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Ebook Pediatric Critical Care PDF Full Chapter PDF
Ebook Pediatric Critical Care PDF Full Chapter PDF
2
Monica Relvas, MD, FAAP, FCCM, MSHA
Medical Director, Pediatric Critical Care Medicine, Covenant Women and Children’s
Hospital, Associate Clinical Professor, Texas Tech University, Lubbock, Texas
Joseph D. Tobias, MD
Chief, Department of Anesthesiology and Pain Medicine, Nationwide Children's Hospital,
Professor of Anesthesiology and Pediatrics, The Ohio State University, Columbus, Ohio
3
Table of Contents
Instructions for online access
Cover image
Title Page
Copyright
Contributors
Preface
Definitions
4
Around the World
High-Mortality Countries
Summary
Acknowledgments
References
PICU as System
Summary
References
Neurocritical Care
Impact on Research
References
Medical Record
Huddles
Checklists
Rounds
Closed-Looped Communication
Transitions of Care
5
Medical Training
Debriefing
Team Training
Conclusion
References
The Stakes
References
Leadership
Nursing Research
Summary
References
Conclusions
References
6
Study Types
Levels of Evidence
Conclusion
References
Historical Perspective
Methods
References
Mitigating Long-Term Morbidity: The Next Frontier for Pediatric Critical Care Medicine
Conclusions
References
Chapter 11 Safety and Quality Assessment in the Pediatric Intensive Care Unit
Brief Consideration of the Relationship Between Safety and Quality
Patient Safety in the Pediatric Intensive Care Unit: Past, Present, and Future
Conclusions
7
References
Telemedicine
Acknowledgments
References
Overcoming Barriers and Challenges to Patient- and Family-Centered Care in the ICU
Summary
References
References
8
Chapter 15 Ethical Issues in Death and Dying
Decision Making at the End of Life
Death Determination
References
Communication
Limitation of Interventions
References
Role of the Pediatric Intensivist and Critical Care Team in the Process of Organ Donation
Diabetes Insipidus
Oliguria
9
Medical Examiner/Coroner Issues and Organ Donation for Children
Summary
References
Summary
References
Pericardiocentesis
Paracentesis
References
Procedural Guidance
Drainage Procedures
Lumbar Puncture
Diagnostic Modalities
10
Conclusion
References
References
Requirements
Acknowledgment
References
Conclusions
11
References
References
Acknowledgment
References
Regional Circulations
References
Conclusions
References
12
Chapter 28 Principles of Invasive Monitoring
Role of Invasive Hemodynamic Monitoring
Principles of Measurement
Invasive Techniques
Catheter Placement
Conclusions
References
Quantity of Therapy
References
13
Mechanical Circulatory Support and Single Ventricle
Outcomes
Conclusions
References
Ventricular Function
Vascular
Catheter Manipulation
Devices
Summary
References
Acknowledgment
References
14
Chapter 33 Pharmacology of the Cardiovascular System
Mechanisms of Response
Acknowledgments
References
References
Approach to Diagnosis
Approach to Therapy
Specific Arrhythmias
References
Treatment of Shock
Obstructive Shock
Distributive Shock
Septic Shock
Summary
References
15
Background
Cardiopulmonary Bypass
References
Neonatal Considerations
Preoperative Care
Postoperative Care
Summary
Acknowledgment
References
Future Management Strategies for Critical Care of Infants and Children With
Cardiopulmonary Failure
References
Definition
16
Management of Low Cardiac Output Syndrome
Heart Transplantation
Conclusion
References
Pharmacology
Vasopressin
Future Directions
References
Other Considerations
Summary
References
17
Developmental Anatomy of the Upper Airway
Acknowledgment
Key References
Lung Circulation
Summary
Acknowledgments
References
Applied Forces
Gas Exchange
Alveolar Ventilation
References
Validation
Sources of Error
Probe Placement
18
Physiologic Basis
Clinical Applications
Transcutaneous Monitoring
Oxygen Monitoring
Conclusion
References
Controls of Breathing
Breathing Failure
Conclusion
References
Distribution of Perfusion
Therapeutic Considerations
References
19
Dissipative Phenomena: Resistive Behavior of the Respiratory System
Conclusion
References
Congenital Malformations
Laryngomalacia
Infectious Processes
Laryngotracheobronchitis
Epiglottitis
Peritonsillar Abscess
Retropharyngeal Abscess
Bacterial Tracheitis
Laryngeal Papillomatosis
Trauma
Angioedema
Tracheostomy
20
Complications
Decannulation
References
Definition
Pathobiology
Ventilator Management
Nonpulmonary Therapies
Noninvasive Support
References
Roles of Tidal Volume, Positive End-Expiratory Pressure, and Overall Lung Distention
References
Chapter 53 Asthma
Epidemiology and Risk Factors
Pathophysiology
Clinical Assessment
21
Laboratory Data
Electrocardiography
Spirometry
Treatment
Mechanical Ventilation
Antibiotics
Bronchoscopy
Prognosis
References
Metabolic Disorders
References
Pathophysiology
Diagnosis
Bacterial Pneumonitis
Viral Pneumonitis
Fungal Pneumonitis
22
Pneumocystis carinii Pneumonia
Chemical Pneumonitis
Summary
References
Transitional Circulation
Prostaglandin E1 (PGE1)
Conclusions
References
Modes of Ventilation
Patient-Ventilator Asynchrony
High-Frequency Ventilation
Specialty Gases
References
23
Chapter 58 Noninvasive Ventilation
Introduction
Historical Perspective
Indications
Interfaces
Equipment
Ventilator Settings
Summary
References
Patient Management
Complications
The Future
References
24
Section IV Central Nervous System
Neurotransmitter Systems
Blood-Brain Barrier
Conclusion
References
Arachnoid Cysts
Chiari Malformations
Dandy-Walker Malformation
Spinal Dysraphism
References
Neuroimaging
References
25
Chapter 63 Neuroimaging
Imaging Modality Overview
Vascular Malformations
Demyelinating Disease
Trauma
Hydrocephalus
Tumor
Seizures
Conclusion
References
References
Identification of Cause
Respiratory Pattern
Eye Examination
Motor Examination
26
Focal Neurologic Lesions Could Be Supratentorial or Subtentorial
Herniation Syndromes
Diagnostic Evaluation
Therapeutic Intervention
Outcome
Ethical Considerations
References
References
Posttraumatic Epilepsy
Pharmacotherapy
Surgical Options
Acknowledgment
References
27
Chapter 68 Hypoxic-Ischemic Encephalopathy
Epidemiology
Clinical Pathophysiology
Futuristic Approaches
Summary
Acknowledgment
References
Pathophysiology
Presentation
Neuroimaging
Laboratory Evaluation
Treatment
Prognosis
Conclusion
References
28
Bacterial Meningitis
Clinical Manifestations
Subdural Empyema
Brain Abscesses
Viral Meningoencephalitis
Conclusion
References
Myasthenia Gravis
Tick Paralysis
Periodic Paralyses
Botulism
Diphtheria
Poliomyelitis
Polio-Like Syndromes
References
Renal Anatomy
Renal Vasculature
29
Nephron Unit
Tubular Anatomy
Summary
References
Sodium
Hyponatremia
Potassium
Hypokalemia
Hyperkalemia
Magnesium
Hypomagnesemia
Hypermagnesemia
Calcium
Hypocalcemia
Hypercalcemia
Hypophosphatemia
Hyperphosphatemia
References
Plasma Markers
Estimating Equations
30
Tubular Function
References
Conclusions
References
Conceptual and Practical Integration of the Tools for Assessing Acid-Base Balance
Metabolic Acidosis
Metabolic Alkalosis
Summary
References
References
31
Basic Physiology of Dialysis and Ultrafiltration
Peritoneal Dialysis
Intermittent Hemodialysis
Summary
References
Terminology
Etiology
Pathophysiology
Endothelial Homeostasis
Renin-Angiotensin-Aldosterone System
Nitric Oxide
Volume Overload
Clinical Presentation
Pharmacologic Therapy
Special Situations
Summary
Acknowledgment
References
32
Impaired Cellular Respiration in Critical Illness
Lactate
Microdialysis
Near-Infrared Spectroscopy
Optical Spectroscopy
NADH Fluorometry
Antioxidants
Glycemic Control
Substrate Provision
Membrane Stabilizers
Hibernation
Conclusions
References
Stress Response
References
33
Chapter 82 Inborn Errors of Metabolism
Pathophysiology of Inborn Errors of Metabolism
Metabolic Acidosis
Hypoglycemia
Neonatal Screening
Conclusion
References
References
34
How Do Cellular Death Mechanisms Propagate Critical Illness?
References
Cortisol Biochemistry
Actions of Cortisol
Hyperglycemia
Glucose Measurement
Future Directions
Hypoglycemia
Acknowledgment
References
Epidemiology
References
Body Composition
Biochemical Assessment
35
Lipid Requirements
Micronutrient Requirements
Refeeding Syndrome
Parenteral Nutrition
Conclusions
References
Hematopoiesis
Lymphopoiesis
References
Oxygen Transport
Blood Flow Disruption During Critical Illness by Maladaptive Red Blood Cell–Based
Signaling
References
36
Chapter 90 Hemoglobinopathies
Perspective
Thalassemia
References
Overview of Hemostasis
Iatrogenic Coagulopathy
Platelet Disorders
Selected Disorders
References
Clinical Features
Diagnosis
Management
Conclusions
Acknowledgment
References
37
Transfusion of Red Blood Cells: Indications (When)
Plasma
Platelets
Cryoprecipitate
Conclusion
References
Oncologic Emergencies
References
Transplant Procedure
References
Pancreas
38
Hepatobiliary System
References
References
Gastrointestinal Hemorrhage
Antibiotic-Associated Diarrhea
Acknowlegment
References
Liver Transplantation
References
39
Physical Exam of the Abdomen
Laboratory Tests
Imaging Options
Intraabdominal Abscess
References
Clinical Manifestations of the Innate Immune Response in the Intensive Care Unit
Conclusion
References
Summary
References
40
Introduction
References
Transfusions
Immunosuppressive Medications
Uremia
Cardiovascular Complications
Renal Failure
Abdominal Complications
Hematologic Complications
Malignancies
Neurologic Complications
Infections of CNS
Summary
References
41
Innate and Adaptive Immunity
Conclusion
References
Summary
Acknowledgments
References
Antibiotic Classes
Antibiotic Resistance
Antimicrobial Stewardship
Summary
References
Viral Pneumonia/Pneumonitis
42
Central Nervous System Infections
References
Necrotizing Fasciitis
Invasive Pneumococcus
Hantavirus
Acknowledgments
References
Specific Health Care−Associated Infection Syndromes in the Pediatric Intensive Care Unit
Acknowledgments
References
Epidemiology
Definitions
Clinical Presentation
Pathogenesis
43
Treatment Strategies
Concluding Perspectives
References
Outcomes
Summary
References
References
Epidemiology
Treatment
References
44
Chapter 115 Accidental Hypothermia
Physiology
Cardiovascular
Respiratory
Renal
Coagulation
Treatment
Outcome
References
Epidemiology
Pathophysiologic Considerations
Management
Prognosis
References
Inhalational Injury
Wound Care
Acknowledgment
References
45
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Fig. 5. Types of spears.
“He stands aghast, with his eyes staring at the treacherous pointer, and
with his hands lifted as though to ward off the lethal medium....”
The most formidable weapons of this kind are those still in daily
use as hunting and fighting spears on Melville and Bathurst Islands
(h). The head of this type has many barbs carved on one side, and
occasionally on two diametrically opposite sides. There are from ten
to thirty barbs pointing backwards, behind which from four to eight
short serrations project straight outwards, whilst beyond them again
occasionally some six or more small barbs point forwards. The
spears have a long, sharp, bladed point. The barbs are
symmetrically carved, and each has sharp lateral edges which end in
a point. The size of the barbs varies in different specimens. Many of
the spears are longitudinally grooved or fluted, either for the whole
length or at the head end only. Usually these weapons are
becomingly decorated with ochre, and may have a collar of human
hair-string wound tightly round the shaft at the base of the head.
Some of the heaviest of these spears are up to sixteen feet long,
and would be more fitly described as lances.
The most elaborate, and at the same time most perfect,
specimens of the single-piece wooden spears of aboriginal
manufacture are the ceremonial pieces of the Melville Islanders.
These have a carved head measuring occasionally over four feet in
length and four inches in width, consisting of from twelve to twenty-
five paired, symmetrical, leaf-shaped or quadrilateral barbs, whose
sides display a remarkable parallelism. The barbs are surmounted
by a long tapering point emanating from the topmost pair; and very
frequently one finds an inverted pair of similar barbs beneath the
series just mentioned. Occasionally, too, the two pairs opposed to
each other at the bottom are fused into one, and a square hole is cut
into the bigger area of wood thus gained on either side of the shaft
(i).
The structure may be further complicated by cutting away the point
at the top, and separating the paired series of barbs by a narrow
vertical cleft down the middle (j).
We shall now turn our attention to spears whose head and shaft
are composed of separate parts. In the construction of these, two
principal objects are aimed at by the aboriginal, the first being to
make the missile travel more accurately through space, and in
accordance with the aim, the second to make the point more cruel
and deadly. Whereas, with one exception, all the single-piece
spears, so far discussed, are projected or wielded with the hand
only, in every instance of the multi-pieced spears, a specially
designed spear-thrower is used for that purpose.
The native has learned by experience that weight in the forepart of
the spear will enable him to throw and aim with greater precision.
One has only to watch the children and youths during a sham-fight to
realize how well it is known that the heavier end of a toy spear must
be directed towards the target whilst the lighter end is held in the
hand. Green shoots of many tussocks, or their seed-stalks, and the
straight stems of reeds or bullrushes, are mostly used. They are cut
or pulled at the root in order that a good butt-end may be obtained,
and carefully stripped of leaves; the toy weapons are then ready for
throwing. One is taken at a time and its thin end held against the
inner side of the point of the right index finger; it is kept in that
position with the middle finger and thumb. Raising the spear in a
horizontal position, the native extends his arm backwards, and,
carefully selecting his mark, shies his weapon with full force at it.
The simplest type of a combination made to satisfy the conditions
of an artificially weighted spear is one in which the shaft consists of
light wood and the head of heavier wood (k). Roughly speaking, the
proportion of light to heavy wood is about half of one to half of the
other. The old Adelaide tribe used to select the combination of the
light pithy flower-stalk of the grass-tree with a straight pointed stick of
mallee. The western coastal tribes of the Northern Territory construct
small, and those of the Northern Kimberleys large spears composed
of a shaft of reed and a head of mangrove; the former being four or
at most five feet long, the latter from ten to twelve. The joint between
the two pieces is effected by inserting the heavier wood into the
lighter and sealing the union with triodia-grass resin or beeswax. The
Adelaide tribe used the gum of the grass-tree.
The River Murray tribes used to make the point of the mallee more
effective by attaching to it a blade-like mass of resin, into both edges
of which they stuck a longitudinal row of quartz flakes.
The Northern Kimberleys natives accomplish the same object by
fixing on to the top end of the mangrove stick a globular mass of
warm, soft resin, in which they embed a stone spear-head (l). In
certain parts of the Northern Territory one occasionally meets with a
similar type of spear, but such in all probability is imported from the
west.
The popular spear of central Australian tribes consists of a light
shaft fashioned out of a shoot of the wild tecoma bush (T. Australis),
which carries a long-bladed head of hard mulga wood. The junction
is made between the two pieces by cutting them both on a slope,
sticking these surfaces together with hot resin, and securely binding
them with kangaroo tendon. The bottom end is similarly bound and a
small hole made in its base to receive the point of the spear-thrower
(m).
As often as not the blade has a single barb of wood bound tightly
against it with tendon.
It is often difficult to find a single piece of tecoma long enough to
make a suitable shaft, in which case two pieces are taken and neatly
joined somewhere within the lower, and thinner, half with tendon.
The shoots, when cut, are always stripped of their bark and
straightened in the fire, the surfaces being subsequently trimmed by
scraping.
A very common type of spear, especially on the Daly River, and
practically all along the coast of the Northern Territory, is one with a
long reed-shaft, to which is attached, by means of a mass of wax or
gum, a stone-head, consisting of either quartzite or slate, or latterly
also of glass. The bottom end is strengthened, to receive the point of
the thrower, by winding around it some vegetable fibre (n).
The natives of Arnhem Land now and then replace the stone by a
short piece of hard wood of lanceolate shape.
If now we consider the only remaining type—a light reed-shaft, to
which is affixed a long head of hard wood, with a number of barbs
cut on one or more edges—we find a great variety of designs. The
difference lies principally in the number and size of the barbs; in
most cases they point backwards, but it is by no means rare to find a
certain number of them pointing the opposite way or standing out at
right angles to the length of the head. These spears belong
principally to the northern tribes of the Northern Territory.
The commonest form is a spear having its head carved into a
number of barbs along one side only, and all pointing backwards (o).
The number ranges from three to over two dozen, the individual
barbs being either short and straight or long and curved, with the
exception of the lowest, which in many examples sticks out at right
angles just above the point of insertion. The point is always long and
tapering. These spears are common to the Larrekiya, Wogait, Wulna,
and all Daly River tribes.
PLATE XXV
1. Aluridja widow.
2. Yantowannta widow.
Stillborn children are usually burnt in a blazing fire since they are
regarded as being possessed of the evil spirit, which was the cause
of the death.
The simplest method universally adopted, either alone or in
conjunction with other procedures, is interment.
Most of the central tribes, like the Dieri, Aluridja, Yantowannta,
Ngameni, Wongapitcha, Kukata, and others, bury their dead, whilst
the northern and southern tribes place the corpse upon a platform,
which they construct upon the boughs of a tree or upon a special set
of upright poles. The Ilyauarra formerly used to practise tree-burial,
but nowadays interment is generally in vogue.
A large, oblong hole, from two to five feet deep, is dug in the
ground to receive the body, which has previously been wrapped in
sheets of bark, skins, or nowadays blankets. Two or three men jump
into the hole and take the corpse out of the hands of other men, who
are kneeling at the edge of the grave, and carefully lower it in a
horizontal position to the bottom of the excavation. The body is made
to lie upon the back, and the head is turned to face the camp last
occupied by the deceased, or in the direction of the supposed
invisible abode of the spirit, which occupied the mortal frame about
to be consigned to the earth. The Arunndta quite occasionally place
the body in a natural sitting position. The Larrekiya, when burying an
aged person, place the body in a recumbent position, usually lying
on its right side, with the legs tucked up against the trunk and the
head reposing upon the hands, the position reminding one of that of
a fœtus in utero.
The body is covered with layers of grass, small sticks, and sheets
of bark, when the earth is scraped back into the hole. But very often
a small passage is left open at the side of the grave, by means of
which the spirit may leave or return to the human shell (i.e. the
skeleton) whenever it wishes.
The place of sepulture is marked in a variety of ways. In many
cases only a low mound is erected over the spot, which in course of
time is washed away and finally leaves a shallow depression.
The early south-eastern (Victorian) and certain central tribes place
the personal belongings, such as spear and spear-thrower in the
case of a man, and yam-stick and cooleman in the case of a woman,
upon the mound, much after the fashion of a modern tombstone. The
now fast-vanishing people of the Flinders Ranges clear a space
around the mound, and construct a shelter of stones and brushwood
at the head end. They cover the corpse with a layer of foliage and
branches, over which they place a number of slabs of slate. Finally a
mound is erected over the site.
The Adelaide and Encounter Bay tribes built wurleys or brushwood
shelters over the mound to serve the spirit of the dead native as a
resting place.
In the Mulluk Mulluk, when a man dies outside his own country, he
is buried immediately. A circular space of ground is cleared, in the
centre of which the grave is dug. After interment, the earth is thrown
back into the hole and a mound raised, which is covered with sheets
of paper-bark. The bark is kept in place by three or four flexible
wands, stuck into the ground at their ends, but closely against the
mound, transversely to its length. A number of flat stones are laid
along the border of the grave and one or two upon the mound.
In the Northern Kimberleys of Western Australia, when an
unauthorized trespasser is killed by the local tribes, the body is
placed into a cavity scooped out of an anthill, and covered up. In a
few hours, the termites rebuild the defective portion of the hill, and
the presence of a corpse is not suspected by an avenging party,
even though it be close on the heels of the murderers.
The Dieri, in the Lake Eyre district of central Australia, dispense
with the mound, but in its place they lay a number of heavy saplings
longitudinally across the grave. Their eastern neighbours, the
Yantowannta, expand this method by piling up an exceptionally large
mound, which they cover with a stout meshwork of stakes, branches,
and brushwood lying closely against the earth (Plate XXV, 1 and 2).
One of the most elaborate methods is that in vogue on Melville
and Bathurst Islands. The ground immediately encompassing the
grave is cleared, for a radius of half a chain or more, and quantities
of clean soil thrown upon it to elevate the space as a whole. The
surface is then sprinkled with ashes and shell debris. The mound
stands in the centre of this space, and is surrounded by a number of
artistically decorated posts of hard and heavy wood, or occasionally
of a lighter fibrous variety resembling that of a palm. Each of the
posts bears a distinctive design drawn in ochre upon it; several of
the series in addition have the top end carved into simple or
complicated knobs; occasionally a square hole is cut right through
the post, about a foot from the top, leaving only a small, vertical strip
of wood at each side to support the knob (Fig. 14). The designs are
drawn in red, yellow, white, and black, and represent human, animal,
emblematical, and nondescript forms.
The Larrekiya erect a sort of sign-post, at some distance from the
grave, consisting of an upright pole, to the top of which a bundle of
grass is fixed. A cross-piece is tied beneath the grass, which projects
unequally at the sides and carries an additional bundle at each
extremity. The structure resembles a scarecrow with outstretched
arms, the longer of which has a small rod inserted into the bundle of
grass to indicate the direction of the grave. Suspended from the
other arm, a few feathers or light pieces of bark are allowed to sway
in the wind and thus serve to attract the attention of any passers-by.
When the body is to be placed upon a platform, it is carried, at the
conclusion of the preliminary mourning ceremonies, shoulder high by
the bereaved relatives to the place previously prepared for the
reception of the corpse. A couple of the men climb upon the platform
and take charge of the body, which is handed to them by those
remaining below. They carefully place it in position, and lay a few
branches over it, after which they again descend to join the
mourners. The platform is constructed of boughs and bark, which are
spread between the forks of a tree or upon specially erected pillars
of wood.
The Adelaide tribe used to tie the bodies of the dead into a sitting
position, with the legs and arms drawn up closely against the chest,
and in that position kept them in the scorching sun until the tissues
were thoroughly dried around the skeleton; then the mummy was
placed in the branches of a tree, usually a casuarina or a ti-tree.
Along the reaches of the River Murray near its mouth, the
mummification of the corpse was accelerated by placing it upon a
platform and smoking it from a big fire, which was kept burning
underneath; all orifices in the body were previously closed up. When
the epidermis peeled off, the whole surface of the corpse was thickly
bedaubed with a mixture of red ochre and grease, which had the
consistency of an ordinary oil-paint. A similar mummification process
is adopted by certain of the coastal tribes of north-eastern
Queensland.
The Larrekiya, Wogait, and other northern tribes smear red ochre
all over the surface of the corpse, prior to placing it aloft, in much the
same manner as they do when going to battle. The mourners,