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Topic 3
Topic 3
Topic 3
Question 1
EASY
A man and a woman have a daughter and a son. Their daughter has normal vision, but their son is colourblind. Which one of these genotypes could be correct for the biological mother?
A. XN Y
B. XnY
C. XN Xn
D. XN XN
Question 2
EASY
The graph below shows the relationship between maternal age and the incidence of non-disjunction. What relationship is suggested by the data in the graph?
Question 3
EASY
A. Metaphase II
B. Metaphase I
C. Anaphase I
D. Telophase I
EASY
Question 4
A. Eukaryotic chromosomes are circular and the DNA is associated with histone proteins
B. Eukaryotic cells have looped DNA molecules which are not associated with proteins in the nucleus
D. Eukaryotic cells have linear DNA molecules that are not associated with histone proteins
Question 5
EASY
Which diagram shows the sex chromosomes of a somatic cell in a human male?
A. B.
C. D.
[Source: Adapted from Nami-ja. (5th March 2009). File chromosomesXXY02.png. Wikimedia commons. Retrieved 18th May 2022 from https://
commons.wikimedia.org/wiki/File.png. Copyright-free]
Question 6
EASY
Which row correctly states the number of alleles of a single gene which would be present in the nucleus of a cell as a result of each process?
Question 7
EASY
A. I and II
B. II only
C. III only
D. I, II and III
Question 8
EASY
There are two alleles for flower colour in snapdragons. However, the result of a cross between two heterozygous plants yielded offspring with three different observed phenotypes, red, white
and pink flowers. Which is the most likely explanation for this observation?
EASY
Question 9
The diagram shows a DNA profile taken from a crime scene.
Following are the DNA profiles of the suspects in this crime. Which one is the guilty individual?
A. B.
C. D.
Question 10
EASY
Bacteria are widely used in genetic modification. Which feature of bacteria makes them suitable for this use?
A. Size
B. Absence of a nucleus
C. Plasmids
Question 11
EASY
Which of the following statement(s) are possible consequences to a polypeptide if a base substitution mutation occurs?
A. I and II only
D. I, II and III
Question 12
EASY
Question 13
EASY
Question 14
EASY
The table shows the nucleotide base sequence and genome size (number of base pairs, bp) for different species.
B. The more closely related two species are, the more similar their base sequences.
D. The base sequence in the table for humans and chimpanzees is the same, therefore they have an identical genetic code.
Mark Scheme Revisit Mark complete Ask Newton
Question 15
EASY
A. 1
B. 2
C. 4
D. 8
Question 16
EASY
Two individuals, heterozygous for a specific trait, were crossed in an experiment. Which row shows the expected phenotypic ratios of the offspring resulting from this cross?
EASY
Question 17
Mendel observed that the seed shape in individual pea plants was either round or wrinkled. The results of an experimental cross yielded 315 offspring with round seeds and 105 offspring with
wrinkled seeds.
Which row in the table below states the most likely genotypes of the parents?
Parent I Parent II
A. RR rr
B. Rr rr
C. Rr Rr
D. Rr RR
Mark Scheme Solutions Revisit Mark complete Ask Newton
Question 18
EASY
In some animals, the agouti allele causes individual hairs to have a banded pattern. The non-agouti allele causes hairs to be a single colour. Individuals who are heterozygous have hairs with a
banded pattern.
Which combination of parent genotypes would allow for production of offspring that do not have the agouti characteristic?
A. One heterozygous parent and one parent who is homozygous for the agouti allele.
C. One parent who is homozygous for the agouti allele, and one parent who is homozygous for the non-agouti allele.
Question 19
EASY
The diagram below represents a cell with a diploid number of 4. Which stage of cell division is the cell currently undergoing?
[ © Revision Village 2022]
A. Metaphase I
B. Anaphase II
C. Metaphase in mitosis
D. Prophase I
EASY
Question 20
Neurons of the fruit fly (Drosophila melanogaster) have 8 chromosomes. How many chromosomes are in a fertilised oocyte of a fruit fly?
A. 8
B. 4
C. 2
D. 16
Question 21
EASY
A. Nitrosamines in tobacco
C. Telophase
D. Radioactive isotopes
Question 22
EASY
Which row correctly describes the DNA and chromosomes of bacterial cells?
EASY
Question 23
EASY
Question 24
The diagram shows normal red blood cells and sickle-shaped red blood cells. Which statement describes the cause of sickle-shaped red blood cells?
D. Error in mitosis
Question 25
EASY
[Source: Adapted from CNX OpenStax, (2016, May). File: Figure 16 03 02.png. Wikimedia commons. Retrieved May 28, 2022, from https://commons.wikimedia.org/wiki/File:
Figure_16_03_02.png. Copyright under CC-BY-4.0]
C. DNA replication
Question 27
EASY
Question 28
EASY
[Source: Adapted from File: Abedi M., Salmaninejad A. and Sakhinia E. (13th November 2017). File: Peripheral-blood-karyotype-result-belonging-to-the-subject-compatible-
with-48-XYYY.png. Wikimedia commons. Retrieved 15th May 2022 from https://commons.wikimedia.org/wiki/File.png.Copyright under Creative Commons 4.0
International.]
Question 29
EASY
The DNA sequence shown has been taken from exon 1 of DNA within the human insulin gene. Which sequence corresponds to a deletion mutation in the sequence?
B. TACAAGAGACAAGCTGCA
C. TACAAGGAAAGCTGCATC
D. TACAAGGACAAGCGGCAT
Question 30
EASY
Which of these statement(s) is/are correct concerning the Polymerase Chain Reaction (PCR)?
A. I only
B. II only
D. I, II and III
Question 31
EASY
EASY
Question 32
Mendel observed that there are two possible variations of flower colour in pea plants, purple and white. After a genetic cross, the ratio of plants with purple flowers to white flowers is 1:1.
What were the genotypes of the parents?
Question 33
EASY
I. It is a reduction division
II. It involves random orientation
III. It produces genetically identical cells
A. I only
B. II only
C. I and II
D. I and III
EASY
Question 34
A. I, II and III
B. I and III
C. II only
D. I and II
Question 35
EASY
Question 36
EASY
ATGGCTACCTGT
A. ATGGCTACTGT
B. ATGGCCTACCTGT
C. ATGGCACCTGT
D. ATGGCCACCTGT
MEDIUM
Question 38
Question 39
MEDIUM
The following table shows the diploid chromosome number of a range of species.
A. The giant panda has more genes than the other species
B. The yellow fever mosquito has the fewest genes from these species
C. The gametes of carrots have 18 chromosomes
D. The chromosome number is a characteristic of a species
Question 40
MEDIUM
Sickle cell anaemia is caused by a recessive allele (HbS ). The dominant allele is HbA . This image shows the inheritance of sickle cell anaemia in a family.
[Source: Adapted from Abedi, M., Salmaninejad, A., Sakhinia, E. (2017, November 13). Peripheral-blood-karyotype-result-belonging-to-the-subject-compatible-with-48-
XYYY.png. Wikipedia Commons. Retrieved May 13, 2022, from https:// commons.wikimedia.org/wiki/File.png. Copyright under CC BY 4.0]
Question 43
MEDIUM
A biological female with blood type A had a child with blood type O. What are the possible genotypes of the biological father?
I. ii
II. IAIi
III. IBIi
A. I only
B. I and II only
MEDIUM
Question 44
Which of the following processes is characteristic of the meiotic and not the mitotic cell cycle?
A. Reduction division
B. Nuclear division
C. Interphase
D. Cytokinesis
Question 45
MEDIUM
The diploid number of the chimpanzee (Pan troglodytes) is 48. Which row shows the correct chromosome number for different cell types and cell division stages?
Question 46
MEDIUM
At the end of which phase of meiosis I does crossing over occur, and what is the outcome of crossing over?
Question 47
MEDIUM
A man is homozygous for blood type B. His wife has blood type AB. What would be the possible blood types for their children?
Question 49
MEDIUM
Question 50
MEDIUM
Shown below is the single base substitution mutation that causes sickle cell anaemia in individuals who are homozygous for the allele. Which of the following is a result of this mutation?
C. Translation of one incorrect amino acid that does not affect the function of haemoglobin
Question 51
MEDIUM
MEDIUM
Question 52
A. X-linked dominant
B. X-linked recessive
C. Autosomal dominant
D. Autosomal recessive
Question 53
MEDIUM
Which row shows the correct annotation of the alleles for blood groups?
A. IA IB i
B. Blood group B Blood group A Blood group O
C. IA IB IB IB IA i
D. A+ B+ O−
A. I and II
B. I only
C. I, II and III
D. II and III
Question 55
MEDIUM
A. Metaphase I
B. Anaphase I
C. Metaphase II
D. Anaphase II
Question 58
MEDIUM
[Source: Adapted from Abedi M., Salmaninejad A. and Sakhinia E. (13 November 2017). File: Peripheral-blood-karyotype-result-belonging-to-the-subject-compatible-with-48-
XYYY.png. Wikimedia commons. Retrieved 20 September 2023 from https://commons.wikimedia.org/wiki/File: Peripheral-blood-karyotype-result-belonging-to-the-subject-
compatible-with-48-XYYY.png Copyright under C.C BY 4.0]
An unfertilised egg cell belonging to the mangrove horseshoe crab (Carcinoscorpius rotundicauda) contains 16 chromosomes. How many chromosomes would be found in a cell from this
species about to undergo meiosis?
A. 8
B. 16
C. 32
D. 64
Question 61
MEDIUM
Question 63
MEDIUM
[Source: Adapted from Wessex Reg. Genetics Centre. (n.d.) Down syndrome human karyotype 47,XY. Retrieved March 29, 2022, from
https://wellcomecollection.org/works/wmcdanw6. Copyright under CC BY 4.0]
Question 64
MEDIUM
This table is a short section of the output from a DNA sequence database comparing the cytochrome C gene sequence in two species. What does it show?
B. There are two differences in the base sequence between the two species
C. There are three differences in the base sequence between the two species
D. There are four differences in the base sequence between the two species
Question 66
MEDIUM
A single base substitution mutation occurs and a stop codon is not produced. Which of the following is not a possible consequence of this type of mutation?
A. The quaternary structure of the protein this gene codes for is altered.
B. No amino acids in the polypeptide this gene codes for are changed.
C. Two amino acids in the polypeptide this gene codes for are changed.
Question 67
MEDIUM
[Source: Adapted from Abedi M., Salmaninejad A. and Sakhinia E. (13th November 2017). File: Peripheral-blood-karyotype-result-belonging-to-the-subject-compatible-with-48-
XYYY.png. Wikimedia commons. Retrieved 15th May 2022 from https://commons.wikimedia.org/wiki/File: Peripheral-blood-karyotype-result-belonging-to-the-subject-
compatible-with-48-XYYY.png. Copyright under Creative Commons 4.0 International ]
A. Sperm
B. Egg
C. Brain cell
D. Skin cell
MEDIUM
Question 68
Question 69
MEDIUM
Question 70
MEDIUM
Which row represents the steps of the polymerase chain reaction (PCR) in the correct order?
I II III IV
A. Sample is heated to 95 At 72⁰C Taq DNA polymerase produces two
Temperature is reduced to 53⁰C Primers attach to both strands
⁰C double-stranded copies
B. Sample is heated to 95 At 72⁰C Taq DNA polymerase produces two
Temperature is reduced to 53⁰C Primers attach to both strands
⁰C double-stranded copies
C. Primers attach to both At 72⁰C Taq DNA polymerase produces two
Sample is heated to 95 ⁰C Temperature is reduced to 53⁰C
strands double-stranded copies
D. Primers attach to both At 72⁰C Taq DNA polymerase produces two
Sample is heated to 95 ⁰C Temperature is reduced to 53⁰C
strands double-stranded copies
MEDIUM
Question 71
What best describes the inheritance of the condition shown in the pedigree chart below?
A. I and III
B. I only
C. III only
D. I and II
Question 72
MEDIUM
A. All three
B. II only
C. I and III
D. I and II
Question 73
MEDIUM
What suggests that the inheritance of the disorder shown in the pedigree chart is X-linked recessive and not autosomal recessive?
Question 80
HARD
The diagrams below show a cell, with a diploid number of 8, in different stages of meiosis. Which row correctly names each stage?
I. II.
III. IV.
[ © Revision Village 2022]
I II III IV
A. Metaphase I Metaphase II Anaphase I Prophase II
B. Metaphase I Metaphase II Prophase II Prophase I
C. Metaphase II Metaphase I Prophase I Anaphase II
D. Telophase I Metaphase II Anaphase I Prophase I
Question 82
HARD
The micrographs show four phases of meiosis I in a plant. In what order do these phases occur?
[Source: Adapted from Windham, M. D., Pryer, K. M., Poindexter, D. B., Li, F.-W., Rothfels, C. J., and Beck, J. B. (2020). A step-by-step protocol for meiotic chromosome
counts in flowering plants: A powerful and economical technique revisited. Retrieved January 4, 2023, from Applications in Plant Sciences 8( 4): e11342. © 2020, Windham et al.
Licensed under CC BY 4.0]
A. X-Y-W-Z
B. W-Z-X-Y
C. Y-X-W-Z
D. Z-W-X-Y
Question 83
HARD
Which of these statements is NOT true for short tandem repeats (STR)?
C. In DNA profiling, short tandem repeats are used to compare DNA samples
HARD
Question 84
A DNA profile was made using DNA from a crime scene. Locus TH01 was used to identify whether a suspect’s DNA matched the crime scene DNA. The suspect’s two alleles of the gene at
Locus TH01 are shown below.
The alleles TH01-6 and TH01-4 were separated and visualised with gel electrophoresis. The resulting gel, with two bands of DNA, is shown below.
What is the DNA in Band B and why is this DNA at this position?
Question 85
HARD