PHARMACEUTICAL CHEMISTRY

2015/2016 MID-SEMESTER EXAMINATION

SECTION B

QUESTION 1

Determining whether there would be rearrangement in carbonations or not and give reasons

5 structures provided

QUESTION 2

4 structures are provided two are planar (one of it is aromatic) and two are aliphatic bonded to bromine
molecule (one is at primary carbon while the other one is on tertiary carbon)

a. Rank the compounds in order of the increasing acidity (3 marks)

b. Using words and illustrations, briefly explain the observed trend (7 marks)

QUESTION 3

Hydrogen bromine (Hbr) reacts differently with benzene and cyclohexane

a. Describe the type of reaction each compound undergoes. (4 marks)

b. Provide reasons and products in each case (6 marks)

QUESTION 4

Stating whether the structure drawn is E- or Z- isomer. 5 structures were provided 10 marks

QUESTION 5

There are two geometric isomers of the cyclic compound C4H6Cl2. Draw the structural formula of two
isomers and explain why these two isomers exist. (10 marks)
 SECTION C

QUESTION TWO

The chemical structure of 3-bromo-2,3-dimethylpentane is shown below. Three alkenes can be formed
from the E1 reaction of this compound

a. Give the structures of the alkenes

b. Rank the above alkenes according to the amount that would be formed and why?

By sacran c Kagoma

Editor; Wiseman Ph.D ( pending……..)