)

a. Describe polymerase chain reaction. (5 marks)

b. i. Highlights the importance of Primer design. (5 marks)
ii. Describe four characteristics of Primer design. (4 marks)
c. Write short note on the following
i. NCBI /PubMed ii. Google Scholar iii. Scopus (9 marks)

Remember! The penalty for examination malpractice is dismissal!!!