Absite Topic Review General Surgery

Nir Hus, MD, PhD. Mount Sinai Medical Center Miami Beach

Transplantation

Q1 Two weeks s/p renal transplant, a pt. developes res. Insufficiency requiring adm. To ICU. CXR shows diffuse infiltrates & BAL show cells w/ inclusion bodies. The most appropriate therapy is: A. B. C. D.

Gangcyclvir Acyclovir Bactrim PCN

Q2 Hyperacute rejection following organ trans. Is most often due: A. B. C. D.

ABO incompatibility Rh incompatibility Previously sensitized T cells Macrophages

Q3 Hyperacute rejection is an example of hypersensitivity reaction type: A. B. C. D.

Type I Type II Type III Type IV

Q4 Successful Tx of hyperacute rejection usually involves

A. B. C. D.

Steroids Removal of the organ & re-trans. OKT3 Rapamycin

Q5 The machanism of cyclosporin is:

A. B. C. D.

Binds FK binding protein Binds cyclophilin protein Inhibits purine synthesis by way of 6mercaptopurine intermidiate. Binds antigen on T cells

Q6 - The mechanism of azathioprine is:

A. B. C. D.

Binds FK binding protein Binds cyclophilin protein Inhibits purine synthesis by way of 6mercaptopurine intermidiate. Binds antigen on T cells

Q7 The most common malignancy following transplantation is: A. B. C. D.

Lung CA Prostate CA Breast CA Skin CA

Q8 A positive cross-match means:

A. B. C. D.

There are no immunologic problems so one may proceed w/ the trans. Will likely result in only mild rejection sometimes after the 1st week. The recipient has preformed AB to donor Ag. Both the donor and recipient are CMV positive.

Q9 A cross-match is performed by:

A. B. C. D.

Mixing donor lymphocytes w/ recipient serum Mixing recipient lymphocytes w/ donor serum Mixing donor plasma w/ recipient serum Mixing recipient plasma w/ donor serum.

Q10 Post-transplant lymphoproliferative disorder has been most commonly linked to: A. B. C. D.

HSV RSV EBV Influenza viruses

Q11 - A 35 yo man POD#6 from a cadaveric renal trans. Developes a rise in Cr. The most appropriate next step is: A. B. C. D.

Emergent reop Angiography OKT3 US

Q12 in the previous pt. the US shows flow acceleration of the renal artery. The next appropriate step is: A. B. C. D.

Emergent reop Angiography OKT3 US

Q13 in the previous pt. the US is normal. The next appropriate step is: A. B. C. D.

Emergent reop Angiography OKT3 Biopsy

Q14 - in the previous pt. the Bx. shows acute tubulitis. This is consistent w/:
A. B. C. D.

Acute rejection UTI Chronic rejection Renal vein thrombosis.

Q15 New proteinnuria in a pt. following renal trans. Is most consistent w/: A. B. C. D.

Acute rejection UTI Chronic rejection Renal vein thrombosis.

Q16 Most common cause of acute death in a living related renal trans. Is: A. B. C. D.

PE Hemorrhage MI Infection

Q17 Most common cause of acute death following renal trans. In a recipient is: A. B. C. D.

PE Hemorrhage MI Infection