Bipolar and Related Disorders

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ABNORMAL PSYCHOLOGY

DSM – 5 – TR
bipolar and related disorders and, therefore, a bipolar I diagnosis.
Note: Criteria A–D constitute a manic episode. At least
one lifetime manic episode is required for the
Bipolar I Disorder diagnosis of bipolar I disorder.
Diagnostic Criteria Hypomanic Episode
For a diagnosis of bipolar I disorder, it is necessary to A. A distinct period of abnormally and persistently
meet the following criteria for a manic episode. The elevated, expansive, or irritable mood and abnormally
manic episode may have been preceded by and may and persistently increased activity or energy, lasting at
be followed by hypomanic or major depressive least 4 consecutive days and present most of the day,
episodes. nearly every day.
Manic Episode B. During the period of mood disturbance and
A. A distinct period of abnormally and persistently increased energy and activity, three (or more) of the
elevated, expansive, or irritable mood and abnormally following symptoms (four if the mood is only irritable)
and persistently increased activity or energy, lasting at have persisted, represent a noticeable change from
least 1 week and present most of the day, nearly every usual behavior, and have been present to a significant
day (or any duration if hospitalization is necessary). degree:
B. During the period of mood disturbance and  Inflated self-esteem or grandiosity.
increased energy or activity, three (or more) of the  Decreased need for sleep (e.g., feels rested
following symptoms (four if the mood is only irritable) after only 3 hours of sleep).
are present to a significant degree and represent a  More talkative than usual or pressure to keep
noticeable change from usual behavior: talking.
 Inflated self-esteem or grandiosity.  Flight of ideas or subjective experience that
 Decreased need for sleep (e.g., feels rested thoughts are racing.
after only 3 hours of sleep).  Distractibility (i.e., attention too easily drawn
 More talkative than usual or pressure to keep to unimportant or irrelevant external stimuli),
talking. as reported or observed.
 Flight of ideas or subjective experience that  Increase in goal-directed activity (either
thoughts are racing. socially, at work or school, or sexually) or
 Distractibility (i.e., attention too easily drawn psychomotor agitation.
to unimportant or irrelevant external stimuli),  Excessive involvement in activities that have a
as reported or observed. high potential for painful consequences (e.g.,
 Increase in goal-directed activity (either engaging in unrestrained buying sprees, sexual
socially, at work or school, or sexually) or indiscretions, or foolish business investments).
psychomotor agitation (i.e., purposeless non- C. The episode is associated with an unequivocal
goal-directed activity). change in functioning that is uncharacteristic of the
 Excessive involvement in activities that have a individual when not symptomatic.
high potential for painful consequences (e.g., D. The disturbance in mood and the change in
engaging in unrestrained buying sprees, sexual functioning are observable by others.
indiscretions, or foolish business investments). E. The episode is not severe enough to cause marked
C. The mood disturbance is sufficiently severe to cause impairment in social or occupational functioning or to
marked impairment in social or occupational necessitate hospitalization. If there are psychotic
functioning or to necessitate hospitalization to prevent features, the episode is, by definition, manic.
harm to self or others, or there are psychotic features. F. The episode is not attributable to the physiological
D. The episode is not attributable to the physiological effects of a substance (e.g., a drug of abuse, a
effects of a substance (e.g., a drug of abuse, a medication, other treatment) or another medical
medication, other treatment) or another medical condition.
condition. Note: A full manic episode that emerges
during antidepressant treatment (e.g., medication,
electroconvulsive therapy) but persists at a fully
syndromal level beyond the physiological effect of that Note: A full hypomanic episode that emerges during
treatment is sufficient evidence for a manic episode
ABNORMAL PSYCHOLOGY
DSM – 5 – TR
antidepressant treatment (e.g., medication,  Diminished ability to think or concentrate, or
electroconvulsive therapy) but persists at a fully indecisiveness, nearly every day (either by
syndromal level beyond the physiological effect of subjective account or as observed by others).
that treatment is sufficient evidence for a hypomanic  Recurrent thoughts of death (not just fear of
episode diagnosis. However, caution is indicated so dying), recurrent suicidal ideation without a
that one or two symptoms (particularly increased specific plan, or a suicide attempt or a specific
irritability, edginess, or agitation following plan for committing suicide.
antidepressant use) are not taken as sufficient for C. The episode is not attributable to the physiological
diagnosis of a hypomanic episode, nor necessarily effects of a substance or another medical condition.
indicative of a bipolar diathesis. Note: Criteria A–C constitute a major depressive
Note: Criteria A–F constitute a hypomanic episode. episode. Major depressive episodes are common in
Hypomanic episodes are common in bipolar I disorder bipolar I disorder but are not required for the
but are not required for the diagnosis of bipolar I diagnosis of bipolar I disorder.
disorder. Note: Responses to a significant loss (e.g.,
bereavement, financial ruin, losses from a natural
disaster, a serious medical illness or disability) may
Major Depressive Episode include the feelings of intense sadness, rumination
A. Five (or more) of the following symptoms have about the loss, insomnia, poor appetite, and weight
been present during the same 2- week period and loss noted in Criterion A, which may resemble a
represent a change from previous functioning; at depressive episode. Although such symptoms may be
least one of the symptoms is either (1) depressed understandable or considered appropriate to the loss,
mood or (2) loss of interest or pleasure. the presence of a major depressive episode in
Note: Do not include symptoms that are clearly addition to the normal response to a significant loss
attributable to another medical condition. should also be carefully considered. This decision
 Depressed mood most of the day, nearly inevitably requires the exercise of clinical judgment
every day, as indicated by either subjective based on the individual’s history and the cultural
report (e.g., feels sad, empty, or hopeless) or norms for the expression of distress in the context of
observation made by others (e.g., appears loss.
tearful). (Note: In children and adolescents, Bipolar I Disorder
can be irritable mood.) A. Criteria have been met for at least one manic
 Markedly diminished interest or pleasure in episode (Criteria A–D under “Manic Episode” above).
all, or almost all, activities most of the day,
B. At least one manic episode is not better explained
nearly every day (as indicated by either
by schizoaffective disorder and is not superimposed
subjective account or observation).
on schizophrenia, schizophreniform disorder,
 Significant weight loss when not dieting or
delusional disorder, or other specified or unspecified
weight gain (e.g., a change of more than 5%
schizophrenia spectrum and other psychotic disorder.
of body weight in a month) or decrease or
increase in appetite nearly every day. (Note:
In children, consider failure to make expected
weight gain.)
 Insomnia or hypersomnia nearly every day.
 Psychomotor agitation or retardation nearly
every day (observable by others, not merely
subjective feelings of restlessness or being
slowed down).
 Fatigue or loss of energy nearly every day.
 Feelings of worthlessness or excessive or
inappropriate guilt (which may be delusional)
nearly every day (not merely self-reproach or
guilt about being sick).
ABNORMAL PSYCHOLOGY
DSM – 5 – TR
Specify if: Differentiated Features
 With anxious distress (pp. 169–170)  Major depressive disorder
 With mixed features (pp. 170–171) With  Other bipolar disorder
rapid cycling (p. 171)  Generalized anxiety disorder, panic disorder,
 With melancholic features (pp. 171–172) posttraumatic stress disorder, or other
With atypical features (pp. 172–173) anxiety disorders.
 With mood-congruent psychotic features (p.  Bipolar and related disorder due to another
173; applies to manic episode and/or major medical condition
depressive episode)  Substance/medication-induced bipolar and
 With mood-incongruent psychotic features related disorder
(p. 173; applies to manic episode and/or  Schizoaffective disorder
major depressive episode)  Attention-deficit/hyperactivity disorder
 With catatonia (p. 173). Coding note: Use  Disruptive mood dysregulation disorder
additional code F06.1.  Personality disorders
 With peripartum onset (pp. 173–174)
 With seasonal pattern (pp. 174–175)

Associated Features
Individuals often do not perceive that they are ill or in
need of treatment and vehemently resist efforts to be
treated
May change their dress, makeup, or personal
appearance to a more sexually suggestive or
flamboyant style
Some perceive a sharper sense of smell, hearing, or
vision
Gambling and antisocial behaviors may accompany
the manic episode
Mood may shift very rapidly to anger or depression;
some individuals may become hostile and physically
threatening to others and, when delusional, become
physically assaultive or suicidal.
Serious consequences of a manic episode (e.g.,
involuntary hospitalization, difficulties with the law,
serious financial difficulties) often result from poor
judgment, loss of insight, and hyperactivity.
Depressive symptoms occur in some 35% of manic
episodes (see “with mixed features” specifier, p. 170),
and mixed features are associated with poorer
outcome and increased suicide attempts.
Bipolar I disorder is also associated with significant
decrements in quality of life and well-being.
Trait-like features associated with the diagnosis
include hyperthymic, depressive, cyclothymic,
anxious, and irritable temperaments, sleep and
circadian rhythm disturbances, reward sensitivity, and
creativity
Having a first-degree relative with bipolar disorder
increases the risk of diagnosis approximately 10-fold.
Bipolar II Disorder
ABNORMAL PSYCHOLOGY
DSM – 5 – TR
Diagnostic Criteria syndromal level beyond the physiological effect of
For a diagnosis of bipolar II disorder, it is necessary to that treatment is sufficient evidence for a hypomanic
meet the following criteria for a current or past episode diagnosis. However, caution is indicated so
hypomanic episode and the following criteria for a that one or two symptoms (particularly increased
current or past major depressive episode: irritability, edginess, or agitation following
Hypomanic Episode antidepressant use) are not taken as sufficient for
A. A distinct period of abnormally and persistently diagnosis of a hypomanic episode, nor necessarily
elevated, expansive, or irritable mood and indicative of a bipolar diathesis.
abnormally and persistently increased activity or Major Depressive Episode
energy, lasting at least 4 consecutive days and present A. Five (or more) of the following symptoms have
most of the day, nearly every day. been present during the same 2- week period and
B. During the period of mood disturbance and represent a change from previous functioning; at
increased energy and activity, three (or more) of the least one of the symptoms is either (1) depressed
following symptoms have persisted (four if the mood mood or (2) loss of interest or pleasure.
is only irritable), represent a noticeable change from Note: Do not include symptoms that are clearly
usual behavior, and have been present to a significant attributable to a medical condition.
degree:  Depressed mood most of the day, nearly
 Inflated self-esteem or grandiosity. every day, as indicated by either subjective
 Decreased need for sleep (e.g., feels rested report (e.g., feels sad, empty, or hopeless) or
after only 3 hours of sleep). observation made by others (e.g., appears
 More talkative than usual or pressure to keep tearful). (Note: In children and adolescents,
talking. can be irritable mood.)
 Flight of ideas or subjective experience that  Markedly diminished interest or pleasure in
thoughts are racing. all, or almost all, activities most of the day,
 Distractibility (i.e., attention too easily drawn nearly every day (as indicated by either
to unimportant or irrelevant external stimuli), subjective account or observation).
as reported or observed.  Significant weight loss when not dieting or
 Increase in goal-directed activity (either weight gain (e.g., a change of more than 5%
socially, at work or school, or sexually) or of body weight in a month), or decrease or
psychomotor agitation. increase in appetite nearly every day. (Note:
 Excessive involvement in activities that have a In children, consider failure to make expected
high potential for painful consequences (e.g., weight gain.)
engaging in unrestrained buying sprees,  Insomnia or hypersomnia nearly every day.
sexual indiscretions, or foolish business  Psychomotor agitation or retardation nearly
investments). every day (observable by others, not merely
C. The episode is associated with an unequivocal subjective feelings of restlessness or being
change in functioning that is uncharacteristic of the slowed down).
individual when not symptomatic.  Fatigue or loss of energy nearly every day.
D. The disturbance in mood and the change in  Feelings of worthlessness or excessive or
functioning are observable by others. inappropriate guilt (which may be delusional)
E. The episode is not severe enough to cause marked nearly every day (not merely self-reproach or
impairment in social or occupational functioning or to guilt about being sick).
necessitate hospitalization. If there are psychotic  Diminished ability to think or concentrate, or
features, the episode is, by definition, manic. indecisiveness, nearly every day (either by
F. The episode is not attributable to the physiological subjective account or as observed by others).
effects of a substance (e.g., a drug of abuse, a  Recurrent thoughts of death (not just fear of
medication, other treatment) or another medical dying), recurrent suicidal ideation without a
condition. specific plan, or a suicide attempt or a specific
Note: A full hypomanic episode that emerges during plan for committing suicide.
antidepressant treatment (e.g., medication,
electroconvulsive therapy) but persists at a fully
ABNORMAL PSYCHOLOGY
DSM – 5 – TR
B. The symptoms cause clinically significant distress or hypomanic episode are not currently met), plus any
impairment in social, occupational, or other of the following hypomanic episode specifiers that
important areas of functioning. are applicable. Note: The specifiers “with rapid
C. The episode is not attributable to the physiological cycling” and “with seasonal pattern” describe the
effects of a substance or another medical condition. pattern of mood episodes.
Note: Criteria A–C constitute a major depressive Specify if:
episode. With anxious distress (p. 169–170)
Note: Responses to a significant loss (e.g., With mixed features (pp. 170–171)
bereavement, financial ruin, losses from a natural With rapid cycling (p. 171)
disaster, a serious medical illness or disability) may With peripartum onset (pp. 173–174)
include the feelings of intense sadness, rumination With seasonal pattern (pp. 174–175)
about the loss, insomnia, poor appetite, and weight If current episode is depressed (or most recent
loss noted in Criterion A, which may resemble a episode if bipolar II disorder is in partial or full
depressive episode. Although such symptoms may be remission): In recording the diagnosis, terms should
understandable or considered appropriate to the loss, be listed in the following order: bipolar II disorder,
the presence of a major depressive episode in current or most recent episode depressed,
addition to the normal response to a significant loss mild/moderate/severe (if full criteria for a major
should be carefully considered. This decision depressive episode are currently met), in partial
inevitably requires the exercise of clinical judgment remission/in full remission (if full criteria for a major
based on the individual’s history and the cultural depressive episode are not currently met) (p. 175),
norms for the expression of distress in the context of plus any of the following major depressive episode
loss. specifiers that are applicable.
Bipolar II Disorder Note: The specifiers “with rapid cycling” and “with
A. Criteria have been met for at least one hypomanic seasonal pattern” describe the pattern of mood
episode (Criteria A–F under “Hypomanic Episode” episodes.
above) and at least one major depressive episode Specify if:
(Criteria A–C under “Major Depressive Episode” With anxious distress (pp. 169–170)
above). With mixed features (pp. 170–171)
B. There has never been a manic episode. With rapid cycling (p. 171)
C. At least one hypomanic episode and at least one With melancholic features (pp. 171–172)
major depressive episode are not better explained by With atypical features (pp. 172–173)
schizoaffective disorder and are not superimposed on With mood-congruent psychotic features (p. 173)
schizophrenia, schizophreniform disorder, delusional With mood-incongruent psychotic features (p. 173)
disorder, or other specified or unspecified With catatonia (p. 173). Coding note: Use additional
schizophrenia spectrum and other psychotic disorder. code F06.1.
D. The symptoms of depression or the With peripartum onset (pp. 172–174)
unpredictability caused by frequent alternation With seasonal pattern (pp. 174–175)
between periods of depression and hypomania Specify course if full criteria for a mood episode are
causes clinically significant distress or impairment in not currently met:
social, occupational, or other important areas of In partial remission (p. 175)
functioning. In full remission (p. 175)
Specify current or most recent episode:
Hypomanic Specify severity if full criteria for a major depressive
Depressed episode are currently met:
If current episode is hypomanic (or most recent Mild (p. 175)
episode if bipolar II disorder is in partial or full Moderate (p. 175) Severe (p. 175)
remission):
In recording the diagnosis, terms should be listed in
the following order: bipolar II disorder, current or
most recent episode hypomanic, in partial
remission/in full remission (p. 175) (if full criteria for a
ABNORMAL PSYCHOLOGY
DSM – 5 – TR
Associated Features
A common feature of bipolar II disorder is impulsivity,
which can contribute to suicide attempts and
substance use disorders.
There may be heightened levels of creativity during
hypomanic episodes in some individuals with a
bipolar II disorder.
However, that relationship may be nonlinear; that is,
greater lifetime creative accomplishments have been
associated with milder forms of bipolar disorder, and
higher creativity has been found in unaffected family
members.
The individual’s attachment to the prospect of
heightened creativity during hypomanic episodes may
contribute to ambivalence about seeking treatment
or undermine adherence to treatment.

Differential Diagnosis
 Major depressive disorder
 Cyclothymic disorder
 Schizophrenia
 Schizoaffective disorder
 Bipolar and related disorder due to another
medical condition
 Substance/medication-induced bipolar and
related disorder
 Attention-deficit/hyperactivity disorder
 Personality disorder
 Other bipolar disorders

Cyclothymic Disorder
Diagnostic Criteria
A. For at least 2 years (at least 1 year in children and
ABNORMAL PSYCHOLOGY
DSM – 5 – TR
adolescents) there have been numerous periods with A. A prominent and persistent disturbance in mood
hypomanic symptoms that do not meet criteria for a that predominates in the clinical picture and is
hypomanic episode and numerous periods with characterized by abnormally elevated, expansive, or
depressive symptoms that do not meet criteria for a irritable mood and abnormally increased activity or
major depressive episode. energy.
B. During the above 2-year period (1 year in children B. There is evidence from the history, physical
and adolescents), Criterion A symptoms have been examination, or laboratory findings of both (1) and
present for at least half the time and the individual (2):
has not been without the symptoms for more than 2  The symptoms in Criterion A developed
months at a time. during or soon after substance intoxication or
C. Criteria for a major depressive, manic, or withdrawal or after exposure to or
hypomanic episode have never been met. withdrawal from a medication.
D. The symptoms in Criterion A are not better  The involved substance/medication is capable
explained by schizoaffective disorder, schizophrenia, of producing the symptoms in Criterion A.
schizophreniform disorder, delusional disorder, or C. The disturbance is not better explained by a bipolar
other specified or unspecified schizophrenia or related disorder that is not substance/medication-
spectrum and other psychotic disorder. induced. Such evidence of an independent bipolar or
E. The symptoms are not attributable to the related disorder could include the following:
physiological effects of a substance (e.g., a drug of The symptoms precede the onset of the
abuse, a medication) or another medical condition substance/medication use; the symptoms persist for a
(e.g., hyperthyroidism). substantial period of time (e.g., about 1 month) after
F. The symptoms cause clinically significant distress or the cessation of acute withdrawal or severe
impairment in social, occupational, or other intoxication; or there is other evidence suggesting the
important areas of functioning. existence of an independent
Specify if: non-substance/medication-induced bipolar and
With anxious distress (see pp. 169–170) related disorder (e.g., a history of recurrent non-
substance/medication-related episodes).
D. The disturbance does not occur exclusively during
Differential Diagnosis the course of a delirium.
 Bipolar and related disorder due to another E. The disturbance causes clinically significant distress
medical condition or impairment in social, occupational, or other
 Substance/medication-induced bipolar and important areas of functioning.
related disorder and substance/medication- Note: This diagnosis should be made instead of a
induced depressive disorder diagnosis of substance intoxication or substance
 Bipolar I disorder, with rapid cycling, and withdrawal only when the symptoms in Criterion A
bipolar II disorder, with rapid cycling predominate in the clinical picture and when they are
 Borderline personality disorder sufficiently severe to warrant clinical attention.
Specify (see Table 1 in the chapter “Substance-
Related and Addictive Disorders,” which indicates
whether “with onset during intoxication” and/or
“with onset during withdrawal” applies to a given
substance class; or specify “with onset after
medication use”):
With onset during intoxication: If criteria are met for
intoxication with the substance and the symptoms
develop during intoxication.
With onset during withdrawal: If criteria are met for
withdrawal from the substance and the symptoms
Substance/Medication-Induced Bipolar and Related develop during, or shortly after, withdrawal.
Disorder With onset after medication use: If symptoms
Diagnostic Criteria developed at initiation of medication, with a change
ABNORMAL PSYCHOLOGY
DSM – 5 – TR
in use of medication, or during withdrawal of
medication.

Associated Features
Substances/medications that are typically considered
to be associated with substance/medicationinduced
bipolar and related disorder include the stimulant
class of drugs, as well as phencyclidine and steroids;
however, a number of potential substances continue
to emerge as new compounds are synthesized (e.g.,
so-called bath salts).

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