Preferred antihypertensive drugs available as SPCs: Adult dosing - UpToDate 1/17/24, 5:11 PM

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Preferred antihypertensive drugs available as single-pill combinations:

Adult dosing *

Once-daily oral dose

Combination
Low dose Moderate dose High dose

Angiotensin-converting enzyme inhibitor and thiazide diuretic

Benazepril- 5 mg/6.25 mg 10 mg/12.5 mg or 20 20 mg/25 mg

hydrochlorothiazide mg/12.5 mg

Enalapril- 5 mg/12.5 mg 10 mg/25 mg Not available

hydrochlorothiazide

Fosinopril- 10 mg/12.5 mg 20 mg/12.5 mg 40 mg/25 mg

hydrochlorothiazide

Lisinopril- 10 mg/12.5 mg 20 mg/12.5 mg or 20 40 mg/25 mg

hydrochlorothiazide mg/25 mg

Perindopril- 2 mg/0.625 mg 4 mg/1.25 mg 8 mg/2.5 mg

indapamide
(United States: Not
available)

Quinapril- 10 mg/12.5 mg 20 mg/12.5 mg 20 mg/12.5 mg

hydrochlorothiazide

Ramipril- 2.5 mg/12.5 mg 5 mg/12.5 mg or 5 10 mg/12.5 mg or 10

hydrochlorothiazide mg/25 mg mg/25 mg
(United States: Not
available)

Angiotensin-converting enzyme inhibitor and dihydropyridine calcium channel blocker

Amlodipine- 2.5 mg/10 mg or 5 5 mg/20 mg 10 mg/20 mg or 10

benazepril mg/10 mg mg/40 mg

Perindopril- 3.5 mg/2.5 mg 7 mg/5 mg 14 mg/10 mg

amlodipine

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Preferred antihypertensive drugs available as SPCs: Adult dosing - UpToDate 1/17/24, 5:11 PM

Ramipril- 2.5 mg/2.5 mg 5 mg/5 mg or 10 mg/5 5 mg/10 mg or 10

amlodipine mg mg/10 mg
(United States: Not
available)

Angiotensin II receptor blocker and thiazide diuretic

Azilsartan- 40 mg/12.5 mg 40 mg/25 mg 40 mg/25 mg

chlorthalidone

Candesartan- 16 mg/12.5 mg 32 mg/12.5 mg 32 mg/25 mg

hydrochlorothiazide

Irbesartan- 150 mg/12.5 mg 300 mg/12.5 mg 300 mg/25 mg

hydrochlorothiazide

Losartan- 50 mg/12.5 mg 100 mg/12.5 mg 100 mg/25 mg

hydrochlorothiazide

Olmesartan- 20 mg/12.5 mg 40 mg/12.5 mg 40 mg/25 mg

hydrochlorothiazide

Telmisartan- 40 mg/12.5 mg 80 mg/12.5 mg 80 mg/25 mg

hydrochlorothiazide

Valsartan- 80 mg/12.5 mg 160 mg/12.5 mg or 320 mg/12.5 mg or

hydrochlorothiazide 160 mg/25 mg 320 mg/25 mg

Angiotensin II receptor blocker and dihydropyridine calcium channel blocker

Amlodipine- 5 mg/20 mg 5 mg/40 mg or 10 10 mg/40 mg

olmesartan mg/20 mg

Amlodipine- 5 mg/160 mg 5 mg/320 mg or 10 10 mg/320 mg

valsartan mg/160 mg

Telmisartan- 40 mg/5 mg 40 mg/10 mg or 80 80 mg/10 mg

amlodipine mg/5 mg

Angiotensin II receptor blocker, calcium channel blocker, and thiazide diuretic

Amlodipine- 5 mg/160 mg/12.5 mg 5 mg/160 mg/25 mg 10 mg/160 mg/12.5

valsartan- mg or 10 mg/160
hydrochlorothiazide mg/25 mg or 10
mg/320 mg/25 mg

Olmesartan- 20 mg/5 mg/12.5 mg 40 mg/5 mg/12.5 mg 40 mg/10 mg/12.5 mg

amlodipine- or 40 mg/5 mg/25 mg or 40 mg/10 mg/25 mg
hydrochlorothiazide

Angiotensin-converting enzyme inhibitors are commonly known as ACE inhibitors. Angiotensin II

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Preferred antihypertensive drugs available as SPCs: Adult dosing - UpToDate 1/17/24, 5:11 PM

receptor blockers are commonly known as ARBs. A low-dose combination product is often prescribed as
initial therapy in patients whose blood pressure is substantially above goal. In addition, a combination
product may be substituted for individual components in patients currently maintained on both agents
separately or in patients not adequately controlled with monotherapy who are currently using one of
the agents or an agent within the same antihypertensive drug class. When using a thiazide diuretic,
UpToDate generally suggests using chlorthalidone or indapamide rather than hydrochlorothiazide;
although, fewer such single-pill combinations are available.

* Combination product components and corresponding doses are listed in the order provided in
licensed product labeling.

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