Topic 3

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IB BIOLOGY SL - 2024 - QUESTIONBANK


Topic 3 All - Genetics
All Questions for Topic 3 (Genetics). Genes, Alleles, and Genomes, Chromosomes, Meiosis, Inheritance, Genetic Modification & Biotechnology
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Question 1
EASY

A man and a woman have a daughter and a son. Their daughter has normal vision, but their son is colourblind. Which one of these genotypes could be correct for the biological mother?

A. XN Y

B. XnY

C. XN Xn

D. XN XN

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Question 2
EASY

The graph below shows the relationship between maternal age and the incidence of non-disjunction. What relationship is suggested by the data in the graph?

[ © Revision Village 2022]

A. There is a positive correlation between age and incidence of non-disjunction.

B. There is a negative correlation between age and incidence of non-disjunction.

C. There is no correlation between age and incidence of non-disjunction.

D. Non-disjunction only happens when maternal age is above 35.

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Question 3
EASY

Which stage of meiosis is represented in the diagram below?


[ © Revision Village 2022]

A. Metaphase II

B. Metaphase I

C. Anaphase I

D. Telophase I

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EASY
Question 4

Which statement about eukaryotic cells is correct?

A. Eukaryotic chromosomes are circular and the DNA is associated with histone proteins

B. Eukaryotic cells have looped DNA molecules which are not associated with proteins in the nucleus

C. Eukaryotic cells have linear DNA molecules associated with proteins

D. Eukaryotic cells have linear DNA molecules that are not associated with histone proteins

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Question 5
EASY

Which diagram shows the sex chromosomes of a somatic cell in a human male?

A. B.

C. D.
[Source: Adapted from Nami-ja. (5th March 2009). File chromosomesXXY02.png. Wikimedia commons. Retrieved 18th May 2022 from https://
commons.wikimedia.org/wiki/File.png. Copyright-free]

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Question 6
EASY

Which row correctly states the number of alleles of a single gene which would be present in the nucleus of a cell as a result of each process?

Mitosis I Meiosis II Fertilisation


A. Two Two Two
B. One One Two
C. Two One Two
D. Two One One

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Question 7
EASY

Which are common features of bacterial cells?

I. Have a single chromosome


II. Have plasmids
III. DNA associated with proteins

A. I and II

B. II only

C. III only

D. I, II and III

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Question 8
EASY

There are two alleles for flower colour in snapdragons. However, the result of a cross between two heterozygous plants yielded offspring with three different observed phenotypes, red, white
and pink flowers. Which is the most likely explanation for this observation?

A. One allele is dominant to the other.

B. There is codominance between alleles.

C. There is incomplete dominance between alleles.

D. The alleles are sex-linked.

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EASY
Question 9
The diagram shows a DNA profile taken from a crime scene.

Following are the DNA profiles of the suspects in this crime. Which one is the guilty individual?

A. B.

C. D.

[ © Revision Village 2022]

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Question 10
EASY

Bacteria are widely used in genetic modification. Which feature of bacteria makes them suitable for this use?

A. Size

B. Absence of a nucleus

C. Plasmids

D. Single loop of DNA

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Question 11
EASY
Which of the following statement(s) are possible consequences to a polypeptide if a base substitution mutation occurs?

I. A shorter polypeptide chain is translated


II. An altered polypeptide chain is translated
III. There is no change to the polypeptide sequence

A. I and II only

B. I and III only

C. II and III only

D. I, II and III

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Question 12
EASY

What is the function of the Polymerase Chain Reaction?

A. To show that DNA replication is semi-conservative

B. To determine the sequence of bases in DNA

C. To make many copies of a sample of DNA

D. To incorporate Taq DNA into the sample

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Question 13
EASY

Which of these statements is a correct definition of a gene?

A. A gene is the length of a chromosome

B. A gene is a length of DNA that is wrapped around histones

C. A gene is a heritable factor made of DNA that influences a specific characteristic

D. Genes control all characteristics of an organism

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Question 14
EASY

The table shows the nucleotide base sequence and genome size (number of base pairs, bp) for different species.

[©Revision Village 2023. ]

Which conclusion can be drawn, based on the table?

A. Genome size is proportional to the size of the species.

B. The more closely related two species are, the more similar their base sequences.

C. Humans have more genes than chimpanzees, mice and horses.

D. The base sequence in the table for humans and chimpanzees is the same, therefore they have an identical genetic code.
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Question 15
EASY

The diagram shows a pair of homologous chromosomes.

How many loci are shown?

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A. 1

B. 2

C. 4

D. 8

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Question 16
EASY

Two individuals, heterozygous for a specific trait, were crossed in an experiment. Which row shows the expected phenotypic ratios of the offspring resulting from this cross?

Offspring phenotypes Ratio


A. All dominant 1
B. Dominant: Recessive 1:1
C. Dominant: Recessive 3:1
D. Dominant: Recessive 1:3

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EASY
Question 17

Mendel observed that the seed shape in individual pea plants was either round or wrinkled. The results of an experimental cross yielded 315 offspring with round seeds and 105 offspring with
wrinkled seeds.

Which row in the table below states the most likely genotypes of the parents?

Parent I Parent II
A. RR rr
B. Rr rr
C. Rr Rr
D. Rr RR
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Question 18
EASY

In some animals, the agouti allele causes individual hairs to have a banded pattern. The non-agouti allele causes hairs to be a single colour. Individuals who are heterozygous have hairs with a
banded pattern.

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Which combination of parent genotypes would allow for production of offspring that do not have the agouti characteristic?

A. One heterozygous parent and one parent who is homozygous for the agouti allele.

B. Two parents who are both heterozygous.

C. One parent who is homozygous for the agouti allele, and one parent who is homozygous for the non-agouti allele.

D. Two parents who are homozygous for the agouti allele.

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Question 19
EASY

The diagram below represents a cell with a diploid number of 4. Which stage of cell division is the cell currently undergoing?
[ © Revision Village 2022]

A. Metaphase I

B. Anaphase II

C. Metaphase in mitosis

D. Prophase I

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EASY
Question 20

Neurons of the fruit fly (Drosophila melanogaster) have 8 chromosomes. How many chromosomes are in a fertilised oocyte of a fruit fly?

A. 8

B. 4

C. 2

D. 16

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Question 21
EASY

Which of these does not cause mutations?

A. Nitrosamines in tobacco

B. Errors by DNA polymerase

C. Telophase

D. Radioactive isotopes

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Question 22
EASY

Which row correctly describes the DNA and chromosomes of bacterial cells?

Shape DNA with proteins Number of chromosomes


A. Looped Yes More than one
B. Linear Yes More than one
C. Looped No One
D. Linear No One

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EASY
Question 23

Which part of the diagram represents the recombinant DNA?


[© Revision Village 2022]

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EASY
Question 24

The diagram shows normal red blood cells and sickle-shaped red blood cells. Which statement describes the cause of sickle-shaped red blood cells?

[© Revision Village 2022]

A. Red blood cells that have been damaged

B. Red blood cells that have been in a hypertonic solution

C. A base substitution mutation

D. Error in mitosis

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Question 25
EASY

The diagram depicts nucleosomes.

[Source: Adapted from CNX OpenStax, (2016, May). File: Figure 16 03 02.png. Wikimedia commons. Retrieved May 28, 2022, from https://commons.wikimedia.org/wiki/File:
Figure_16_03_02.png. Copyright under CC-BY-4.0]

What is the role of X?


A. Joins nucleosomes together

B. Packages DNA into nucleosomes through coiling

C. DNA replication

D. Carries genetic material

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Question 27
EASY

What is the role of Taq polymerase in the PCR process?

A. Copies DNA segments at a high temperature

B. Used to separate the DNA double helix

C. Used to cut DNA into fragments for use in electrophoresis

D. Attaches DNA primers to target sequences

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Question 28
EASY

This karyogram is for an individual with Down syndrome.

[Source: Adapted from File: Abedi M., Salmaninejad A. and Sakhinia E. (13th November 2017). File: Peripheral-blood-karyotype-result-belonging-to-the-subject-compatible-
with-48-XYYY.png. Wikimedia commons. Retrieved 15th May 2022 from https://commons.wikimedia.org/wiki/File.png.Copyright under Creative Commons 4.0
International.]

Which statement is not correct?

A. Down syndrome is caused by trisomy 21

B. Down syndrome is caused by a trisomy of sex chromosomes

C. Down syndrome is caused by a trisomy of autosomes

D. Down syndrome is caused by an incorrect number of chromosomes

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Question 29
EASY

The DNA sequence shown has been taken from exon 1 of DNA within the human insulin gene. Which sequence corresponds to a deletion mutation in the sequence?

[Source: Adapted from NCBI]


A. TACAAGGACAAGCTGCAT

B. TACAAGAGACAAGCTGCA

C. TACAAGGAAAGCTGCATC

D. TACAAGGACAAGCGGCAT

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Question 30
EASY

Which of these statement(s) is/are correct concerning the Polymerase Chain Reaction (PCR)?

I. It creates RNA copies of DNA


II. It uses a special DNA polymerase that can withstand high temperatures
III. It requires helicase and ligase to work

A. I only

B. II only

C. II and III only

D. I, II and III

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Question 31
EASY

What is a possible cause of a genetic mutation?

A. An organism’s need to adapt to the environment

B. Random errors during DNA replication

C. Physical damage to body tissue

D. Random errors during transcription

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EASY
Question 32

Mendel observed that there are two possible variations of flower colour in pea plants, purple and white. After a genetic cross, the ratio of plants with purple flowers to white flowers is 1:1.
What were the genotypes of the parents?

A. Both parents are heterozygous.

B. One parent is heterozygous and the other is homozygous recessive.

C. Both parents are homozygous recessive.

D. One parent is heterozygous and the other is homozygous dominant.

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Question 33
EASY

Which of the following statements is/are correct for meiosis?

I. It is a reduction division
II. It involves random orientation
III. It produces genetically identical cells

A. I only

B. II only

C. I and II

D. I and III

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EASY
Question 34

Which of these answers is true in relation to the polymerase chain reaction?

I. High temperatures are used


II. It produces exact copies of a segment of DNA
III. It requires DNA ligase and restriction endonucleases

A. I, II and III

B. I and III

C. II only

D. I and II

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Question 35
EASY

Which row contains correct information about clones?

Genetically identical to parents Number of parents Result of


A. Yes 1 Asexual reproduction
B. Yes 2 Asexual reproduction
C. No 1 Asexual reproduction
D. No 2 Sexual reproduction

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Question 36
EASY

The sequence of nucleotides in a section of DNA is as follows:

ATGGCTACCTGT

Which of the following mutations would represent a substitution?

A. ATGGCTACTGT

B. ATGGCCTACCTGT

C. ATGGCACCTGT

D. ATGGCCACCTGT

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MEDIUM
Question 38

Which row correctly describes diploid and haploid cells in humans?


Haploid cell Diploid cell
A. Chromosomes not in pairs; have two sex chromosomes Chromosomes not in pairs; have one sex chromosome
B. Chromosomes not in pairs; have one sex chromosome Chromosomes in pairs; have two sex chromosomes
C. Chromosomes in pairs; have two sex chromosomes Chromosomes not in pairs; have one sex chromosome
D. Chromosomes in pairs; have one sex chromosome Chromosomes in pairs; have two sex chromosomes

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Question 39
MEDIUM

The following table shows the diploid chromosome number of a range of species.

Organism Diploid chromosome number


Yellow fever mosquito (Aedes egypti) 6
Fruit fly (Drosophila melanogaster) 8
Spinach (Spinacia oleracea) 12
Carrot (Daucus carota) 18
Rice (Oryza sativa) 24
Giraffe (Giraffa camelopardalis) 30
Giant panda (Ailuropoda melanoleuca) 42

Which of these statements is correct?

A. The giant panda has more genes than the other species
B. The yellow fever mosquito has the fewest genes from these species
C. The gametes of carrots have 18 chromosomes
D. The chromosome number is a characteristic of a species

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Question 40
MEDIUM

Sickle cell anaemia is caused by a recessive allele (HbS ). The dominant allele is HbA . This image shows the inheritance of sickle cell anaemia in a family.

[ © Revision Village 2022]

What are the genotypes for individuals 1 and 7?


Individual 1 Individual 7
A. HbA HbS HbS HbS
B. HbA HbS HbA HbS
C. HbA HbA HbA HbS
D. HbA HbA HbS HbS

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Question 42
MEDIUM

What conclusion can be drawn from the karyogram below?

[Source: Adapted from Abedi, M., Salmaninejad, A., Sakhinia, E. (2017, November 13). Peripheral-blood-karyotype-result-belonging-to-the-subject-compatible-with-48-
XYYY.png. Wikipedia Commons. Retrieved May 13, 2022, from https:// commons.wikimedia.org/wiki/File.png. Copyright under CC BY 4.0]

A. Crossing over occurred during mitosis

B. Crossing over occurred during meiosis

C. Non-disjunction occurred during mitosis

D. Non-disjunction occurred during meiosis

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Question 43
MEDIUM

A biological female with blood type A had a child with blood type O. What are the possible genotypes of the biological father?

I. ii
II. IAIi
III. IBIi

A. I only

B. I and II only

C. II and III only

D. I, II, and III

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MEDIUM
Question 44

Which of the following processes is characteristic of the meiotic and not the mitotic cell cycle?

A. Reduction division

B. Nuclear division

C. Interphase

D. Cytokinesis

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Question 45
MEDIUM
The diploid number of the chimpanzee (Pan troglodytes) is 48. Which row shows the correct chromosome number for different cell types and cell division stages?

Sperm cell Brain cell Cell in prophase I Cell in metaphase II


A. 48 24 24 48
B. 24 48 24 48
C. 24 48 48 24
D. 48 24 48 24

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Question 46
MEDIUM

At the end of which phase of meiosis I does crossing over occur, and what is the outcome of crossing over?

Meiotic phase Outcome


A. Prophase I increased genetic variation
B. Prophase I halved chromosome number
C. Anaphase I increased genetic variation
D. Anaphase I halved chromosome number

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Question 47
MEDIUM

A man is homozygous for blood type B. His wife has blood type AB. What would be the possible blood types for their children?

Type A Type B Type AB


A. 25% 75% 0%
B. 50% 50% 0%
C. 25% 50% 25%
D. 0% 50% 50%

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Question 49
MEDIUM

Which row in the table below is true of meiosis?

The number of cells produced Type of cells produced Function


A. Two Haploid Sexual reproduction
B. Four Haploid Sexual reproduction
C. Four Haploid Asexual reproduction
D. Two Diploid Sexual reproduction

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Question 50
MEDIUM

Shown below is the single base substitution mutation that causes sickle cell anaemia in individuals who are homozygous for the allele. Which of the following is a result of this mutation?

[© Revision Village 2022]


A. Translation of one incorrect amino acid that affects the function of haemoglobin

B. Production of haemoglobin that cannot bind to oxygen

C. Translation of one incorrect amino acid that does not affect the function of haemoglobin

D. Translation of two incorrect amino acids

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Question 51
MEDIUM

Which statement about mutations in germ and/or somatic cells is correct?

A. Mutations in somatic cells can be inherited by offspring

B. Mutations in germ cells cannot increase the likelihood of developing cancer

C. Mutations in both somatic and germ cells can be inherited by offspring

D. Mutations in somatic cells can be acquired during a lifetime

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MEDIUM
Question 52

What type of inheritance is shown in this pedigree chart?

[©Revision Village 2023. Created with BioRender.com]

A. X-linked dominant

B. X-linked recessive

C. Autosomal dominant

D. Autosomal recessive

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Question 53
MEDIUM

Which row shows the correct annotation of the alleles for blood groups?

A. IA IB i
B. Blood group B Blood group A Blood group O
C. IA IB IB IB IA i
D. A+ B+ O−

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Question 54
MEDIUM

Which of these statements are true for alleles?

I. Alleles are versions of a gene


II. Alleles differ by one or more base
III. Alleles affect the same characteristic

A. I and II

B. I only

C. I, II and III

D. II and III

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Question 55
MEDIUM

Which stage of meiosis involves the separation of homologous chromosomes?

A. Metaphase I

B. Anaphase I

C. Metaphase II

D. Anaphase II

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Question 58
MEDIUM

What can be concluded from the following karyogram?

[Source: Adapted from Abedi M., Salmaninejad A. and Sakhinia E. (13 November 2017). File: Peripheral-blood-karyotype-result-belonging-to-the-subject-compatible-with-48-
XYYY.png. Wikimedia commons. Retrieved 20 September 2023 from https://commons.wikimedia.org/wiki/File: Peripheral-blood-karyotype-result-belonging-to-the-subject-
compatible-with-48-XYYY.png Copyright under C.C BY 4.0]

A. There was non-disjunction during meiosis in the mother.

B. There was non-disjunction during meiosis in the father.

C. There is one missing chromosome.

D. There is one extra chromosome.

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Question 60
MEDIUM

An unfertilised egg cell belonging to the mangrove horseshoe crab (Carcinoscorpius rotundicauda) contains 16 chromosomes. How many chromosomes would be found in a cell from this
species about to undergo meiosis?

A. 8

B. 16

C. 32

D. 64

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Question 61
MEDIUM

How does meiosis result in variation?

A. New combinations of gametes fuse together.

B. New combinations of alleles are produced in body cells.

C. New combinations of alleles are produced in gametes.

D. New combinations of alleles are produced by base substitution.

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Question 63
MEDIUM

The image shows an abnormal human karyotype.

[Source: Adapted from Wessex Reg. Genetics Centre. (n.d.) Down syndrome human karyotype 47,XY. Retrieved March 29, 2022, from
https://wellcomecollection.org/works/wmcdanw6. Copyright under CC BY 4.0]

What is the abnormality in this karyotype and its cause?

Abnormality Possible Cause


A. X and Y chromosomes are different in size Non-disjunction in anaphase I or II
B. X and Y chromosomes are different in size Crossing-over in prophase I
C. 3 copies of Chromosome 21 Non-disjunction in anaphase I or II
D. 3 copies of Chromosome 21 Crossing-over in prophase I

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Question 64
MEDIUM
This table is a short section of the output from a DNA sequence database comparing the cytochrome C gene sequence in two species. What does it show?

[© Revision Village 2022]

A. These sequences are for two different genes

B. There are two differences in the base sequence between the two species

C. There are three differences in the base sequence between the two species

D. There are four differences in the base sequence between the two species

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Question 66
MEDIUM

A single base substitution mutation occurs and a stop codon is not produced. Which of the following is not a possible consequence of this type of mutation?

A. The quaternary structure of the protein this gene codes for is altered.

B. No amino acids in the polypeptide this gene codes for are changed.

C. Two amino acids in the polypeptide this gene codes for are changed.

D. DNA repair mechanisms are activated, producing a stop codon.

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Question 67
MEDIUM

What type of human cell does the following karyogram represent?

[Source: Adapted from Abedi M., Salmaninejad A. and Sakhinia E. (13th November 2017). File: Peripheral-blood-karyotype-result-belonging-to-the-subject-compatible-with-48-
XYYY.png. Wikimedia commons. Retrieved 15th May 2022 from https://commons.wikimedia.org/wiki/File: Peripheral-blood-karyotype-result-belonging-to-the-subject-
compatible-with-48-XYYY.png. Copyright under Creative Commons 4.0 International ]

A. Sperm

B. Egg

C. Brain cell

D. Skin cell

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MEDIUM
Question 68

Which statement is correct for plasmids?

A. Plasmids are found in all prokaryotic cells

B. Plasmids are found in some eukaryotic cells

C. Plasmids are the only genetic material found in prokaryotic cells

D. Plasmids can be cut using restriction endonucleases

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Question 69
MEDIUM

Which is a potential cause of Trisomy 21 or Down syndrome?

A. Improper alignment of homologous chromosomes during metaphase II

B. Formation of multiple chiasma on chromosome 21 during prophase I

C. Formation of a polar body in telophase I

D. Failure of sister chromatids to separate during anaphase II

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Question 70
MEDIUM

Which row represents the steps of the polymerase chain reaction (PCR) in the correct order?

I II III IV
A. Sample is heated to 95 At 72⁰C Taq DNA polymerase produces two
Temperature is reduced to 53⁰C Primers attach to both strands
⁰C double-stranded copies
B. Sample is heated to 95 At 72⁰C Taq DNA polymerase produces two
Temperature is reduced to 53⁰C Primers attach to both strands
⁰C double-stranded copies
C. Primers attach to both At 72⁰C Taq DNA polymerase produces two
Sample is heated to 95 ⁰C Temperature is reduced to 53⁰C
strands double-stranded copies
D. Primers attach to both At 72⁰C Taq DNA polymerase produces two
Sample is heated to 95 ⁰C Temperature is reduced to 53⁰C
strands double-stranded copies

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MEDIUM
Question 71

What best describes the inheritance of the condition shown in the pedigree chart below?

[ © Revision Village 2022]


I. Sex-linked trait

II. Dominant trait

III. Recessive trait

A. I and III

B. I only

C. III only

D. I and II

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Question 72
MEDIUM

Which of these statements about genetic disorders is/are correct?

I. The majority of genetic disorders are caused by recessive alleles.


II. Genetic disorders can be sex-linked.
III. Offspring of two parents with the same genetic disease will always be affected.

A. All three

B. II only

C. I and III

D. I and II

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Question 73
MEDIUM

What suggests that the inheritance of the disorder shown in the pedigree chart is X-linked recessive and not autosomal recessive?

[© Revision Village 2022]

A. Two unaffected individuals can have affected offspring.

B. An unaffected female can produce unaffected sons.

C. Males are more likely to be affected than females.

D. Both males and females can be affected.

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Question 80
HARD

The diagrams below show a cell, with a diploid number of 8, in different stages of meiosis. Which row correctly names each stage?

I. II.

III. IV.
[ © Revision Village 2022]
I II III IV
A. Metaphase I Metaphase II Anaphase I Prophase II
B. Metaphase I Metaphase II Prophase II Prophase I
C. Metaphase II Metaphase I Prophase I Anaphase II
D. Telophase I Metaphase II Anaphase I Prophase I

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Question 82
HARD

The micrographs show four phases of meiosis I in a plant. In what order do these phases occur?

[Source: Adapted from Windham, M. D., Pryer, K. M., Poindexter, D. B., Li, F.-W., Rothfels, C. J., and Beck, J. B. (2020). A step-by-step protocol for meiotic chromosome
counts in flowering plants: A powerful and economical technique revisited. Retrieved January 4, 2023, from Applications in Plant Sciences 8( 4): e11342. © 2020, Windham et al.
Licensed under CC BY 4.0]

A. X-Y-W-Z

B. W-Z-X-Y

C. Y-X-W-Z

D. Z-W-X-Y

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Question 83
HARD

Which of these statements is NOT true for short tandem repeats (STR)?

A. They can be found at the ends of chromosomes in regions called telomeres

B. An allele is a short tandem repeat

C. In DNA profiling, short tandem repeats are used to compare DNA samples

D. The number of short tandem repeats varies between alleles

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HARD
Question 84

A DNA profile was made using DNA from a crime scene. Locus TH01 was used to identify whether a suspect’s DNA matched the crime scene DNA. The suspect’s two alleles of the gene at
Locus TH01 are shown below.

[© Revision Village 2022]

The alleles TH01-6 and TH01-4 were separated and visualised with gel electrophoresis. The resulting gel, with two bands of DNA, is shown below.

[© Revision Village 2022]

What is the DNA in Band B and why is this DNA at this position?

A. TH01-4; smaller fragments travel faster and farther in the gel

B. TH01-4; smaller fragments are more attracted to the negative pole

C. TH01-6; larger fragments travel faster and farther in the gel

D. TH01-6; larger fragments are more attracted to the positive pole

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Question 85
HARD

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