PHARMACOTHERAPUTICS

7N

OBSTETRICS

11 is important to seecognise cutat type of drugs. can be used in labour, and achartage and
disadvantage of those bags.

DRURS USED IN PREGNANCY -

 ERGOT DERIVATIVES
 PROSTAGLANDINS
 ANTI HYPERTENSIVE DRUGS
 TOCOLYTIC AGENTS
 ANTICONPULSANTS
 ANTICOAGULANTS
 DIURETICS

ERGOT DERIVATIVES

→ERGOMETRINE ERGOMET RINE (ERGONOVINE)

→METHERGIN (METHYL-ERGONOLINE)

→ SYNTOMETRING (SAN 002)

PROSTAGLANDINES:

DA*E_{2}

pGEq

ANTINYPERTENSIVE
→METHYLDOPA

NIFEDIPINE

HYDRALAZZNE

TOCOLYTIC AGENTS-

→MAGNESEUM SULPHATE

→CALCIUM CHANNEL BLOCKERS

ANTE CONVLILSIVE-

→DIAZEPAM

→MEGNESIUM SULPHATE

DIURETICS

→PHENYTOIN

→FRUSEMIDE

OXYTOCIN-

Dale is the first one who discovered oxytocin in 1990, oxytocin is an octapeptide syntocinon in the
Lypothalames and stored in the paverion pituitary.

MECHANISIR OF ACTION:- Acts directly on myofobrils producing aterrine antraction and stimulates
milk ejection by the breast.

HSE-
→ To induce abortion

→ To stop bleeding following evacuation.

induce Labocor

→ to prevent and tecat postporten harmstockage.

DOSE-

controlled infscavensas infusion, 10 concts of

oxytocin on 1000 m of RL/5s Dextrsse.

SIDE EFFECTS:

нейнe suptiore.

→Fetal disfres and fetal death.

→Hypotension.

→Neonatal Jaundice,

→ Hypertonic utoine activity.

NURSING CONSIDERATION:-

ASSE &S-

→ Intake and cutpat ratio.

→ Uterine contractions and FHR.

→Blood pressore, pulse and respiration.

EVALUATE!-

→Length and duration of contraction.

→Nority physician of contraction. TEACH! To report incacared blood dons, increased komperatore

2) ERGOT DERIVATIVES:-

Esegot alkaloids are either national or

Semi-Synthetic.

Mode of Action-

Forgometrine aos directly on the myomekiam It stimeclates uterine contraction and decxcares
bleeding!

DOSE! - Esegometrine - 0.25-0.5mg amp 0.5-1ing tab. Methergöre - 0.125-0.250mg amp. 0.125-
0.5mg tab.
ROHTES-

IM

Oral

SIDE EFFECTS:-

common side effects are nausea and vomiting.

→Prolonged use may lead to gangorane of the toes due to its vasoconstrictive effects.

→ Bealonged use in puerpericom may interfere with lactatison of lowering prolacton effect.

NURSING CONSIDERATION

ASSESS-

→Blood presscore, pulse and respiratia

→Watch fore signs of Laemooxlage.

EVALUATE

Therapeutic effect-decreased blood 1005.

TEACH A

to report increase blood loss, abdominal Creamps, nausea, vomiting or dyspnoea.

8) PROSTAGLANDINES!-

Brostaglandins are synthesized from one of the essential fatty aads, arachidonic acid ashich is widely
diskwbuted Hocoughout the boy,

ACTIONI- Both P682 and P682 have an orgstaiselas on the preggrant cloves when used in appropriate
dise, Pas also sensitise the myomerciam. to agrocin.

DOSE: Tab. Beaston E2 0.5mg Vaginal suppository - 1968220mg on par250mg vaginal pessary PGE2
3mg Infectable Amp or viel - Boston Ed song fire, PGF2 bomg.

SEDE EFFECT-Headache, dizziness, leg Bramas, Jout saclling.

NAROING CONSIDERATION ー

ASSESS Respiratory rate, sefython and depth.

laginal discharge, itching on isoritarion indicative of infectio.

EVALHATE! For Length and duration of contractions notify physician of contractions lasting over one
mindite or absence of contseactions,

Fever and chillis.

TEACH to remaèn supine for 10-15 mint, after vaginal Insertion,

4) METHYLDOPA :- (ANTIHYPERTENSIVE)

Antihypertensive drugs are essential when the BD 13 160/80 mm of its to protect the mother from
eclampsia, cerebral Laemorrhage, cardiac faileore and placental aborception.
ACTION! Centreal and peripheral antwadegregic achorn. Effective and cafe for mother and the fetus.

DOSE!-

Orally 250ng BD

IV infusion- -250-500mg.

610E EFFECT

→ Nausea, vomiting

→Diarrhoea, constipation

→ Bradycardia.

→Headache, depression, dizziness.

→ Orowsiness, leucopenia.

NURSING CONSIDERATION!

ADESS

Blood values -- Neutrophils, platelets, Renal Stadies-- Brotein, BUN, creatinine

LFT

EVALLIATE Decrease in blood pressure.

• Allorgic reaction-Rask, fever, witscaria.

•Symptoms of congestive Leart failure.

TEACH: Storage of fablets in tight containers.

5) NIFEDIPINE:-

ACTION-

• Calcium channel blocker.

• Produces direct arteriolar vasodilatation by sendibition of inaared calciun channels in vascular

omook,

SIDE EFFECTS

• Flashing, Lypotension, palpitation.

• Bradycardia, inhibition of labsor, Leadache, fatigue

• Nacusca, romoting, drowsiness.

00558-

Orally 5-10mg TOS.

NURSING CONSIDERATION! –

ADESS

• Blood levels of the bag, therapeatoes levels 0.02.

EVALUATE!

• Therapeutic response.

Cardiac status, Bo, pulse, respiration.

ECC.

TEACH

• To limit caffeine consumption

• To avand OTC bags wonders directed physician.

Stress partient compliance to all aspects of brug.

MAGNESIUM SULPHATE-

ACTION-

• Decreases acetylcholic in motor roove forminds.

Decreases Antracranial vedema.

Depressant action on the uterine masde and CNS,

LUSE

It is valuable beag with pregnancy induced Lyporfension.

DOSE

• 20ml of 20% solation IV slowly.• come of 80%, solution IM

Continued 4 Locorly Hill 24 Lowrs.

SIDE EFFECTS:-

•Materral!-severe CNS depression, evidence of muscular paresis.

• Fefal :- Tachycardia, Lypoglycemia, Headache, srestlessness.

• Nausea, vomiting, ansorexia.

NURSING CONSIDERATION! -

ASSESS

• Matorrar and fetal heart tones during infusion.

• Intensity and length of towne ontseaction.

• Flaid intake to prevent flard overload, discontinue if this occions,

EVALUATE Decreased intensity.

• Length of contraction.

• Absence of preterm laвосы,

• Decreased BP.

TEACH

To remain in bed daring infusion,

7) PHENYTOIN!

ACTION—

Inhabits spread of seizure actively on more

Cose fex.

DOSE

* Eclampsia-10mg/kg sv

* Epilepsy 300-400 mg daily orcally,

SIDE EFFECT

• ypotension, cardiac. aortythmias and phlebitas ate injection site,

Brolonged use by epileptic patients may cause craniofocal abnormalities,

Mental scefardation, microcephaly and growth deficiency.

NURSING CONSIDERATION! -

ASSESS

• Blood studies - CBC, platelets every 2 wks untel

Stabilized, Discontinue berg of neutrophils <1600/mont

EVALUATE!-

• Mental statas, sensoricim, affect, memory,

• Respiratory depression,

• Blood dyscrasis-sore Moroat, bruising,

TEACH

• All aspects of bang administration when to nototy physician,

8)

ACTION:-

• 11 decreases the acetylcholine release Scom the rove endings and plate reduces the motir end
plate sensitivity to acetylcholine.

• It also blocks the calcian channels.

DOSE:-

IM lomy deep IM

10---4-6mg ル

SIDE EFFECT!

Hypotension, Respiratory failove.

21 does not affect the duration of labour.

NURSING CONSIDERATION -

ASSESS-

Blood presscore, pulse.

Respiration.

Heart rate,

EVALUATE!-

Decreased blood prrecove.

Restlessnes

Therapeutic response, cardiac status.

TRACH-

To remain in bed dwcing infusion,

All aspects of bags administerration when to nothing physician.

CONCLUTION-

→ All the drugs are use in obsterwes patient.

→1ts prevent infection.

→7ts provide maternal and Atal growth,

→Its controlled micro-organism groask.

→ 3/3 treated Lifferent disease.

SUMMARISATION

DRUAS

MODE OF ACTION

DOSE

SIDE EFFECTS

NURSING CONSIDERATION

CONCL 4570N
REFERENCE